The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Candida dubliniensis sp. nov.: phenotypic and molecular characterization of a novel species associated with oral candidosis in HIV-infected individuals
Abstract
Atypical oral Candida isolates were recovered from 60 HIV-infected and three HIV-negative individuals. These organisms were germ-tube-positive and produced abundant chlamydospores which were frequently arranged in triplets or in contiguous pairs. They belonged to C. albicans serotype A and had atypical carbohydrate assimilation profiles. Fingerprinting the genomic DNA of a selection of these organisms with the C. albicans-specific probe 27A and five separate oligonucleotides, homologous to eukaryotic microsatellite repeat sequences, demonstrated that they had a very distinct genomic organization compared to C. albicans and C. stellatoidea. This was further established by random amplified polymorphic DNA (RAPD) and karyotype analysis. Comparison of 500 bp of the V3 variable region of the large ribosomal subunit genes from nine atypical isolates and the corresponding sequences determined from C. albicans, C. stellatoidea, C. tropicalis, C. parapsilosis, C. glabrata, C. kefyr and C. krusei showed that they atypical organisms formed a homogeneous cluster (100% similarity) that was significantly different from the other Candida species analysed, but was most closely related to C. albicans and C. stellatoidea. These genetic data combined with the phenotypic characteristics of these atypical organisms strongly suggest that they constitute a novel species within the genus Candida for which the name Candida dubliniensis is proposed.
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“The closely related species Candida dubliniensis, Candida parapsilosis, Candida tropicalis, and Candida krusei have all been implicated in biofilm-associated infections (73, 157, 187).”
From Candida albicans Biofilms and Human Disease (2015) · cites this paper as [187]
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Metadata
- Authors
- Sullivan, D. J., Haynes, K. A., Bennett, D. E., Coleman, D. C., & Westerneng, T. J.
- Affiliations
- Trinity College Dublin (IE)
- Corresponding author
- Coleman, David C.
- Venue
- Microbiology
- Publisher
- Microbiology Society
- Published
- 1995-07-01
- Volume
- 141
- Issue
- 7
- Pages
- 1507-1521
- ISSN
- 1350-0872 (ISSN-L)
- 1465-2080
- OpenAlex
- W2082335793
- Semantic Scholar
- bc1866fcc82d470795213926e69431c4af69d52c
- Cited by
- 763
- References
- 24
- Citations by year
- 2026: 8 · 2025: 10 · 2024: 10 · 2023: 17 · 2022: 12 · 2021: 14 · 2020: 14 · 2019: 6 · 2018: 16 · 2017: 21 · 2016: 20 · 2015: 32 · 2014: 42 · 2013: 26 · 2012: 27
- FWCI
- 13.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Immunology and Microbiology › Microbiology › Yeasts and Rust Fungi Studies
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Pathogens and Fungal Diseases
- Keywords
- Candida dubliniensis, oral candidiasis, HIV infection, chlamydospores, germ tube formation, carbohydrate assimilation, microsatellite fingerprinting, RAPD, karyology, Candida albicans, Candida stellatoidea
- MeSH terms
- Acquired Immunodeficiency Syndrome, Base Sequence, Candida, Candidiasis, Oral, DNA, Fungal, DNA, Ribosomal, Humans, Karyotyping, Molecular Sequence Data, Phenotype, Phylogeny, Spores, Polymerase Chain Reaction, DNA Fingerprinting, AIDS-Related Opportunistic Infections, Carbohydrate Metabolism
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