CoChat
Sign Up
Cited by 5Antifungal resistance and susceptibilityFungal Infections and StudiesActinomycetales infections and treatment

In vitro inhibitory effect of statins on planktonic cells and biofilms of the Sporothrix schenckii species complex

Brilhante, Raimunda Sâmia Nogueira, Fonseca, Xhaulla Maria Quariguasi Cunha, Pereira, Vandbergue Santos, Araújo, Géssica dos Santos, Oliveira, Jonathas Sales de, Garcia, Lana Glerieide Silva, Rodrigues, Anderson Messias, Camargo, Zoilo Pires de +5 more·2020·Journal of Medical Microbiology
DOI 10.1099/jmm.0.001195
Open this paper in CoChat — free account

Abstract

Introduction. Sporotrichosis, caused by species of the Sporothrix schenckii complex, is the most prevalent subcutaneous mycosis in many areas of Latin America. Statins are a class of drugs widely used for lowering high sterol levels through their action on 3-hydroxy-3-methylglutaryl-CoA reductase, a key enzyme in the synthesis of sterol. Aim. In this study, the antifungal activity of statins (simvastatin, atorvastatin, pravastatin) against planktonic cells and biofilms of S. schenckii complex species was evaluated, as well as the interaction of pravastatin with classical antifungals (amphotericin B, itraconazole, terbinafine). Methodology. Eighteen strains of Sporothrix species were used. The antifungal susceptibility assay was performed using the broth microdilution method. Mature biofilms were exposed to statins and metabolic activity was measured by the XTT reduction assay. Results. MICs of statins ranged from 8 to 512 μg ml−1 and from 8 to 256 μg ml−1 for filamentous and yeast forms, respectively. Regarding mature biofilms, MICs of 50 % inhibition (SMIC50) were 128 μg ml−1 for simvastatin and atorvastatin and >2048 μg ml−1 for pravastatin. MICs of 90 % inhibition (SMIC90) were 512 μg ml−1 for simvastatin and >2048 μg ml−1 for atorvastatin and pravastatin. Conclusion. These results highlight the antifungal and antibiofilm potential of statins against S. schenckii complex species.

Integrity signals

Registry

Crossref · 10.1099/jmm.0.001195

Cites

25 of 25 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Statins exhibit a broad spectrum of biological activities, including antimicrobial, antiparasitic, antibacterial, antiviral, and antifungal potential.

    “Moreover, statins exhibit a broad spectrum of biological activities, including antimicrobial, antiparasitic, antibacterial, antiviral, and antifungal potential [110, 111, 112, 113].”

    From Statins as Antifungal Agents: A Review on Drug Repurposing and Nanotechnology-Driven Delivery Strategies (2025) · cites this paper as [113]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Brilhante, R. S. N., Fonseca, X. M. Q. C., Pereira, V. S., Araújo, G. D. S., Oliveira, J. S. D., Garcia, L. G. S., Rodrigues, A. M., Camargo, Z. P. D., Pereira-Neto, W. A., Castelo-Branco, D. D. S. C. M., Cordeiro, R. D. A., Sidrim, J. J. C., & Rocha, M. F. G.
Affiliations
  • Universidade Federal do Ceará (BR)
  • Universidade Estadual do Ceará (BR)
  • Universidade Federal de São Paulo (BR)
  • Cellular Biology Division, Department of Microbiology, Immunology and Parasitology, Federal University of São Paulo, Sao Paulo, São Paulo, 04023-062, Brazil
  • Specialized Center in Medical Mycology, Postgraduate Program in Medical Microbiology, Department of Pathology and Forensic Medicine, Federal University of Ceará, Fortaleza, Ceará, 60430-275, Brazil
ORCID
Venue
Journal of Medical Microbiology
Publisher
Microbiology Society
Published
2020-06-01
Volume
69
Issue
6
Pages
838-843
ISSN
  • 0022-2615 (ISSN-L)
  • 1473-5644
DOI
10.1099/jmm.0.001195
OpenAlex
W3028310048
Cited by
5
References
25
Citations by year
2026: 1 · 2025: 1 · 2024: 1 · 2023: 2
FWCI
0.07
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Medical Microbiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
CNPq (305024/2017-5)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
  • Health Sciences › Medicine › Microbiology › Actinomycetales infections and treatment
Keywords
Sporothrix schenckii, sporotrichosis, statins, antifungal activity, biofilm, planktonic cells, pravastatin, simvastatin, atorvastatin, 3-hydroxy-3-methylglutaryl-CoA reductase, antifungal drug interactions, amphotericin B, itraconazole, terbinafine, subcutaneous mycosis, minimum inhibitory concentration
MeSH terms
Antifungal Agents, Microbial Sensitivity Tests, Plankton, Sporothrix, Biofilms, Hydroxymethylglutaryl-CoA Reductase Inhibitors

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review