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Extant hybrids of RNA viruses and viroid-like elements
Open accessPreprint — published as 10.1038/s41467-023-38301-2
Abstract
Earth’s life may have originated as self-replicating RNA. Some of the simplest current RNA replicators are RNA viruses, defined by linear RNA genomes encoding an RNA-dependent RNA polymerase (RdRP), and subviral agents with single-stranded, circular RNA genomes, such as viroids encoding paired self-cleaving ribozymes. Amongst a massive expansion of candidate viroid and viroid-like elements, we report that fungal pathogens, ambiviruses, are viroid-like elements which undergo rolling circle replication and encode their own viral RdRP, thus they are a distinct hybrid infectious agent. These findings point to a deep evolutionary history between modern RNA viruses and sub-viral elements and offer new perspectives on the evolution of primordial infectious agents, and RNA life. One-Sentence Summary: Novel infectious agents resembling self-cleaving viroid-like RNAs whilst encoding a viral RNA-dependent RNA polymerase.
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Highly accurate protein structure prediction with AlphaFold
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Metadata
- Authors
- Forgia, M., Navarro, B., Daghino, S., Cervera, A., Gisel, A., Perotto, S., Aghayeva, D. N., Akinyuwa, M. F., Gobbi, E., Zheludev, I. N., Edgar, R. C., Chikhi, R., Turina, M., Babaian, A., Serio, F. D., & de la Peña, M.
- Affiliations
- Institute for Sustainable Plant Protection (IT)
- Consejo Superior de Investigaciones Científicas (ES)
- International Institute of Tropical Agriculture (NG)
- University of Turin (IT)
- Institute of Botany (AZ)
- University of Padua (IT)
- University of Brescia (IT)
- Stanford University (US)
- Institut Pasteur (FR)
- University of Toronto (CA)
- Corresponding author
- Turina, Massimo
- Babaian, Artem
- Serio, Francesco Di
- de la Peña, Marcos
- ORCID
- Venue
- Nature Communications
- Publisher
- openRxiv
- Published
- 2022-08-21
- Volume
- 14
- Issue
- 1
- Pages
- 2591-2591
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC10162972
- OpenAlex
- W4372331783
- Cited by
- 83
- References
- 1
- Citations by year
- 2026: 13 · 2025: 20 · 2024: 33 · 2023: 16 · 2022: 1
- FWCI
- 15.21
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Nature Communications (publishedVersion, cc-by)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HAL (submittedVersion, cc-by)
- CGSPace A Repository of Agricultural Research Outputs (Consultative Group for International Agricultural Research) (submittedVersion, cc-by)
- Institutional Research Information System (Università degli Studi di Brescia) (submittedVersion, cc-by-nc-nd)
- Institutional Research Information System University of Turin (University of Turin) (submittedVersion, public-domain)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- European Commission
- Ministerio de Economía y Competitividad (PID2020-116008GB-I00, PID2020)
- University of British Columbia
- Canadian Institutes of Health Research
- Erasmus+
- Topics
- Life Sciences › Immunology and Microbiology › Virology › Plant and Fungal Interactions Research
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Virus Research Studies
- Life Sciences › Immunology and Microbiology › Virology › Bacteriophages and microbial interactions
- Keywords
- RNA viruses, mycoviruses, rolling circle replication, RNA-dependent RNA polymerase, self-cleaving ribozymes, circular RNA, RNA world, origin of life
- MeSH terms
- Fungi, RNA, RNA-Dependent RNA Polymerase, RNA Viruses, RNA, Viral, Viroids, Virus Replication, RNA, Catalytic
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