Synaptic Dysfunction in Neurodevelopmental Disorders Associated with Autism and Intellectual Disabilities

Cited by (797)

Items 701–797 of 797

1. Brunner syndrome associated MAOA dysfunction in human dopaminergic neurons results in NMDAR hyperfunction and increased network activity
   Yan Shi, Jon-Ruben van Rhijn, Maren Bormann, Britt Mossink, Monica Frega, Hatice Recaioglu, Marina Hakobjan, Teun M. Klein Gunnewiek, Chantal Schoenmaker, Elizabeth E. Palmer et al. · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
2. Definitions of Technical Terms
   Denis R. Alexander · 2020 · Cambridge University Press eBooks
3. Optogenetic stimulation of BLA terminals in the BNST elicits long term synaptic plasticity and restores synaptic alterations induced by adolescent Shank3 downregulation
   Christelle Glangetas, Alessandro Contestabile, Pedro Espinosa, Giulia Casarotto, Stefano Musardo, Camilla Bellone · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
4. What Is Behavioural Genetics?
   D. Alexander · 2020 · Cambridge University Press eBooks
5. Genes and Environments in Human Development
   Denis R. Alexander · 2020 · Cambridge University Press eBooks
6. Genes, Personality and Personality Disorders
   Denis R. Alexander · 2020 · Cambridge University Press eBooks
7. Genes and Mental Health
   Denis R. Alexander · 2020 · Cambridge University Press eBooks
8. Genes and Human Identity
   Denis R. Alexander · 2020 · Cambridge University Press eBooks
9. Сигнальные каскады белкового фосфорилирования при аутизме (с акцентом на путь mTOR)
   И. С. Бокша, T. A. Prokhorova, Е. Б. Терешкина, Olga Konstantinovna Savushkina, Г.Ш. Бурбаева · 2021 · Biochemistry (Moscow)
10. Mutations of the Histone Linker H1-4: An Expanded Cohort and Functional Characterization of Frameshift Mutant H1.4 in Neurons
    Martine W. Tremblay, Matthew V. Green, Jill Anne Rosenfeld, Haley E. Streff, William James Craigen, Nasim Bekheirnia, Saeed Al Tala, Wendy D Tan, Anne E. West, Yong‐hui Jiang · 2020
11. Genes, Religiosity and Political Commitment
    Denis R. Alexander · 2020 · Cambridge University Press eBooks
12. Genes, Education and Intelligence
    Denis R. Alexander · 2020 · Cambridge University Press eBooks
13. Are We Slaves to Our Genes?
    Denis R. Alexander · 2020 · Cambridge University Press eBooks
14. Genes, Food, Exercise and Weight
    Denis R. Alexander · 2020 · Cambridge University Press eBooks
15. Genetic Confusion
    Denis R. Alexander · 2020 · Cambridge University Press eBooks
16. References
    Denis R. Alexander · 2020 · Cambridge University Press eBooks
17. Preface
    Denis R. Alexander · 2020 · Cambridge University Press eBooks
18. Loss of NF1 causes tactile hypersensitivity and impaired synaptic transmission in a Drosophila model of autism spectrum disorder
    Alex Dyson, Shruti Garg, D. Gareth Evans, Richard Baines · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
19. Gene Regulatory Networks in Autism
    Melody E. Oliphant, Thomas V. Fernandez · 2017 · Springer eBooks
20. Index
    Denis R. Alexander · 2020 · Cambridge University Press eBooks
21. Excessive Cap-dependent Translation as a Molecular Mechanism Underlying ASD
    Eric Klann · 2014 · Defense Technical Information Center (DTIC)
22. Molecular mechanisms of neurodegeneration in neuropsychiatric diseases
    A. A. Farooqui · 2020 · Elsevier eBooks
23. Notes
    Denis R. Alexander · 2020 · Cambridge University Press eBooks
24. Faculty Opinions recommendation of A computational tool (H-MAGMA) for improved prediction of brain-disorder risk genes by incorporating brain chromatin interaction profiles.
    Vijay Kumar Tiwari, Aditi Puri Singh · 2020 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
25. Gene Regulatory Networks in Autism
    Melody E. Oliphant, Thomas V. Fernandez · 2021 · Springer eBooks
26. The Progress of Different Pathways for Shank3 to Cause Autism Spectrum Disorder
    Lipiäinen Stephanie, Xiaoyu Song, Zishan Lin · 2022 · Highlights in Science Engineering and Technology
27. Perturbations of a causal synaptic molecular network in autism and schizophrenia revealed with multiplexed imaging
    Reuven Falkovich, Eric Danielson, Karen Perez de Arce, Eike‐Christian Wamhoff, Jeffrey R. Cottrell, Morgan Sheng, Mark Bathe · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
28. Leveraging Microelectrode Array Technology for Phenotyping Stem Cell-Derived Neurodevelopmental Disease Models
    Shan Wang, Eline van Hugte, Ummi Ciptasari, Nael Nadif Kasri · 2022 · Neuromethods
29. A Consequence of Immature Breathing induces Persistent Changes in Hippocampal Synaptic Plasticity and Behavior: A Role of Pro-Oxidant State and NMDA Receptor Imbalance
    Alejandra Arias‐Cavieres, Alfredo J. Garcia · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
30. Abnormal mTOR Signaling Pathway Activity in Autism Spectrum Disorders: Prospects of Mechanism-Based Therapy
    Ekaterina A. Trifonova, Анастасия Анатольевна Котлярова, Alex V. Kochetov · 2023 · Molecular Biology
31. Deletion of VPS50 protein in mice brain impairs synaptic function and behavior
    Constanza Ahumada-Marchant, Carlos Ancatén-González, Henny Haensgen, Felipe Arancibia, Bastián Brauer, Rita Droste, Howard Robert Horvitz, Martha Constantine‐Paton, Gloria Arriagada, Andrés E. Chávez et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
32. Regulation of hippocampal mossy fiber-CA3 synapse function by a Bcl11b/C1ql2/Nrxn3(25b+) pathway
    Artemis Koumoundourou, Märt Rannap, Elodie De Bruyckere, Sigrun Nestel, Carsten Reißner, Alexei V. Egorov, Pentao Liu, Markus Missler, Bernd Heimrich, Andreas Draguhn et al. · 2023 · eLife
33. A comprehensive bioinformatics analysis of circRNA expression in the brain of distinct mouse models of Autism Spectrum Disorder
    Guilherme Bauer‐Negrini, Guilherme Cordenonsi da Fonseca, Carmem Gottfried · 2023 · Research in Autism
34. Exploring the interconnection of autism and intellectual disability: Advancements in current research overview
    Piyush Anand, Shamsher Singh · 2023 · Pharmaspire
35. Synaptic dysfunctions caused by SHANK3 mutation in relation to autism-like behaviors
    Yuxuan Jing · 2024 · International Conference on Biological Engineering and Medical Science (ICBioMed)
36. Social Cognition
    Heather Bortfeld, Silvia A. Bunge · 2024 · Cambridge University Press eBooks
37. Regulation of hippocampal mossy fiber-CA3 synapse function by a Bcl11b/C1ql2/Nrxn3(25b+) pathway
    Artemis Koumoundourou, Märt Rannap, Elodie De Bruyckere, Sigrun Nestel, Carsten Reißner, Alexei V. Egorov, Pentao Liu, Markus Missler, Bernd Heimrich, Andreas Draguhn et al. · 2024 · eLife
38. Insulin signaling accelerates the anterograde movement of Rab4 vesicles in axons through Klp98A/KIF16B recruitment via Vps34-PI3Kinase
    Kamaldeep Singh, Semanti Das, Sabyasachi Sutradhar, Jonathon Howard, Krishanu Ray · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
39. Translational study on the role of genetic and prenatal risk factors in neurodevelopmental psychiatric disorders
    Anna Y. Yotova · 2024
40. eLife Assessment: A deep learning framework for automated and generalized synaptic event analysis
    Dion K. Dickman · 2024 · eLife
41. Reviewer #3 (Public Review): A deep learning framework for automated and generalized synaptic event analysis
    2024 · eLife
42. Reviewer #1 (Public Review): A deep learning framework for automated and generalized synaptic event analysis
    2024 · eLife
43. Reviewer #2 (Public Review): A deep learning framework for automated and generalized synaptic event analysis
    2024 · eLife
44. Impact of intragenic NRXN1 deletions on early cortical development
    Lucia Dutan Polit, Nicholas J. F. Gatford, Thaise Nayane Ribeiro Carneiro, Roland Nagy, Victoria Higgs, APEX Consortia, Aïcha Massrali, Arkoprovo Paul, Maria Fasolino, Zhaolan Zhou et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
45. Understanding the Neurobiological Components of Neurodevelopmental Disorders
    Barbara L. Thompson · 2024 · Contemporary clinical neuroscience
46. Novel de novo intronic variant of SYNGAP1 associated with the neurodevelopmental disorders
    Baoqiong Liao, Wuming Xie, Mei Shuai, Rutian Liu, Qi Zhang, Min Hong, Shuwen He · 2024 · Research Square
47. Upregulation of ACSL, ND75, Vha26 and sesB genes by antiepileptic drugs resulted in genotoxicity in drosophila
    R. Shamapari, Kakanahalli Nagaraj · 2024 · Toxicology Research
48. Rapid long-range synaptic remodeling in hyperacute ischemic stroke
    Huanhuan Chen, Ye Wei, Luminiţa Ruje, Qi Wan, Mikhail Spivakov, Oleg O. Glebov · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
49. PI(3)P signaling regulates endosomal flux underlying developmental synaptic remodeling via Rab4
    Kamaldeep Singh, Semanti Das, Dipti Rai, Sabyasachi Sutradhar, Asmita Sarkar, Jonathon Howard, Krishanu Ray · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
50. New Approach Methodologies for Developmental Neurotoxicity Testing: Understanding How the Underlying Biology and Assay Characteristics Build Confidence in Using Data to Support Regulatory Decisions
    S. Boyd, Kelly E. Carstens, Anna Lowit, Elizabeth Méndez, Monique M. Perron, Iris Mangas, Timothy J. Shafer · 2025 · Elsevier eBooks
51. Differential analysis of tsRNAs in bovine colostrum and mature milk exosomes: implications for milk powder nutritional fortification
    Hong Jun Yu, Xinping Chen, shuang chun wu, Qi Wang, Nan Zhao, Mei Yang, Handong Wu · 2025 · SSRN Electronic Journal
52. Early postsynaptic potentiation in hippocampal somatostatin interneurons is mTORC1-dependent and disrupted in Fmr1 mice
    Mohammad Javad Eslamizade, Fatemeh Saffarzadeh, Argel Aguilar‐Valles · 2025 · Neuroscience
53. Additional file 3 of Increased ribosomal protein levels and protein synthesis in the striatal synaptosome of Shank3-overexpressing transgenic mice
    Chunmei Jin, Yeunkum Lee, Kang, Hyojin, Kwon Jeong, Joori Park, Yinhua Zhang, Hyae Rim Kang, Ruiying Ma, Hyunyoung Seong, Kim, Yoonhee et al. · 2021 · Figshare
54. Additional file 1 of Increased ribosomal protein levels and protein synthesis in the striatal synaptosome of Shank3-overexpressing transgenic mice
    Chunmei Jin, Yeunkum Lee, Kang, Hyojin, Kwon Jeong, Joori Park, Yinhua Zhang, Hyae Rim Kang, Ruiying Ma, Hyunyoung Seong, Kim, Yoonhee et al. · 2021 · Figshare
55. Additional file 1 of De novo missense variants disrupting protein–protein interactions affect risk for autism through gene co-expression and protein networks in neuronal cell types
    Chen, Siwei, Wang, Jiebiao, Cicek, Ercument, Kathryn Roeder, Yu, Haiyuan, Bernie Devlin · 2020 · Figshare
56. Epileptic Encephalopathy Associated with NBEA Gene Mutation: A Case Report and Literature Review
    新岭 滕 · 2025 · Advances in Clinical Medicine
57. Tetraspanin 6
    Isabel H Salas · 2017 · VUBIR (Vrije Universiteit Brussel)
58. Reinterpreting autism through the analogy of inflammation: a hypothesis of non-specific neurodevelopmental response
    Zhengbing Zhou, Saralah Devi Mariamdaran Chethiyar, Beiyong Cui · 2025 · Medical Hypotheses
59. Advances of Genomic Medicine in Neurodevelopmental Disorders
    Hosneara Akter, Mohammed J. Uddin, A.H.M. Nurun Nabi · 2026 · Interdisciplinary biotechnological advances
60. An R83W mutation in Rab3A causes autosomal-dominant cerebellar ataxia
    Ryosuke Miyamoto, Ayuko Sakane, Hiroyuki Morino, Kodai Kume, Tomoyasu Matsubara, Tatsuya Fukumoto, Yusuke Osaki, Ryosuke Oki, Kenta Hanada, Konoka Tachibana et al. · 2026 · Human Molecular Genetics
61. A neuro-computational framework for modeling the development of cross-sensory interactions in Autism: from mechanistic understanding to targeted intervention
    Melissa Monti, Sophie Molholm, John J. Foxe, Cristiano Cuppini · 2026 · Research Square
62. Erythropoietin alleviates syndrome-associated intellectual disability and autism-like behavior in Zbtb20-haploinsufficient Primrose syndrome mouse model
    Martin Hindermann, Justus B. H. Wilke, Yasmina Curto, Stefan N. Oline, Vinícius Daguano Gastaldi, Umer Javed Butt, Rakshit Dadarwal, Umut Çakır, Anja Ronnenberg, Kurt Hammerschmidt et al. · 2026 · JCI Insight
63. Ischemic stroke triggers brain-wide synaptic remodeling within four hours
    Huanhuan Chen, Ye Wei, Luminiţa Ruje, Fusheng Du, Zhendong Feng, Qi Wan, Mikhail Spivakov, Oleg O. Glebov · 2026 · PLoS Biology
64. Temporal and Cell‐Specific Regulation of Synaptic Homeostasis by the Chromatin Remodeler Chd1
    Danielle T. Morency, Tao Cui, Yimei Cai, Chloe Lok, Rachel E. Nokku, Ruoxian Huang, Grace L. Chu, Yumeng Xie, Saleem W. Abu‐Tayeh, Kaikai He et al. · 2026 · Advanced Science
65. O-GlcNAc transferase controls excitatory synapse development and AMPA receptor expression in an activity-dependent manner
    Linkun Han, Olof Lagerlöf · 2026 · Frontiers in Cellular Neuroscience
66. Advances in brain connectomics: integrating light and electron microscopy for multiscale neural mapping
    Istiaque Ahmed, Bao-Lei Zhang, Biao Yue, Nahida Islam, Md Ashfaqure Rahman, Md Miftahul Mithu, Xinhui Tang · 2026 · New medicine.
67. Récepteurs synaptiques et troubles du neuro-développement : approches translationnelles pour la caractérisation fonctionnelle des gènes PTCHD1 et GRID1
    Dévina C. Ung · 2017 · theses.fr (ABES)
68. Déterminants moteurs des troubles du spectre autistiques (TSA)
    Tareq Al Sagheer · 2017 · theses.fr (ABES)
69. Activité hippocampique associée aux stimuli sociaux chez la souris Shank3 modèle des Troubles du Spectre Autistique.
    Loïc Bordes · 2019 · theses.fr (ABES)
70. Génétique et physiopathologie du syndrome de Lowe, analyse des aspects neurologiques
    Anne Héritier · 2019 · theses.fr (ABES)
71. Impact of open channel blockers on the surface dynamics and organization of NMDA receptors
    Alexandra Fernandes · 2020 · theses.fr (ABES)
72. Développement d’une méthode de mesure et d’analyse du transport intraneuronal dans le cerveau de larve de poissons-zèbre par suivi de nanocristaux non-linéaires en microscopie de second-harmonique : application à l’étude d’anomalies de transport chez des poissons portant une mutation retrouvée dans des neuropathies humaines.
    Fériel Terras · 2020
73. Evaluation of the effects of inflammation and combined exposure to environmental toxicants during the perinatal period : a potential etiological factor of neurodegenerative pathologies ?
    Asma Oummadi · 2023 · theses.fr (ABES)
74. Etude du développement cortical à travers la caractérisation d'un modèle murin d'autisme et l'inférence des interactions cellulaires par séquençage en cellules uniques
    Rémi Mathieu · 2022
75. The role of transcription factor Neurod2 in cortex development and its implications in neurodevelopmental disorders
    Karen Runge · 2022 · theses.fr (ABES)
76. Autism-associated ARHGEF9 variants impair GABAergic synapses and ultrasonic communication by reducing gephyrin phosphorylation
    H. Jung, B. Kim, G. Jang, Lee, H., Kim, Y., Kim, H., Lee, H., D. Kim, Yang, Y., W. Jeong et al. · 2026 · MPG.PuRe (Max Planck Society)
77. Mitochondrial–Epigenetic Crosstalk in Autism Spectrum Disorder: Linking Cellular Stress to Synaptic Dysfunction and Treatment Resistance
    Dijie Liu, Kai Tao, Yuxia Wang, Yuanhao Sun, Shiyong Wang · 2026 · Molecular Neurobiology
78. Brain structure abnormalities in neurodevelopmental synaptopathies
    Júlia Romagosa, Juliana Ribeiro‐Constante, Natalia Juliá‐Palacios, Alejandra Darling, Rosanna Marí-Vico, Arnau Valls-Esteve, Mireia Olivella, Xavier Altafaj, Christian Stephan‐Otto, Àngels García‐Cazorla · 2026 · NeuroImage Clinical
79. A massively parallel CRISPR-based screening platform for modifiers of neuronal depolarization
    Steven C. Boggess, Vaidehi Gandhi, Ming‐Chi Tsai, Emily Marzette, Noam Teyssier, Joanna Yu-Ying Chou, Xiaoyu Hu, Amber L. Cramer, Lin Yadanar, Kunal Shroff et al. · 2026 · Nature Communications
80. NTI164, a novel medicinal cannabis extract, improves core symptoms of autism spectrum disorder: Results from a double-blind, randomised, controlled trial (The Harmony study)
    Brooke A. Keating, Y. Ogru, Esra Isikgel, Kanan Sharma, Dima El-Sukkari, Michael C. Fahey · 2026 · Neurotherapeutics
81. Gut Microbiota-Elicited Aberrant Phosphorylation Induces Protein Structural Anomalies: A Non-Negligible Pathogenic Driver of Autism Spectrum Disorder
    Yongsheng Ge, Zhi Li, Caiyun Yu, Weitong Guo, Guangying Fan, Guiyu Lin, Han Yu, Ying Wang · 2026 · Microorganisms
82. Expression of the Human R163C-RYR1 Gain-of-Function Mutation Modified 2,2′,3,5′,6-Pentachlorobiphenyl (PCB 95) Developmental Neurotoxicity in Weanling Mice
    Christopher D. Barnhart, Rebecca J. Wilson, Sunjay Sethi, Hao Chen, Kim M. Truong, Izabela Kania‐Korwel, Hans‐Joachim Lehmler, Isaac N. Pessah, Pamela J. Lein · 2026 · International Journal of Molecular Sciences
83. Neuroimmune Dysregulation and Synaptic Pruning in Autism Spectrum Disorder
    Abdel Bernal-Reyes, Ormany Soriano-Torres, Iris Rodríguez, Deanira Patrone, Nicola Antonucci, Dario Siniscalco, María de los Ángeles Robinson‐Agramonte · 2026 · Biology
84. Neural networks and brain plasticity
    Shampa Ghosh, Dr. Krishna Kumar Singh, Jitendra Kumar Sinha · 2026 · Elsevier eBooks
85. Drosophila melanogaster as a Model for Autism Spectrum Disorder: Insights into Lifelong Neuronal Vulnerability
    Angelina Palacios-Muñoz · 2026 · International Journal of Molecular Sciences
86. Epigenetic Hierarchies in Autism from Folate–SAM Metabolism to LSD1 and G9a
    Nuria Pérez, Aina Bellver‐Sanchís, Fahad Hussain, Elena Huerta‐Ramos, Núria Tous, Richard E. Frye, Christian Griñán‐Ferré · 2026 · Biomolecules
87. Developmental Timing of Neonatal Inflammatory Pain Differentially Alters Adult Dentate Gyrus Plasticity in Male Wistar Rats
    Laura N. C. Braga, Gisele Silva Nogueira, Arthur Carvalho Pires, Antônio Márcio Rodrigues, Carla A Scorza, Fulvio A. Scorza, Luciene Covolan, Antônio-Carlos G. Almeida · 2026 · Research Square
88. Dysregulation of cAMP-PKA-mediated mechanisms disrupts basal synaptic function in the absence of presynaptic FMRP
    Simon Lecomte, Bruna Correa de Mira, Noëlle Grosjean, Christophe Mulle · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
89. HPSC-derived mesenchymal stromal cells ameliorate murine autistic-like phenotypes through activating oxytocinergic neurons
    Yinong Huang, Yixuan Liu, Yilin Liu, Hongjie Liang, Yunli Tong, Ruijie Li, Xiaoran Zhang, Yiling Wang, Yiwen Deng, Jihao Wu et al. · 2026 · Science Advances
90. Decoding Parental Expression Patterns of Imprinted Genes: A Pathway to Regulate the Neuropsychiatric and Affective Disorders
    Yuhan Fu, Yan Zhang, Zhenzhen Wang, Guodong Peng, Siqi Li, Nan Miao, Tao Sun · 2026 · ACS Pharmacology & Translational Science
91. NLGN3 autism variants have distinct functional impact on synapses and sleep behavior in Drosophila
    Rebekah Townsley, Jonathan C. Andrews, Saurabh Srivastav, Sharayu V. Jangam, Shabab B. Hannan, Oguz Kanca, Paul C. Marcogliese, Shinya Yamamoto, Michael F. Wangler · 2026 · PLoS Genetics
92. Autism: epidemiology, genetics, molecular mechanisms, clinical features, diagnosis, and management
    Ruonan Fan, Yilin Wang, Tingting Miao · 2026 · Molecular Biomedicine
93. Genetics of Autism
    Mahreen Khan, MICHAEL RUTTER, A Thapar, Ryan K. C. Yuen · 2026 · Wiley eBooks
94. Altered developmental trajectories in neurodevelopmental disorders: mechanisms, human models and translational perspectives
    Florence Desprez, Dévina C. Ung · 2026 · Journal of Neural Transmission
95. Bipolar Disorder in Tuberous Sclerosis Complex: A Case Report
    Aayush Rana, Tanaz Shergill, Poonam Bharti, Daya Ram, Shagun Saini · 2026 · Journal of Pediatric Neurosciences
96. Convergent molecular pathways and shared genetic mechanisms in classic syndromic autism spectrum disorders: a narrative review
    Ryan Bourgaize, Aderonke O. Oyetunji, Merlin G. Butler · 2026 · Frontiers in Genetics
97. Repetitive Transcranial Magnetic Stimulation as a possible new treatment strategy to improve social skills in Autism Spectrum Disorder
    Michelle Achterberg · 2014 · Utrecht University Repository (Utrecht University)