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Cited by 417

The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.

Sequence analysis and genetic classification of tick-borne encephalitis viruses from Europe and Asia.

Ecker, M, Allison, S L, Meixner, T, Heinz, F X·1999·Journal of General Virology

Abstract

The epidemiology of tick-borne encephalitis virus was investigated by comparative sequence analysis of virus strains isolated in endemic areas of Europe and Asia. Phylogenetic relationships were determined from the nucleotide and amino acid sequences of the major envelope (E) protein of 16 newly sequenced strains and nine previously published sequences. Three genetic lineages could be clearly distinguished, corresponding to a European, a Far Eastern and a Siberian subtype. Amino acids characteristic for each of the subtypes ('signature' amino a cids) were identified and their location in the atomic structure of protein E was determined. The degree of variation between strains within subtypes was low and exhibited a maximum of only 2.2% at the amino acid level. A maximum difference of 5.6% was found between the three subtypes, which is in the range of variation reported for other flaviviruses.

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Metadata

Authors
Ecker, M., Allison, S. L., Meixner, T., & Heinz, F. X.
Venue
Journal of General Virology
Published
1999-01-01
Volume
80
Issue
1
Pages
179-185
ISSN
  • 0022-1317 (ISSN-L)
  • 1465-2099
OpenAlex
W2141604566
Cited by
417
References
16
FWCI
4.47
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Sequence analysis and genetic classification of tick-borne encephalitis viruses from Europe and Asia. https://app.cochat.ai/papers/10.1099/0022-1317-80-1-179
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Ecker, M., Allison, S. L., Meixner, T., & Heinz, F. X. (1999). Sequence analysis and genetic classification of tick-borne encephalitis viruses from Europe and Asia. Journal of General Virology. https://doi.org/10.1099/0022-1317-80-1-179

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