The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Hepatitis C virus core protein induces hepatic steatosis in transgenic mice.
Abstract
Hepatitis C virus (HCV) is a major cause of chronic hepatitis worldwide, which finally leads to development of hepatocellular carcinoma. Chronic hepatitis C is characterized by several histological features in the liver which discriminate it from other forms of hepatitis: bile duct damage, lymphoid follicles and steatosis (fatty change). Little is known, however, about the role of HCV or its viral proteins in the pathogenesis of hepatitis. Recently, the core protein of HCV has been suggested to have a transcriptional regulatory function, and thereby to be involved in inducing phenotypic changes in hepatocytes. To clarify whether or not the HCV core protein has an effect on pathological phenotypes in the liver, two independent transgenic mouse lines carrying the HCV core gene were established. These mice developed progressive hepatic steatosis, indicating that the HCV core protein plays a direct role in the development of hepatic steatosis, which characterizes hepatitis C. This transgenic mouse system would be a good animal model for the study of pathogenesis in human HCV infection.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.
Gavrieli, Y., Sherman, Y., & Ben-Sasson, S. A. (1992) · The Journal of cell biology · doi:10.1083/jcb.119.3.493 · Cited by 9,444
Hepatitis C virus infection is associated with the development of hepatocellular carcinoma.
Saito, I., Miyamura, T., Ohbayashi, A., Harada, H., Katayama, T., Kikuchi, S., Watanabe, Y., Koi, S., Onji, M., & Ohta, Y. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.17.6547 · Cited by 1,089
Self-citationExpression and identification of hepatitis C virus polyprotein cleavage products
Grakoui, A., Wychowski, C., Lin, C., Feinstone, S. M., & Rice, C. M. (1993) · Journal of Virology · doi:10.1128/jvi.67.3.1385-1395.1993 · Cited by 898
Houghton, M., Weiner, A., Han, J., Kuo, G., & Choo, Q.-L. (1991) · Hepatology · doi:10.1002/hep.1840140227 · Cited by 863
Scheuer, P. J., Ashrafzadeh, P., Sherlock, S., Brown, D., & Dusheiko, G. M. (1992) · Hepatology · doi:10.1002/hep.1840150402 · Cited by 537
Bach, N., Thung, S. N., & Schaffner, F. (1992) · Hepatology · doi:10.1002/hep.1840150403 · Cited by 500
Lefkowitch, J. H., Schiff, E. R., Davis, G. L., Perrillo, R. P., Lindsay, K., Bodenheimer, H. C., Balart, L. A., Ortego, T. J., Payne, J., Dienstag, J. L., et al. (1993) · Gastroenterology · doi:10.1016/0016-5085(93)90432-c · Cited by 368
Shih, C. M., Lo, S. J., Miyamura, T., Chen, S. Y., & Lee, Y. H. (1993) · Journal of Virology · doi:10.1128/jvi.67.10.5823-5832.1993 · Cited by 332
Self-citationHigh-level expression of hepatitis B virus HBx gene and hepatocarcinogenesis in transgenic mice
Koike, K., Moriya, K., Iino, S., Yotsuyanagi, H., Endo, Y., Miyamura, T., & Kurokawa, K. (1994) · Hepatology · doi:10.1002/hep.1840190403 · Cited by 287
Self-citationTranscriptional regulation of cellular and viral promoters by the hepatitis C virus core protein
Ray, R. B., Martin Lagging, L., Meyer, K., Steele, R., & Ray, R. (1995) · Virus Research · doi:10.1016/0168-1702(95)00034-n · Cited by 253
Cited by
The lipid droplet is an important organelle for hepatitis C virus production
Miyanari, Y., Atsuzawa, K., Usuda, N., Watashi, K., Hishiki, T., Zayas, M., Bartenschlager, R., Wakita, T., Hijikata, M., & Shimotohno, K. (2007) · Nature Cell Biology · doi:10.1038/ncb1631 · Cited by 1,249
The core protein of hepatitis C virus induces hepatocellular carcinoma in transgenic mice
Moriya, K., Fujie, H., Shintani, Y., Yotsuyanagi, H., Tsutsumi, T., Ishibashi, K., Matsuura, Y., Kimura, S., Miyamura, T., & Koike, K. (1998) · Nature Medicine · doi:10.1038/2053 · Cited by 1,206
Self-citationAGA technical review on nonalcoholic fatty liver disease
Sanyal, A. J. (2002) · Gastroenterology · doi:10.1053/gast.2002.36572 · Cited by 1,072
Lipid droplets and liver disease: from basic biology to clinical implications
Gluchowski, N. L., Becuwe, M., Walther, T. C., & Farese, R. V. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.32 · Cited by 677
Fibrosis in Chronic Hepatitis C Correlates Significantly With Body Mass Index and Steatosis
Hourigan, L. F., Macdonald, G. A., Purdie, D., Whitehall, V. H., Shorthouse, C., Clouston, A., & Powell, E. E. (1999) · Hepatology · doi:10.1002/hep.510290401 · Cited by 674
Metadata
- Authors
- Moriya, K., Matsuura, Y., Miyamura, T., Koike, K., Shintani, Y., Ishibashi, K., Fujie, H., & Yotsuyanagi, H.
- Venue
- Journal of General Virology
- Publisher
- Microbiology Society
- Published
- 1997-07-01
- Volume
- 78
- Issue
- 7
- Pages
- 1527-1531
- ISSN
- 0022-1317 (ISSN-L)
- 1465-2099
- OpenAlex
- W2123511080
- Cited by
- 624
- References
- 13
- FWCI
- 8.88
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Hepatitis C virus core protein induces hepatic steatosis in transgenic mice. https://app.cochat.ai/papers/10.1099/0022-1317-78-7-1527
- The paper
- Moriya, K., Matsuura, Y., Miyamura, T., Koike, K., Shintani, Y., Ishibashi, K., Fujie, H., & Yotsuyanagi, H. (1997). Hepatitis C virus core protein induces hepatic steatosis in transgenic mice. Journal of General Virology. https://doi.org/10.1099/0022-1317-78-7-1527
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
