The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Regulation of Cholesterol and Fatty Acid Synthesis
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Overexpression of an active form of SREBP1c develops steatosis as a result of elevation of lipogenesis.
“The critical role of SREBP1c in hepatic lipogenesis is supported by gain-and loss-of-function studies showing that overexpression of an active form develops steatosis as a result of elevation of lipogenesis, and conversely defi ciency of hepatic SREBP1c fails to induce lipogenic gene expression ( 54 ).”
From KSRP is critical in governing hepatic lipid metabolism through controlling Per2 expression (2015) · cites this paper as [54]
Deficiency of hepatic SREBP1c fails to induce lipogenic gene expression.
“The critical role of SREBP1c in hepatic lipogenesis is supported by gain-and loss-of-function studies showing that overexpression of an active form develops steatosis as a result of elevation of lipogenesis, and conversely defi ciency of hepatic SREBP1c fails to induce lipogenic gene expression ( 54 ).”
From KSRP is critical in governing hepatic lipid metabolism through controlling Per2 expression (2015) · cites this paper as [54]
SREBP1c is a transcription factor that increases lipogenesis by promoting expression of lipogenic genes such as Acaca, Fasn, and Scd1.
“SREBP1c is a transcription factor that increases lipogenesis by promoting expression of lipogenic genes such as Acaca , Fasn , and Scd1 .”
From KSRP is critical in governing hepatic lipid metabolism through controlling Per2 expression (2015) · cites this paper as [54]
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Citations
Cites
Li, S., Brown, M. S., & Goldstein, J. L. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914798107 · Cited by 733 · cited 1×
“Recent studies have implicated a kinase complex designated the mammalian target of rapamycin complex 1 (mTORC1) in the insulin-mediated induction of SREBP-1c transcription (Li et al. 2010).”
BackgroundLiang, G., Yang, J., Horton, J. D., Hammer, R. E., Goldstein, J. L., & Brown, M. S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111421200 · Cited by 669
Flagged first, then by citations
Research works printed but not linked: 2
- Horton JD, Shimomura I, Brown MS, Hammer RE, Gold- stein JL, Shimano H. 1998. Activation of cholesterol syn- thesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2. J Clin Invest 101: 2331-2339.
- Ye J, Dave UP, Grishin NV, Goldstein JL, Brown MS. 2000. Asparagine-proline sequence within membrane-span- ning segment of SREBP triggers intramembrane cleavage by site-2 protease. Proc Natl Acad Sci 97: 5123-5128. Regulation of Cholesterol and Fatty Acid Synthesis Cite this article as Cold Spring Harb Perspect Biol 2011;3:a004754 6, 2011 2011; doi: 10.1101/cshperspect.a004754 originally published online April Cold Spring Harb Perspect Biol
Cited by
Sorted by citations
Lipid and Lipoprotein Metabolism in Microglia
Loving, B. A., & Bruce, K. D. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00393 · Cited by 255
KSRP is critical in governing hepatic lipid metabolism through controlling Per2 expression
Chou, C.-F., Zhu, X., Lin, Y.-Y., Gamble, K. L., Garvey, W. T., & Chen, C.-Y. (2015) · Journal of Lipid Research · doi:10.1194/jlr.m050724 · Cited by 20
Metadata
- Authors
- Ye, J., & DeBose-Boyd, R. A.
- Venue
- Cold Spring Harbor Perspectives in Biology
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2011-04-06
- Volume
- 3
- Issue
- 7
- Pages
- a004754-a004754
- ISSN
- 1943-0264
- Cited by
- 223
- References
- 2
- Language
- en
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