The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Identification of 2019-nCoV related coronaviruses in Malayan pangolins in southern China
Abstract
The ongoing outbreak of viral pneumonia in China and beyond is associated with a novel coronavirus, provisionally termed 2019-nCoV. This outbreak has been tentatively associated with a seafood market in Wuhan, China, where the sale of wild animals may be the source of zoonotic infection. Although bats are likely reservoir hosts for 2019-nCoV, the identity of any intermediate host facilitating transfer to humans is unknown. Here, we report the identification of 2019-nCoV related coronaviruses in pangolins ( Manis javanica ) seized in anti-smuggling operations in southern China. Metagenomic sequencing identified pangolin associated CoVs that belong to two sub-lineages of 2019-nCoV related coronaviruses, including one very closely related to 2019-nCoV in the receptor-binding domain. The discovery of multiple lineages of pangolin coronavirus and their similarity to 2019-nCoV suggests that pangolins should be considered as possible intermediate hosts for this novel human virus and should be removed from wet markets to prevent zoonotic transmission.
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Cites
A new coronavirus associated with human respiratory disease in China
Wu, F., Zhao, S., Yu, B., Chen, Y.-M., Wang, W., Song, Z.-G., Hu, Y., Tao, Z.-W., Tian, J.-H., Pei, Y.-Y., et al. (2020) · Nature · doi:10.1038/s41586-020-2008-3 · Cited by 11,688
Wan, Y., Shang, J., Graham, R., Baric, R. S., & Li, F. (2020) · Journal of Virology · doi:10.1128/jvi.00127-20 · Cited by 4,341
Cited by
Coronavirus Disease 2019 (COVID-19): A Perspective from China
Zu, Z. Y., Jiang, M. D., Xu, P. P., Chen, W., Ni, Q. Q., Lu, G. M., & Zhang, L. J. (2020) · Radiology · doi:10.1148/radiol.2020200490 · Cited by 2,070
“On the basis of current data, it seems that COVID-19 might be initially hosted by bats, and might have been transmitted to humans via pangolin (22) or other wild animals (17,23) sold at the Huanan seafood market but subsequent spread via human-to-human transmission.”
Virology, Epidemiology, Pathogenesis, and Control of COVID-19
Jin, Y., Yang, H., Ji, W., Wu, W., Chen, S., Zhang, W., & Duan, G. (2020) · Viruses · doi:10.3390/v12040372 · Cited by 1,603
Wang, Y., Wang, Y., Chen, Y., & Qin, Q. (2020) · Journal of Medical Virology · doi:10.1002/jmv.25748 · Cited by 1,531
The SARS-CoV-2 outbreak: What we know
Wu, D., Wu, T., Liu, Q., & Yang, Z. (2020) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2020.03.004 · Cited by 1,431
Probable Pangolin Origin of SARS-CoV-2 Associated with the COVID-19 Outbreak
Zhang, T., Wu, Q., & Zhang, Z. (2020) · Current Biology · doi:10.1016/j.cub.2020.03.022 · Cited by 1,397
Metadata
- Authors
- Lam, T. T.-Y., Shum, M. H.-H., Zhu, H.-C., Tong, Y.-G., Ni, X.-B., Liao, Y.-S., Wei, W., Cheung, W. Y.-M., Li, W.-J., Li, L.-F., Leung, G. M., Holmes, E. C., Hu, Y.-L., & Guan, Y.
- Venue
- The Sydney eScholarship Repository (The University of Sydney)
- Publisher
- openRxiv
- Published
- 2020-02-18
- OpenAlex
- W4252589030
- Cited by
- 208
- References
- 2
- Type
- posted content
- Language
- en
- Open access
- closed
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- Lam, T. T.-Y., Shum, M. H.-H., Zhu, H.-C., Tong, Y.-G., Ni, X.-B., Liao, Y.-S., Wei, W., Cheung, W. Y.-M., Li, W.-J., Li, L.-F., Leung, G. M., Holmes, E. C., Hu, Y.-L., & Guan, Y. (2020). Identification of 2019-nCoV related coronaviruses in Malayan pangolins in southern China. The Sydney eScholarship Repository (The University of Sydney). https://doi.org/10.1101/2020.02.13.945485
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