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Molecular evolution and phylogeny of dengue-4 viruses.

Lanciotti, R S, Trent, D W, Gubler, D J·1997·Journal of General Virology

Abstract

Nucleotide sequences of the envelope protein genes of 19 geographically and temporally distinct dengue (DEN)-4 viruses were determined. Nucleic acid sequence comparison revealed that the identity among the DEN-4 viruses was greater than 92%. Similarity among deduced amino acids was between 96 and 100%; in most cases identical amino acid substitutions occurred among viruses from similar geographical regions. Alignment of nucleic acid sequences followed by parsimony analysis generated phylogenetic trees, which indicated that geographically independent evolution of DEN-4 viruses had occurred. DEN-4 viruses were separated into two genetically distinct subtypes (genotypes). Genotype-1 contains viruses from the Philippines, Thailand and Sri Lanka; genotype-2 consists of viruses from Indonesia, Tahiti, the Caribbean Islands (Puerto Rico, Dominica) and Central and South America.

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Metadata

Authors
Lanciotti, R. S., Trent, D. W., & Gubler, D. J.
Venue
Journal of General Virology
Published
1997-09-01
Volume
78
Issue
9
Pages
2279-2284
ISSN
  • 0022-1317 (ISSN-L)
  • 1465-2099
OpenAlex
W2142033967
Cited by
256
References
0
FWCI
6.15
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Molecular evolution and phylogeny of dengue-4 viruses. https://app.cochat.ai/papers/10.1099/0022-1317-78-9-2279
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Lanciotti, R. S., Trent, D. W., & Gubler, D. J. (1997). Molecular evolution and phylogeny of dengue-4 viruses. Journal of General Virology. https://doi.org/10.1099/0022-1317-78-9-2279

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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