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An Enzymic Analysis of NADPH Production and Consumption in Candida utilis
Open accessAbstract
Candida utilis CBS 621 was grown in chemostat cultures at D = 0.1 h-1 on glucose, xylose, gluconate, acetate, or ethanol as the growth-limiting substrate with ammonia or nitrate as the nitrogen source and analysed for NADPH-producing and NADPH-consuming enzyme activities. Nitrate and nitrite reductases were strictly NADPH-dependent. For all carbon sources, growth with nitrate resulted in elevated levels of HMP pathway enzymes. NADP+-linked isocitrate dehydrogenase did not vary significantly with the NADPH requirement for biosynthesis. Growth on ethanol strongly enhanced activity of NADP+-linked aldehyde dehydrogenase. Neither NADP+-linked malic enzyme nor transhydrogenase activities were detectable under any of the growth conditions. The absence of transhydrogenase was confirmed by the enzyme profiles of cells grown on mixtures of glucose and formate. It is concluded that the HMP pathway and possibly NADP+-linked isocitrate dehydrogenase are the major sources of NADPH in Candida utilis.
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Citations
Cited by
Redox balances in the metabolism of sugars by yeasts
VANDIJKEN, J., & SCHEFFERS, W. (1986) · FEMS Microbiology Letters · doi:10.1016/0378-1097(86)90291-0 · Cited by 641
Self-citationFlux Distributions in Anaerobic, Glucose-Limited Continuous Cultures of Saccharomyces Cerevisiae
Nissen, T. L., Schulze, U., Nielsen, J., & Villadsen, J. (1997) · Microbiology · doi:10.1099/00221287-143-1-203 · Cited by 376
Mitochondrial NADPH, transhydrogenase and disease
Rydström, J. (2006) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2006.03.010 · Cited by 256
Bakker, B. M., Bro, C., Kötter, P., Luttik, M. A. H., van Dijken, J. P., & Pronk, J. T. (2000) · Journal of Bacteriology · doi:10.1128/jb.182.17.4730-4737.2000 · Cited by 171
Oxygen dependence of metabolic fluxes and energy generation of Saccharomyces cerevisiae CEN.PK113-1A
Jouhten, P., Rintala, E., Huuskonen, A., Tamminen, A., Toivari, M., Wiebe, M., Ruohonen, L., Penttilä, M., & Maaheimo, H. (2008) · BMC Systems Biology · doi:10.1186/1752-0509-2-60 · Cited by 131
Metadata
- Authors
- Bruinenberg, P. M., Van Dijken, J. P., & Scheffers, W. A.
- Venue
- Microbiology
- Publisher
- Microbiology Society
- Published
- 1983-04-01
- Volume
- 129
- Issue
- 4
- Pages
- 965-971
- ISSN
- 1350-0872 (ISSN-L)
- 1465-2080
- OpenAlex
- W2139499351
- Cited by
- 243
- References
- 0
- FWCI
- 4.14
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Bruinenberg, P. M., Van Dijken, J. P., & Scheffers, W. A. (1983). An Enzymic Analysis of NADPH Production and Consumption in Candida utilis. Microbiology. https://doi.org/10.1099/00221287-129-4-965
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