The DOI matches its Crossref record; 203 of the 203 references it cites were found in a registry or an index.
Lipid droplets and liver disease: from basic biology to clinical implications
Open accessAbstract
Lipid droplets are dynamic organelles that store neutral lipids during times of energy excess and serve as an energy reservoir during deprivation. Many prevalent metabolic diseases, such as the metabolic syndrome or obesity, often result in abnormal lipid accumulation in lipid droplets in the liver, also called hepatic steatosis. Obesity-related steatosis, or NAFLD in particular, is a major public health concern worldwide and is frequently associated with insulin resistance and type 2 diabetes mellitus. Here, we review the latest insights into the biology of lipid droplets and their role in maintaining lipid homeostasis in the liver. We also offer a perspective of liver diseases that feature lipid accumulation in these lipid storage organelles, which include NAFLD and viral hepatitis. Although clinical applications of this knowledge are just beginning, we highlight new opportunities for identifying molecular targets for treating hepatic steatosis and steatohepatitis.
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Cited by
Bersuker, K., Peterson, C. W. H., To, M., Sahl, S. J., Savikhin, V., Grossman, E. A., Nomura, D. K., & Olzmann, J. A. (2018) · Developmental Cell · doi:10.1016/j.devcel.2017.11.020 · Cited by 346
Alcohol effects on hepatic lipid metabolism
Jeon, S., & Carr, R. (2020) · Journal of Lipid Research · doi:10.1194/jlr.r119000547 · Cited by 326
Benedé-Ubieto, R., Cubero, F. J., & Nevzorova, Y. A. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2331460 · Cited by 242
The intersection between alcohol-related liver disease and nonalcoholic fatty liver disease
Díaz, L. A., Arab, J. P., Louvet, A., Bataller, R., & Arrese, M. (2023) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-023-00822-y · Cited by 207
Lipid Droplets as Immune Modulators in Myeloid Cells
den Brok, M. H., Raaijmakers, T. K., Collado-Camps, E., & Adema, G. J. (2018) · Trends in Immunology · doi:10.1016/j.it.2018.01.012 · Cited by 203
Metadata
- Authors
- Gluchowski, N. L., Becuwe, M., Walther, T. C., & Farese, R. V.
- Venue
- Nature Reviews Gastroenterology & Hepatology
- Published
- 2017-04-21
- Volume
- 14
- Issue
- 6
- Pages
- 343-355
- ISSN
- 1759-5045 (ISSN-L)
- 1759-5053
- OpenAlex
- W2605610684
- Cited by
- 677
- References
- 203
- FWCI
- 2.80
- Type
- journal article
- Language
- en
- Open access
- green
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- Gluchowski, N. L., Becuwe, M., Walther, T. C., & Farese, R. V. (2017). Lipid droplets and liver disease: from basic biology to clinical implications. Nature Reviews Gastroenterology & Hepatology. https://doi.org/10.1038/nrgastro.2017.32
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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