Investigating the oxidative stress-vascular brain injury axis in mild cognitive impairment of the Alzheimer type
Open accessAbstract
INTRODUCTION: Oxidative stress may contribute to brain injury in Alzheimer disease (AD) continuum. The antioxidant glutathione (GSH) can be assessed with magnetic resonance spectroscopy (MRS). Since the relationship between GSH and vascular-brain injury is unknown in the AD continuum, we address this gap in mild cognitive impairment (MCI). METHODS: 3T MRI/MRS data were obtained from 31 MCI participants. GSH and total N-acetylaspartate (tNAA; neuroaxonal integrity marker) were measured in posterior cingulate cortex (PCC) and frontal white matter (FWM). Cerebrovascular injury was assessed using white matter hyperintensity (WMH) volume. Global and regional brain tissue integrity were assessed using normalized brain (NBV) and hippocampal volumes. RESULTS: Significant associations were reported in FWM between GSH/total creatine (tCr) and tNAA/tCr, and between GSH and both WMH and NBV. tNAA, GSH/tCr, and tNAA/tCr were higher in PCC than FWM. DISCUSSION: Our results suggest that oxidative stress contributes to vascular-brain injury in MCI.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The reported loss in GSH in given brain areas in some human diseases is likely to be at least in part the consequence of a loss of astrocytic GSH and/or of alterations in the GSH metabolism of astrocytes.
“As a consequence of the high abundance of astrocytes in the brain and of the well‐known pivotal role of astrocytes in brain GSH metabolism, it can be concluded that the reported loss in GSH in given brain areas in some human diseases (Detcheverry et al. 2024; Iskusnykh et al. 2022) is likely to be at least in part the consequence of a loss of astrocytic GSH and/or of alterations in the GSH”
From Glutathione Metabolism of the Brain—The Role of Astrocytes (2025) · cites this paper as Detcheverry et al. 2024
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Oxidative stress in the progression of Alzheimer disease in the frontal cortex
Ansari, M. A., & Scheff, S. W. (2010) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3181cb5af4 · Cited by 605 · see citing works
Oxidative stress in Alzheimer disease
Gella, A., & Durany, N. (2009) · Cell Adhesion & Migration · doi:10.4161/cam.3.1.7402 · Cited by 459 · see citing works
Multi-modal image registration based on gradient orientations of minimal uncertainty
De Nigris, D., Collins, D. L., & Arbel, T. (2012) · IEEE Transactions on Medical Imaging · doi:10.1109/tmi.2012.2218116 · Cited by 73 · see citing works
Flagged first, then by citations
Research works printed but not linked: 4
- Detcheverry F, Senthil S, Narayanan S, Badhwar A (2023) Changes in levels of the antioxidant glutathione in brain and blood across the age span of healthy adults: A systematic review. NeuroImage: Clinical 103503.
- Pareek V, Nath B, Roy PK (2019) Role of Neuroimaging Modality in the Assessment of Oxidative Stress in Brain: A Comprehensive Review. CNS Neurol Disord Drug Targets 18, 372-381.
- Shukla D, Mandal PK, Tripathi M, Vishwakarma G, Mishra R, Sandal K (2020) Quantitation of in vivo brain glutathione conformers in cingulate cortex among age-matched control, MCI, and AD patients using MEGA-PRESS. Hum Brain Mapp 41, 194-217.
- Gouw AA, Seewann A, van der Flier WM, Barkhof F, Rozemuller AM, Scheltens P, Geurts JJG (2011) Heterogeneity of small vessel disease: a systematic review of MRI and histopathology correlations. J Neurol Neurosurg Psychiatry 82, 126-135.
Cited by
Sorted by citations
Glutathione Metabolism of the Brain—The Role of Astrocytes
Dringen, R., & Arend, C. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.70073 · Cited by 46 · see citing works
- Authors
- Detcheverry, F. E., Senthil, S., Motue, W. L. K., Hosein, C., Arnaoutelis, R., Araujo, D., Fetco, D., Assemlal, H.-E., Antel, S., Arnold, D. L., Near, J., Schipper, H. M., Badhwar, A., & Narayanan, S.
- Affiliations
- Institut Universitaire de Gériatrie de Montréal (CA)
- Montreal Neurological Institute and Hospital (CA)
- Jewish General Hospital (CA)
- University of Toronto (CA)
- Corresponding author
- Badhwar, AmanPreet
- Narayanan, Sridar
- ORCID
- Venue
- Alzheimer s & Dementia
- Publisher
- openRxiv
- Published
- 2024-09-26
- Volume
- 21
- Issue
- 9
- Pages
- e70456-e70456
- ISSN
- 1552-5260 (ISSN-L)
- PMC
- PMC12434610
- OpenAlex
- W4414167573
- Cited by
- 9
- References
- 3
- Citations by year
- 2026: 7 · 2025: 2
- FWCI
- 5.34
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Alzheimer s & Dementia (publishedVersion, cc-by)
- medRxiv (acceptedVersion)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed (publishedVersion)
- PubMed Central (publishedVersion, cc-by)
- Funders
- Courtois Foundation
- Canadian Institutes of Health Research (153005)
- Fonds de Recherche du Québec - Santé (#352199, 332672, Junior 1, 283967)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- oxidative stress, mild cognitive impairment
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Aspartic Acid, Brain, Female, Glutathione, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Magnetic Resonance Spectroscopy, Oxidative Stress, Cognitive Dysfunction, White Matter
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
