Long wavelength light that improves aged mitochondrial function selectively increases cytokine expression in serum and the retina
Open accessAbstract
Aged mitochondrial function can be improved with long wavelength light exposure. This reduces cellular markers of inflammation and can improve system function from fly though to human. Here, we ask what impact 670nm light has on cytokine expression using a 40 cytokine array in blood serum and retina in C57Bl6 mice. There was a relatively uniform increase in cytokine expression between 3 and 12 months of age in serum and retina. 670nm exposure was delivered daily for a week in 12 month old mice. This shifted patterns of cytokine expression in both serum and retina inducing a selective increase with some in serum increasing >5 fold. Changes in retina were smaller. In serum there were major increases in IL-7, 6, 13, 16 and 23, also in TNF-α and CXCL 9 and 10. In retina the increases were found mainly in some IL (interleukins) and CXCL’s (chemokines). A few cytokines were reduced by light exposure. Changes in serum cytokines implies that long wavelengths impacts systemically even to unexposed tissues deep in the body. In the context of wider literature, increased cytokine expression may be protective. However, their upregulation by light merits further analysis as cytokines upregulation can also be negative.
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CCL11, CXCL11, and IL-1β are elevated in aged mouse retinae.
“Transfer of young donor microbiota results in a decrease in aged mice of cytokines involved in inflammatory immune cell recruitment and pro-inflammatory signaling, including CCL11 (eotaxin), CXCL11, and IL-1β [23, 62, 84], all of which are elevated in aged mouse retinae [108].”
From Fecal microbiota transfer between young and aged mice reverses hallmarks of the aging gut, eye, and brain (2022) · cites this paper as [108]
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- Authors
- Shinhmar, H., Hogg, C., & Jeffery, G.
- Affiliations
- University College London (GB)
- Corresponding author
- Jeffery, Glen
- ORCID
- Jeffery, Glen
- Venue
- bioRxiv (Cold Spring Harbor Laboratory)
- Publisher
- openRxiv
- Published
- 2021-11-10
- OpenAlex
- W3213105152
- Cited by
- 1
- References
- 39
- Citations by year
- 2022: 1
- Type
- posted content
- Language
- en
- Open access
- green
- doi.org
- Locations
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion)
- Funders
- Biotechnology and Biological Sciences Research Council (N000250/1, BB/N000250/1, BBSRC BB/N000250/1)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Laser Applications in Dentistry and Medicine
- Health Sciences › Medicine › Ophthalmology › Ocular and Laser Science Research
- Health Sciences › Medicine › Physiology › Biofield Effects and Biophysics
- Keywords
- long-wavelength light, mitochondrial aging, mitochondrial function, cytokine expression, serum cytokines, retina, inflammation, interleukins, chemokines, TNF-α, CXCL9, CXCL10
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