Small Self-cleaving Ribozymes

In Vitro Selection of Functional Nucleic Acids

Wilson, D. S., & Szostak, J. W. (1999) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.68.1.611 · Cited by 1,217

A general two-metal-ion mechanism for catalytic RNA

Steitz, T. A., & Steitz, J. A. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.14.6498 · Cited by 1,171

Control of gene expression by a natural metabolite-responsive ribozyme

Winkler, W. C., Nahvi, A., Roth, A., Collins, J. A., & Breaker, R. R. (2004) · Nature · doi:10.1038/nature02362 · Cited by 976

Three-dimensional structure of a hammerhead ribozyme

Pley, H. W., Flaherty, K. M., & McKay, D. (1994) · Nature · doi:10.1038/372068a0 · Cited by 946

A small catalytic oligoribonucleotide

Uhlenbeck, O. C. (1987) · Nature · doi:10.1038/328596a0 · Cited by 932

Crystal structure of a hepatitis delta virus ribozyme

Ferré-D’Amaré, A. R., Zhou, K., & Doudna, J. A. (1998) · Nature · doi:10.1038/26912 · Cited by 790

Riboswitches and the RNA WorldPreprint

Breaker, R. R. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a003566 · Cited by 712

The crystal structure of an AII-RNAhammerhead ribozyme: A proposed mechanism for RNA catalytic cleavage

Scott, W. G., Finch, J. T., & Klug, A. (1995) · Cell · doi:10.1016/s0092-8674(05)80004-2 · Cited by 684

Autolytic Processing of Dimeric Plant Virus Satellite RNA

Prody, G. A., Bakos, J. T., Buzayan, J. M., Schneider, I. R., & Bruening, G. E. (1986) · Science · doi:10.1126/science.231.4745.1577 · Cited by 634

The origins of the RNA world

Robertson, M. P., & Joyce, G. F. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a003608 · Cited by 556

A generalizable scaffold-based approach for structure determination of RNAs by cryo-EM

Langeberg, C. J., & Kieft, J. S. (2023) · Nucleic Acids Research · doi:10.1093/nar/gkad784 · Cited by 21

Review of computer simulations of isotope effects on biochemical reactions: From the Bigeleisen equation to Feynman's path integral

Wong, K. Y., Xu, Y., & Xu, L. (2015) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2015.04.021 · Cited by 20

Diversity and evolution of viroids and viroid-like agents with circular RNA genomes revealed by metatranscriptome mining

Koonin, E. V., & Lee, B. D. (2024) · Nucleic Acids Research · doi:10.1093/nar/gkae1278 · Cited by 18

Metabolite-binding ribozymes

Ramesh, A., & Winkler, W. C. (2014) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2014.04.015 · Cited by 19

Native RNA Purification by Gel Filtration Chromatography

Booy, E. P., Meng, H., & McKenna, S. A. (2012) · Methods in molecular biology · doi:10.1007/978-1-62703-113-4_6 · Cited by 18

Evolution of Protein Physical Structures in Insect Chemosensory Systems

Picimbon, J. (2019) · Springer eBooks · doi:10.1007/978-3-030-05165-5_10 · Cited by 17

Assessing the Potential Effects of Active Site Mg2+ Ions in the glmS Ribozyme–Cofactor Complex

Zhang, S., Stevens, D. R., Goyal, P., Bingaman, J. L., Bevilacqua, P. C., & Hammes‐Schiffer, S. (2016) · The Journal of Physical Chemistry Letters · doi:10.1021/acs.jpclett.6b01854 · Cited by 17

Direct screening for ribozyme activity in mammalian cells

Nomura, Y., Chien, H., & Yokobayashi, Y. (2017) · Chemical Communications · doi:10.1039/c7cc07815c · Cited by 17

RNA polymerase II-driven CRISPR-Cas9 system for efficient non-growth-biased metabolic engineering of Kluyveromyces marxianus

Bever, D., Wheeldon, I. R., & Silva, N. D. (2022) · Metabolic Engineering Communications · doi:10.1016/j.mec.2022.e00208 · Cited by 16

Ribozymes: Flexible molecular devices at work

Talini, G., Branciamore, S., & Gallori, E. (2011) · Biochimie · doi:10.1016/j.biochi.2011.06.026 · Cited by 18

RNA ligase ribozymes with a small catalytic core

Nomura, Y., & Yokobayashi, Y. (2023) · Scientific Reports · doi:10.1038/s41598-023-35584-9 · Cited by 17

A divalent cation-dependent variant of the glmS ribozyme with stringent Ca2+ selectivity co-opts a preexisting nonspecific metal ion-binding site

Lau, M. W. L., Trachman, R. J., & Ferré-D’Amaré, A. R. (2016) · RNA · doi:10.1261/rna.059824.116 · Cited by 15

Deciphering the Self-Cleavage Reaction Mechanism of Hairpin Ribozyme

Kumar, N., & Marx, D. (2020) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.0c03768 · Cited by 13

Viroid-like RNA-dependent RNA polymerase-encoding ambiviruses are abundant in complex fungi

Chong, L. C., & Lauber, C. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1144003 · Cited by 14

Ab initio path‐integral calculations of kinetic and equilibrium isotope effects on base‐catalyzed RNA transphosphorylation models

Wong, K. Y., Xu, Y., & York, D. M. (2014) · Journal of Computational Chemistry · doi:10.1002/jcc.23628 · Cited by 14

Sequestration and delays enable the synthesis of a molecular derivative operator

Samaniego, C. C., Kim, J., & Franco, E. (2020) · IEEE Conference on Decision and Control (CDC) · doi:10.1109/cdc42340.2020.9304515 · Cited by 13

Circular RNAs Biogenesis in Eukaryotes Through Self-Cleaving Hammerhead Ribozymes

de la Peña, M. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-1426-1_5 · Cited by 13

Genetic disruption of the bacterial raiA motif noncoding RNA causes defects in sporulation and aggregation

Soares, L. W., King, C. G., Fernando, C. M., Roth, A., & Breaker, R. R. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2318008121 · Cited by 12

Chemically Cross-Linked Hammerhead Ribozyme as an Efficient RNA Interference Tool

Wang, L., Wu, C., Zhang, Q., Wang, Y., Liu, Y., Yang, W., Ye, S.-L., Tian, Y., & Xu, L. (2024) · Journal of the American Chemical Society · doi:10.1021/jacs.3c12702 · Cited by 13

A Mini‐Twister Variant and Impact of Residues/Cations on the Phosphodiester Cleavage of this Ribozyme Class

Košutić, M., Neuner, S., Ren, A., Flür, S., Wunderlich, C. H., Mairhofer, E., Vušurović, N., Seikowski, J., Breuker, K., Höbartner, C., et al. (2015) · Angewandte Chemie · doi:10.1002/ange.201506601 · Cited by 12

Exploring the Potential and Advancements of Circular RNA Therapeutics

Wang, L., Wang, L., Dong, C., Liu, J., Cui, G., Gao, S., & Liu, Z. (2025) · Exploration · doi:10.1002/exp.20240044 · Cited by 15

Predicting higher-order mutational effects in an RNA enzyme by machine learning of high-throughput experimental data

Beck, J. D., Roberts, J. M., Kitzhaber, J., Trapp, A., Serra, E., Spezzano, F., & Hayden, E. J. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.893864 · Cited by 11

In vitro evolution of coenzyme-independent variants from the glmS ribozyme structural scaffold

Lau, M. W. L., & Ferré-D’Amaré, A. R. (2016) · Methods · doi:10.1016/j.ymeth.2016.04.027 · Cited by 11

Rolling Circles as a Means of Encoding Genes in the RNA World

Rivera-Madrinan, F., Iorio, K. D., & Higgs, P. G. (2022) · Life · doi:10.3390/life12091373 · Cited by 8

The discovery and development of RNA-based therapies for treatment of HIV-1 infection

Chen, M. J., Gatignol, A., & Scarborough, R. J. (2022) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2022.2117296 · Cited by 9

Biologically-supported structural model for a viral satellite RNA

Ashton, P. D., Wu, B., D'Angelo, J., Grigull, J., & White, K. A. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv917 · Cited by 9

Direct testing of natural twister ribozymes from over a thousand organisms reveals a broad tolerance for structural imperfections

McKinley, L. N., Meyer, M. O., Sebastian, A., Chang, B. K., Messina, K. J., Albert, I. U., & Bevilacqua, P. C. (2024) · Nucleic Acids Research · doi:10.1093/nar/gkae908 · Cited by 7

Engineering and comparison of cas12a ‐based genome editing systems in plants

Bircheneder, M., & Parniske, M. (2025) · The Plant Journal · doi:10.1111/tpj.70410 · Cited by 8

Finding aptamers and small ribozymes in unexpected places

Matylla-Kulińska, K., Boots, J. L., Zimmermann, B., & Schroeder, R. (2011) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.105 · Cited by 7

The epsilon motif of hepatitis B virus RNA exhibits a potassium‐dependent ribonucleolytic activity

Chakraborty, D., & Ghosh, S. (2017) · FEBS Journal · doi:10.1111/febs.14050 · Cited by 7

Structures of Large RNA Molecules and Their Complexes

(2015) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(15)x0011-5 · Cited by 7

Empirical analysis of RNA robustness and evolution using high-throughput sequencing of ribozyme reactions

Hayden, E. J. (2016) · Methods · doi:10.1016/j.ymeth.2016.05.014 · Cited by 7

Preparation of NanoMEDIC Extracellular Vesicles to Deliver CRISPR-Cas9 Ribonucleoproteins for Genomic Exon Skipping

Watanabe, K., Gee, P., & Hotta, A. (2022) · Methods in molecular biology · doi:10.1007/978-1-0716-2772-3_22 · Cited by 6

Tunable self-cleaving ribozymes for modulating gene expression in eukaryotic systems

Jacobsen, T. L., Yi, G., Asafen, H. A., Jermusyk, A. A., Beisel, C. L., & Reeves, G. T. (2020) · PLoS ONE · doi:10.1371/journal.pone.0232046 · Cited by 6

Virus-associated ribozymes and nano carriers against COVID-19

Dönmüş, B., ÜNAL, S., Kırmızıtaş, F. C., & Laçin, N. T. (2021) · Artificial Cells Nanomedicine and Biotechnology · doi:10.1080/21691401.2021.1890103 · Cited by 6

Prediction of hammerhead ribozyme intracellular activity with the catalytic core fingerprint

Gabryelska, M., Wyszko, E., Szymański, M., Popenda, M., & Barciszewski, J. (2013) · Biochemical Journal · doi:10.1042/bj20121761 · Cited by 6

An Individual Amino Acid as a Possible Prebiotic Catalyst

Agazani, O., Tulpin, A., & Reches, M. (2021) · ChemSystemsChem · doi:10.1002/syst.202100005 · Cited by 6

Mechanistic Insights Into Catalytic RNA–Protein Complexes Involved in Translation of the Genetic Code

Routh, S. B., & Sankaranarayanan, R. (2017) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2017.04.002 · Cited by 6

On the emergence of structural complexity in RNA replicators

Oliver, C., Reinharz, V., & Waldispühl, J. (2019) · RNA · doi:10.1261/rna.070391.119 · Cited by 5

Less Can Be More: RNA-Adapters May Enhance Coding Capacity of Replicators

de Boer, F. K., & Hogeweg, P. (2012) · PLoS ONE · doi:10.1371/journal.pone.0029952 · Cited by 5

Molecular dynamics analysis of Mg 2+ ‐dependent cleavage of a pistol ribozyme reveals a fail‐safe secondary ion for catalysis

Joseph, N. N., Roy, R. N., & Steitz, T. A. (2020) · Journal of Computational Chemistry · doi:10.1002/jcc.26179 · Cited by 5

VR-SCOSMO: A smooth conductor-like screening model with charge-dependent radii for modeling chemical reactions

Kuechler, E. R., Giese, T. J., & York, D. M. (2016) · The Journal of Chemical Physics · doi:10.1063/1.4946779 · Cited by 5

Crucial Roles of Two Hydrated Mg2+ Ions in Reaction Catalysis of the Pistol Ribozyme

Teplova, M., Falschlunger, C., Krasheninina, O. A., Egger, M., Ren, A., Patel, D. J., & Micura, R. (2019) · Angewandte Chemie · doi:10.1002/ange.201912522 · Cited by 5

Characterization of the Reaction Path and Transition States for RNA Transphosphorylation Models from Theory and Experiment

Wong, K. Y., Gu, H., Zhang, S., Piccirilli, J. A., Harris, M. E., & York, D. M. (2011) · Angewandte Chemie · doi:10.1002/ange.201104147 · Cited by 5

A vast world of viroid-like circular RNAs revealed by mining metatranscriptomesPreprint

Lee, B. D., Neri, U., Roux, S., Wolf, Y. I., Camargo, A. P., Krupovìč, M., Peter Simmonds, K., Kyrpides, N. C., Gophna, U., Dolja, V. V., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.07.19.500677 · Cited by 5

Minimal twister sister-like self-cleaving ribozymes in the human genome revealed by deep mutational scanning

Zhou, Y., Zhang, Z., Xu, H. L., Xiong, P., Wang, J., & Zhan, J. (2023) · eLife · doi:10.7554/elife.90254 · Cited by 5

Recent Development of Glucosamine‐6‐phosphate Derivatives as Potential Antibacterial Agents

Liu, X., & Ma, S. (2020) · ChemistrySelect · doi:10.1002/slct.201904075 · Cited by 5

Long-term Expression of Apolipoprotein B mRNA-specific Hammerhead Ribozyme via scAAV8.2 Vector Inhibits Atherosclerosis in Mice

Nischal, H., Sun, H., Wang, Y., Ford, D. A., Cao, Y., Wei, P., & Teng, B.-B. (2013) · Molecular Therapy — Nucleic Acids · doi:10.1038/mtna.2013.53 · Cited by 4

Therapeutic Potential of Ribozymes

Balke, D., & Müller, S. (2019) · Royal Society of Chemistry eBooks · doi:10.1039/9781788015714-00434 · Cited by 4

Cotranscriptional Assembly and Native Purification of Large RNA–RNA Complexes for Structural Analyses

Sapkota, K. P., Li, S., & Zhang, J. (2022) · Methods in molecular biology · doi:10.1007/978-1-0716-2687-0_1 · Cited by 3

RNA and the Cellular Biochemistry Revisited

Farrell, R. E. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-374727-3.00001-2 · Cited by 2

Application of RtcB ligase to monitor self-cleaving ribozyme activity by RNA-seq

Olzog, V. J., Freist, L. I., Goldmann, R., Fallmann, J., & Weinberg, C. E. (2022) · Biological Chemistry · doi:10.1515/hsz-2021-0408 · Cited by 3

RloC: A Translation-Disabling tRNase Implicated in Phage Exclusion During Recovery from DNA Damage

Kaufmann, G., Davidov, E., Steinfels, E., Krutkina, E., Klaiman, D., Margalit, T., Chai-Danino, M., & Kotlyar, A. B. (2011) · InTech eBooks · doi:10.5772/23591 · Cited by 2

Riboswitches: Regulatory ncRNAs in Archaea

Swati, D. (2017) · Springer eBooks · doi:10.1007/978-3-319-65536-9_17 · Cited by 2

RNAs That Behave Like Prions

Mushegian, A. R., & Elena, S. F. (2020) · mSphere · doi:10.1128/msphere.00520-20 · Cited by 2

Life: The Physical Underpinnings of Replication

Turk-MacLeod, R. M., Gerland, U., & Chen, I. A. (2012) · Springer eBooks · doi:10.1007/978-3-642-31730-9_9 · Cited by 2

A Web Service for Automated Design of Multiple Types of Ribozymes Targeting RNA: from minimal hammerhead to aptazymesPreprint

Najeh, S., Kharma, N., Vaudry-Read, T., Haurie, A., Paslawski, C., Adams, D., Ferreira, S., & Perreault, J. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.09.30.560155 · Cited by 2

Formation of RNA spatial structures

Леонова, Е. И., Baranov, M. V., & Galzitskaya, O. V. (2012) · Molecular Biology · doi:10.1134/s0026893312010104 · Cited by 1

Novel DNA and RNA Elements

Pitzer, J., Hove, B. V., Love, A. M., Ajikumar, P. K., Mey, M. D., & Glieder, A. (2015) · Springer eBooks · doi:10.1007/978-3-319-22708-5_2 · Cited by 2

Screening of Genetic Switches Based on the Twister Ribozyme Motif

Felletti, M., Klauser, B., & Hartig, J. S. (2015) · Methods in molecular biology · doi:10.1007/978-1-4939-3197-2_19 · Cited by 1

Development of in vitro ribosome assembly system for ribosome engineering with ribosome biogenesis factors YrdC and SrmB

Kwon, Y., Maeng, M., Joo, S., Kim, Y., Khobragade, T. P., Giri, P., Ghosh, R., Jung, S., Yoon, H., Cho, S., et al. (2025) · Biotechnology and Bioprocess Engineering · doi:10.1007/s12257-025-00205-x · Cited by 1

RNA Technologies for Mitochondrial Genetics

Dietrich, A., Rolle, K., Gabryelska, M. M., Wyszko, E., Val, R., Szymanski, M., Valentin, C., Cosset, A., & Barciszewski, J. (2012) · RNA technologies · doi:10.1007/978-3-642-27426-8_13

The Birth of Life

Ligrone, R. (2019) · Springer eBooks · doi:10.1007/978-3-030-16057-9_3 · Cited by 1

Catalytic RNA

Burke, C. R., & Lupták, A. (2012) · Wiley eBooks · doi:10.1002/9780470015902.a0000870.pub2 · Cited by 1

Human Lantern Ribozymes: Smallest Known Self-cleaving RibozymesPreprint

Zhou, Y., Zhang, Z., Xu, H. L., Xiong, P., Wang, J., & Zhan, J. (2023) · eLife · doi:10.21203/rs.3.rs-2567304/v1 · Cited by 1

Global effects of plant virus infection, viral noncoding RNAs, and unfolded protein response on plant gene expression

Kanodia, P. (2021) · doi:10.31274/td-20240329-367 · Cited by 1

Charge-dependent non-bonded interaction methods for use in quantum mechanical modeling of condensed phase reactions

Kuechler, E. R. (2015) · University of Minnesota Digital Conservancy (University of Minnesota)

Analysis and kinase-mediated decay of RNAs with 5´-hydroxyl termini

Peach, S. E. (2016) · doi:10.25677/rar5-j081

Assessment and Improvement of Computational Models to Study Biological Catalysis

Huang, M. S. (2014) · University of Minnesota Digital Conservancy (University of Minnesota)

Development of hammerhead ribozymes targeting miR-21

Belter, A., & Naskręt-Barciszewska, M. Z. (2015) · Biotechnologia · doi:10.5114/bta.2014.56599

IDENTIFICATION OF RNA STRUCTURES MODULATING THE EXPRESSION OF THE mRNA BIOGENESIS FACTOR SUS1

AbuQattam, A. (2017) · RiuNet (Universitat Politècnica de València) · doi:10.4995/thesis/10251/90524

Studying Parasite Gene Function and Interaction Through Ribozymes and Riboswitches Design Mechanism

Shukla, H., & Tripathi, T. (2018) · Springer eBooks · doi:10.1007/978-981-10-8693-9_4

RNA and the Cellular Biochemistry Revisited

Farrell, R. E. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804678-4.00001-4

Nucleic Acid Architectures for Therapeutics, Diagnostics, Devices and Materials

Afonin, K. A. (2019) · MDPI eBooks · doi:10.3390/books978-3-03921-260-6

Resurrecting self-cleaving mini-ribozymes from 40-million-year-old LINE-1 elements in human genomePreprint

Zhang, Z., Xiong, P., Wang, J., Zhan, J., & Zhou, Y. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.04.06.438727

Chemical Modifications in Natural and Engineered Ribozymes

Kath‐Schorr, S. (2021) · Wiley eBooks · doi:10.1002/9783527814527.ch18

Faculty Opinions recommendation of A widespread self-cleaving ribozyme class is revealed by bioinformatics.

Batey, R. (2013) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.718178547.793487805

Faculty Opinions recommendation of In-line alignment and Mg²⁺ coordination at the cleavage site of the env22 twister ribozyme.

Lilley, D. M. J. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.725242655.793563676

Catalytic RNA

Kent, A. D., Burke, C. R., & Lupták, A. (2021) · Wiley eBooks · doi:10.1002/9780470015902.a0029295

Faculty Opinions recommendation of Structural basis for the fast self-cleavage reaction catalyzed by the twister ribozyme.

Lilley, D. M. J. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.718544521.793563675

Faculty Opinions recommendation of Biochemical analysis of hatchet self-cleaving ribozymes.

Lilley, D. M. J. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.725799554.793563685

Faculty Opinions recommendation of A widespread self-cleaving ribozyme class is revealed by bioinformatics.

Lilley, D. M. J. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.718178547.793563674

Faculty Opinions recommendation of Pistol ribozyme adopts a pseudoknot fold facilitating site-specific in-line cleavage.

Lilley, D. M. J. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.726494083.793563683

Faculty Opinions recommendation of Biochemical analysis of pistol self-cleaving ribozymes.

Lilley, D. M. J. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.725799557.793563682

Faculty Opinions recommendation of New classes of self-cleaving ribozymes revealed by comparative genomics analysis.

Lilley, D. M. J. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.725633870.793563673

Faculty Opinions recommendation of Inosine, but none of the 8-oxo-purines, is a plausible component of a primordial version of RNA.

Vicens, Q. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.734557924.793556325

Structural Analysis of Ribozymes

Ouellet, J., Ananvoranich, S., & Perreault, J. (2000) · Encyclopedia of Analytical Chemistry · doi:10.1002/9780470027318.a1427.pub2

RNA

(2015) · Wiley eBooks · doi:10.1002/9781118539385.ch6 · Cited by 1

Faculty Opinions recommendation of Crystal structure of Pistol, a class of self-cleaving ribozyme.

Lilley, D. M. J. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.727215310.793563684

Scaling Catalytic Contributions of Small Self‐Cleaving Ribozymes

Egger, M., Bereiter, R., Mair, S., & Micura, R. (2022) · Angewandte Chemie · doi:10.1002/ange.202207590

Improving the Ribozyme Toolbox

Roberts, J. M. (2022) · ScholarWorks (Boise State University) · doi:10.18122/td.1991.boisestate

Development of a framework to characterise and evolve riboswitches

Jessen, M. X. L. (2023) · Queensland University of Technology · doi:10.5204/thesis.eprints.237756

Minimal twister sister (TS)-like self-cleaving ribozymes in the human genome revealed by deep mutational scanningPreprint

Zhang, Z., Xu, H. L., Xiong, P., Wang, J., Zhan, J., & Zhou, Y. (2024) · Research Square · doi:10.21203/rs.3.rs-2567304/v3

Minimal twister sister (TS)-like self-cleaving ribozymes in the human genome revealed by deep mutational scanningPreprint

Zhang, Z., Xu, H. L., Xiong, P., Wang, J., Zhou, Y., & Zhan, J. (2024) · eLife · doi:10.7554/elife.90254.2

CHiTA: A scarless high-throughput pipeline for characterization of ribozymes

McKinley, L. N., & Bevilacqua, P. C. (2024) · Methods · doi:10.1016/j.ymeth.2024.12.007

Intracellular auto-circularizing RNA using human tRNA splicing elementsPreprint

Ma, Q., Tang, C., Wang, J., Liu, Y., Sun, X., & Zhao, S. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.07.28.667085

Characterization and engineering of highly efficient Cas12j genome editorsPreprint

Rao, G. S., Jiang, W., Aouida, M., Wang, Q., Kazlak, A. M., Elbehery, A. H. A., Saleh, A., Masood, M., Ghouneimy, A., & Mahfouz, M. M. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.16.676532

Engineered pistol ribozymes selectively target KRAS G12V with enhanced efficacy by capping modification

Li, Z., Zhao, M., Xi, Z., Bai, J., Zhang, Y., Zhan, X., Yang, Y., & Liu, Y. (2026) · Cell chemical biology · doi:10.1016/j.chembiol.2026.03.001

Contributions to the study of the architecture and evolution of ribozymes

Meyer, M. (2013) · theses.fr (ABES) · doi:10.70675/540f098az4750z490azb17czf674f30ed399

Engineering cis- and trans-acting RNA regulators for next-generation prokaryotic synthetic biology

Tong, S., & Tong, Y. (2026) · Biotechnology Advances · doi:10.1016/j.biotechadv.2026.108882

Structure-based mechanistic insights into catalysis by small self-cleaving ribozymes

Ren, A., Micura, R., & Patel, D. J. (2017) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2017.09.017 · Cited by 72

Comparative Enzymology and Structural Biology of RNA Self-Cleavage

Fedor, M. J. (2009) · Annual Review of Biophysics · doi:10.1146/annurev.biophys.050708.133710 · Cited by 130

Ribozyme Structures and Mechanisms

Doherty, E. A., & Doudna, J. A. (2001) · Annual Review of Biophysics and Biomolecular Structure · doi:10.1146/annurev.biophys.30.1.457 · Cited by 195

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