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Acute and chronic stage adaptations of vascular architecture and cerebral blood flow in a mouse model of TBI
Open accessPreprint — published as 10.1016/j.neuroimage.2019.116101 · Paper page
Abstract
The 3D organization of cerebral blood vessels determines the overall capacity of the cerebral circulation to meet the metabolic requirements of the brain. This study used Arterial Spin Labeling (ASL) MRI with a hypercapnic challenge and ex vivo Serial Two-Photon Tomography (STPT) to examine the relationship between blood flow and 3D microvascular structure following traumatic brain injury (TBI) in a mouse. Mice were exposed to a controlled cortical impact TBI and allowed to recover for either 1 day or 4 weeks. At each time point, ASL MRI was performed to quantify cerebral perfusion and the brain vasculature was imaged in 3D with STPT. Registration of ASL to STPT enabled flow changes to be related to the underlying microvascular structure in each ASL voxel. Hypoperfusion under rest and hypercapnia was observed both 1 day and 4 weeks post-TBI. Vessel density and vascular volume were reduced 1 day post-TBI, recovering by 4 weeks; however, the reorganized vasculature at the latter time point possessed an abnormal radial pattern. Our findings demonstrate functionally significant long-term changes in the vascular architecture following injury and illustrate why metrics beyond traditional measures of vessel density are required to understand the impact of vascular structure on function.
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Metadata
- Authors
- Steinman, J., Cahill, L. S., Koletar, M. M., Stefanovic, B., & Sled, J. G.
- Affiliations
- University of Toronto (CA)
- Hospital for Sick Children (CA)
- Sunnybrook Hospital (CA)
- Corresponding author
- Steinman, Joe
- Venue
- NeuroImage
- Publisher
- openRxiv
- Published
- 2018-11-27
- Volume
- 202
- Pages
- 116101-116101
- ISSN
- 1053-8119 (ISSN-L)
- OpenAlex
- W2967240311
- Cited by
- 24
- References
- 1
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 4 · 2023: 4 · 2022: 4 · 2021: 7 · 2020: 2
- FWCI
- 2.20
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- NeuroImage (publishedVersion)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research (FRN \u2013 152961, 152961, FRN – 152961)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury Research
- Keywords
- traumatic brain injury, cerebral blood flow, cerebral microvasculature, vascular architecture, vessel density, cerebral perfusion, hypercapnia, arterial spin labeling, controlled cortical impact, mouse model
- MeSH terms
- Brain Injuries, Traumatic, Animals, Brain, Cerebrovascular Circulation, Disease Models, Animal, Female, Image Processing, Computer-Assisted, Male, Magnetic Resonance Angiography, Optical Imaging
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