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The Crabtree Effect: A Regulatory System in Yeast
Abstract
SUMMARY: When Saccharomyces cerevisiae is growing exponentially on glucose or fructose as carbon plus energy source, and in the presence of air, the glucose degradation proceeds mainly via aerobic fermentation. When the yeast is growing on mannose or galactose, degradation proceeds simultaneously via respiration and fermentation. This situation results from a repression of the of the respiratory enzymes synthesis by high fermentation rates. This regulatory system, called the “Crabtree effect”, consists actually of a repression of an energy source (respiration) by another energy source (fermentation). Various yeast strains were tested; the regulatory system was present in about 50% of them.
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Cited by
Biochemistry and Evolution of Anaerobic Energy Metabolism in Eukaryotes
Müller, M., Mentel, M., van Hellemond, J. J., Henze, K., Woehle, C., Gould, S. B., Yu, R.-Y., van der Giezen, M., Tielens, A. G. M., & Martin, W. F. (2012) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.05024-11 · Cited by 838
Overflow metabolism in Escherichia coli results from efficient proteome allocation
Basan, M., Hui, S., Okano, H., Zhang, Z., Shen, Y., Williamson, J. R., & Hwa, T. (2015) · Nature · doi:10.1038/nature15765 · Cited by 785
Redox balances in the metabolism of sugars by yeasts
VANDIJKEN, J., & SCHEFFERS, W. (1986) · FEMS Microbiology Letters · doi:10.1016/0378-1097(86)90291-0 · Cited by 641
Increased demand for NAD(+) relative to ATP drives aerobic glycolysis
Luengo, A., Li, Z., Gui, D. Y., Sullivan, L. B., Zagorulya, M., Do, B. T., Ferreira, R., Naamati, A., Ali, A., Lewis, C. A., et al. (2021) · Molecular Cell · doi:10.1016/j.molcel.2020.12.012 · Cited by 547
An evolutionary perspective on the Crabtree effect
Pfeiffer, T., & Morley, A. (2014) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2014.00017 · Cited by 318
Metadata
- Authors
- DE DEKEN, R. H.
- Venue
- Journal of General Microbiology
- Publisher
- Microbiology Society
- Published
- 1966-08-01
- Volume
- 44
- Issue
- 2
- Pages
- 149-156
- ISSN
- 0022-1287 (ISSN-L)
- OpenAlex
- W2123782813
- Cited by
- 876
- References
- 0
- FWCI
- 2.59
- Type
- journal article
- Language
- en
- Open access
- closed
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- DE DEKEN, R. H. (1966). The Crabtree Effect: A Regulatory System in Yeast. Journal of General Microbiology. https://doi.org/10.1099/00221287-44-2-149
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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