Lipid and Lipoprotein Metabolism in Microglia

Copper-Zinc Superoxide Dismutase (SOD1) Is Released by Microglial Cells and Confers Neuroprotection against 6-OHDA Neurotoxicity

Polazzi, E., Mengoni, I., Caprini, M., Peña‐Altamira, E., Kurtys, E., & Monti, B. (2012) · Neurosignals · doi:10.1159/000337115 · Cited by 9,023 · see citing works

Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo

Nimmerjahn, A., Kirchhoff, F., & Helmchen, F. (2005) · Science · doi:10.1126/science.1110647 · Cited by 5,827 · see citing works

A Unique Microglia Type Associated with Restricting Development of Alzheimer’s Disease

Keren-Shaul, H., Spinrad, A., Weiner, A., Matcovitch-Natan, O., Dvir-Szternfeld, R., Ulland, T. K., David, E., Baruch, K., Lara-Astaiso, D., Toth, B., et al. (2017) · Cell · doi:10.1016/j.cell.2017.05.018 · Cited by 5,493 · see citing works

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

Ginhoux, F., Greter, M., Leboeuf, M., Nandi, S., See, P., Gokhan, S., Mehler, M. F., Conway, S. J., Ng, L. G., Stanley, E. R., et al. (2010) · Science · doi:10.1126/science.1194637 · Cited by 5,175 · see citing works

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

Zhang, Y., Chen, K., Sloan, S. A., Bennett, M. L., Scholze, A. R., O'Keeffe, S., Phatnani, H. P., Guarnieri, P., Caneda, C., Ruderisch, N., et al. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.1860-14.2014 · Cited by 4,875 · see citing works

The metabolism of tumors in the body

Warburg, O., Wind, F., & Negelein, E. (1927) · Journal of General Physiology · doi:10.1085/jgp.8.6.519 · Cited by 4,416 · see citing works

Synaptic Pruning by Microglia Is Necessary for Normal Brain Development

Paolicelli, R. C., Bolasco, G., Pagani, F., Maggi, L., Scianni, M., Panzanelli, P., Giustetto, M., Ferreira, T. A., Guiducci, E., Dumas, L., et al. (2011) · Science · doi:10.1126/science.1202529 · Cited by 4,244 · see citing works

Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

Schafer, D. P., Lehrman, E. K., Kautzman, A. G., Koyama, R., Mardinly, A. R., Yamasaki, R., Ransohoff, R. M., Greenberg, M. E., Barres, B. A., & Stevens, B. (2012) · Neuron · doi:10.1016/j.neuron.2012.03.026 · Cited by 4,089 · see citing works

ATP mediates rapid microglial response to local brain injury in vivo

Davalos, D., Grutzendler, J., Yang, G., Kim, J. V., Zuo, Y., Jung, S., Littman, D. R., Dustin, M. L., & Gan, W.-B. (2005) · Nature Neuroscience · doi:10.1038/nn1472 · Cited by 3,913 · see citing works

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

Harold, D., Abraham, R., Hollingworth, P., Sims, R., Gerrish, A., Hamshere, M. L., Pahwa, J. S., Moskvina, V., Dowzell, K., Williams, A., et al. (2009) · Nature Genetics · doi:10.1038/ng.440 · Cited by 3,326 · see citing works

Pro-resolving lipid mediators are leads for resolution physiology

Serhan, C. N. (2014) · Nature · doi:10.1038/nature13479 · Cited by 3,041 · see citing works

The Importance of the Omega-6/Omega-3 Fatty Acid Ratio in Cardiovascular Disease and Other Chronic Diseases

Simopoulos, A. P. (2008) · Experimental Biology and Medicine · doi:10.3181/0711-mr-311 · Cited by 2,934 · see citing works

Microglia Function in the Central Nervous System During Health and Neurodegeneration

Colonna, M., & Butovsky, O. (2017) · Annual Review of Immunology · doi:10.1146/annurev-immunol-051116-052358 · Cited by 2,894 · see citing works

15-Deoxy-Δ12,14-Prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ

FORMAN, B. M., Tontonoz, P., Chen, J., Brun, R. P., Spiegelman, B. M., & Evans, R. M. (1995) · Cell · doi:10.1016/0092-8674(95)90193-0 · Cited by 2,858 · see citing works

Analysis of Fractalkine Receptor CX₃CR1 Function by Targeted Deletion and Green Fluorescent Protein Reporter Gene Insertion

Jung, S., Aliberti, J., Graemmel, P., Sunshine, M. J., Kreutzberg, G. W., Sher, A., & Littman, D. R. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.11.4106-4114.2000 · Cited by 2,632 · see citing works

Identification of a unique TGF-β–dependent molecular and functional signature in microglia

Butovsky, O., Jedrychowski, M. P., Moore, C. S., Cialic, R., Lanser, A. J., Gabriely, G., Koeglsperger, T., Dake, B., Wu, P. M., Doykan, C. E., et al. (2014) · Nature Neuroscience · doi:10.1038/nn.3599 · Cited by 2,543 · see citing works

Schizophrenia risk from complex variation of complement component 4

Sekar, A., Bialas, A. R., de Rivera, H., Davis, A., Hammond, T. R., Kamitaki, N., Tooley, K., Presumey, J., Baum, M., Van Doren, V., et al. (2016) · Nature · doi:10.1038/nature16549 · Cited by 2,394 · see citing works

Brain energy metabolism: focus on Astrocyte-neuron metabolic cooperation

Bélanger, M., Allaman, I., & Magistretti, P. J. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.08.016 · Cited by 2,313 · see citing works

Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse

Zhang, Y., Sloan, S. A., Clarke, L. E., Caneda, C., Plaza, C. A., Blumenthal, P. D., Vogel, H., Steinberg, G. K., Edwards, M. S. B., Li, G., et al. (2016) · Neuron · doi:10.1016/j.neuron.2015.11.013 · Cited by 2,295 · see citing works

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

the European Alzheimer's Disease Initiative Investigators, Lambert, J.-C., Heath, S., Even, G., Campion, D., Sleegers, K., Hiltunen, M., Combarros, O., Zelenika, D., Bullido, M. J., et al. (2009) · Nature Genetics · doi:10.1038/ng.439 · Cited by 2,234 · see citing works

Complex cell-state changes revealed by single cell RNA sequencing of 76,149 microglia throughout the mouse lifespan and in the injured brain

Hammond, T. R., Dufort, C., Dissing-Olesen, L., Giera, S., Young, A., Wysoker, A., Walker, A. J., Segel, M., Nemesh, J., Saunders, A., et al. (2018) · doi:10.1101/406140 · Cited by 2,225 · see citing works

Network Integration of Parallel Metabolic and Transcriptional Data Reveals Metabolic Modules that Regulate Macrophage Polarization

Jha, A. K., Huang, S. C.-C., Sergushichev, A., Lampropoulou, V., Ivanova, Y., Loginicheva, E., Chmielewski, K., Stewart, K. M., Ashall, J., Everts, B., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.02.005 · Cited by 2,066 · see citing works

Heterogeneity in the distribution and morphology of microglia in the normal adult mouse brain

Lawson, L. J., Perry, V. H., Dri, P., & Gordon, S. (1990) · Neuroscience · doi:10.1016/0306-4522(90)90229-w · Cited by 2,045 · see citing works

A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation

Kliewer, S. A., Lenhard, J. M., Willson, T. M., Patel, I., Morris, D. C., & Lehmann, J. M. (1995) · Cell · doi:10.1016/0092-8674(95)90194-9 · Cited by 2,028 · see citing works

Microglia and macrophages in brain homeostasis and disease

Li, Q., & Barres, B. A. (2018) · Nature Reviews Immunology · doi:10.1038/nri.2017.125 · Cited by 1,999 · see citing works

Metabolic reprogramming in macrophages and dendritic cells in innate immunity

Kelly, B., & O'Neill, L. A. (2015) · Cell Research · doi:10.1038/cr.2015.68 · Cited by 1,876 · see citing works

Obesity is associated with hypothalamic injury in rodents and humans.

Thaler, J. P., Yi, C.-X., Schur, E. A., Guyenet, S. J., Hwang, B. H., Dietrich, M. O., Zhao, X., Sarruf, D. A., Izgur, V., Maravilla, K. R., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59660 · Cited by 1,857 · see citing works

Apolipoprotein E: Far More Than a Lipid Transport Protein

Mahley, R. W., & Rall, S. C. (2000) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.1.1.507 · Cited by 1,836 · see citing works

TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model

Wang, Y., Cella, M., Mallinson, K., Ulrich, J. D., Young, K. L., Robinette, M. L., Gilfillan, S., Krishnan, G. M., Sudhakar, S., Zinselmeyer, B. H., et al. (2015) · Cell · doi:10.1016/j.cell.2015.01.049 · Cited by 1,736 · see citing works

Marine omega-3 fatty acids and inflammatory processes: effects, mechanisms and clinical relevance

Calder, P. C. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.08.010 · Cited by 1,717 · see citing works

CNS synaptogenesis promoted by glia-derived cholesterol

Mauch, D. H., Nägler, K., Schumacher, S., Göritz, C., Müller, E.-C., Otto, A., & Pfrieger, F. W. (2001) · Science · doi:10.1126/science.294.5545.1354 · Cited by 1,711 · see citing works

An Increase in the Omega-6/Omega-3 Fatty Acid Ratio Increases the Risk for Obesity

Simopoulos, A. P. (2016) · Nutrients · doi:10.3390/nu8030128 · Cited by 1,673 · see citing works

Tlr signalling augments macrophage bactericidal activity through mitochondrial ros

West, A. P., Brodsky, I. E., Rahner, C., Woo, D. K., Erdjument-Bromage, H., Tempst, P., Walsh, M. C., Choi, Y., Shadel, G. S., & Ghosh, S. (2011) · Nature · doi:10.1038/nature09973 · Cited by 1,659 · see citing works

Local self-renewal can sustain CNS microglia maintenance and function throughout adult life

Ajami, B., Bennett, J. L., Krieger, C., Tetzlaff, W., & Rossi, F. M. V. (2007) · Nature Neuroscience · doi:10.1038/nn2014 · Cited by 1,643 · see citing works

Decreased Dendritic Spine Density on Prefrontal Cortical Pyramidal Neurons in Schizophrenia

Glantz, L. A., & Lewis, D. A. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.1.65 · Cited by 1,636 · see citing works

Resting Microglia Directly Monitor the Functional State of Synapses <i>In Vivo</i> and Determine the Fate of Ischemic Terminals

Wake, H., Moorhouse, A. J., Jinno, S., Kohsaka, S., & Nabekura, J. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.4363-08.2009 · Cited by 1,619 · see citing works

A polarizing question: do M1 and M2 microglia exist?

Ransohoff, R. M. (2016) · Nature Neuroscience · doi:10.1038/nn.4338 · Cited by 1,573 · see citing works

Control of microglial neurotoxicity by the fractalkine receptor

Cardona, A. E., Pioro, E. P., Sasse, M. E., Kostenko, V., Cardona, S. M., Dijkstra, I. M., Huang, D., Kidd, G., Dombrowski, S., Dutta, R., et al. (2006) · Nature Neuroscience · doi:10.1038/nn1715 · Cited by 1,531 · see citing works

A receptor for phosphatidylserine-specific clearance of apoptotic cells

Fadok, V. A., Bratton, D. L., Rose, D. M., Pearson, A. M., Ezekowitz, R. A. B., & Henson, P. M. (2000) · Nature · doi:10.1038/35011084 · Cited by 1,491 · see citing works

Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways

Kierdorf, K., Erny, D., Goldmann, T., Sander, V., Schulz, C., Perdiguero, E. G., Wieghofer, P., Heinrich, A., Riemke, P., Hölscher, C., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3318 · Cited by 1,457 · see citing works

Cell death and control of cell survival in the oligodendrocyte lineage

Barres, B. A., Hart, I. K., Coles, H. S. R., Burne, J. F., Voyvodic, J. T., Richardson, W. D., & Raff, M. C. (1992) · Cell · doi:10.1016/0092-8674(92)90531-g · Cited by 1,345 · see citing works

Human ApoE isoforms differentially regulate brain amyloid-β peptide clearance

Castellano, J. M., Kim, J., Stewart, F. R., Jiang, H., DeMattos, R. B., Patterson, B. W., Fagan, A. M., Morris, J. C., Mawuenyega, K. G., Cruchaga, C., et al. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002156 · Cited by 1,227 · cited 1× · see citing works

Origin, fate and dynamics of macrophages at central nervous system interfaces

Goldmann, T., Wieghofer, P., Jordão, M. J. C., Prutek, F., Hagemeyer, N., Frenzel, K., Amann, L., Staszewski, O., Kierdorf, K., Krueger, M., et al. (2016) · Nature Immunology · doi:10.1038/ni.3423 · Cited by 1,209 · see citing works

Role for Neuronally Derived Fractalkine in Mediating Interactions between Neurons and CX3CR1-Expressing Microglia

Harrison, J. K., Jiang, Y., Chen, S., Xia, Y., Maciejewski, D., McNamara, R. K., Streit, W. J., Salafranca, M. N., Adhikari, S., Thompson, D. A., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.18.10896 · Cited by 1,176 · see citing works

Distribution, interconversion, and dose response of n-3 fatty acids in humans.

Arterburn, L. M., Hall, E. B., & Oken, H. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.6.1467s · Cited by 1,162 · see citing works

A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment

Van Hove, H., Martens, L., Scheyltjens, I., De Vlaminck, K., Pombo Antunes, A. R., De Prijck, S., Vandamme, N., De Schepper, S., Van Isterdael, G., Scott, C. L., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0393-4 · Cited by 1,160 · see citing works

Microglial brain region-dependent diversity and selective regional sensitivities to aging

Grabert, K., Michoel, T., Karavolos, M. H., Clohisey, S., Baillie, J. K., Stevens, M. P., Freeman, T. C., Summers, K. M., & McColl, B. W. (2016) · Nature Neuroscience · doi:10.1038/nn.4222 · Cited by 1,151 · see citing works

Developmental Heterogeneity of Microglia and Brain Myeloid Cells Revealed by Deep Single-Cell RNA Sequencing

Li, Q., Cheng, Z., Zhou, L., Darmanis, S., Neff, N. F., Okamoto, J., Gulati, G., Bennett, M. L., Sun, L. O., Clarke, L. E., et al. (2019) · Neuron · doi:10.1016/j.neuron.2018.12.006 · Cited by 1,129 · see citing works

Amyloidogenic processing of the Alzheimer β-amyloid precursor protein depends on lipid rafts

Ehehalt, R., Keller, P., Haass, C., Thiele, C., & Simons, K. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200207113 · Cited by 1,107 · see citing works

Thematic review series: brain lipids. Cholesterol metabolism in the central nervous system during early development and in the mature animal

Dietschy, J. M., & Turley, S. D. (2004) · Journal of Lipid Research · doi:10.1194/jlr.r400004-jlr200 · Cited by 1,095 · see citing works

LRP: a multifunctional scavenger and signaling receptor

Herz, J., & Strickland, D. K. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13992 · Cited by 1,094 · see citing works

Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid

Nguyen, L. N., Ma, D., Shui, G., Wong, P., Cazenave-Gassiot, A., Zhang, X., Wenk, M. R., Goh, E. L. K., & Silver, D. L. (2014) · Nature · doi:10.1038/nature13241 · Cited by 1,048 · see citing works

Linking lipids to Alzheimer's disease: cholesterol and beyond

Di Paolo, G., & Kim, T.-W. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3012 · Cited by 972 · see citing works

Synaptic Targeting by Alzheimer's-Related Amyloid β Oligomers

Lacor, P. N., Buniel, M. C., Chang, L., Fernandez, S. J., Gong, Y., Viola, K. L., Lambert, M. P., Velasco, P. T., Bigio, E. H., Finch, C. E., et al. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.3432-04.2004 · Cited by 954 · see citing works

TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia

Yeh, F. L., Wang, Y., Tom, I., Gonzalez, L. C., & Sheng, M. (2016) · Neuron · doi:10.1016/j.neuron.2016.06.015 · Cited by 943 · see citing works

LRP: a multifunctional scavenger and signaling receptor

Herz, J., & Strickland, D. K. (2001) · Journal of Clinical Investigation · doi:10.1172/jci200113992 · Cited by 906 · see citing works

Microglia derive from progenitors, originating from the yolk sac, and which proliferate in the brain

Alliot, F., Godin, I., & Pessac, B. (1999) · Developmental Brain Research · doi:10.1016/s0165-3806(99)00113-3 · Cited by 884 · see citing works

A Breakdown in Metabolic Reprogramming Causes Microglia Dysfunction in Alzheimer's Disease

Baik, S. H., Kang, S., Lee, W., Choi, H., Chung, S., Kim, J.-I., & Mook-Jung, I. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.06.005 · Cited by 843 · see citing works

Apolipoprotein E associated with astrocytic glia of the central nervous system and with nonmyelinating glia of the peripheral nervous system.

Boyles, J. K., Pitas, R. E., Wilson, E., Mahley, R. W., & Taylor, J. M. (1985) · Journal of Clinical Investigation · doi:10.1172/jci112130 · Cited by 829 · see citing works

High cholesterol level is essential for myelin membrane growth

Saher, G., Brügger, B., Lappe-Siefke, C., Möbius, W., Tozawa, R.-I., Wehr, M. C., Wieland, F., Ishibashi, S., & Nave, K.-A. (2005) · Nature Neuroscience · doi:10.1038/nn1426 · Cited by 799 · see citing works

Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction

Weinhard, L., di Bartolomei, G., Bolasco, G., Machado, P., Schieber, N. L., Neniskyte, U., Exiga, M., Vadisiute, A., Raggioli, A., Schertel, A., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-03566-5 · Cited by 790 · see citing works

Increased synapse elimination by microglia in schizophrenia patient-derived models of synaptic pruning

Sellgren, C. M., Gracias, J., Watmuff, B., Biag, J. D., Thanos, J. M., Whittredge, P. B., Fu, T., Worringer, K. A., Brown, H. E., Wang, J. P., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-018-0334-7 · Cited by 784 · see citing works

Identification, Cloning, Expression, and Purification of Three Novel Human Calcium-independent Phospholipase A2 Family Members Possessing Triacylglycerol Lipase and Acylglycerol Transacylase Activities

Jenkins, C. M., Mancuso, D. J., Yan, W., Sims, H. F., Gibson, B., & Gross, R. W. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m407841200 · Cited by 778 · see citing works

Temporal Tracking of Microglia Activation in Neurodegeneration at Single-Cell Resolution

Mathys, H., Adaikkan, C., Gao, F., Young, J. Z., Manet, E., Hemberg, M., De Jager, P. L., Ransohoff, R. M., Regev, A., & Tsai, L.-H. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.09.039 · Cited by 740 · see citing works

Coupled Proliferation and Apoptosis Maintain the Rapid Turnover of Microglia in the Adult Brain

Askew, K., Li, K., Olmos-Alonso, A., Garcia-Moreno, F., Liang, Y., Richardson, P., Tipton, T., Chapman, M. A., Riecken, K., Beccari, S., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2016.12.041 · Cited by 726 · see citing works

Diverse Requirements for Microglial Survival, Specification, and Function Revealed by Defined-Medium Cultures

Bohlen, C. J., Bennett, F. C., Tucker, A. F., Collins, H. Y., Mulinyawe, S. B., & Barres, B. A. (2017) · Neuron · doi:10.1016/j.neuron.2017.04.043 · Cited by 676 · see citing works

cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain

Lund, E. G., Guileyardo, J. M., & Russell, D. W. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.13.7238 · Cited by 668 · see citing works

Phagocytosis of Microglia in the Central Nervous System Diseases

Fu, R., Shen, Q., Xu, P., Luo, J. J., & Tang, Y. (2014) · Molecular Neurobiology · doi:10.1007/s12035-013-8620-6 · Cited by 646 · see citing works

Comparative Lipidomic Analysis of Mouse and Human Brain with Alzheimer Disease

Chan, R. B., Oliveira, T. G., Cortes, E. P., Honig, L. S., Duff, K. E., Small, S. A., Wenk, M. R., Shui, G., & Di Paolo, G. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.274142 · Cited by 630 · see citing works

Evolutionary Aspects of Diet: The Omega-6/Omega-3 Ratio and the Brain

Simopoulos, A. P. (2011) · Molecular Neurobiology · doi:10.1007/s12035-010-8162-0 · Cited by 627 · see citing works

Lipoprotein lipase enhances the binding of chylomicrons to low density lipoprotein receptor-related protein.

Beisiegel†, U., Weber, W., & Bengtsson-Olivecrona, G. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.19.8342 · Cited by 626 · see citing works

Transcription factors in myeloid development: balancing differentiation with transformation

Rosenbauer, F., & Tenen, D. G. (2007) · Nature Reviews Immunology · doi:10.1038/nri2024 · Cited by 606 · see citing works

Regulated Accumulation of Desmosterol Integrates Macrophage Lipid Metabolism and Inflammatory Responses

Spann, N. J., Garmire, L. X., McDonald, J. G., Myers, D. S., Milne, S. B., Shibata, N., Reichart, D. R., Fox, J. N., Shaked, I., Heudobler, D., et al. (2012) · Cell · doi:10.1016/j.cell.2012.06.054 · Cited by 605 · see citing works

Progressive Reduction in Cortical Thickness as Psychosis Develops: A Multisite Longitudinal Neuroimaging Study of Youth at Elevated Clinical Risk

Cannon, T. D., Chung, Y., He, G., Sun, D., Jacobson, A., van Erp, T. G. M., McEwen, S., Addington, J., Bearden, C. E., Cadenhead, K., et al. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.05.023 · Cited by 599 · see citing works

Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP/PS1 mice

Shi, Q., Chowdhury, S., Ma, R., Le, K. X., Hong, S., Caldarone, B. J., Stevens, B., & Lemere, C. A. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aaf6295 · Cited by 593 · see citing works

Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2)

Atagi, Y., Liu, C.-C., Painter, M. M., Chen, X.-F., Verbeeck, C., Zheng, H., Li, X., Rademakers, R., Kang, S. S., Xu, H., et al. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.679043 · Cited by 587 · see citing works

The TREM receptor family and signal integration

Klesney‐Tait, J., Turnbull, I. R., & Colonna, M. (2006) · Nature Immunology · doi:10.1038/ni1411 · Cited by 586 · see citing works

Defective cholesterol clearance limits remyelination in the aged central nervous system

Cantuti-Castelvetri, L., Fitzner, D., Bosch-Queralt, M., Weil, M.-T., Su, M., Sen, P., Ruhwedel, T., Mitkovski, M., Trendelenburg, G., Lütjohann, D., et al. (2018) · Science · doi:10.1126/science.aan4183 · Cited by 586 · see citing works

Dendritic spine pathology in schizophrenia

Glausier, J. R., & Lewis, D. A. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2012.04.044 · Cited by 581 · see citing works

Complement: a unique innate immune sensor for danger signals

GASQUE, P. (2004) · Molecular Immunology · doi:10.1016/j.molimm.2004.06.011 · Cited by 552 · see citing works

Isoform-specific binding of apolipoprotein E to beta-amyloid.

LaDu, M. J., Falduto, M. T., Manelli, A. M., Reardon, C. A., Getz, G. S., & Frail, D. E. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31529-6 · Cited by 540 · see citing works

A novel microglial subset plays a key role in myelinogenesis in developing brain

Wlodarczyk, A., Holtman, I. R., Krueger, M., Yogev, N., Bruttger, J., Khorooshi, R., Benmamar‐Badel, A., de Boer‐Bergsma, J. J., Martin, N. A., Karram, K., et al. (2017) · The EMBO Journal · doi:10.15252/embj.201696056 · Cited by 535 · see citing works

Association of Chronic Active Multiple Sclerosis Lesions With Disability In Vivo

Absinta, M., Sati, P., Masuzzo, F., Nair, G., Sethi, V., Kolb, H., Ohayon, J., Wu, T., Cortese, I. C. M., & Reich, D. S. (2019) · JAMA Neurology · doi:10.1001/jamaneurol.2019.2399 · Cited by 534 · see citing works

Profile and Regulation of Apolipoprotein E (ApoE) Expression in the CNS in Mice with Targeting of Green Fluorescent Protein Gene to the ApoE Locus

Xu, Q., Bernardo, A., Walker, D., Kanegawa, T., Mahley, R. W., & Huang, Y. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.5476-05.2006 · Cited by 524 · see citing works

Central Nervous System Lipoproteins: ApoE and Regulation of Cholesterol Metabolism

Mahley, R. W. (2016) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.116.307023 · Cited by 516 · see citing works

New insights into the role of TREM2 in Alzheimer’s disease

Gratuze, M., Leyns, C. E. G., & Holtzman, D. M. (2018) · Molecular Neurodegeneration · doi:10.1186/s13024-018-0298-9 · Cited by 489 · see citing works

Single-cell RNA sequencing reveals functional heterogeneity of glioma-associated brain macrophages

Ochocka, N., Segit, P., Walentynowicz, K. A., Wojnicki, K., Cyranowski, S., Swatler, J., Mieczkowski, J., & Kaminska, B. (2021) · Nature Communications · doi:10.1038/s41467-021-21407-w · Cited by 466 · see citing works

Acceleration of Alzheimer's fibril formation by apolipoprotein E in vitro.

(1994) · PubMed Central · Cited by 441 · see citing works

Energy Contribution of Octanoate to Intact Rat Brain Metabolism Measured by ¹³ C Nuclear Magnetic Resonance Spectroscopy

Ebert, D., Haller, R. G., & Walton, M. E. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-13-05928.2003 · Cited by 427 · see citing works

TREM2 in Neurodegenerative Diseases

Jay, T. R., von Saucken, V. E., & Landreth, G. E. (2017) · Molecular Neurodegeneration · doi:10.1186/s13024-017-0197-5 · Cited by 427 · see citing works

Anti-inflammatory effects of omega-3 fatty acids in the brain: physiological mechanisms and relevance to pharmacology

Layé, S., Nadjar, A., Joffre, C., & Bazinet, R. P. (2018) · Pharmacological Reviews · doi:10.1124/pr.117.014092 · Cited by 420 · see citing works

Liver X receptor in cholesterol metabolism

Zhao, C., & Dahlman‐Wright, K. (2009) · Journal of Endocrinology · doi:10.1677/joe-09-0271 · Cited by 418 · see citing works

CD36, a Class B Scavenger Receptor, Is Expressed on Microglia in Alzheimer's Disease Brains and Can Mediate Production of Reactive Oxygen Species in Response to β-Amyloid Fibrils

Coraci, I. S., Husemann, J., Berman, J. W., Hulette, C., Dufour, J. H., Campanella, G. K., Luster, A. D., Silverstein, S. C., & El Khoury, J. B. (2002) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)64354-4 · Cited by 398 · see citing works

Mitochondrial control of immunity: beyond ATP

Mehta, M., Weinberg, S. E., & Chandel, N. S. (2017) · Nature reviews. Immunology · doi:10.1038/nri.2017.66 · Cited by 398 · see citing works

Ontogeny and homeostasis of CNS myeloid cells

Prinz, M., Erny, D., & Hagemeyer, N. (2017) · Nature Immunology · doi:10.1038/ni.3703 · Cited by 391 · see citing works

Deficiency of ABCA1 Impairs Apolipoprotein E Metabolism in Brain

Hirsch-Reinshagen, V., Zhou, S., Burgess, B. L., Bernier, L., McIsaac, S. A., Chan, J. Y., Tansley, G. H., Cohn, J. S., Hayden, M. R., & Wellington, C. L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m407962200 · Cited by 385 · see citing works

Clusterin in Alzheimer’s Disease: Mechanisms, Genetics, and Lessons From Other Pathologies

Foster, E. M., Dangla-Valls, A., Lovestone, S., Ribe, E. M., & Buckley, N. J. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00164 · Cited by 381 · see citing works

Enhanced synaptic connectivity and epilepsy in C1q knockout mice

Chu, Y., Jin, X., Parada, I., Pesic, A., Stevens, B., Barres, B., & Prince, D. A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0913449107 · Cited by 364 · see citing works

Identification of a microglia phenotype supportive of remyelination

Olah, M., Amor, S., Brouwer, N., Vinet, J., Eggen, B., Biber, K., & Boddeke, H. W. G. M. (2012) · Glia · doi:10.1002/glia.21266 · Cited by 358 · see citing works

Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer’s Disease Neurons

van der Kant, R., Langness, V. F., Herrera, C. M., Williams, D. A., Fong, L. K., Leestemaker, Y., Steenvoorden, E., Rynearson, K. D., Brouwers, J. F., Helms, J. B., et al. (2019) · Cell Stem Cell · doi:10.1016/j.stem.2018.12.013 · Cited by 350 · see citing works

Microglia receptors and their implications in the response to amyloid β for Alzheimer’s disease pathogenesis

Doens, D., & Fernández, P. L. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-48 · Cited by 348 · see citing works

The fractalkine receptor but not CCR2 is present on microglia from embryonic development throughout adulthood

Mizutani, M., Pino, P. A., Saederup, N., Charo, I. F., Ransohoff, R. M., & Cardona, A. E. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1100421 · Cited by 346 · see citing works

Mitochondrial Dynamics at the Interface of Immune Cell Metabolism and Function

Rambold, A. S., & Pearce, E. L. (2017) · Trends in Immunology · doi:10.1016/j.it.2017.08.006 · Cited by 341 · see citing works

Microglia: gatekeepers of central nervous system immunology

Tambuyzer, B. R., Ponsaerts, P., & Nouwen, E. J. (2008) · Journal of Leukocyte Biology · doi:10.1189/jlb.0608385 · Cited by 331 · see citing works

Type 1 Interferons Induce Changes in Core Metabolism that Are Critical for Immune Function

Wu, D., Sanin, D. E., Everts, B., Chen, Q., Qiu, J., Buck, M. D., Patterson, A. E., Smith, A. M., Chang, C., Liu, Z., et al. (2016) · Immunity · doi:10.1016/j.immuni.2016.06.006 · Cited by 331 · see citing works

Microglial Physiology and Pathophysiology: Insights from Genome-wide Transcriptional Profiling

Crotti, A., & Ransohoff, R. M. (2016) · Immunity · doi:10.1016/j.immuni.2016.02.013 · Cited by 323 · see citing works

Oligodendrocyte development and the onset of myelination in the human fetal brain

Jakovcevski, I. (2009) · Frontiers in Neuroanatomy · doi:10.3389/neuro.05.005.2009 · Cited by 323 · see citing works

Upregulation of TREM2 Ameliorates Neuropathology and Rescues Spatial Cognitive Impairment in a Transgenic Mouse Model of Alzheimer’s Disease

Jiang, T., Tan, L., Zhu, X.-C., Zhang, Q.-Q., Cao, L., Tan, M.-S., Gu, L.-Z., Wang, H.-F., Ding, Z.-Z., Zhang, Y.-D., et al. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.164 · Cited by 320 · see citing works

The clearance of dying cells: table for two

Green, D. R., Oguin, T. H., & Martinez, J. (2016) · Cell Death &amp; Differentiation · doi:10.1038/cdd.2015.172 · Cited by 314 · see citing works

Marked differences in cholesterol synthesis between neurons and glial cells from postnatal rats

Nieweg, K., Schaller, H., & Pfrieger, F. W. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.05917.x · Cited by 307 · see citing works

Compartmentalization of β-secretase (Asp2) into low-buoyant density, noncaveolar lipid rafts

Riddell, D. R., Christie, G., Hussain, I., & Dingwall, C. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00394-3 · Cited by 303 · see citing works

Microglial phagocytosis induced by fibrillar β-amyloid is attenuated by oligomeric β-amyloid: implications for Alzheimer’s disease

Pan, X.-D., Zhu, Y.-G., Lin, N., Zhang, J., Ye, Q.-Y., Huang, H.-P., & Chen, X.-C. (2011) · Molecular Neurodegeneration · doi:10.1186/1750-1326-6-45 · Cited by 292 · see citing works

Bioenergetic regulation of microglia

Ghosh, S., Castillo, E., Frias, E. S., & Swanson, R. A. (2017) · Glia · doi:10.1002/glia.23271 · Cited by 290 · see citing works

Regulation of Cholesterol and Fatty Acid SynthesisPreprint

Ye, J., & DeBose‐Boyd, R. A. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a004754 · Cited by 270 · see citing works

Anti-inflammatory effects of BHBA in both in vivo and in vitro Parkinson’s disease models are mediated by GPR109A-dependent mechanisms

Fu, S., Wang, J., Xue, W.-J., Liu, H., Liu, B.-R., Zeng, Y., Li, S., Huang, B., Lv, Q.-K., Wang, W., et al. (2015) · Journal of Neuroinflammation · doi:10.1186/s12974-014-0230-3 · Cited by 269 · see citing works

Omega-3 polyunsaturated fatty acid attenuates the inflammatory response by modulating microglia polarization through SIRT1-mediated deacetylation of the HMGB1/NF-κB pathway following experimental traumatic brain injury

Chen, X., Chen, C., Fan, S., Wu, S., Yang, F., Fang, Z., Fu, H., & Li, Y. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1151-3 · Cited by 267 · see citing works

Multiple sclerosis. Oligodendrocyte survival and proliferation in an active established lesion.

Raine, C. S., Scheinberg, L. C., & Waltz, J. M. (1981) · PubMed · Cited by 264 · see citing works

Lipid Processing in the Brain: A Key Regulator of Systemic Metabolism

Bruce, K. D., Zsombok, A., & Eckel, R. H. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00060 · Cited by 264 · see citing works

The Role of Lipids in Parkinson’s Disease

Xicoy, H., Wieringa, B., & Martens, G. J. M. (2019) · Cells · doi:10.3390/cells8010027 · Cited by 255 · see citing works

A quantitative method for measuring regional in vivo fatty-acid incorporation into and turnover within brain phospholipids: review and critical analysis

Robinson, P. J., Noronha, J. G. L., DeGeorge, J. J., Freed, L. M., Nariai, T., & Рапопорт, С. И. (1992) · Brain Research Reviews · doi:10.1016/0165-0173(92)90016-f · Cited by 250 · see citing works

Mechanisms of triglyceride accumulation in activated macrophages

Feingold, K. R., Shigenaga, J. K., Kazemi, M. R., McDonald, C. M., Patzek, S. M., Cross, A. S., Moser, A. H., & Grünfeld, C. (2012) · Journal of Leukocyte Biology · doi:10.1189/jlb.1111537 · Cited by 249 · see citing works

Role of the peroxisome proliferator‐activated receptor‐γ (PPAR‐γ) and its natural ligand 15‐deoxy‐Δ^12,14‐prostaglandin J₂in the regulation of microglial functions

Bernardo, A., Levi, G., & Minghetti, L. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00110.x · Cited by 222 · see citing works

MFG-E8 Mediates Primary Phagocytosis of Viable Neurons during Neuroinflammation

Fricker, M., Neher, J. J., Zhao, J.-W., Théry, C., Tolkovsky, A. M., & Brown, G. C. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.4837-11.2012 · Cited by 218 · see citing works

ACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with AD

Bryleva, E. Y., Rogers, M. A., Chang, C. C. Y., Buen, F., Harris, B. T., Rousselet, E., Seidah, N. G., Oddo, S., LaFerla, F. M., Spencer, T. A., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0913828107 · Cited by 209 · see citing works

Microglia function during brain development: New insights from animal models

Bilimoria, P. M., & Stevens, B. (2015) · Brain Research · doi:10.1016/j.brainres.2014.11.032 · Cited by 204 · see citing works

Regulation of Dynamic Behavior of Retinal Microglia by CX3CR1 Signaling

Liang, K. J., Lee, J. E., Wang, Y. D., Ma, W., Fontainhas, A. M., Fariss, R. N., & Wong, W. T. (2009) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.08-3357 · Cited by 202 · see citing works

Enhanced fatty acid oxidation in adipocytes and macrophages reduces lipid-induced triglyceride accumulation and inflammation

Malandrino, M. I., Fucho, R., Weber, M., Calderón‐Domínguez, M., Mir, J. F., Valcárcel-Jiménez, L., Escoté, X., Gómez‐Serrano, M., Peral, B., Salvadó, L., et al. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00362.2014 · Cited by 200 · see citing works

CYP46A1, the rate-limiting enzyme for cholesterol degradation, is neuroprotective in Huntington’s disease

Boussicault, L., Alves, S., Lamazière, A., Planques, A., Heck, N., Moumné, L., Després, G., Bolte, S., Hu, A., Pagès, C., et al. (2016) · Brain · doi:10.1093/brain/awv384 · Cited by 198 · see citing works

Local cholesterol increase triggers amyloid precursor protein‐Bacel clustering in lipid rafts and rapid endocytosis

Marquer, C., Devauges, V., Cossec, J., Liot, G., Lécart, S., Saudou, F., Duyckaerts, C. J., Lévêque‐Fort, S., & Potier, M. (2011) · The FASEB Journal · doi:10.1096/fj.10-168633 · Cited by 188 · see citing works

Lipids in Alzheimer’s disease: A century-old story

Foley, P. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2010.05.004 · Cited by 186 · see citing works

Metabolism Supports Macrophage Activation

Langston, P. K., Shibata, M., & Horng, T. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00061 · Cited by 185 · see citing works

Imaging Neuroinflammation in Alzheimer's Disease with Radiolabeled Arachidonic Acid and PET

Esposito, G., Giovacchini, G., Liow, J., Bhattacharjee, A. K., Greenstein, D. K., Schapiro, M. B., Hallett, M., Herscovitch, P., Eckelman, W. C., Carson, R. E., et al. (2008) · Journal of Nuclear Medicine · doi:10.2967/jnumed.107.049619 · Cited by 182 · see citing works

Poly(ADP-Ribose) Polymerase-1 Promotes Microglial Activation, Proliferation, and Matrix Metalloproteinase-9-Mediated Neuron Death

Kauppinen, T. M., & Swanson, R. A. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.4.2288 · Cited by 181 · see citing works

Brain Uptake and Utilization of Fatty Acids, Lipids and Lipoproteins: Application to Neurological Disorders

Hamilton, J. A., Hillard, C. J., Spector, A. A., & Watkins, P. A. (2007) · Journal of Molecular Neuroscience · doi:10.1007/s12031-007-0060-1 · Cited by 180 · see citing works

Fat-1 transgenic mice: A new model for omega-3 research

Kang, J. X. (2007) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2007.10.010 · Cited by 179 · see citing works

CNS myelination and remyelination depend on fatty acid synthesis by oligodendrocytes

Dimas, P., Montani, L., Pereira, J. A., Moreno, D., Trötzmüller, M., Gerber, J., Semenkovich, C. F., Köfeler, H. C., & Suter, U. (2019) · eLife · doi:10.7554/elife.44702 · Cited by 178 · see citing works

The complement system in B cell regulation

Carroll, M. C. (2004) · Molecular Immunology · doi:10.1016/j.molimm.2004.03.017 · Cited by 177 · see citing works

Microglial Phagocytosis and Its Regulation: A Therapeutic Target in Parkinson’s Disease?

Janda, E., Boi, L., & Carta, A. R. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00144 · Cited by 175 · see citing works

Microglial progenitors with a high proliferative potential in the embryonic and adult mouse brain.

Alliot, F., Lecain, É., Grima, B., & Pessac, B. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.4.1541 · Cited by 174 · see citing works

Comprehensive gene expression meta-analysis identifies signature genes that distinguish microglia from peripheral monocytes/macrophages in health and glioma

Haage, V. C., Semtner, M., Vidal, R. O., Pérez-Hernández, D., Pong, W. W., Chen, Z., Hambardzumyan, D., Magrini, V. J., Ly, A., Walker, J., et al. (2019) · Acta Neuropathologica Communications · doi:10.1186/s40478-019-0665-y · Cited by 172 · see citing works

Macrophage fatty acid oxidation and its roles in macrophage polarization and fatty acid-induced inflammation

Namgaladze, D., & Brüne, B. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2016.09.002 · Cited by 163 · see citing works

Progressive Structural Brain Changes During Development of Psychosis

Ziermans, T. B., Schothorst, P. F., Schnack, H. G., Koolschijn, P. C. M. P., Kahn, R. S., van Engeland, H., & Durston, S. (2010) · Schizophrenia Bulletin · doi:10.1093/schbul/sbq113 · Cited by 157 · see citing works

The low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor binds and mediates catabolism of bovine milk lipoprotein lipase.

Chappell, D. A., Fry, G. L., Waknitz, M. A., Iverius, P., Williams, S. E., & Strickland, D. K. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)35675-8 · Cited by 156 · see citing works

Myelin debris regulates inflammatory responses in an experimental demyelination animal model and multiple sclerosis lesions

Clarner, T., Diederichs, F., Berger, K., Denecke, B., Gan, L., van der Valk, P., Beyer, C., Amor, S., & Kipp, M. (2012) · Glia · doi:10.1002/glia.22367 · Cited by 155 · see citing works

Mfsd2a is a transporter for the essential ω-3 fatty acid docosahexaenoic acid (DHA) in Eye and is important for photoreceptor cell development

Wong, B. H., Chan, J. P., Cazenave-Gassiot, A., Poh, R. W., Foo, J. C., Galam, D. L. A., Ghosh, S., Nguyen, L. N., Barathi, V. A., Yeo, S. W., et al. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.721340 · Cited by 155 · see citing works

Activation of Microglial Poly(ADP-Ribose)-Polymerase-1 by Cholesterol Breakdown Products during Neuroinflammation

Diestel, A., Aktas, O., Hackel, D., Häke, I., Meier, S., Raine, C. S., Nitsch, R., Zipp, F., & Ullrich, O. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030975 · Cited by 155 · see citing works

The synthesis and transport of lipids for axonal growth and nerve regeneration

Vance, J. E., Campenot, R. B., & Vance, D. E. (2000) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(00)00050-0 · Cited by 154 · see citing works

Microglia-Specific Metabolic Changes in Neurodegeneration

Aldana, B. I. (2019) · Journal of Molecular Biology · doi:10.1016/j.jmb.2019.03.006 · Cited by 153 · see citing works

Cholesterol efflux is differentially regulated in neurons and astrocytes: Implications for brain cholesterol homeostasis

Chen, J., Zhang, X., Kusumo, H., Costa, L. G., & Guizzetti, M. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2012.09.007 · Cited by 153 · see citing works

Peering through the Windows of the Brain

Gross, P. M., Weindl, A., & Knigge, K. M. (1987) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1987.120 · Cited by 152 · see citing works

High‐affinity interactions and signal transduction between Aβ oligomers and TREM2

Lessard, C. B., Malnik, S. L., Zhou, Y., Ladd, T. B., Cruz, P. E., Ran, Y., Chakrabaty, P., Mahan, T. E., Holtzman, D. M., Ulrich, J. D., et al. (2018) · EMBO Molecular Medicine · doi:10.15252/emmm.201809027 · Cited by 151 · see citing works

Glycerophosphate/Acylglycerophosphate Acyltransferases

Yamashita, A., Hayashi, Y., Matsumoto, N., Nemoto‐Sasaki, Y., Oka, S., Tanikawa, T., & Sugiura, T. (2014) · Biology · doi:10.3390/biology3040801 · Cited by 148 · see citing works

Fractalkine (CX3CL1) Is Involved in the Early Activation of Hypothalamic Inflammation in Experimental Obesity

Morari, J., Anhê, G. F., do Nascimento, L. F. R., de Moura, R. F., Razolli, D. S., Solon, C., Guadagnini, D., de Souza, G. F. P., Mattos, A. H. B., Tobar, N., et al. (2014) · Diabetes · doi:10.2337/db13-1495 · Cited by 147 · see citing works

Neuroinflammatory Signaling Upregulation in Alzheimer's Disease

Lukiw, W. J., & Bazan, N. G. (2000) · Neurochemical Research · doi:10.1023/a:1007627725251 · Cited by 146 · see citing works

n-3 PUFA supplementation benefits microglial responses to myelin pathology

Chen, S., Zhang, H., Pu, H., Wang, G., Li, W., Leak, R. K., Chen, J., Liou, A. K. F., & Hu, X. (2014) · Scientific Reports · doi:10.1038/srep07458 · Cited by 144 · see citing works

Myelin as an inflammatory mediator: Myelin interactions with complement, macrophages, and microglia in spinal cord injury

Kopper, T. J., & Gensel, J. C. (2017) · Journal of Neuroscience Research · doi:10.1002/jnr.24114 · Cited by 141 · see citing works

How to reprogram microglia toward beneficial functions

Fumagalli, M., Lombardi, M., Gressèns, P., & Verderio, C. (2018) · Glia · doi:10.1002/glia.23484 · Cited by 134 · see citing works

The influence of environment and origin on brain resident macrophages and implications for therapy

Bennett, M. L., & Bennett, F. C. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0545-6 · Cited by 131 · see citing works

Two distinct ontogenies confer heterogeneity to mouse brain microglia

De, S., Deren, D. A. V., Peden, E., Hockin, M., Boulet, A. M., Titen, S. W. A., & Capecchi, M. R. (2018) · Development · doi:10.1242/dev.152306 · Cited by 130 · see citing works

Expression of complement system components during aging and amyloid deposition in APP transgenic mice

Reichwald, J., Danner, S., Wiederhold, K., & Staufenbiel, M. (2009) · Journal of Neuroinflammation · doi:10.1186/1742-2094-6-35 · Cited by 122 · see citing works

Reduced AMPK activation and increased HCAR activation drive anti-inflammatory response and neuroprotection in glaucoma

Harun-Or-Rashid, M., & Inman, D. M. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1346-7 · Cited by 121 · see citing works

Aminophospholipids are signal-transducing TREM2 ligands on apoptotic cells

Shirotani, K., Hori, Y., Yoshizaki, R., Higuchi, E., Colonna, M., Saito, T., Hashimoto, S., Saito, T., Saido, T. C., & Iwata, N. (2019) · Scientific Reports · doi:10.1038/s41598-019-43535-6 · Cited by 116 · see citing works

Human Acyl-CoA:Cholesterol Acyltransferase-1 (ACAT-1) Gene Organization and Evidence That the 4.3-Kilobase ACAT-1 mRNA Is Produced from Two Different Chromosomes

Li, B.-L., Li, X.-L., Duan, Z., Lee, O., Song, L., Ma, Z., Chang, C. C. Y., Yang, X., Park, J. P., Mohandas, T. K., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.16.11060 · Cited by 115 · see citing works

Defective macroautophagic turnover of brain lipids in the TgCRND8 Alzheimer mouse model: prevention by correcting lysosomal proteolytic deficits

Yang, D.-S., Stavrides, P., Saito, M., Kumar, A., Rodriguez-Navarro, J. A., Pawlik, M., Huo, C., Walkley, S. U., Saito, M., Cuervo, A. M., et al. (2014) · Brain · doi:10.1093/brain/awu278 · Cited by 114 · see citing works

β-oxidation and rapid metabolism, but not uptake regulate brain eicosapentaenoic acid levels

Chen, C. T., & Bazinet, R. P. (2014) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2014.05.007 · Cited by 110 · see citing works

Omega-3 and Omega-6 Intake Modifies Asthma Severity and Response to Indoor Air Pollution in Children

Brigham, E. P., Woo, H., McCormack, M. C., Rice, J. L., Koehler, K., Vulcain, T., Wu, T. D., Koch, A. L., Sharma, S., Kolahdooz, F., et al. (2019) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201808-1474oc · Cited by 109 · see citing works

N-3 polyunsaturated fatty acids in animal models with neuroinflammation: An update

Trépanier, M., Hopperton, K. E., Orr, S. K., & Bazinet, R. P. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.05.045 · Cited by 109 · see citing works

A chemical proteomic atlas of brain serine hydrolases identifies cell type-specific pathways regulating neuroinflammation

Viader, A., Ogasawara, D., Joslyn, C. M., Sánchez-Alavez, M., Mori, S., Nguyen, W., Conti, B., & Cravatt, B. F. (2016) · eLife · doi:10.7554/elife.12345 · Cited by 109 · see citing works

The lysolipid transporter Mfsd2a regulates lipogenesis in the developing brain

Chan, J. P., Wong, B. H., Chin, C. F., Galam, D. L. A., Foo, J. C., Wong, L. C., Ghosh, S., Wenk, M. R., Cazenave‐Gassiot, A., & Silver, D. L. (2018) · PLoS Biology · doi:10.1371/journal.pbio.2006443 · Cited by 108 · see citing works

Low‐density lipoprotein receptors regulate microglial inflammation through c‐Jun N‐terminal kinase

Pocivavsek, A., Burns, M. P., & Rebeck, G. W. (2008) · Glia · doi:10.1002/glia.20772 · Cited by 106 · see citing works

BACE1 interacts with lipid raft proteins

Hattori, C., Asai, M., Onishi, H., Sasagawa, N., Hashimoto, Y., Saido, T. C., Maruyama, K., Mizutani, S., & Ishiura, S. (2006) · Journal of Neuroscience Research · doi:10.1002/jnr.20981 · Cited by 101 · see citing works

Cholesterol Biosynthesis Supports Myelin Gene Expression and Axon Ensheathment through Modulation of P13K/Akt/mTor Signaling

Mathews, E. S., & Appel, B. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.0726-16.2016 · Cited by 97 · see citing works

Polyunsaturated fatty acids and the risk of multiple sclerosis

Bjørnevik, K., Chitnis, T., Ascherio, A., & Munger, K. L. (2017) · Multiple Sclerosis Journal · doi:10.1177/1352458517691150 · Cited by 97 · see citing works

Neuroprotective Effects of Endurance Exercise Against High‐Fat Diet‐Induced Hippocampal Neuroinflammation

Kang, E., Koo, J., Jang, Y. C., Yang, C. ‐., Lee, Y., Cosío-Lima, L., & Cho, J. (2016) · Journal of Neuroendocrinology · doi:10.1111/jne.12385 · Cited by 96 · see citing works

Lipoprotein Lipase Is a Feature of Alternatively-Activated Microglia and May Facilitate Lipid Uptake in the CNS During Demyelination

Bruce, K. D., Gorkhali, S., Given, K., Coates, A. M., Boyle, K. E., Macklin, W. B., & Eckel, R. H. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00057 · Cited by 94 · see citing works

Intravenously Injected Human Apolipoprotein A‐I Rapidly Enters the Central Nervous System via the Choroid Plexus

Stukas, S. K., Robert, J., Lee, M., Kulić, I., Carr, M., Tourigny, K., Fan, J., Namjoshi, D., Lemke, K., DeValle, N., et al. (2014) · Journal of the American Heart Association · doi:10.1161/jaha.114.001156 · Cited by 91 · see citing works

Metabolic regulation of macrophages in tissues

den Bossche, J. V., & Saraber, D. L. (2018) · Cellular Immunology · doi:10.1016/j.cellimm.2018.01.009 · Cited by 89 · see citing works

Oxysterols and cholesterol precursors correlate to magnetic resonance imaging measures of neurodegeneration in multiple sclerosis

van de Kraats, C., Killestein, J., Popescu, V., Rijkers, E., Vrenken, H., Lütjohann, D., Barkhof, F., Polman, C. H., & Teunissen, C. E. (2013) · Multiple Sclerosis Journal · doi:10.1177/1352458513499421 · Cited by 86 · see citing works

Linoleic acid rescues microglia inflammation triggered by saturated fatty acid

Tu, T. H., Kim, H., Yang, S., Kim, J. K., & Kim, J. G. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.03.047 · Cited by 84 · see citing works

Inhibition of macrophage fatty acid β-oxidation exacerbates palmitate-induced inflammatory and endoplasmic reticulum stress responses

Namgaladze, D., Lips, S., Leiker, T. J., Murphy, R. C., Ekroos, K., Ferreirós, N., Geißlinger, G., & Brüne, B. (2014) · Diabetologia · doi:10.1007/s00125-014-3173-4 · Cited by 83 · see citing works

Anti-inflammatory and cognitive effects of interferon-β1a (IFNβ1a) in a rat model of Alzheimer’s disease

Mudò, G., Frinchi, M., Nuzzo, D., Scaduto, P., Plescia, F., Massenti, M. F., Carlo, M. D., Cannizzaro, C., Cassata, G., Cicero, L. L., et al. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1417-4 · Cited by 82 · see citing works

Effects of central administration of distinct fatty acids on hypothalamic neuropeptide expression and energy metabolism

Schwinkendorf, D. R., Tsatsos, N. G., Gosnell, B. A., & Mashek, D. G. (2010) · International Journal of Obesity · doi:10.1038/ijo.2010.159 · Cited by 81 · see citing works

Microglial Cell Activation Increases Saturated and Decreases Monounsaturated Fatty Acid Content, but Both Lipid Species are Proinflammatory

Button, E. B., Mitchell, A. S., Domingos, M. M., Chung, J. H. ‐., Bradley, R. M., Hashemi, A., Marvyn, P. M., Patterson, A. C., Stark, K. D., Quadrilatero, J., et al. (2014) · Lipids · doi:10.1007/s11745-014-3882-y · Cited by 79 · see citing works

Activation of Wnt/β-catenin Pathway by Exogenous Wnt1 Protects SH-SY5Y Cells Against 6-Hydroxydopamine Toxicity

Wei, L., Sun, C., Lei, M., Li, G., Yi, L., Luo, F., Li, Y., Ding, L., Liu, Z., Li, S., et al. (2012) · Journal of Molecular Neuroscience · doi:10.1007/s12031-012-9900-8 · Cited by 79 · see citing works

Inhibition of Neuroinflammation by AIBP: Spinal Effects upon Facilitated Pain States

Woller, S. A., Choi, S.-H., An, E. J., Low, H., Schneider, D. A., Ramachandran, R., Kim, J., Bae, Y. S., Sviridov, D., Corr, M., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.04.110 · Cited by 79 · see citing works

Energy Consumption by Phospholipid Metabolism in Mammalian Brain

Purdon, A. D., Rosenberger, T. A., Shetty, H. U., & Рапопорт, С. И. (2002) · Neurochemical Research · doi:10.1023/a:1021635027211 · Cited by 79 · see citing works

Brain omega-3 polyunsaturated fatty acids modulate microglia cell number and morphology in response to intracerebroventricular amyloid-β 1-40 in mice

Hopperton, K. E., Trépanier, M., Giuliano, V., & Bazinet, R. P. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0721-5 · Cited by 78 · see citing works

ω-3 Intake and Visual Acuity in Patients With Retinitis Pigmentosa Receiving Vitamin A

Berson, E. L., Rosner, B., Sandberg, M. A., Weigel-DiFranco, C., & Willett, W. C. (2012) · Archives of Ophthalmology · doi:10.1001/archophthalmol.2011.2580 · Cited by 78 · see citing works

In Vivo Fatty Acid Incorporation into Brain Phospholipids in Relation to Signal Transduction and Membrane Remodeling

Rapoport, S. I. (1999) · Neurochemical Research · doi:10.1023/a:1022584707352 · Cited by 77 · see citing works

Reduced immune cell infiltration and increased pro-inflammatory mediators in the brain of Type 2 diabetic mouse model infected with West Nile virus

Kumar, M., Roe, K., Nerurkar, P. V., Orillo, B., Thompson, K. S., Verma, S., & Nerurkar, V. R. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-80 · Cited by 74 · see citing works

Siglec receptors and hiding plaques in Alzheimer's disease

Salminen, A., & Kaarniranta, K. (2009) · Journal of Molecular Medicine · doi:10.1007/s00109-009-0472-1 · Cited by 73 · see citing works

Neonatal overfeeding alters hypothalamic microglial profiles and central responses to immune challenge long-term

Ziko, I., Luca, S. N. D., Dinan, T., Barwood, J. M., Sominsky, L., Cai, G., Kenny, R., Stokes, L., Jenkins, T. A., & Spencer, S. J. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.06.014 · Cited by 73 · see citing works

Lipids in human lipofuscin-enriched subcellular fractions of two age populations. Comparison with rod outer segments and neural retina.

Bazán, H. E. P., Bazan, N. G., Feeney-Burns, L., & Berman, E. R. (1990) · PubMed · Cited by 72 · see citing works

ACAT inhibition and amyloid beta reduction

Bhattacharyya, R., & Kovacs, D. M. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2010.04.003 · Cited by 71 · see citing works

ApoE2 and Alzheimer′s disease: time to take a closer look

Zhao, L., & Wu, L. (2016) · Neural Regeneration Research · doi:10.4103/1673-5374.179044 · Cited by 70 · see citing works

Lipoprotein Lipase Is a Novel Amyloid β (Aβ)-binding Protein That Promotes Glycosaminoglycan-dependent Cellular Uptake of Aβ in Astrocytes

Nishitsuji, K., Hosono, T., Uchimura, K., & Michikawa, M. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.172106 · Cited by 69 · see citing works

Lipid synthesis in macrophages during inflammation in vivo: Effect of agonists of peroxisome proliferator activated receptors α and γ and of retinoid X receptors

Posokhova, E. N., Хощенко, О. М., Chasovskikh, M. I., Pivovarova, E. N., & Dushkin, M. I. (2008) · Biochemistry (Moscow) · doi:10.1134/s0006297908030097 · Cited by 68 · see citing works

Strategies to increase the activity of microglia as efficient protectors of the brain against infections

Nau, R., Ribes, S., Djukic, M., & Eiffert, H. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00138 · Cited by 68 · see citing works

Mitochondrial dysfunctions in 7-ketocholesterol-treated 158N oligodendrocytes without or with α-tocopherol: Impacts on the cellular profil of tricarboxylic cycle-associated organic acids, long chain saturated and unsaturated fatty acids, oxysterols, cholesterol and cholesterol precursors

Leoni, V., Nury, T., Véjux, A., Zarrouk, A., Caccia, C., Debbabi, M., Fromont, A., Sghaier, R., Moreau, T., & Lizard, G. (2016) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2016.03.029 · Cited by 68 · see citing works

Microglia Phenotypes in Aging and Neurodegenerative Diseases

Wendimu, M. Y., & Hooks, S. B. (2022) · Cells · doi:10.3390/cells11132091 · Cited by 336 · see citing works

Lipid accumulation induced by APOE4 impairs microglial surveillance of neuronal-network activity

Victor, M. B., Leary, N., Luna, X., Meharena, H. S., Scannail, A. N., Bozzelli, P. L., Samaan, G., Murdock, M. H., von Maydell, D., Effenberger, A. H., et al. (2022) · Cell Stem Cell · doi:10.1016/j.stem.2022.07.005 · Cited by 316 · see citing works

Apolipoprotein E in lipid metabolism and neurodegenerative disease

Yang, L. G., March, Z. M., Stephenson, R. A., & Narayan, P. S. (2023) · Trends in Endocrinology &amp; Metabolism · doi:10.1016/j.tem.2023.05.002 · Cited by 286 · see citing works

A TREM2-activating antibody with a blood–brain barrier transport vehicle enhances microglial metabolism in Alzheimer’s disease models

van Lengerich, B., Zhan, L., Xia, D., Chan, D., Joy, D., Park, J. I., Tatarakis, D., Calvert, M., Hummel, S., Lianoglou, S., et al. (2023) · Nature Neuroscience · doi:10.1038/s41593-022-01240-0 · Cited by 233 · see citing works

Cholesterol and Alzheimer’s Disease; From Risk Genes to Pathological Effects

Feringa, F. M., & van der Kant, R. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.690372 · Cited by 226 · see citing works

TREM2 in the pathogenesis of AD: a lipid metabolism regulator and potential metabolic therapeutic target

Li, R.-Y., Qin, Q., Yang, H.-C., Wang, Y.-Y., Mi, Y.-X., Yin, Y.-S., Wang, M., Yu, C.-J., & Tang, Y. (2022) · Molecular Neurodegeneration · doi:10.1186/s13024-022-00542-y · Cited by 204 · see citing works

Lysosomal acidification dysfunction in microglia: an emerging pathogenic mechanism of neuroinflammation and neurodegeneration

Quick, J. D., Silva, C., Wong, J. H., Lim, K. L., Reynolds, R., Barron, A. M., Zeng, J., & Lo, C. H. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02866-y · Cited by 203 · see citing works

TREM2 dependent and independent functions of microglia in Alzheimer’s disease

Hou, J., Chen, Y., Grajales-Reyes, G., & Colonna, M. (2022) · Molecular Neurodegeneration · doi:10.1186/s13024-022-00588-y · Cited by 191 · see citing works

Single-cell RNA sequencing reveals time- and sex-specific responses of mouse spinal cord microglia to peripheral nerve injury and links ApoE to chronic pain

Tansley, S. N., Uttam, S., Guzmán, A. U., Yaqubi, M., Pacis, A., Parisien, M., Deamond, H., Wong, C., Rabau, O., Brown, N., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-28473-8 · Cited by 187 · see citing works

Epigallocatechin-3-Gallate (EGCG): New Therapeutic Perspectives for Neuroprotection, Aging, and Neuroinflammation for the Modern Age

Payne, A., Nahashon, S. N., Taka, E., Adinew, G. M., & Soliman, K. F. A. (2022) · Biomolecules · doi:10.3390/biom12030371 · Cited by 171 · see citing works

Microglia and lipids: how metabolism controls brain innate immunity

Chausse, B., Kakimoto, P. A., & Kann, O. (2021) · Seminars in Cell &amp; Developmental Biology · doi:10.1016/j.semcdb.2020.08.001 · Cited by 181 · see citing works

Microglial lipid droplet accumulation in tauopathy brain is regulated by neuronal AMPK

Li, Y., Munoz-Mayorga, D., Nie, Y., Kang, N., Tao, Y., Lagerwall, J., Pernaci, C., Curtin, G., Coufal, N. G., Mertens, J., et al. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.03.014 · Cited by 160 · see citing works

Long-term high-fat diet consumption by mice throughout adulthood induces neurobehavioral alterations and hippocampal neuronal remodeling accompanied by augmented microglial lipid accumulation

Zhuang, H., Yao, X., Li, H., Li, Q., Yang, C., Wang, C., Xu, D., Xiao, Y., Gao, Y. J., Gao, J., et al. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.11.018 · Cited by 147 · see citing works

Focused ultrasound/microbubbles-assisted BBB opening enhances LNP-mediated mRNA delivery to brain

Ogawa, K., Kato, N., Yoshida, M., Hiu, T., Matsuo, T., Mizukami, S., Omata, D., Suzuki, R., Maruyama, K., Mukai, H., et al. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.05.042 · Cited by 144 · see citing works

Molecular and metabolic heterogeneity of astrocytes and microglia

Hasel, P., Aisenberg, W. H., Bennett, F. C., & Liddelow, S. A. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2023.03.006 · Cited by 129 · see citing works

Decoding microglial immunometabolism: a new frontier in Alzheimer's disease research

Jung, E. S., Choi, H., & Mook-Jung, I. (2025) · Molecular Neurodegeneration · doi:10.1186/s13024-025-00825-0 · Cited by 124 · see citing works

Lipoprotein Lipase Regulates Microglial Lipid Droplet Accumulation

Loving, B. A., Tang, M., Neal, M. C., Gorkhali, S., Murphy, R., Eckel, R. H., & Bruce, K. D. (2021) · Cells · doi:10.3390/cells10020198 · Cited by 105 · see citing works

Emerging Evidence of Pathological Roles of Very-Low-Density Lipoprotein (VLDL)

Huang, J.-K., & Lee, H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23084300 · Cited by 111 · see citing works

Fueling neurodegeneration: metabolic insights into microglia functions

Sadeghdoust, M., Das, A., & Kaushik, D. K. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03296-0 · Cited by 101 · see citing works

Lipoproteins in the Central Nervous System: From Biology to Pathobiology

Raulin, A.-C., Martens, Y. A., & Bu, G. (2022) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-032620-104801 · Cited by 89 · see citing works

Metabolic regulation of microglial phagocytosis: Implications for Alzheimer's disease therapeutics

Lepiarz-Raba, I., Gbadamosi, I., Florea, R., Paolicelli, R. C., & Jawaid, A. (2023) · Translational Neurodegeneration · doi:10.1186/s40035-023-00382-w · Cited by 90 · see citing works

Elevated microglial oxidative phosphorylation and phagocytosis stimulate post-stroke brain remodeling and cognitive function recovery in mice

Song, S., Yu, L., Hasan, M. N., Paruchuri, S. S., Mullett, S. J., Sullivan, M. L. G., Fiesler, V. M., Young, C. B., Stolz, D. B., Wendell, S. G., et al. (2022) · Communications Biology · doi:10.1038/s42003-021-02984-4 · Cited by 83 · see citing works

Opposing effects of apoE2 and apoE4 on microglial activation and lipid metabolism in response to demyelination

Wang, N., Wang, M., Jeevaratnam, S., Rosenberg, C., Ikezu, T. C., Shue, F., Doss, S. V., Alnobani, A., Martens, Y. A., Wren, M., et al. (2022) · Molecular Neurodegeneration · doi:10.1186/s13024-022-00577-1 · Cited by 82 · see citing works

APOE4 confers transcriptomic and functional alterations to primary mouse microglia

Machlovi, S. I., Neuner, S. M., Hemmer, B. M., Khan, R., Liu, Y., Huang, M., Zhu, J. D., Castellano, J. M., Cai, D., Marcora, E., et al. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105615 · Cited by 73 · see citing works

Brain metabolism in Alzheimer’s disease: biological mechanisms of exercise

Xu, L., Liu, R., Qin, Y., & Wang, T. (2023) · Translational Neurodegeneration · doi:10.1186/s40035-023-00364-y · Cited by 78 · see citing works

The CD33 short isoform is a gain-of-function variant that enhances Aβ1–42 phagocytosis in microglia

Bhattacherjee, A., Jung, J., Zia, S., Ho, M. F. S., Eskandari‐Sedighi, G., Laurent, C. D. S., McCord, K. A., Bains, A., Sidhu, G., Sarkar, S., et al. (2021) · Molecular Neurodegeneration · doi:10.1186/s13024-021-00443-6 · Cited by 76 · see citing works

CD33 isoforms in microglia and Alzheimer's disease: Friend and foe

Eskandari‐Sedighi, G., Jung, J., & Macauley, M. S. (2022) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2022.101111 · Cited by 68 · see citing works

Reducing microglial lipid load enhances β amyloid phagocytosis in an Alzheimer’s disease mouse model

Wu, X., Miller, J. A., Lee, B. T. K., Wang, Y., & Ruedl, C. (2025) · Science Advances · doi:10.1126/sciadv.adq6038 · Cited by 67 · see citing works

Soluble TAM receptors sAXL and sTyro3 predict structural and functional protection in Alzheimer’s disease

Brosseron, F., Maaß, A., Kleineidam, L., Ravichandran, K. A., García‐González, P., McManus, R. M., Ising, C., Santarelli, F., Kolbe, C., Häsler, L. M., et al. (2022) · Neuron · doi:10.1016/j.neuron.2021.12.016 · Cited by 64 · see citing works

Ferroptosis of Microglia in Aging Human White Matter Injury

Adeniyi, P. A., Gong, X., MacGregor, E., Degener-O’Brien, K., McClendon, E., Garcia, M., Romero, O., Russell, J., Srivastava, T., Miller, J. A., et al. (2023) · Annals of Neurology · doi:10.1002/ana.26770 · Cited by 62 · see citing works

Microglial Function and Regulation during Development, Homeostasis and Alzheimer’s Disease

Casali, B. T., & Reed-Geaghan, E. G. (2021) · Cells · doi:10.3390/cells10040957 · Cited by 64 · see citing works

Transcriptional landscape of human microglia implicates age, sex, and APOE‐related immunometabolic pathway perturbations

Patel, T., Carnwath, T., Wang, X., Allen, M., Lincoln, S., Lewis‐Tuffin, L. J., Quicksall, Z., Lin, S., Tutor‐New, F. Q., Ho, C. C. G., et al. (2022) · Aging Cell · doi:10.1111/acel.13606 · Cited by 60 · see citing works

Brain Lipids and Lipid Droplet Dysregulation in Alzheimer’s Disease and Neuropsychiatric Disorders

Zhao, X., Zhang, S., Sanders, A. R., & Duan, J. (2023) · Complex Psychiatry · doi:10.1159/000535131 · Cited by 54 · see citing works

The role of microglia immunometabolism in neurodegeneration: Focus on molecular determinants and metabolic intermediates of metabolic reprogramming

Wang, Q., Lu, M., Zhu, X., Gu, X., Zhang, T., Xia, C., Yang, L., Xu, Y., & Zhou, M. (2022) · Biomedicine &amp; Pharmacotherapy · doi:10.1016/j.biopha.2022.113412 · Cited by 52 · see citing works

LPS-induced lipid alterations in microglia revealed by MALDI mass spectrometry-based cell fingerprinting in neuroinflammation studies

Blank, M., Enzlein, T., & Hopf, C. (2022) · Scientific Reports · doi:10.1038/s41598-022-06894-1 · Cited by 48 · see citing works

Spatial neurolipidomics—MALDI mass spectrometry imaging of lipids in brain pathologies

Jha, D., Blennow, K., Zetterberg, H., Savas, J. N., & Hanrieder, J. (2024) · Journal of Mass Spectrometry · doi:10.1002/jms.5008 · Cited by 47 · see citing works

Lipid droplets in central nervous system and functional profiles of brain cells containing lipid droplets in various diseases

Zhang, L., Zhou, Y., Yang, Z., Jiang, L., Yan, X., Zhu, W., Shen, Y., Wang, B., Li, J., & Song, J. (2025) · Journal of Neuroinflammation · doi:10.1186/s12974-025-03334-5 · Cited by 47 · see citing works

Obesity-Related Neuroinflammation: Magnetic Resonance and Microscopy Imaging of the Brain

Woo, A., Botta, A. M., Shi, S. S. W., Paus, T., & Pausová, Z. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158790 · Cited by 46 · see citing works

Microglial Lipid Biology in the Hypothalamic Regulation of Metabolic Homeostasis

Folick, A., Koliwad, S. K., & Valdearcos, M. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.668396 · Cited by 45 · see citing works

Neuroimmunometabolism: A New Pathological Nexus Underlying Neurodegenerative Disorders

Mitra, S., Banik, A., Saurabh, S., Maulik, M., & Khatri, S. (2022) · Journal of Neuroscience · doi:10.1523/jneurosci.0998-21.2022 · Cited by 44 · see citing works

A microglial activity state biomarker panel differentiates FTD-granulin and Alzheimer’s disease patients from controls

Pesämaa, I., Müller, S. A., Robinson, S., Darcher, A., Paquet, D., Zetterberg, H., Lichtenthaler, S. F., & Haass, C. (2023) · Molecular Neurodegeneration · doi:10.1186/s13024-023-00657-w · Cited by 42 · see citing works

Microglial Phagocytosis—Rational but Challenging Therapeutic Target in Multiple Sclerosis

Pinto, M. V., & Fernandes, A. M. A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21175960 · Cited by 41 · see citing works

The microglial lysosomal system in Alzheimer’s disease: Guardian against proteinopathy

Acker, Z. P. V., Perdok, A., Bretou, M., & Annaert, W. G. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101444 · Cited by 45 · see citing works

Molecular Mechanisms of the Anti-Inflammatory Effects of Epigallocatechin 3-Gallate (EGCG) in LPS-Activated BV-2 Microglia Cells

Payne, A., Taka, E., Adinew, G. M., & Soliman, K. F. A. (2023) · Brain Sciences · doi:10.3390/brainsci13040632 · Cited by 40 · see citing works

Lipids, lipid-modifying drug target genes and migraine: a Mendelian randomization study

Bi, Y., Zhu, Y., Tang, S., & Huang, Y. (2023) · The Journal of Headache and Pain · doi:10.1186/s10194-023-01633-x · Cited by 41 · see citing works

The Role of Sphingolipids and Specialized Pro-Resolving Mediators in Alzheimer’s Disease

de Wit, N. M., Mol, K., Rodríguez‐Lorenzo, S., de Vries, H. E., & Kooij, G. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.620348 · Cited by 39 · see citing works

Metabolic Control of Smoldering Neuroinflammation

Peruzzotti‐Jametti, L., Willis, C. M., Hamel, R., Krzak, G., & Pluchino, S. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.705920 · Cited by 36 · see citing works

Synapses, Microglia, and Lipids in Alzheimer’s Disease

Paasila, P. J., Aramideh, J. A., Sutherland, G. T., & Graeber, M. B. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.778822 · Cited by 38 · see citing works

Minocycline suppresses disease-associated microglia (DAM) in a model of photoreceptor cell degeneration

Ozaki, E., Delaney, C. P., Campbell, M., & Doyle, S. (2022) · Experimental Eye Research · doi:10.1016/j.exer.2022.108953 · Cited by 36 · see citing works

Lipid metabolism transcriptomics of murine microglia in Alzheimer’s disease and neuroinflammation

Shippy, D. C., & Ulland, T. K. (2023) · Scientific Reports · doi:10.1038/s41598-023-41897-6 · Cited by 35 · see citing works

Regulation of microglia phagocytosis and potential involvement of exercise

Li, C., Wang, Y., Xing, Y., Han, J., Zhang, Y., Zhang, A., Hu, J., Hua, Y., & Bai, Y. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.953534 · Cited by 36 · see citing works

The uses of transcriptomics and lipidomics indicated that direct contact with graphene oxide altered lipid homeostasis through ER stress in 3D human brain organoids

Liu, X., Yang, C., Chen, P., Zhang, L., & Cao, Y. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.157815 · Cited by 35 · see citing works

Metabolic dysregulation in Huntington's disease: Neuronal and glial perspectives

Chang, C., Wu, C.-W., & Chern, Y. (2024) · Neurobiology of Disease · doi:10.1016/j.nbd.2024.106672 · Cited by 35 · see citing works

Lipids: Emerging Players of Microglial Biology

Prakash, P., Randolph, C. E., Walker, K. A., & Chopra, G. (2024) · Glia · doi:10.1002/glia.24654 · Cited by 36 · see citing works

Single-cell network biology characterizes cell type gene regulation for drug repurposing and phenotype prediction in Alzheimer’s disease

Gupta, C., Xu, J., Jin, T., Khullar, S., Liu, X., Alatkar, S., Cheng, F., & Wang, D. (2022) · PLOS Computational Biology · doi:10.1371/journal.pcbi.1010287 · Cited by 33 · see citing works

Balancing cholesterol in the brain: from synthesis to disposal

Qian, L., Chai, A. B., Gelissen, I. C., & Brown, A. J. (2022) · Exploration of Neuroprotective Therapy · doi:10.37349/ent.2022.00015 · Cited by 36 · see citing works

Long-term diet-induced obesity does not lead to learning and memory impairment in adult mice

Leyh, J., Winter, K., Reinicke, M., Ceglarek, U., Bechmann, I., & Landmann, J. (2021) · PLoS ONE · doi:10.1371/journal.pone.0257921 · Cited by 32 · see citing works

Therapy-induced shaping of the glioblastoma microenvironment: Macrophages at play

Erbani, J. M., Boon, M., & Akkari, L. (2022) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2022.05.003 · Cited by 32 · see citing works

Ethanol Induces Extracellular Vesicle Secretion by Altering Lipid Metabolism through the Mitochondria-Associated ER Membranes and Sphingomyelinases

Ibáñez, F., Montesinos, J., Área-Gómez, E., Guerri, C., & Pascual, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168438 · Cited by 31 · see citing works

Emerging Alzheimer’s disease therapeutics: promising insights from lipid metabolism and microglia-focused interventions

Tobeh, N. S., & Bruce, K. D. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1259012 · Cited by 31 · see citing works

Interferon-gamma ameliorates experimental autoimmune encephalomyelitis by inducing homeostatic adaptation of microglia

Tichauer, J. E., Arellano, G., Acuña, E., González, L. F., Kannaiyan, N. R., Murgas, P., Panadero-Medianero, C., Ibañez-Vega, J., Burgos, P. I., Loda, E., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1191838 · Cited by 30 · see citing works

The immunometabolic reprogramming of microglia in Alzheimerʼs disease

Chen, H., Guo, Z., Sun, Y., & Dai, X. (2023) · Neurochemistry International · doi:10.1016/j.neuint.2023.105614 · Cited by 30 · see citing works

Neuroinflammation and immunometabolism in neurodegenerative diseases

Lonkar, N., Latz, E., & McManus, R. M. (2025) · Current Opinion in Neurology · doi:10.1097/wco.0000000000001356 · Cited by 29 · see citing works

Ketogenic diet changes microglial morphology and the hippocampal lipidomic profile differently in stress susceptible versus resistant male mice upon repeated social defeat

González Ibáñez, F., Halvorson, T., Sharma, K., McKee, C. G., Carrier, M., Picard, K., Vernoux, N., Bisht, K., Deslauriers, J., Lalowski, M., et al. (2023) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2023.09.006 · Cited by 28 · see citing works

Blood lipid markers are associated with hippocampal viscoelastic properties and memory in humans

Sanjana, F., Delgorio, P. L., Hiscox, L. V., DeConne, T. M., Hobson, J. C., Cohen, M. L., Johnson, C. L., & Martens, C. R. (2020) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x20968032 · Cited by 26 · see citing works

Honing the Double-Edged Sword: Improving Human iPSC-Microglia Models

Hedegaard, A., Stodolak, S., James, W., & Cowley, S. A. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.614972 · Cited by 27 · see citing works

Is carbonyl/AGE/RAGE stress a hallmark of the brain aging?

Semchyshyn, H. M. (2021) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-021-02529-y · Cited by 27 · see citing works

TREM2, Driving the Microglial Polarization, Has a TLR4 Sensitivity Profile After Subarachnoid Hemorrhage

Hu, Y., Li, C., Wang, X., Chen, W., Yu, Q., & Dai, X. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.693342 · Cited by 27 · see citing works

Paraoxonase-1 and -3 Protein Expression in the Brain of the Tg2576 Mouse Model of Alzheimer’s Disease

Salazar, J. G., Marsillach, J., Reverte, I., Mackness, B., Mackness, M., Joven, J., Camps, J., & Colomina, M. T. (2021) · Antioxidants · doi:10.3390/antiox10030339

High-fat diet increases gliosis and immediate early gene expression in APOE3 mice, but not APOE4 mice.

Jones, N. S., Watson, K. Q., & Rebeck, G. W. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02256-2 · Cited by 26 · see citing works

Blocking cholesterol storage to treat Alzheimer’s disease

Chang, T., Chang, C. C. Y., Harned, T. C., Torre, A. L. D. L., Lee, J., Huynh, T. N. T., & Gow, J. G. (2021) · Exploration of Neuroprotective Therapy · doi:10.37349/ent.2021.00014 · Cited by 26 · see citing works

ABCA7 Regulates Brain Fatty Acid Metabolism During LPS-Induced Acute Inflammation

Aikawa, T., Ren, Y., Holm, M., Asmann, Y. W., Alam, A., Fitzgerald, M. L., Bu, G., & Kanekiyo, T. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.647974 · Cited by 24 · see citing works

Fatty acid sensing in the brain: The role of glial-neuronal metabolic crosstalk and horizontal lipid flux

Cleland, N. R. W., & Bruce, K. D. (2022) · Biochimie · doi:10.1016/j.biochi.2022.08.012 · Cited by 23 · see citing works

Lipid in microglial biology — from material to mediator

Yamamoto, S., & Masuda, T. (2023) · Inflammation and Regeneration · doi:10.1186/s41232-023-00289-z · Cited by 25 · see citing works

An ANXA11 P93S variant dysregulates TDP‐43 and causes corticobasal syndrome

Snyder, A., Ryan, V. H., Hawrot, J., Lawton, S., Ramos, D. M., Qi, Y. A., Johnson, K. R., Reed, X., Johnson, N. L., Kollasch, A. W., et al. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.13915 · Cited by 21 · see citing works

Neuroinflammation and Alzheimer's disease: Unravelling the molecular mechanisms

Kakkar, A., Singh, H., Singh, B. K., Kumar, A., Mishra, A. K., & Chopra, H. (2025) · Journal of Alzheimer s Disease · doi:10.1177/13872877251374353 · Cited by 23 · see citing works

Projecting genetic associations through gene expression patterns highlights disease etiology and drug mechanisms

Pividori, M., Lu, S., Li, B., Su, C., Johnson, M. E., Wei, W., Feng, Q., Namjou, B., Kiryluk, K., Kullo, I. J., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-41057-4 · Cited by 22 · see citing works

Alzheimer’s disease is an inherent, natural part of human brain aging: an integrated perspective

Ferrer, I. (2022) · Free Neuropathology · doi:10.17879/freeneuropathology-2022-3806 · Cited by 21 · see citing works

Lysophosphatidic Acid Induces Aerobic Glycolysis, Lipogenesis, and Increased Amino Acid Uptake in BV-2 Microglia

Joshi, L., Plastira, I., Bernhart, E. M., Reicher, H., Koyani, C. N., Madl, T., Madreiter‐Sokolowski, C. T., Koshenov, Z., Graier, W. F., Hallström, S., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041968 · Cited by 22 · see citing works

Loss of CLN3 in microglia leads to impaired lipid metabolism and myelin turnover

Yaşa, S., Butz, E. S., Colombo, A. V., Chandrachud, U., Montore, L., Tschirner, S. K., Prestel, M., Sheridan, S. D., Müller, S. A., Groh, J., et al. (2024) · Communications Biology · doi:10.1038/s42003-024-07057-w · Cited by 20 · see citing works

Exploring novel roles of lipid droplets and lipid metabolism in regulating inflammation and blood–brain barrier function in neurological diseases

Fu, L., Luo, T., Hao, Z., Pan, Y., Xin, W., Zhang, L., Lai, Z., Zhang, H., Liu, H., & Wei, W. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2025.1603292 · Cited by 20 · see citing works

Fundamental Neurochemistry Review: Lipids across microglial states

Traetta, M. E., Vecchiarelli, H. A., & Tremblay, M. (2024) · Journal of Neurochemistry · doi:10.1111/jnc.16259 · Cited by 19 · see citing works

Bioinformatics analysis identified apolipoprotein E as a hub gene regulating neuroinflammation in macrophages and microglia following spinal cord injury

Yao, X., Chen, J., Yu, Z., Huang, Z., Hamel, R., Zeng, Y.-Q., Huang, Z., Tu, K.-W., Liu, J.-H., Lu, Y., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.964138 · Cited by 19 · see citing works

Lipid Signatures and Inter-Cellular Heterogeneity of Naıve and Lipopolysaccharide-Stimulated Human Microglia-like Cells

Müller, M. A., Zweig, N., Spengler, B., Weinert, M., & Heiles, S. (2023) · Analytical Chemistry · doi:10.1021/acs.analchem.3c01533 · Cited by 19 · see citing works

A new method for obtaining bankable and expandable adult-like microglia in mice

You, M., Rim, C., Kang, Y., & Kwon, M. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02351-4 · Cited by 16 · see citing works

Microglia in Brain Aging and Age-Related Diseases: Friends or Foes?

Ishikawa, K., Fujikawa, R., Okita, K., Kimura, F., Watanabe, T., Katsurabayashi, S., & Iwasaki, K. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262311494 · Cited by 17 · see citing works

A molecular framework for autistic experiences: Mitochondrial allostatic load as a mediator between autism and psychopathology

Mahony, C., & O’Ryan, C. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.985713 · Cited by 16 · see citing works

Alternations of Lipoprotein Profiles in the Plasma as Biomarkers of Huntington’s Disease

Chang, K., Cheng, M., Lo, C.-J., Fan, C.-M., Wu, Y., & Chen, C. (2023) · Cells · doi:10.3390/cells12030385 · Cited by 17 · see citing works

Peroxisomal defects in microglial cells induce a disease-associated microglial signature

Raas, Q., Tawbeh, A., Tahri-Joutey, M., Gondcaille, C., Keime, C., Kaiser, R., Trompier, D., Nasser, B., Leoni, V., Bellanger, E., et al. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1170313 · Cited by 16 · see citing works

Genetic evidence for the liver-brain axis: lipid metabolism and neurodegenerative disease risk

Wang, Z., Yin, Z., Sun, G., Zhang, D., & Zhang, J. (2025) · Lipids in Health and Disease · doi:10.1186/s12944-025-02455-3 · Cited by 16 · see citing works

The role of n-3-derived specialised pro-resolving mediators (SPMs) in microglial mitochondrial respiration and inflammation resolution in Alzheimer’s disease

Slayo, M., Rummel, C. D., Singhaarachchi, P. H., Feldotto, M., & Spencer, S. J. (2025) · Molecular Neurodegeneration · doi:10.1186/s13024-025-00824-1 · Cited by 16 · see citing works

Palmitic acid–induced autolysosomal dysfunction and lipotoxicity in neuroinflammation and neurodegeneration

Saipuljumri, E. N., Zeng, J., & Lo, C. H. (2025) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-25-00432 · Cited by 16 · see citing works

Interleukin-17-mediated protective cytokine signaling against degeneration of the retinal pigment epithelium

Chen, Y., Bounds, S. E., Ma, X., Karmoker, J. R., Liu, Y., Ma, J., & Cai, J. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2311647120 · Cited by 16 · see citing works

Convergent Canonical Pathways in Autism Spectrum Disorder from Proteomic, Transcriptomic and DNA Methylation Data

Mahony, C., & O’Ryan, C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910757 · Cited by 14 · see citing works

Voluntary wheel exercise ameliorates cognitive impairment, hippocampal neurodegeneration and microglial abnormalities preceded by demyelination in a male mouse model of noise-induced hearing loss

Zhuang, H., Li, Q., Sun, C., Xu, D., Gan, G., Zhang, C., Chen, C., Yuan, Y., Liu, L., Xiao, Y. M., et al. (2023) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.09.002 · Cited by 15 · see citing works

Large-scale lipidomic profiling identifies novel potential biomarkers for prion diseases and highlights lipid raft-related pathways

Kim, Y., Lee, J., Lee, D., & Jeong, B. (2021) · Veterinary Research · doi:10.1186/s13567-021-00975-1 · Cited by 15 · see citing works

Alzheimer’s-Associated Upregulation of Mitochondria-Associated ER Membranes After Traumatic Brain Injury

Agrawal, R., Larrea, D., Xu, Y., Shi, L., Zirpoli, H., Cummins, L., Emmanuele, V., Song, D., Yun, T. D., Macaluso, F., et al. (2020) · bioRxiv · doi:10.1007/s10571-022-01299-0 · Cited by 13 · see citing works

Endo-lysosomal dysfunction and neuronal–glial crosstalk in Niemann–Pick type C disease

Malara, M., Prestel, M., & Tahirović, S. (2024) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2022.0388 · Cited by 14 · see citing works

Synergistic reduction in interfacial flexibility of TREM2 R47H and ApoE4 may underlie AD pathology

Lietzke, E. E., Saeb, D., Aldrich, E. C., Bruce, K. D., & Sprenger, K. G. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70120 · Cited by 14 · see citing works

Huang-Lian-Jie-Du decoction alleviates cognitive impairment in high-fat diet-induced obese mice via Trem2/Dap12/Syk pathway

Zheng, J., Pang, R.-K., Ye, J.-H., Su, S., Shi, J., Qiu, Y.-H., Pan, H., Zheng, R.-Y., Hu, X.-R., Deng, Q.-W., et al. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.156248 · Cited by 13 · see citing works

Lipid metabolism in microglia: Emerging mechanisms and therapeutic opportunities for neurodegenerative diseases (Review)

Sun, Y., Wei, K., Liao, X., Wang, J., Gao, L., & Pang, B. (2025) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2025.5580 · Cited by 57 · see citing works

Microglia and lipids: how metabolism controls brain innate immunity

Chausse, B., Kakimoto, P. A., & Kann, O. (2021) · Seminars in Cell &amp; Developmental Biology · doi:10.1016/j.semcdb.2020.08.001 · Cited by 181 · see citing works

Lipid in microglial biology — from material to mediator

Yamamoto, S., & Masuda, T. (2023) · Inflammation and Regeneration · doi:10.1186/s41232-023-00289-z · Cited by 25 · see citing works

Microglial ‘fat shaming’ in development and disease

Zareba, J., & Peri, F. (2021) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2021.07.007 · Cited by 15 · see citing works

The role of ApoE-mediated microglial lipid metabolism in brain aging and disease

Yen, J.-H. J., & Yu, I.-C. I. (2023) · Immunometabolism · doi:10.1097/in9.0000000000000018 · Cited by 37 · see citing works