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Blood clearance rates of adenovirus type 5 in mice
Abstract
Persistence of adenovirus type 5 in blood has implications for the pathogenicity of the virus infection and for the use of this virus in oncolysis and gene therapy. In this study, the kinetics of adenovirus clearance from blood in mice has been evaluated. After a single inoculation of concentrated virus into the vena cava, virus half-life was less than 2 min. Depletion of Kupffer cells (KC) resulted in increased viraemia. After tail-vein injection, virus and latex beads co-localized within KC. An important factor in clearance by KC is the negative charge of particles. Deletion of the hexon hypervariable region 1 acidic stretch decreased the negative charge of the virion but it did not increase blood persistence. Coating with PEG (‘PEGylation’) reduced the clearance rate but also reduced infectivity.
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Cited by
Russell, S. J., Peng, K.-W., & Bell, J. C. (2012) · Nature Biotechnology · doi:10.1038/nbt.2287 · Cited by 1,428
Singh, R., Pantarotto, D., Lacerda, L., Pastorin, G., Klumpp, C., Prato, M., Bianco, A., & Kostarelos, K. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509009103 · Cited by 1,043
Human Bone Marrow–Derived Mesenchymal Stem Cells in the Treatment of Gliomas
Nakamizo, A., Marini, F., Amano, T., Khan, A., Studeny, M., Gumin, J., Chen, J., Hentschel, S., Vecil, G., Dembinski, J., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-1874 · Cited by 1,035
Polymers for gene delivery across length scales
Putnam, D. (2006) · Nature Materials · doi:10.1038/nmat1645 · Cited by 572
Parker, A. L., Waddington, S. N., Nicol, C. G., Shayakhmetov, D. M., Buckley, S. M., Denby, L., Kemball-Cook, G., Ni, S., Lieber, A., McVey, J. H., et al. (2006) · Blood · doi:10.1182/blood-2006-04-008532 · Cited by 297
Metadata
- Authors
- Alemany, R., Suzuki, K., & Curiel, D. T.
- Venue
- Journal of General Virology
- Publisher
- Microbiology Society
- Published
- 2000-11-01
- Volume
- 81
- Issue
- 11
- Pages
- 2605-2609
- ISSN
- 0022-1317 (ISSN-L)
- 1465-2099
- OpenAlex
- W2095615635
- Cited by
- 413
- References
- 0
- FWCI
- 7.24
- Type
- journal article
- Language
- en
- Open access
- closed
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- Alemany, R., Suzuki, K., & Curiel, D. T. (2000). Blood clearance rates of adenovirus type 5 in mice. Journal of General Virology. https://doi.org/10.1099/0022-1317-81-11-2605
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