The molecular basis for the genetic code.
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Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences.
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The structure of the SGC is nonrandom.
“The structure of the SGC is nonrandom”
From Origin and Evolution of the Universal Genetic Code (2017) · cites this paper as [84]
The structure of the SGC is manifestly regular with respect to multiple criteria.
“The structure of the SGC-that is, the mapping of 64 codons to 20 amino acids and the stop signal-is manifestly regular with respect to multiple criteria (44, 84).”
From Origin and Evolution of the Universal Genetic Code (2017) · cites this paper as [84]
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“Therefore, in order to calculate error minimization, substitution derived amino acid similarity matrices should be avoided, and matrices based on physicochemical amino acid similarity are more appropriate, the first of which was derived specifically in order to examine genetic code evolution [24].”
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- Authors
- Woese, C. R., Dugre, D. H., Saxinger, W. C., & Dugre, S. A.
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1966-04
- Volume
- 55
- Issue
- 4
- Pages
- 966-974
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC224258
- OpenAlex
- W1970443025
- Cited by
- 270
- References
- 6
- Citations by year
- 2026: 12 · 2025: 7 · 2024: 6 · 2023: 16 · 2022: 2 · 2021: 12 · 2020: 13 · 2019: 12 · 2018: 13 · 2017: 12 · 2016: 11 · 2015: 9 · 2014: 12 · 2013: 6 · 2012: 4
- FWCI
- 1.90
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Origins and Evolution of Life
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
- Keywords
- genetic code, codon, amino acid assignment, protein synthesis
- MeSH terms
- Amino Acids, Chemistry, Chromatography, Paper, Genetic Code, Pyridines, Solvents, Protein Biosynthesis, Water, Chemical Phenomena
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