The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Antifungal activity of the essential oil of Thymus pulegioides on Candida, Aspergillus and dermatophyte species
Abstract
The composition of the essential oil of Thymus pulegioides and its antifungal activity on Candida, Aspergillus and dermatophyte fungal strains were studied. Essential oil from the aerial parts of the plant was obtained by hydrodistillation and analysed by GC and GC-MS. The oil showed high contents of carvacrol and thymol. The MIC and minimal lethal concentration were used to evaluate the antifungal activity against Candida (seven clinical isolates and four ATCC type strains), Aspergillus [five clinical isolates, and two Colección Española de Cultivos Tipo (CECT) and two ATCC type strains] and five clinical dermatophyte strains. Antifungal activity was evaluated for the essential oil and for its main components. To clarify its mechanism of action on yeasts and filamentous fungi, flow-cytometric studies of cytoplasmic membrane integrity were performed, and the effect on the amount of ergosterol was investigated. Results showed that T. pulegioides essential oil exhibited a significant activity against clinically relevant fungi, mainly due to lesion formation in the cytoplasmic membrane and a considerable reduction of the ergosterol content. The present study indicates that T. pulegioides essential oil has considerable antifungal activity, deserving further investigation for clinical applications.
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Cites
Trends in Mortality Due to Invasive Mycotic Diseases in the United States, 1980–1997
McNeil, M. M., Nash, S. L., Hajjeh, R. A., Phelan, M. A., Conn, L. A., Plikaytis, B. D., & Warnock, D. W. (2001) · Clinical Infectious Diseases · doi:10.1086/322606 · Cited by 657
Arthington-Skaggs, B. A., Jradi, H., Desai, T., & Morrison, C. J. (1999) · Journal of Clinical Microbiology · doi:10.1128/jcm.37.10.3332-3337.1999 · Cited by 365
Antifungal activity of Thymus oils and their major compounds
Pina‐Vaz, C., Gonçalves Rodrigues, A., Pinto, E., Costa‐de‐Oliveira, S., Tavares, C., Salgueiro, L., Cavaleiro, C., Gonçalves, M., & Martinez‐de‐Oliveira, J. (2004) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/j.1468-3083.2004.00886.x · Cited by 359
Self-citation
Cited by
Pinto, E., Vale-Silva, L., Cavaleiro, C., & Salgueiro, L. (2009) · Journal of Medical Microbiology · doi:10.1099/jmm.0.010538-0 · Cited by 699
Self-citationEl-Saber Batiha, G., Alkazmi, L. M., Wasef, L. G., Beshbishy, A. M., Nadwa, E. H., & Rashwan, E. K. (2020) · Biomolecules · doi:10.3390/biom10020202 · Cited by 643
Ahmad, A., Khan, A., Akhtar, F., Yousuf, S., Xess, I., Khan, L. A., & Manzoor, N. (2011) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-010-1050-8 · Cited by 431
Medicinal Plants of the Family Lamiaceae in Pain Therapy: A Review
Uritu, C. M., Mihai, C. T., Stanciu, G.-D., Dodi, G., Alexa-Stratulat, T., Luca, A., Leon-Constantin, M.-M., Stefanescu, R., Bild, V., Melnic, S., et al. (2018) · Pain Research and Management · doi:10.1155/2018/7801543 · Cited by 367
Tian, J., Huang, B., Luo, X., Zeng, H., Ban, X., He, J., & Wang, Y. (2012) · Food Chemistry · doi:10.1016/j.foodchem.2011.07.061 · Cited by 273
Metadata
- Authors
- Pinto, E., Pina-Vaz, C., Salgueiro, L., Gonçalves, M. J., Costa-de-Oliveira, S., Cavaleiro, C., Palmeira, A., Rodrigues, A., & Martinez-de-Oliveira, J.
- Venue
- Journal of Medical Microbiology
- Publisher
- Microbiology Society
- Published
- 2006-10-01
- Volume
- 55
- Issue
- 10
- Pages
- 1367-1373
- ISSN
- 0022-2615 (ISSN-L)
- 1473-5644
- OpenAlex
- W2141078073
- Cited by
- 330
- References
- 3
- FWCI
- 11.84
- Type
- journal article
- Language
- en
- Open access
- closed
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- Pinto, E., Pina-Vaz, C., Salgueiro, L., Gonçalves, M. J., Costa-de-Oliveira, S., Cavaleiro, C., Palmeira, A., Rodrigues, A., & Martinez-de-Oliveira, J. (2006). Antifungal activity of the essential oil of Thymus pulegioides on Candida, Aspergillus and dermatophyte species. Journal of Medical Microbiology. https://doi.org/10.1099/jmm.0.46443-0
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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