Cited by 341Cytomegalovirus and herpesvirus researchViral-associated cancers and disordersHerpesvirus Infections and Treatments

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Latent human herpesvirus 6 infection of human monocytes/macrophages

Kondo, K., Kondo, T., Okuno, T., Takahashi, M., Yamanishi, K.·1991·Journal of General Virology

DOI 10.1099/0022-1317-72-6-1401

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Abstract

Human herpesvirus 6 (HHV-6) DNA was detected in peripheral blood from exanthem subitum patients during the acute and convalescent phases of infection using the polymerase chain reaction. Although DNA could be detected in non-adherent and adherent mononuclear cells during the acute phase, it was detected predominantly in adherent cells during the convalescent phase; furthermore, viral DNA was found in adherent cells of healthy adults. When adherent mononuclear cells were cultured in vitro, virus was found to replicate well in differentiated cells cultured for 7 days in vitro before infection. When cells were cultured for more than 1 month, no detectable antigen and no evidence of virus growth was observed, but viral DNA could be detected. These apparently latently infected monocytes were treated with phorbol ester, after which virus could be recovered from the cultures. Therefore, we have developed an in vitro latency system for HHV-6; our results suggest that HHV-6 may latently infect monocytes in vivo and in vitro and that it may be reactivated in cells by some factors.

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Authors: Kondo, K., Kondo, T., Okuno, T., Takahashi, M., & Yamanishi, K.
Affiliations: Research Institute for Microbial Diseases, The University of Osaka (JP)
ORCID: Kondo, K.
Takahashi, M.
Yamanishi, K.
Venue: Journal of General Virology
Publisher: Microbiology Society
Published: 1991-06-01
Volume: 72
Issue: 6
Pages: 1401-1408
ISSN: 0022-1317 (ISSN-L)
1465-2099
DOI: 10.1099/0022-1317-72-6-1401
OpenAlex: W2158864742
Cited by: 341
References: 28
Citations by year: 2026: 2 · 2025: 5 · 2024: 3 · 2023: 4 · 2022: 5 · 2021: 6 · 2020: 11 · 2019: 6 · 2018: 8 · 2017: 10 · 2016: 9 · 2015: 10 · 2014: 15 · 2013: 10 · 2012: 11
FWCI: 15.16
Type: journal article
Language: en
Open access: closed
Locations: Journal of General Virology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
Health Sciences › Medicine › Oncology › Viral-associated cancers and disorders
Health Sciences › Medicine › Infectious Diseases › Herpesvirus Infections and Treatments
Keywords: human herpesvirus 6, viral latency, monocytes, macrophages, exanthem subitum, viral DNA detection, phorbol ester, viral reactivation
MeSH terms: Adult, Antigens, Viral, Base Sequence, Cell Adhesion, Cells, Cultured, DNA, Viral, Fluorescent Antibody Technique, Herpesviridae Infections, Humans, Macrophages, Molecular Sequence Data, Monocytes, Reference Values, Tetradecanoylphorbol Acetate, Time Factors, Virus Activation, Oligonucleotide Probes, Herpesvirus 6, Human, Polymerase Chain Reaction

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