The effect of lactulose on the faecal flora of patients with hepatic encephalopathy
Abstract
SUMMARY The changes that occurred in the faecal flora during the separate administration of lactulose and magnesium sulphate were studied in five patients with hepatic encephalopathy. Lactulose therapy produced significant increases in lactobacillus counts in three patients, and two of these patients showed clinical improvement. No systematic change occurred in the counts of other organisms during either treatment; in particular it was not possible to correlate clinical improvement with a reduction in the count of the two groups of organisms-enterobacteria and Bacteroides spp.-that are considered to be most active in the production of ammonia.
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In the large intestine, lactulose is broken down by colonic bacteria primarily to lactic acid, and also to small amounts of formic and acetic acids.
“In the large intestine lactulose is broken down by the action of colonic bacteria primarily to lactic acid, and also to small amounts of formic and acetic acids [56,57].”
From Nitrate reduction to nitrite, nitric oxide and ammonia by gut bacteria under physiological conditions (2015) · cites this paper as [57]
Cites
TREATMENT OF CHRONIC HEPATIC ENCEPHALOPATHY WITH LACTULOSE
Fung, W. P., & Khoo, O. T. (1968) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.1968.tb29379.x · Cited by 20 · see citing works
Control of chronic portal-systemic encephalopathy by lactulose.
Elkington, S. G., Mh, F., & Conn, H. O. (1969) · PubMed · Cited by 7 · see citing works
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Tiso, M., & Schechter, A. N. (2015) · PLOS ONE · doi:10.1371/journal.pone.0119712 · Cited by 311 · see citing works
Anticarcinogenic, hypocholesterolemic, and antagonistic activities of Lactobacillus acidophilus
Mitall, B. K., & Garg, S. K. (1995) · Critical Reviews in Microbiology · doi:10.3109/10408419509113540 · Cited by 97 · see citing works
Comparative modes of action of lactitol and lactulose in the treatment of hepatic encephalopathy.
Patil, D. H., Westaby, D., Mahida, Y. R., Palmer, K. R., Rees, R., Clark, M. L., Dawson, A. M., & Silk, D. B. (1987) · Gut · doi:10.1136/gut.28.3.255 · Cited by 87 · see citing works
Self-citation
- Authors
- VINCE, A., ZEEGEN, R., DRINKWATER, J. E., O'GRADY, F., & DAWSON, A. M.
- Affiliations
- St Bartholomew's Hospital (GB)
- Venue
- Journal of Medical Microbiology
- Publisher
- Microbiology Society
- Published
- 1974-05-01
- Volume
- 7
- Issue
- 2
- Pages
- 163-168
- ISSN
- 0022-2615 (ISSN-L)
- 1473-5644
- OpenAlex
- W2014254393
- Cited by
- 41
- References
- 2
- Citations by year
- 2021: 1 · 2020: 1 · 2019: 1 · 2017: 1 · 2015: 1 · 2014: 1 · 2012: 1
- FWCI
- 1.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Medical Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- lactulose, hepatic encephalopathy, fecal microbiota, lactobacilli, magnesium sulfate, ammonia synthesis, Enterobacteriaceae, Bacteroides, gut microbiota
- MeSH terms
- Bacteria, Bacteriological Techniques, Bacteroides, Cell Count, Clostridium, Computers, Diet Therapy, Dietary Proteins, Disaccharides, Escherichia coli, Feces, Female, Hepatic Encephalopathy, Humans, Lactobacillus, Lactulose, Magnesium Sulfate, Male, Species Specificity, Streptococcus
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