Oxidative stress in the progression of Alzheimer disease in the frontal cortex
Open accessAbstract
We investigated oxidative stress in human postmortem frontal cortexfrom individuals characterized as mild cognitive impairment (n= 8), mild/moderate Alzheimer disease (n = 4), and late-stage Alzheimer disease (n = 9). Samples from subjects with no cognitive impairment (n = 10) that were age- and postmortem interval-matched with these cases were used as controls. The short postmortem intervalbrain samples were processed for postmitochondrial supernatant, nonsynaptic mitochondria, and synaptosome fractions. Samples were analyzed for several antioxidants (glutathione, glutathione peroxidase, glutathione reductase, glutathione-S-transferase, glucose-6-phosphate dehydrogenase, superoxide dismutase, catalase) and the oxidative marker, thiobarbituric acid reactive substances. The tissue was also analyzed for possible changes in protein damage using neurochemical markers for protein carbonyls, 3-nitrotyrosine, 4-hydroxynonenal, andacrolein. All 3 neuropil fractions (postmitochondrial supernatant, mitochondrial, and synaptosomal) demonstrated significant disease-dependent increases in oxidative markers. The highest changes were observed in the synaptosomal fraction. Both mitochondrial and synaptosomal fractions had significant declines in antioxidants (glutathione, glutathione peroxidase, glutathione-S-transferase, and superoxide dismutase). Levels of oxidative markers significantly correlated with Mini-Mental Status Examination scores. Oxidative stress was more localized to the synapses, with levels increasing in a disease-dependent fashion. These correlations implicate an involvement of oxidative stress in Alzheimer disease-related synaptic loss.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Tunneling nanotube formation is often associated with oxidative stress, another key feature of Alzheimer's disease.
“Moreover, TNT formation is often associated with oxidative stress, another key feature of AD [120,121,122].”
From The Impact of Neurotoxin Proteins Trafficked by Primary Cilia and Extracellular Vesicles in Neurodegenerative Diseases (2025) · cites this paper as [121]
The Discussion reports that oxidative stress increases with Alzheimer disease progression, supporting its description as a feature of AD. The paper does not address tunneling nanotubes or an association between their formation and oxidative stress. (LLM, conf=0.86)
Experimental — accuracy not yet measured3-Nitrotyrosine and protein carbonyls are used as biomarkers of oxidative damage in the brain of Alzheimer's disease and mild cognitive impairment.
“3-nitrotyrosine and protein carbonyls, these last produced mainly by the action of free radicals on the peptide chain or by oxidation of amino acids, are used as biomarkers of oxidative damage in the brain of AD and MCI [18,24,31,32,33].”
From Role of Oxidative Damage in Alzheimer’s Disease and Neurodegeneration: From Pathogenic Mechanisms to Biomarker Discovery (2021) · cites this paper as [31]
In response to OS in the brain, compensatory induction of antioxidant enzymes such as superoxide dismutase, glutathione reductase, catalase has been found in vulnerable neurons in AD.
“In response to OS in the brain, a number of protective mechanisms are up regulated to maintain the oxidative balance, in particular compensatory induction of antioxidant enzymes such as superoxide dismutase, glutathione reductase, catalase have been found in vulnerable neurons in AD [31].”
From Role of Oxidative Damage in Alzheimer’s Disease and Neurodegeneration: From Pathogenic Mechanisms to Biomarker Discovery (2021) · cites this paper as [31]
Reduction of antioxidants such as glutathione, glutathione peroxidase, glutathione-S-transferase, and superoxide dismutase is demonstrated post-mortem in mitochondrial and synaptosomal fractions in the frontal cortex of MCI and AD patients.
“Reduction of antioxidants such as glutathione, glutathione peroxidase, glutathione-S-transferase, and superoxide dismutase are demonstrated post-mortem in the mitochondrial and synaptosomal fractions in the frontal cortex of MCI and AD patients [31].”
From Role of Oxidative Damage in Alzheimer’s Disease and Neurodegeneration: From Pathogenic Mechanisms to Biomarker Discovery (2021) · cites this paper as [31]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984) · Neurology · doi:10.1212/wnl.34.7.939 · Cited by 27,915 · see citing works
Beckman, J. S., Beckman, T. W., Chen, J., Marshall, P. A., & Freeman, B. A. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.4.1620 · Cited by 7,029 · see citing works
Current concepts in mild cognitive impairment
Petersen, R. C., Doody, R., Kurz, A., Mohs, R. C., Morris, J. C., Rabins, P. V., Ritchie, K., Rossor, M., Thal, L., & Winblad, B. (2001) · Archives of Neurology · doi:10.1001/archneur.58.12.1985 · Cited by 4,781 · see citing works
Reactive Oxygen Species and the Central Nervous System
Halliwell, B. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb10990.x · Cited by 2,947 · see citing works
Oxidative Damage Is the Earliest Event in Alzheimer Disease
Nunomura, A., Perry, G., Aliev, G., Hirai, K., Takeda, A., Balraj, E. K., Jones, P. K., Ghanbari, H., Wataya, T., Shimohama, S., et al. (2001) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/60.8.759 · Cited by 1,885 · see citing works
Mild Cognitive Impairment Represents Early-Stage Alzheimer Disease
Morris, J. C., Storandt, M., Miller, J. P., McKeel, D. W., Price, J. L., Rubin, E. H., & Berg, L. (2001) · Archives of Neurology · doi:10.1001/archneur.58.3.397 · Cited by 1,833 · see citing works
Halliwell, B. (2001) · Drugs & Aging · doi:10.2165/00002512-200118090-00004 · Cited by 1,502 · see citing works
Synaptic Activity Regulates Interstitial Fluid Amyloid-β Levels In Vivo
Cirrito, J. R., Yamada, K. A., Finn, M. B., Sloviter, R. S., Bales, K. R., May, P. C., Schoepp, D. D., Paul, S. M., Mennerick, S., & Holtzman, D. M. (2005) · Neuron · doi:10.1016/j.neuron.2005.10.028 · Cited by 1,265 · see citing works
Widespread Peroxynitrite-Mediated Damage in Alzheimer’s Disease
Smith, M. A., Richey Harris, P. L., Sayre, L. M., Beckman, J. S., & Perry, G. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-08-02653.1997 · Cited by 1,239 · see citing works
Soluble oligomers of the amyloid β-protein impair synaptic plasticity and behavior
Selkoe, D. J. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.02.016 · Cited by 1,038 · see citing works
Sayre, L., Zelasko, D. A., Harris, P. L. R., Perry, G., Salomon, R. G., & Smith, M. A. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.68052092.x · Cited by 1,032 · see citing works
Reactive Oxygen-Mediated Protein Oxidation in Aging and Disease
Stadtman, E. R., & Berlett, B. S. (1998) · Drug Metabolism Reviews · doi:10.3109/03602539808996310 · Cited by 892 · see citing works
De Felice, F. G., Velasco, P. T., Lambert, M. P., Viola, K., Fernandez, S. J., Ferreira, S. T., & Klein, W. L. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m607483200 · Cited by 882 · see citing works
Mild cognitive impairment in the elderly: Predictors of dementia
Flicker, C., Ferris, S. H., & Reisberg, B. (1991) · Neurology · doi:10.1212/wnl.41.7.1006 · Cited by 838 · see citing works
Oxidative stress in brain agingImplications for therapeutics of neurodegenerative diseases
Floyd, R. A., & Hensley, K. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00019-2 · Cited by 830 · see citing works
Synaptic alterations in CA1 in mild Alzheimer disease and mild cognitive impairment
Scheff, S. W., Price, D. A., Schmitt, F. A., DeKosky, S. T., & Mufson, E. J. (2007) · Neurology · doi:10.1212/01.wnl.0000260698.46517.8f · Cited by 824 · see citing works
Self-citationHensley, K., Hall, N., Subramaniam, R., Cole, P., Harris, M., Aksenov, M., Aksenova, M., Gabbita, S. P., Wu, J. F., Carney, J. M., et al. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.65052146.x · Cited by 779 · see citing works
Bains, J. S., & Shaw, C. A. (1997) · Brain Research Reviews · doi:10.1016/s0165-0173(97)00045-3 · Cited by 716 · see citing works
Reactive Oxygen-Mediated Protein Oxidation in Aging and Disease
Stadtman, E. R., & Berlett, B. S. (1997) · Chemical Research in Toxicology · doi:10.1021/tx960133r · Cited by 645 · see citing works
Lovell, M. A., Ehmann, W. D., Butler, S. M., & Markesbery, W. R. (1995) · Neurology · doi:10.1212/wnl.45.8.1594 · Cited by 644 · see citing works
Evidence of neuronal oxidative damage in Alzheimer's disease.
Good, P. F., Werner, P., Hsu, A., Olanow, C. W., & Perl, D. P. (1996) · Europe PMC (PubMed Central) · Cited by 600 · see citing works
Evidence of increased oxidative damage in subjects with mild cognitive impairment
Keller, J. N., Schmitt, F. A., Scheff, S. W., Ding, Q., Chen, Q., Butterfield, D. A., & Markesbery, W. R. (2005) · Neurology · doi:10.1212/01.wnl.0000156156.13641.ba · Cited by 539 · see citing works
Self-citationLyras, L., Cairns, N. J., Jenner, A., Jenner, P., & Halliwell, B. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.68052061.x · Cited by 531 · see citing works
Autopsy Samples of Alzheimer's Cortex Show Increased Peroxidation In Vitro
Subbarao, K. V., Richardson, J. S., & Ang, L. C. (1990) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1990.tb08858.x · Cited by 463 · see citing works
Peroxide detoxification by brain cells
Dringen, R., Pawlowski, P. G., & Hirrlinger, J. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20280 · Cited by 452 · see citing works
Increased oxidative damage in nuclear and mitochondrial DNA in Alzheimer's disease
Wang, J., Xiong, S., Xie, C., Markesbery, W. R., & Lovell, M. A. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03053.x · Cited by 452 · see citing works
Calingasan, N. Y., Uchida, K., & Gibson, G. E. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0720751.x · Cited by 400 · see citing works
Williams, T. I., Lynn, B. C., Markesbery, W. R., & Lovell, M. A. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.06.004 · Cited by 391 · see citing works
Mild cognitive impairment: transition between aging and Alzheimer's disease.
Petersen, R. C. (2000) · PubMed · Cited by 383 · see citing works
“Preclinical” AD revisited: Neuropathology of cognitively normal older adults
Schmitt, F. A., Davis, D. G., Wekstein, D. R., Smith, C. D., Ashford, J. W., & Markesbery, W. R. (2000) · Neurology · doi:10.1212/wnl.55.3.370 · Cited by 369 · see citing works
Brain oxidative stress in a triple-transgenic mouse model of Alzheimer disease
Resende, R., Moreira, P. I., Proença, T., Deshpande, A., Busciglio, J., Pereira, C., & Oliveira, C. R. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.03.012 · Cited by 343 · see citing works
Baez, S., Segura‐Aguilar, J., Widersten, M., Johansson, A.-S., & Mannervik, B. (1997) · Biochemical Journal · doi:10.1042/bj3240025 · Cited by 340 · see citing works
Oxidative stress and modification of synaptic proteins in hippocampus after traumatic brain injury
Ansari, M. A., Roberts, K. N., & Scheff, S. W. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.04.038 · Cited by 327 · see citing works
Self-citationSynaptic Mitochondria Are More Susceptible to Ca2+Overload than Nonsynaptic Mitochondria
Brown, M. R., Sullivan, P. G., & Geddes, J. W. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m510303200 · Cited by 297 · see citing works
Dendritic Spine Loss and Synaptic Alterations in Alzheimer’s Disease
Knobloch, M., & Mansuy, I. M. (2008) · Molecular Neurobiology · doi:10.1007/s12035-008-8018-z · Cited by 296 · see citing works
Are mitochondria critical in the pathogenesis of Alzheimer's disease?
Reddy, P. H., & Beal, M. F. (2005) · Brain Research Reviews · doi:10.1016/j.brainresrev.2005.03.004 · Cited by 289 · see citing works
Haroutunian, V. (1998) · Archives of Neurology · doi:10.1001/archneur.55.9.1185 · Cited by 289 · see citing works
Benzi, G., & Moretti, A. (1995) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(94)00244-e · Cited by 283 · see citing works
Lipid peroxidation is an early event in the brain in amnestic mild cognitive impairment
Markesbery, W. R., Kryscio, R. J., Lovell, M. A., & Morrow, J. D. (2005) · Annals of Neurology · doi:10.1002/ana.20629 · Cited by 272 · see citing works
Butterfield, D. A., & Debra Boyd-kimball, A. (2004) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2004.10.014 · Cited by 267 · see citing works
Sources and Targets of Reactive Oxygen Species in Synaptic Plasticity and Memory
Kishida, K. T., & Klann, E. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.9.233 · Cited by 264 · see citing works
Mitochondria dysfunction of Alzheimer's disease cybrids enhances Aβ toxicity
Cardoso, S. M., Santana, I. J., Swerdlow, R. H., & Oliveira, C. R. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02438.x · Cited by 262 · see citing works
Amyloid β-peptide induces apoptosis-related events in synapses and dendrites
Mattson, M. P., Partin, J. V., & Begley, J. G. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00763-x · Cited by 260 · see citing works
Sheehan, J. P., Swerdlow, R. H., Miller, S. W., Davis, R. E., Parks, J. K., Parker, W. D., & Tuttle, J. B. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-12-04612.1997 · Cited by 249 · see citing works
Butterfield, D. A., Reed, T., Perluigi, M., De Marco, C., Coccia, R., Cini, C., & Sultana, R. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2005.12.017 · Cited by 246 · see citing works
Sources and Targets of Reactive Oxygen Species in Synaptic Plasticity and Memory
Kishida, K. T., & Klann, E. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.9.ft-8 · Cited by 245 · see citing works
Luis, C. A., Loewenstein, D., Acevedo, A., Barker, W. W., & Duara, R. (2003) · Neurology · doi:10.1212/01.wnl.0000080366.90234.7f · Cited by 245 · see citing works
Neuroprotection by crocetin in a hemi-parkinsonian rat model
Ahmad, A. S., Ansari, M. A., Ahmad, M., Saleem, S., Yousuf, S., Hoda, M. N., & Islam, F. (2005) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2005.06.007 · Cited by 237 · see citing works
Self-citationMartins, R. N., Harper, C. G., Stokes, G. B., & Masters, C. L. (1986) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1986.tb00615.x · Cited by 234 · see citing works
Mitochondria and the Bcl-2 family proteins in apoptosis signaling pathways
Antonsson, B. E. (2003) · Molecular and Cellular Biochemistry · doi:10.1023/b:mcbi.0000009865.70898.36 · Cited by 232 · see citing works
Lipid peroxidation and oxidative imbalance: early functional events in Alzheimer's disease
Praticò, D., & Sung, S. (2004) · Journal of Alzheimer s Disease · doi:10.3233/jad-2004-6209 · Cited by 229 · see citing works
Smith, M. A., Sayre, L. M., Anderson, V. E., Harris, P. L. R., Beal, M. F., Kowall, N. W., & Perry, G. L. (1998) · Journal of Histochemistry & Cytochemistry · doi:10.1177/002215549804600605 · Cited by 222 · see citing works
Nucleic acid oxidation in Alzheimer disease
Moreira, P. I., Nunomura, A., Nakamura, M., Takeda, A., Shenk, J. C., Aliev, G., Smith, M. A., & Perry, G. L. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.01.002 · Cited by 206 · see citing works
Synaptic localization of a functional NADPH oxidase in the mouse hippocampus
Tejada-Simon, M. V., Serrano, F., Villasana, L., Kanterewicz, B. I., Wu, G., Quinn, M. T., & Klann, E. (2005) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2005.01.007 · Cited by 203 · see citing works
Evidence of an oxidative challenge in the Alzheimer's brain
Balázs, L., & Leon, M. (1994) · Neurochemical Research · doi:10.1007/bf00965146 · Cited by 196 · see citing works
Ishrat, T., Khan, M. B., Hoda, M. N., Yousuf, S., Ahmad, M., Ansari, M. A., Ahmad, A. S., & Islam, F. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.03.009 · Cited by 190 · see citing works
Self-citationReactive oxygen species: influence on cerebral vascular tone
Faraci, F. M. (2006) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01044.2005 · Cited by 189 · see citing works
Damage to Lipids, Proteins, DNA, and RNA in Mild Cognitive Impairment
Markesbery, W. R., & Lovell, M. A. (2007) · Archives of Neurology · doi:10.1001/archneur.64.7.954 · Cited by 182 · see citing works
Ansari, M. A., Roberts, K. N., & Scheff, S. W. (2008) · Journal of Neurotrauma · doi:10.1089/neu.2007.0451 · Cited by 181 · see citing works
Self-citationSelective increase in lipid peroxidation in the inferior temporal cortex in Alzheimer's disease
Palmer, A. M., & Burns, M. A. (1994) · Brain Research · doi:10.1016/0006-8993(94)91670-5 · Cited by 168 · see citing works
DNA Oxidation in Alzheimer's Disease
Markesbery, W. R., & Lovell, M. A. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.8.2039 · Cited by 151 · see citing works
Naga, K. K., Sullivan, P. G., & Geddes, J. W. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0646-07.2007 · Cited by 146 · see citing works
Culmsee, C., & Landshamer, S. (2006) · Current Alzheimer Research · doi:10.2174/156720506778249461 · Cited by 144 · see citing works
Absence of cognitive impairment or decline in preclinical Alzheimer’s disease
Goldman, W. P., Price, J. L., Storandt, M., Grant, E., McKeel, D. W., Rubin, E. H., & Morris, J. C. (2001) · Neurology · doi:10.1212/wnl.56.3.361 · Cited by 143 · see citing works
Bayır, H., Kagan, V. E., Clark, R. S. B., Janesko‐Feldman, K. L., Rafikov, R., Huang, Z., Zhang, X., Vagni, V., Billiar, T. R., & Kochanek, P. M. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04353.x · Cited by 140 · see citing works
Gillardon, F., Rist, W., Kußmaul, L., Vogel, J., Berg, M., Danzer, K. M., Kraut, N., & Hengerer, B. (2007) · PROTEOMICS · doi:10.1002/pmic.200600728 · Cited by 137 · see citing works
Russell, R. L., Siedlak, S., Raina, A., Bautista, J., Smith, M. A., & Perry, G. (1999) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1999.1404 · Cited by 135 · see citing works
Mitochondrial failures in Alzheimer's disease
Zhu, X., Smith, M. A., Perry, G. L., & Aliev, G. M. (2004) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/153331750401900611 · Cited by 120 · see citing works
Lange, M. L. B., Cenini, G., Piroddi, M., Abdul, H. M., Rukhsana Sultana, A., Galli, F., Memo, M., & Butterfield, D. A. (2007) · Neurobiology of Disease · doi:10.1016/j.nbd.2007.11.004 · Cited by 110 · see citing works
Manganese Superoxide Dismutase Protects against 6-Hydroxydopamine Injury in Mouse Brains
Callio, J., Oury, T. D., & Chu, C. T. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413224200 · Cited by 103 · see citing works
Selenium Protects Cerebral Ischemia in Rat Brain Mitochondria
Ansari, M. A., Ahmad, A. S., Ahmad, M., Salim, S., Yousuf, S., Ishrat, T., & Islam, F. (2004) · Biological Trace Element Research · doi:10.1385/bter:101:1:73 · Cited by 97 · see citing works
Self-citationSensitivity of Protein Sulfhydryl Repair Enzymes to Oxidative Stress
Starke, D. W., Chen, Y., Bapna, C. P., Lesnefsky, E. J., & Mieyal, J. J. (1997) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(97)00009-9 · Cited by 97 · see citing works
Urano, S., Asai, Y., Makabe, S., Matsuo, M., Izumiyama, N., OHTSUBO, K., & Endō, T. (1997) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1997.00064.x · Cited by 96 · see citing works
Efficacy and Safety of OK-432 Sclerotherapy for Giant Cystic Hygroma in a Newborn
Samuel, M., McCarthy, L., & Boddy, S. A. (2000) · Fetal Diagnosis and Therapy · doi:10.1159/000020983 · Cited by 92 · see citing works
Ansari, M. A., Gururaj Joshi, A., Huang, Q., Opii, W. O., Abdul, H. M., Rukhsana Sultana, A., & Butterfield, D. A. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.09.002 · Cited by 92 · see citing works
Self-citationSynaptic dysfunction and oxidative stress in Alzheimer's disease: Emerging mechanisms
Forero, D. A., Casadesús, G., Perry, G. L., & Arboleda, H. (2006) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2006.tb00439.x · Cited by 87 · see citing works
A Comparison of Methodologies for the Study of Functional Transmitter Neurochemistry in Human Brain
Dodd, P. R., Hambley, J. W., Cowburn, R. F., & Hardy, J. (1988) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1988.tb03013.x · Cited by 83 · see citing works
Oxidative damage in the olfactory system in Alzheimer's disease
Perry, G. L., Castellani, R. J., Smith, M. A., Harris, P. L. R., Kubat, Z., Ghanbari, K., Jones, P. K., Cordone, G., Tabaton, M., Wolozin, B. L., et al. (2003) · Acta Neuropathologica · doi:10.1007/s00401-003-0761-7 · Cited by 79 · see citing works
Gilman, C. P., Chan, S. L., Guo, Z., Zhu, X., Greig, N. H., & Mattson, M. P. (2003) · NeuroMolecular Medicine · doi:10.1385/nmm:3:3:159 · Cited by 77 · see citing works
Cruz, V. L. L., González-Cortés, C., Galván-Arzate, S., Medina-Campos, O., Pérez-Severiano, F., Ali, S., Pedraza-Chaverri, J., & Santamaría, A. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.06.027 · Cited by 75 · see citing works
Glutathione transferase protects neuronal cultures against four hydroxynonenal toxicity
Xie, C., Lovell, M. A., & Markesbery, W. R. (1998) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00186-5 · Cited by 72 · see citing works
Shah, Z. A., & Vohora, S. B. (2002) · Pharmacology & Toxicology · doi:10.1034/j.1600-0773.2002.900505.x · Cited by 71 · see citing works
Alzheimer's Disease: Role of Aging in Pathogenesis
Harman, D. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb02109.x · Cited by 64 · see citing works
Marcello, E. E., Epis, R., & Luca, M. D. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.11.083 · Cited by 61 · see citing works
Mitochondrial genomic contribution to mitochondrial dysfunction in Alzheimer's disease
Onyango, I. G., Khan, S. M., Miller, B. B., Swerdlow, R. H., Trimmer, P. A., & Bennett, J. P. (2006) · Journal of Alzheimer s Disease · doi:10.3233/jad-2006-9210 · Cited by 60 · see citing works
Cardoso, S. M., Pereira, C., & Oliveira, C. R. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.8563 · Cited by 58 · see citing works
Cortical biochemistry in MCI and Alzheimer disease
Forman, M. S., Mufson, E. J., Leurgans, S. E., Praticò, D., Joyce, S. C., Leight, S., Lee, V. M.-Y., & Trojanowski, J. Q. (2007) · Neurology · doi:10.1212/01.wnl.0000256373.39415.b1 · Cited by 54 · see citing works
Sources and mechanisms of cytoplasmic oxidative damage in Alzheimer's disease
Marlatt, M. W., Lee, H., Perry, G. L., Smith, M. A., & Zhu, X. (2004) · Acta Neurobiologiae Experimentalis · doi:10.55782/ane-2004-1493 · Cited by 50 · see citing works
Brain monoaminergic and neuropeptidergic variations in human aging
Arranz, B., Blennow, K., Ekman, R., Eriksson, A., Mnsson, J. E., & Marcusson, J. O. (1996) · Journal of Neural Transmission · doi:10.1007/bf01292620 · Cited by 49 · see citing works
Are post-mortem biochemical studies of human brain worthwhile?
Palmer, A. M., Lowe, S. L., Francis, P. T., & Bowen, D. M. (1988) · Biochemical Society Transactions · doi:10.1042/bst0160472 · Cited by 37 · see citing works
Mantha, A. K., Moorthy, K., Cowsik, S. M., & Baquer, N. Z. (2006) · Biogerontology · doi:10.1007/s10522-005-6043-0 · Cited by 35 · see citing works
Book Review: Is Alzheimer’s Disease a Mitochondrial Disorder?
Cash, A., Perry, G. L., Ogawa, O., Raina, A. K., Zhu, X., & Smith, M. A. (2002) · The Neuroscientist · doi:10.1177/107385802236968 · Cited by 32 · see citing works
Martı́nez, M., Ferrándiz, M. L., Dı́ez, A., & Miquel, J. (1995) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(95)01644-f · Cited by 29 · see citing works
Mercapturate Metabolism of 4-Hydroxy-2-Nonenal in Rat and Human Cerebrum
Sidell, K. R., Montine, K. S., Picklo, M. J., Olsen, S. J., Amarnath, V., & Montine, T. J. (2003) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/62.2.146 · Cited by 27 · see citing works
Postmortem isolation of synaptosomes from human brain
Garey, R. E., Harper, J. W., & Heath, R. G. (1974) · Brain Research · doi:10.1016/0006-8993(74)90900-7 · Cited by 18 · see citing works
Faff-Michalak, L., & Albrecht, J. (1993) · Neurochemical Research · doi:10.1007/bf01474673 · Cited by 11 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Targeting oxidative stress in disease: Promise and limitations of antioxidant therapy
Forman, H. J., & Zhang, H. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-021-00233-1 · Cited by 2,900 · see citing works
Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease
Zhang, B., Gaiteri, C., Bodea, L.-G., Wang, Z., McElwee, J., Podtelezhnikov, A. A., Zhang, C., Xie, T., Tran, L., Dobrin, R., et al. (2013) · Cell · doi:10.1016/j.cell.2013.03.030 · Cited by 1,657 · see citing works
Oxidative Stress in Neurodegenerative Diseases
Simonian, N. A., & Coyle, J. T. (1996) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.36.040196.000503 · Cited by 1,377 · see citing works
Metals, oxidative stress and neurodegenerative disorders
Jomová, K., Vondráková, D., Lawson, M. K., & Valko, M. (2010) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-010-0563-x · Cited by 1,053 · see citing works
Oxidative Stress and the Pathogenesis of Alzheimer's Disease
Zhao, Y., & Zhao, B. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/316523 · Cited by 855 · see citing works
Oxidative stress in Alzheimer’s disease
Chen, Z., & Zhong, C. (2014) · Neuroscience Bulletin · doi:10.1007/s12264-013-1423-y · Cited by 797 · see citing works
Oxidative Stress in Neurodegenerative Diseases
Niedzielska, E., Smaga, I., Gawlik, M., Moniczewski, A., Stankowicz, P., Pera, J., & Filip, M. (2016) · Molecular Neurobiology · doi:10.1007/s12035-015-9337-5 · Cited by 800 · see citing works
Oxidative stress: The core pathogenesis and mechanism of Alzheimer’s disease
Bai, R., Guo, J., Ye, X.-Y., Xie, Y., & Xie, T. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101619 · Cited by 813 · see citing works
Oxidative Stress and Antioxidants in Neurodegenerative Disorders
Olufunmilayo, E. O., Gerke-Duncan, M. B., & Holsinger, R. M. D. (2023) · Antioxidants · doi:10.3390/antiox12020517 · Cited by 722 · see citing works
Apoptosis and Oxidative Stress in Neurodegenerative Diseases
Radi, E., Formichi, P., Battisti, C., & Federico, A. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-132738 · Cited by 632 · see citing works
González-Reyes, R. E., Nava-Mesa, M. O., Vargas-Sánchez, K., Ariza-Salamanca, D. F., & Mora-Muñoz, L. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00427 · Cited by 525 · see citing works
Sultana, R., Perluigi, M., & Butterfield, D. A. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.09.027 · Cited by 478 · see citing works
Batiha, G. E., Beshbishy, A. M., El‐Mleeh, A., Abdel‐Daim, M. M., & Devkota, H. P. (2020) · Biomolecules · doi:10.3390/biom10030352 · Cited by 488 · see citing works
The essential elements of Alzheimer’s disease
Lei, P., Ayton, S., & Bush, A. I. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.rev120.008207 · Cited by 336 · see citing works
Nrf2—a therapeutic target for the treatment of neurodegenerative diseases
Johnson, D. A., & Johnson, J. A. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.07.147 · Cited by 328 · see citing works
Oxidative Stress in Alzheimer’s Disease: Why Did Antioxidant Therapy Fail?
Persson, T., Popescu, B. O., & Cedazo-Mı́nguez, Á. (2014) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2014/427318 · Cited by 318 · see citing works
Redox regulation of mitochondrial function with emphasis on cysteine oxidation reactions
Mailloux, R. J., Jin, X., & Willmore, W. G. (2013) · Redox Biology · doi:10.1016/j.redox.2013.12.011 · Cited by 312 · see citing works
Oxidative stress and β-amyloid protein in Alzheimer’s disease
Cai, Z., Zhao, B., & Ratka, A. (2011) · NeuroMolecular Medicine · doi:10.1007/s12017-011-8155-9 · Cited by 279 · see citing works
Fernández‐Bachiller, M. I., Pérez, C., Monjas, L., Rademann, J., & Rodrı́guez-Franco, M. I. (2012) · Journal of Medicinal Chemistry · doi:10.1021/jm201460y · Cited by 271 · see citing works
Fernández‐Bachiller, M. I., Pérez, C., González-Muñoz, G. C., Conde, S., López, M. G., Villarroya, M., Garcı́a, A. G., & Rodrı́guez-Franco, M. I. (2010) · Journal of Medicinal Chemistry · doi:10.1021/jm100329q · Cited by 270 · see citing works
Molecular mechanisms of cognitive dysfunction following traumatic brain injury
Walker, K. R., & Tesco, G. (2013) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2013.00029 · Cited by 265 · see citing works
Mecocci, P., Boccardi, V., Cecchetti, R., Bastiani, P., Scamosci, M., Ruggiero, C., & Baroni, M. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-170732 · Cited by 256 · see citing works
Oxidative stress and mitochondrial impairment: Key drivers in neurodegenerative disorders
Wen, P., Sun, Z., Gou, F., Wang, J., Fan, Q., Zhao, D., & Yang, L. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102667 · Cited by 253 · see citing works
Murakami, K., Murata, N., Noda, Y., Tahara, S., Kaneko, T., Kinoshita, N., Hatsuta, H., Murayama, S., Barnham, K. J., Irie, K., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.279208 · Cited by 241 · see citing works
Neuronal cell death mechanisms in Alzheimer’s disease: An insight
Goel, P., Chakrabarti, S., Goel, K., Bhutani, K., Chopra, T., & Bali, S. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.937133 · Cited by 235 · see citing works
Venkateshappa, C., Harish, G., Mahadevan, A., Srinivas Bharath, M. M., & Shankar, S. K. (2012) · Neurochemical Research · doi:10.1007/s11064-012-0755-8 · Cited by 232 · see citing works
Dewanjee, S., Chakraborty, P., Bhattacharya, H., Chacko, L., Singh, B., Chaudhary, A., Javvaji, K., Pradhan, S. R., Vallamkondu, J., Dey, A., et al. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.09.032 · Cited by 235 · see citing works
Impaired Glutathione Synthesis in Neurodegeneration
Aoyama, K., & Nakaki, T. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms141021021 · Cited by 226 · see citing works
Oxidant/Antioxidant Imbalance in Alzheimer’s Disease: Therapeutic and Diagnostic Prospects
Wojsiat, J., Zoltowska, K. M., Laskowska-Kaszub, K., & Wojda, U. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/6435861 · Cited by 221 · see citing works
Metabolic Dysregulation Contributes to the Progression of Alzheimer’s Disease
Yan, X., Hu, Y., Wang, B., Wang, S., & Zhang, X. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.530219 · Cited by 217 · see citing works
Ferroptosis as a mechanism of neurodegeneration in Alzheimer's disease
Jakaria, M., Belaidi, A. A., Bush, A. I., & Ayton, S. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15519 · Cited by 212 · see citing works
Castelli, V., Benedetti, E., Antonosante, A., Catanesi, M., Pitari, G., Ippoliti, R., Cimini, A., & d’Angelo, M. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00132 · Cited by 211 · see citing works
Dysfunctional synapse in Alzheimer's disease – A focus on NMDA receptors
Mota, S. I., Ferreira, I. L., & Rego, A. C. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.08.013 · Cited by 206 · see citing works
Role of reactive oxygen species in the progression of Alzheimer’s disease
Bhatt, S., Puli, L., & Patil, C. R. (2020) · Drug Discovery Today · doi:10.1016/j.drudis.2020.12.004 · Cited by 207 · see citing works
Saha, S., Buttari, B., Profumo, E., Tucci, P., & Saso, L. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.787258 · Cited by 206 · see citing works
Molecular Mechanisms and Genetics of Oxidative Stress in Alzheimer’s Disease
Cioffi, F., Adam, R. H. I., & Broersen, K. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-190863 · Cited by 204 · see citing works
“corroborates the thought that oxidative stress is an 799 early stage pathological feature of AD [188].”
BackgroundOxidative stress and Alzheimer’s disease: dietary polyphenols as potential therapeutic agents
Darvesh, A. S., Carroll, R. T., Bishayee, A., Geldenhuys, W. J., & der Schyf, C. J. V. (2010) · Expert Review of Neurotherapeutics · doi:10.1586/ern.10.42 · Cited by 203 · see citing works
Oxidized cholesterol as the driving force behind the development of Alzheimer’s disease
Gamba, P., Testa, G., Gargiulo, S., Staurenghi, E., Poli, G., & Leonarduzzi, G. (2015) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00119 · Cited by 202 · see citing works
Mandal, P. K., Tripathi, M., & Sugunan, S. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.11.047 · Cited by 199 · see citing works
Molecular Mechanism of Acrylamide Neurotoxicity: Lessons Learned from Organic Chemistry
LoPachin, R. M., & Gavin, T. (2012) · Environmental Health Perspectives · doi:10.1289/ehp.1205432 · Cited by 200 · see citing works
The influence of common free radicals and antioxidants on development of Alzheimer’s Disease
Wojtunik‐Kulesza, K. A., Oniszczuk, A., Oniszczuk, T., & Waksmundzka‐Hajnos, M. (2016) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2015.12.024 · Cited by 195 · see citing works
Wang, C., Xu, Y., Wang, X., Guo, C., Wang, T., & Wang, Z. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7440 · Cited by 189 · see citing works
Diogo, V. S., Ferreira, H. A., Prata, D. P., & Initiative, A. D. N. (2022) · Alzheimer s Research & Therapy · doi:10.1186/s13195-022-01047-y · Cited by 189 · see citing works
Roy, R. G., Mandal, P. K., & Maroon, J. C. (2023) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.3c00486 · Cited by 194 · see citing works
Schmitt, F. A., Nelson, P. T., Abner, E. L., Scheff, S. W., Jicha, G. A., Smith, C. D., Cooper, G. E., Mendiondo, M. S., Danner, D. D., Eldik, L. J. V., et al. (2012) · Current Alzheimer Research · doi:10.2174/156720512801322591 · Cited by 184 · see citing works
Self-citationAlves, F. M., Lane, D. J. R., Nguyen, T. P. M., Bush, A. I., & Ayton, S. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-02088-5 · Cited by 197 · see citing works
Selenium and Alzheimer's Disease: A Systematic Review
Loef, M., Schrauzer, G. N., & Walach, H. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-110414 · Cited by 182 · see citing works
Actin dynamics and cofilin‐actin rods in alzheimer disease
Bamburg, J. R., & Bernstein, B. W. (2016) · Cytoskeleton · doi:10.1002/cm.21282 · Cited by 181 · see citing works
Buccellato, F. R., D’Anca, M., Fenoglio, C., Scarpini, E., & Galimberti, D. (2021) · Antioxidants · doi:10.3390/antiox10091353 · Cited by 179 · see citing works
Mitochondrial DNA Oxidative Damage and Repair in Aging and Alzheimer's Disease
Santos, R. X., Correia, S. C., Zhu, X., Smith, M. A., Moreira, P. I., Castellani, R. J., Nunomura, A., & Perry, G. L. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.5039 · Cited by 176 · see citing works
Iron Dyshomeostasis and Ferroptosis: A New Alzheimer’s Disease Hypothesis?
Wang, F., Wang, J., Shen, Y., Li, H., Rausch, W., & Huang, X. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.830569 · Cited by 173 · see citing works
The emerging role of glutathione in Alzheimer’s disease
Saharan, S., & Mandal, P. K. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-132483 · Cited by 168 · see citing works
Neuroinflammation, microglia and implications for anti-inflammatory treatment in Alzheimer’s disease
Krause, D. L., & Müller, N. (2010) · International Journal of Alzheimer's Disease · doi:10.4061/2010/732806 · Cited by 168 · see citing works
Redox Proteomics in Selected Neurodegenerative Disorders: From Its Infancy to Future Applications
Butterfield, D. A., Marzia Perluigi, A., Reed, T. T., Muharib, T., Hughes, C. P., Robinson, R. A. S., & Rukhsana Sultana, A. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4109 · Cited by 167 · see citing works
Ayton, S., Portbury, S. D., Kalinowski, P., Agarwal, P., Diouf, I., Schneider, J. A., Morris, M. C., & Bush, A. I. (2021) · Alzheimer s & Dementia · doi:10.1002/alz.12282 · Cited by 168 · see citing works
Nrf2 Suppresses Oxidative Stress and Inflammation in App Knock-In Alzheimer’s Disease Model Mice
Uruno, A., Matsumaru, D., Ryoke, R., Saito, R., Kadoguchi, S., Saigusa, D., Saito, T., Saido, T. C., Kawashima, R., & Yamamoto, M. P. (2020) · Molecular and Cellular Biology · doi:10.1128/mcb.00467-19 · Cited by 166 · see citing works
Synaptic Change in the Posterior Cingulate Gyrus in the Progression of Alzheimer's Disease
Scheff, S. W., PRICE, D. A., Ansari, M. A., Roberts, K. N., Schmitt, F. A., Ikonomović, M. D., & Mufson, E. J. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-141518 · Cited by 163 · see citing works
Self-citationRole of By-Products of Lipid Oxidation in Alzheimer's Disease Brain: A Focus on Acrolein
Singh, M., Nam, D. T., Arseneault, M., & Ramassamy, C. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-100405 · Cited by 162 · see citing works
Wang, Y., Wu, S., Li, Q., Sun, H., & Wang, H. (2023) · Advanced Science · doi:10.1002/advs.202300325 · Cited by 161 · see citing works
Ferroptosis and NRF2: an emerging battlefield in the neurodegeneration of Alzheimer's disease
Lane, D. J. R., Metselaar, B., Greenough, M., Bush, A. I., & Ayton, S. (2021) · Essays in Biochemistry · doi:10.1042/ebc20210017 · Cited by 159 · see citing works
Ferreiro, E. B., Baldeiras, I., Ferreira, I. L., Costa, R. O., Rego, A. C., Pereira, C., & Oliveira, C. R. (2012) · International Journal of Cell Biology · doi:10.1155/2012/735206 · Cited by 152 · see citing works
Dwivedi, D., Megha, K., Mishra, R., & Mandal, P. K. (2020) · Neurochemical Research · doi:10.1007/s11064-020-03030-1 · Cited by 154 · see citing works
Glutathione: Role in Oxidative/Nitrosative Stress, Antioxidant Defense, and Treatments
Raj, S. R., Bhattacharyya, C., Sarkar, A., Chakraborty, S., Sircar, E., Dutta, S., & Sengupta, R. (2021) · ChemistrySelect · doi:10.1002/slct.202100773 · Cited by 147 · see citing works
Diabetes drugs in the fight against Alzheimer's disease
Boccardi, V., Murasecco, I., & Mecocci, P. (2019) · Ageing Research Reviews · doi:10.1016/j.arr.2019.100936 · Cited by 142 · see citing works
The neuropathological profile of mild cognitive impairment (MCI): a systematic review
Stephan, B. C. M., Hunter, S., Harris, D., Llewellyn, D. J., Siervo, M., Matthews, F. E., & Brayne, C. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.147 · Cited by 139 · see citing works
Derry, P. J., Hegde, M. L., Jackson, G. R., Kayed, R., Tour, J. M., Tsai, A.-L., & Kent, T. A. (2019) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2019.101716 · Cited by 142 · see citing works
Oxidant/antioxidant imbalance and the risk of Alzheimer's disease
Moneim, A. (2015) · Current Alzheimer Research · doi:10.2174/1567205012666150325182702 · Cited by 136 · see citing works
NADPH-oxidase activation and cognition in Alzheimer disease progression
Ansari, M. A., & Scheff, S. W. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.03.025 · Cited by 131 · see citing works
Self-citationGlutathione relates to neuropsychological functioning in mild cognitive impairment
Duffy, S. L., Lagopoulos, J., Hickie, I. B., Diamond, K., Graeber, M. B., Lewis, S. J. G., & Naismith, S. L. (2013) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2013.01.005 · Cited by 130 · see citing works
Neuroinflammation in Alzheimer’s Disease
Reinisch, V. M., Krause, D., & Müller, N. (2014) · Springer eBooks · doi:10.1007/978-1-4939-1071-7_9 · Cited by 140 · see citing works
Molecular and cellular pathophysiology of preclinical Alzheimer’s disease
Mufson, E. J., Ikonomović, M. D., Counts, S., Perez, S. E., Malek‐Ahmadi, M. H., Scheff, S. W., & Ginsberg, S. D. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.05.030 · Cited by 129 · see citing works
Self-citationLee, J., & Hyun, D. (2023) · Antioxidants · doi:10.3390/antiox12040918 · Cited by 137 · see citing works
Burke, K. A., Yates, E. A., & Legleiter, J. (2013) · Frontiers in Neurology · doi:10.3389/fneur.2013.00017 · Cited by 127 · see citing works
Mitochondrial Dysfunction in Neural Injury
Zhao, X., Lu, M., Yuan, D., Xu, D.-E., Yao, P.-P., Ji, W., Chen, H., Liu, W., Yan, C.-X., Xia, Y., et al. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00030 · Cited by 126 · see citing works
Ghosh, D., LeVault, K. R., & Brewer, G. J. (2014) · Aging Cell · doi:10.1111/acel.12216 · Cited by 126 · see citing works
Glutathione transferases and neurodegenerative diseases
Mazzetti, A. P., Fiorile, M. C., Primavera, A., & Bello, M. L. (2015) · Neurochemistry International · doi:10.1016/j.neuint.2015.01.008 · Cited by 124 · see citing works
Telomere Shortening and Alzheimer’s Disease
Cai, Z., Yan, L., & Ratka, A. (2012) · NeuroMolecular Medicine · doi:10.1007/s12017-012-8207-9 · Cited by 120 · see citing works
High molecular weight amyloid β 1‐42 oligomers induce neurotoxicity via plasma membrane damage
Yasumoto, T., Takamura, Y., Tsuji, M., Watanabe‐Nakayama, T., Imamura, K., Inoue, H., Nakamura, S., Inoue, T., Kimura, A., Yano, S., et al. (2019) · The FASEB Journal · doi:10.1096/fj.201900604r · Cited by 120 · see citing works
Redox signaling at the crossroads of human health and disease
Zuo, J., Zhang, Z., Luo, M., Zhou, L., Nice, E. C., Zhang, W., Wang, C., & Huang, C. (2022) · MedComm · doi:10.1002/mco2.127 · Cited by 120 · see citing works
Lee, H. G., Won, S. M., Gwag, B. J., & Lee, Y. B. (2011) · Experimental & Molecular Medicine · doi:10.3858/emm.2011.43.1.001 · Cited by 118 · see citing works
Zuo, L., Hemmelgarn, B. T., Chuang, C., & Best, T. M. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2015/604658 · Cited by 118 · see citing works
Mechanisms of Altered Redox Regulation in Neurodegenerative Diseases—Focus on S-Glutathionylation
Liedhegner, E. S., Gao, X., & Mieyal, J. J. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4119 · Cited by 116 · see citing works
Apolipoprotein E potently inhibits ferroptosis by blocking ferritinophagy
Belaidi, A. A., Masaldan, S., Southon, A. G., Kalinowski, P., Acevedo, K. M., Appukuttan, A. T., Portbury, S. D., Lei, P., Agarwal, P., Leurgans, S. E., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01568-w · Cited by 116 · see citing works
Qiang, X., Sang, Z., Yuan, W., Li, Y., Liu, Q., Bai, P., Shi, Y., Ang, W., Tan, Z., & Deng, Y. (2014) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2014.02.045 · Cited by 113 · see citing works
Wang, Y., Kan, H., Yin, Y., Wu, W., Hu, W., Wang, M., Li, W., & Li, W. (2014) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2014.02.012 · Cited by 113 · see citing works
Salminen, L. E., & Paul, R. H. (2014) · Reviews in the Neurosciences · doi:10.1515/revneuro-2014-0046 · Cited by 113 · see citing works
One-Carbon Metabolism: Pulling the Strings behind Aging and Neurodegeneration
Lionaki, E., Ploumi, C., & Tavernarakis, N. (2022) · Cells · doi:10.3390/cells11020214 · Cited by 110 · see citing works
On the central role of mitochondria dysfunction and oxidative stress in Alzheimer’s disease
Tobore, T. O. (2019) · Neurological Sciences · doi:10.1007/s10072-019-03863-x · Cited by 110 · see citing works
Uddin, M. S., Mamun, A. A., Hossain, M. S., Akter, F., Iqbal, M. A., & Asaduzzaman, M. (2016) · Annals of Neurosciences · doi:10.1159/000449482 · Cited by 109 · see citing works
Chiang, M., Nicol, C. J. B., & Cheng, Y. (2017) · Neurochemistry International · doi:10.1016/j.neuint.2017.10.002 · Cited by 109 · see citing works
Mishra, C. B., Kumari, S., Manral, A., Prakash, A., Saini, V., Lynn, A. M., & Tiwari, M. (2016) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2016.09.057 · Cited by 108 · see citing works
Maher, P. A., Currais, A. J. M., & Schubert, D. A. (2020) · Cell chemical biology · doi:10.1016/j.chembiol.2020.10.010 · Cited by 107 · see citing works
Keri, R. S., Quintanova, C., Marques, S. M., Esteves, A. R., Cardoso, S. M., & Santos, M. A. (2013) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2013.05.028 · Cited by 107 · see citing works
Lanza, I. R., Bhagra, S., Nair, K. S., & Port, J. D. (2011) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.22733 · Cited by 103 · see citing works
Banik, A., Brown, R. E., Bamburg, J., Lahiri, D. K., Khurana, D., Friedland, R. P., Chen, W., Ding, Y., Mudher, A., Padjen, A. L., et al. (2015) · Journal of Alzheimer’s Disease · doi:10.3233/jad-150136 · Cited by 102 · see citing works
Neuronal and Vascular Oxidative Stress in Alzheimers Disease
Massaad, C. A. (2011) · Current Neuropharmacology · doi:10.2174/157015911798376244 · Cited by 102 · see citing works
Ferroptosis regulation through Nrf2 and implications for neurodegenerative diseases
Xiang, Y., Song, X., & Long, D. (2024) · Archives of Toxicology · doi:10.1007/s00204-023-03660-8 · Cited by 109 · see citing works
Mitochondrial protein tyrosine nitration
Castro, L., Demicheli, V., Tórtora, V., & Radí, R. (2010) · Free Radical Research · doi:10.3109/10715762.2010.516254 · Cited by 100 · see citing works
Wang, B., Wu, C., Chen, Z., Zheng, P.-P., Liu, Y.-Q., Xiong, J., Xu, J., Li, P., Mamun, A. A., Ye, L., et al. (2021) · Acta Pharmacologica Sinica · doi:10.1038/s41401-020-00583-3 · Cited by 101 · see citing works
Berberine ameliorates iron levels and ferroptosis in the brain of 3 × Tg-AD mice
Li, X., Chen, J., Feng, W., Wang, C., Chen, M., Li, Y., Chen, J., Liu, X., Liu, Q., & Tian, J. (2023) · Phytomedicine · doi:10.1016/j.phymed.2023.154962 · Cited by 101 · see citing works
- Authors
- Ansari, M. A., & Scheff, S. W.
- Affiliations
- University of Kentucky (US)
- Corresponding author
- Scheff, Stephen W.
- ORCID
- Ansari, Mubeen A.
- Venue
- Journal of Neuropathology & Experimental Neurology
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-02
- Volume
- 69
- Issue
- 2
- Pages
- 155-167
- ISSN
- 0022-3069 (ISSN-L)
- 1554-6578
- PMC
- PMC2826839
- OpenAlex
- W2031762170
- Cited by
- 605
- References
- 96
- Citations by year
- 2026: 29 · 2025: 38 · 2024: 44 · 2023: 40 · 2022: 51 · 2021: 56 · 2020: 44 · 2019: 38 · 2018: 30 · 2017: 31 · 2016: 41 · 2015: 29 · 2014: 31 · 2013: 24 · 2012: 31
- FWCI
- 21.61
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Neuropathology & Experimental Neurology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (AG-028383, AG27219, P30AG028383, P01AG014449, R01AG043375, R01AG027219)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Keywords
- oxidative stress, Alzheimer's disease, frontal cortex, synaptosomes, mitochondria, antioxidants, glutathione, superoxide dismutase, lipid peroxidation, protein carbonyls, nitrotyrosine, 4-hydroxynonenal, acrolein, synaptic loss, disease progression, mild cognitive impairment, postmortem brain
- MeSH terms
- Aged, Aged, 80 and over, Aldehydes, Alzheimer Disease, Antioxidants, Female, Frontal Lobe, Humans, Male, Mental Status Schedule, Synapses, Tissue Distribution, Tyrosine, Biomarkers, Thiobarbituric Acid Reactive Substances, Oxidative Stress, Disease Progression, Protein Carbonylation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
