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PreprintCited by 17Multiple Myeloma Research and TreatmentsNutritional Studies and DietNutrition and Health Studies

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Dietary risk factors for monoclonal gammopathy of undetermined significance in a racially diverse population

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Joseph, Janine M., Hillengass, Jens, Tang, Li, Lesokhin, Alexander M., Landgren, Ola, Usmani, Saad Z., Moysich, Kirsten B., McCann, Susan E., Shah, Urvi A.·2023·Blood Advances
DOI 10.1101/2023.09.05.23294947PMC PMC10835229

Preprint — published as 10.1182/bloodadvances.2023011608

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Abstract

Monoclonal gammopathy of undetermined significance (MGUS) – a precursor of multiple myeloma – is associated with shorter lifespan and cardiac, renal, neurologic, and immune-related comorbidities. There is little known about modifiable risk factors for this condition. To determine if risk of MGUS is associated with dietary factors in a racially diverse population, we conducted a United States population-based case-control study from the National Health and Nutrition Examination Survey (1988-2004), which included 373 individuals with MGUS and 1,406 matched controls. Diet was characterized by one 24-hour dietary recall, with gram intake of individual foods and beverages aggregated into groups. Unconditional multivariable logistic regressions were used to model associations between intake of several food groups and MGUS, with odds ratios (OR) and 95% confidence intervals (95% CI) reported for the highest relative to the lowest quantile of intake. Daily gram intake of several food and beverage groups were significantly associated with MGUS. MGUS was inversely associated with whole-grain bread, oats, and rice (OR 0.70; 95% CI 0.48-1.00; P <0.05), fruits (excluding juice) and vegetables (OR 0.69; 95% CI 0.52-0.93; P =0.02), vegetables (OR 0.75; 95% CI 0.56-0.99; P <0.05), tomatoes (OR 0.72; 95% CI 0.51-1.00; P <0.05), and cruciferous vegetables (OR 0.44; 95% CI 0.26-0.74; P <0.01). Direct associations were observed for sugar-sweetened beverages (OR 1.34; 95% CI 1.00-1.78; P <0.05), sugar-sweetened soft drinks (OR 1.41; 95% CI 1.01-1.96; P =0.04), and artificially sweetened soft drinks (OR 1.55; 95% CI 1.04-2.33; P =0.03). Our study shows that diet is potentially a modifiable risk factor for MGUS.

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Metadata

Authors
Joseph, J. M., Hillengass, J., Tang, L., Lesokhin, A. M., Landgren, O., Usmani, S. Z., Moysich, K. B., McCann, S. E., & Shah, U. A.
Affiliations
  • Roswell Park Comprehensive Cancer Center (US)
  • Memorial Sloan Kettering Cancer Center (US)
  • University of Miami (US)
Corresponding author
  • Joseph, Janine M.
  • Shah, Urvi A.
ORCID
Venue
Blood Advances
Publisher
openRxiv
Published
2023-09-07
Volume
8
Issue
3
Pages
538-548
ISSN
2473-9529 (ISSN-L)
DOI
10.1101/2023.09.05.23294947
PMC
PMC10835229
OpenAlex
W4389399721
Cited by
17
References
1
Citations by year
2026: 8 · 2025: 5 · 2024: 4
FWCI
3.50
Type
journal article
Language
en
Open access
Licence
cc-by-nc-nd
Locations
  • Blood Advances (publishedVersion, cc-by-nc-nd)
  • medRxiv (acceptedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Funders
  • Sanofi
  • Celgene
  • Memorial Sloan-Kettering Cancer Center (CA008748, P30 CA008748)
  • Parker Institute for Cancer Immunotherapy
  • National Institutes of Health (CA008748)
  • National Cancer Institute (CA008748, P50CA247749, CA184746, P30CA008748, R25CA203650, K12CA184746)
  • Janssen Biotech
Topics
  • Health Sciences › Medicine › Hematology › Multiple Myeloma Research and Treatments
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutrition and Health Studies
Keywords
monoclonal gammopathy of undetermined significance, dietary risk factors, sugar-sweetened beverages, whole grains, cruciferous vegetables, tomato, fruit and vegetable intake, modifiable risk factors, racial diversity, NHANES, dietary intake, comorbidities
MeSH terms
Diet, Humans, Monoclonal Gammopathy of Undetermined Significance, Nutrition Surveys, Risk Factors, Sweetening Agents, Case-Control Studies

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