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Treatment of experimental infections of mice with bacteriophages
Abstract
Bacteriophages for Acinetobacter baumanii, Pseudomonas aeruginosa and Staphylococcus aureus were tested in experimental infections of mice to investigate their potential for the treatment of infections of man. As few as 10(2) particles of an acinetobacter phage protected mice against 5 LD50 (1 x 10(8)) of a virulent strain of A. baumanii, and phage was demonstrated to have multiplied in the mice. A pseudomonas phage protected mice against 5 LD50 of a virulent strain of P. aeruginosa, with a PD50 of 1.2 x 10(7) particles. A staphylococcal phage failed to protect mice infected with a strain of S. aureus. These studies support the view that bacteriophages could be useful in the treatment of human infections caused by antibiotic-resistant strains of bacteria.
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Citations
Cited by
Emerging Strategies to Combat ESKAPE Pathogens in the Era of Antimicrobial Resistance: A Review
Mulani, M. S., Kamble, E. E., Kumkar, S. N., Tawre, M. S., & Pardesi, K. R. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.00539 · Cited by 1,644
Wong, T. Y., Preston, L. A., & Schiller, N. L. (2000) · Annual Review of Microbiology · doi:10.1146/annurev.micro.54.1.289 · Cited by 669
Summers, W. C. (2001) · Annual Review of Microbiology · doi:10.1146/annurev.micro.55.1.437 · Cited by 474
Barrow, P., Lovell, M., & Berchieri, A. (1998) · Clinical Diagnostic Laboratory Immunology · doi:10.1128/cdli.5.3.294-298.1998 · Cited by 293
Metadata
- Authors
- SOOTHILL, J. S.
- Venue
- Journal of Medical Microbiology
- Publisher
- Microbiology Society
- Published
- 1992-10-01
- Volume
- 37
- Issue
- 4
- Pages
- 258-261
- ISSN
- 0022-2615 (ISSN-L)
- 1473-5644
- OpenAlex
- W2071250637
- Cited by
- 220
- References
- 0
- FWCI
- 2.42
- Type
- journal article
- Language
- en
- Open access
- closed
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- SOOTHILL, J. S. (1992). Treatment of experimental infections of mice with bacteriophages. Journal of Medical Microbiology. https://doi.org/10.1099/00222615-37-4-258
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
