The DOI matches its Crossref record; 253 of the 253 references it cites were found in a registry or an index.
Biochemistry and Cell Biology of Tau Protein in Neurofibrillary Degeneration
Open accessAbstract
Tau represents the subunit protein of one of the major hallmarks of Alzheimer disease (AD), the neurofibrillary tangles, and is therefore of major interest as an indicator of disease mechanisms. Many of the unusual properties of Tau can be explained by its nature as a natively unfolded protein. Examples are the large number of structural conformations and biochemical modifications (phosphorylation, proteolysis, glycosylation, and others), the multitude of interaction partners (mainly microtubules, but also other cytoskeletal proteins, kinases, and phosphatases, motor proteins, chaperones, and membrane proteins). The pathological aggregation of Tau is counterintuitive, given its high solubility, but can be rationalized by short hydrophobic motifs forming β structures. The aggregation of Tau is toxic in cell and animal models, but can be reversed by suppressing expression or by aggregation inhibitors. This review summarizes some of the structural, biochemical, and cell biological properties of Tau and Tau fibers. Further aspects of Tau as a diagnostic marker and therapeutic target, its involvement in other Tau-based diseases, and its histopathology are covered by other chapters in this volume.
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Cites
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“Another recent development is derived from the earlier observation that Tau pathology spreads in the brain in a well-defined manner, so that its distribution can be correlated with the clinical stages of the disease (Braak stages; Braak and Braak 1991).”
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Cited by
Tau in physiology and pathology
Wang, Y., & Mandelkow, E. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2015.1 · Cited by 2,251
Self-citationPathology of Neurodegenerative Diseases
Dugger, B. N., & Dickson, D. W. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a028035 · Cited by 1,665
Roles of tau protein in health and disease
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Network abnormalities and interneuron dysfunction in Alzheimer disease
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The release and trans-synaptic transmission of Tau via exosomes
Wang, Y., Balaji, V., Kaniyappan, S., Krüger, L., Irsen, S., Tepper, K., Chandupatla, R., Maetzler, W., Schneider, A., Mandelkow, E., et al. (2017) · Molecular Neurodegeneration · doi:10.1186/s13024-016-0143-y · Cited by 674
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Metadata
- Authors
- Mandelkow, E.-M., & Mandelkow, E.
- Venue
- Cold Spring Harbor Perspectives in Medicine
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2012-03-20
- Volume
- 2
- Issue
- 7
- Pages
- a006247-a006247
- ISSN
- 2157-1422 (ISSN-L)
- OpenAlex
- W2099795098
- Cited by
- 847
- References
- 253
- Type
- posted content
- Language
- en
- Open access
- bronze
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