CoChat
Sign Up
PreprintCited by 112Plant Molecular Biology ResearchLight effects on plantsPlant nutrient uptake and metabolism

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

ABLs and TMKs are co-receptors for extracellular auxin

Open access
Yu, Yongqiang, Tang, Wenxin, Lin, Wenwei, Li, Wei, Zhou, Xiang, Li, Ying, Chen, Rong, Zheng, Rui, Qin, Guochen, Cao, Wenhan, Perez, Patricio, Huang, Rongfeng, Ma, Jun, Lin, Juncheng, Jiang, Liwen, Xu, Tongda, Yang, Zhenbiao·2022·Cell
DOI 10.1101/2022.11.28.518138PMC PMC10827329

Preprint — published as 10.1016/j.cell.2023.10.017

Open this paper in CoChat — free account

Abstract

SUMMARY: Extracellular perception of auxin, an essential phytohormone in plants, has been debated for decades. Auxin binding protein 1 (ABP1) physically interacts with quintessential transmembrane kinases (TMKs) and was proposed to act as an extracellular auxin receptor, but its role was disputed because abp1 knockout mutants lack obvious morphological phenotypes. Here we identified two new auxin-binding proteins, ABL1 and ABL2, that are localized to the apoplast and directly interact with the extracellular domain of TMKs in an auxin-dependent manner. Furthermore, functionally redundant ABL1 and ABL2 genetically interact with TMKs and exhibit functions that are overlapping with those of ABP1 as well as independent of ABP1. Importantly, the extracellular domain of TMK1 itself binds auxin and synergizes with either ABP1 or ABL1 in auxin binding. Thus, our findings discovered new auxin receptors ABL1 and ABL2 having functions overlapping with but distinct from ABP1 and acting together with TMKs as co-receptors for extracellular auxin.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1101/2022.11.28.518138

Cites

1 of 1 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Flagged first, then by citations

Research works printed but not linked: 78

  1. 10.1016/j.tplants.2021.11.006 · DOI
  2. 10.1016/j.cell.2010.09.003 · DOI
  3. 10.1038/s41586-022-05187-x · DOI
  4. 10.1007/BF00397530 · DOI
  5. 10.1104/pp.110.3.1007 · DOI
  6. 10.1038/s41467-018-03582-5 · DOI
  7. 10.1101/cshperspect.a039891 · DOI
  8. 10.1105/tpc.114.133744 · DOI
  9. 10.1038/nchembio.926 · DOI
  10. 10.1038/nature03542 · DOI
  11. 10.1038/nature03543 · DOI · Paper page
  12. 10.1038/s41586-022-05369-7 · DOI
  13. 10.1016/j.pbi.2006.07.006 · DOI
  14. 10.1038/s41586-021-03976-4 · DOI
  15. 10.1126/science.1245125 · DOI
  16. 10.1038/s41467-019-08575-6 · DOI
  17. 10.1038/s41477-018-0190-1 · DOI
  18. 10.1146/annurev-arplant-073019-025907 · DOI
  19. 10.1038/s41477-021-00969-z · DOI
  20. Kuhn A, R.M. , Carrasco P , Mutte S , Bronkhorst J , Dubey S , Galen M , Monzer A , Nishihama R , Kohchi T , Fendrych M , Friml J , Sprakel J , Weijers D (2022). A RAF-like kinase mediates a deeply conserved, ultra-rapid auxin response. Cell Submitted. · DOI
  21. Roosjen M, K.A. , Mutte S.K , Boeren S , Krupar P , Koehorst J , Fendrych M , Friml J and Weijers D (2022). An ultra-fast, proteome-wide response to the plant hormone. Cell Submitted. · DOI
  22. 10.1016/j.pbi.2019.10.003 · DOI
  23. 10.1038/d41586-022-02339-x · DOI
  24. 10.1016/j.tplants.2006.06.002 · DOI
  25. 10.1038/ncb1205-1057 · DOI
  26. 10.1093/emboj/18.8.2066 · DOI
  27. 10.1038/nature03184 · DOI
  28. 10.1101/cshperspect.a039875 · DOI
  29. 10.1038/s41586-018-0186-z · DOI
  30. 10.1111/nph.18602 · DOI
  31. 10.1038/s41586-021-04037-6 · DOI
  32. 10.1073/pnas.2102544118 · DOI
  33. 10.1038/s41586-019-1069-7 · DOI
  34. 10.1073/pnas.1910916116 · DOI
  35. 10.1038/s41467-020-14395-w · DOI
  36. 10.1073/pnas.1500365112 · DOI
  37. 10.1371/journal.pone.0060990 · DOI
  38. 10.1007/s004250050133 · DOI
  39. 10.1242/dev.129.17.3965 · DOI
  40. 10.1093/jxb/erv177 · DOI
  41. 10.1093/emboj/21.12.2877 · DOI
  42. 10.1104/pp.75.4.1111 · DOI
  43. 10.1093/glycob/cwx080 · DOI
  44. 10.1126/science.1243825 · DOI
  45. 10.1038/cr.2013.131 · DOI · Paper page
  46. 10.1016/j.molp.2017.07.004 · DOI
  47. 10.1038/35066597 · DOI · Paper page
  48. 10.1105/tpc.15.00214 · DOI
  49. 10.1111/jipb.12339 · DOI
  50. 10.1105/tpc.111.087064 · DOI
  51. Andre Kuhn, M.R. , Polet Carrillo Carrasco , Sumanth Mutte , Jochem Bronkhorst , Shiv Mani Dubey , Martijn van Galen , Aline Monzer , Ryuichi Nishihama , Takayuki Kohchi , Matyáš Fendrych , Jiří Friml , Joris Sprakel , Dolf Weijers (2022). A RAF-like kinase mediates a deeply conserved, ultra-rapid auxin response. Cell Submitted. · DOI
  52. 10.1016/j.gene.2007.07.009 · DOI
  53. 10.1016/j.tplants.2010.05.001 · DOI
  54. 10.1038/ncomms4978 · DOI
  55. Mark Roosjen , A.K., Sumanth K . Mutte, Sjef Boeren , Pavel Krupar , Jasper Koehorst , Matyas Fendrych , Jiri Friml , and Dolf Weijers (2022). An ultra-fast, proteome-wide response to the plant hormone. Cell Submitted. · DOI
  56. 10.4161/sgtp.29711 · DOI
  57. 10.1016/j.molp.2021.11.010 · DOI
  58. 10.1146/annurev-arplant-073019-025927 · DOI
  59. 10.1007/s42994-019-00011-z · DOI
  60. 10.1046/j.1365-313x.1998.00343.x · DOI
  61. 10.1385/0-89603-332-5:157 · DOI
  62. 10.1104/pp.17.00961 · DOI
  63. 10.1007/978-1-61779-809-2_10 · DOI
  64. 10.1038/s41477-018-0328-1 · DOI · Paper page
  65. 10.1093/plcell/koac195 · DOI
  66. 10.1016/S0006-3495(04)74307-6 · DOI
  67. 10.1007/978-1-4939-0922-3_1 · DOI
  68. 10.1016/j.cell.2010.09.027 · DOI
  69. 10.3389/fpls.2016.00940 · DOI
  70. 10.1002/jgm.696 · DOI
  71. 10.1016/B978-0-12-418687-3.00018-5 · DOI
  72. 10.1186/s13007-020-00641-1 · DOI
  73. 10.1038/s41586-020-2094-2 · DOI
  74. 10.1021/acs.jcim.1c00203 · DOI
  75. 10.1002/jcc.21334 · DOI · Paper page
  76. 10.1038/s41467-021-20929-7 · DOI
  77. 10.1105/tpc.113.112342 · DOI
  78. 10.1111/nph.14014 · DOI

Metadata

Authors
Yu, Y., Tang, W., Lin, W., Li, W., Zhou, X., Li, Y., Chen, R., Zheng, R., Qin, G., Cao, W., Perez, P., Huang, R., Ma, J., Lin, J., Jiang, L., Xu, T., & Yang, Z.
Affiliations
  • Chinese Academy of Sciences (CN)
  • Fujian Agriculture and Forestry University (CN)
  • Nanjing Agricultural University (CN)
  • Chinese University of Hong Kong (HK)
  • University of California, Riverside (US)
Corresponding author
  • Xu, Tongda
  • Yang, Zhenbiao
ORCID
Venue
Cell
Publisher
openRxiv
Published
2022-11-28
Volume
186
Issue
25
Pages
5457-5471.e17
ISSN
0092-8674 (ISSN-L)
DOI
10.1101/2022.11.28.518138
PMC
PMC10827329
OpenAlex
W4388759124
Cited by
112
References
1
Citations by year
2026: 27 · 2025: 43 · 2024: 31 · 2023: 10 · 2022: 1
FWCI
17.44
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Cell (publishedVersion, cc-by)
  • bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Natural Science Foundation of China (32130010)
  • Chinese Academy of Sciences
  • Fujian Agriculture and Forestry University
  • National Institute of General Medical Sciences (R01GM100130, GM100130)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Light effects on plants
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant nutrient uptake and metabolism
Keywords
auxin receptor, auxin-binding protein, c-Abl, ABL2, ABP1, co-receptors, apoplast, genetic interactions, plant hormone signaling
MeSH terms
Indoleacetic Acids, Plant Growth Regulators, Plant Proteins, Receptors, Cell Surface, Arabidopsis, Arabidopsis Proteins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review