The DOI matches its Crossref record; 173 of the 173 references it cites were found in a registry or an index.
Neuroblastoma and MYCN
Open accessAbstract
Neuroblastoma, the most common extracranial solid tumor of childhood, is thought to originate from undifferentiated neural crest cells. Amplification of the MYC family member, MYCN, is found in ∼25% of cases and correlates with high-risk disease and poor prognosis. Currently, amplification of MYCN remains the best-characterized genetic marker of risk in neuroblastoma. This article reviews roles for MYCN in neuroblastoma and highlights recent identification of other driver mutations. Strategies to target MYCN at the level of protein stability and transcription are also reviewed.
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Cites
Induction of apoptosis in fibroblasts by c-myc protein
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BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc
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Cited by
The bright side of dark matter: lncRNAs in cancer
Evans, J. R., Feng, F. Y., & Chinnaiyan, A. M. (2016) · Journal of Clinical Investigation · doi:10.1172/jci84421 · Cited by 451
An Overview of MYC and Its Interactome
Conacci-Sorrell, M., McFerrin, L., & Eisenman, R. N. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a014357 · Cited by 408
Carabet, L. A., Rennie, P. S., & Cherkasov, A. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms20010120 · Cited by 172
“For in-depth coverage of strategies targeting both c-Myc and N-Myc, their preclinical stage, and clinical applicability, the reader is directed to several recent publications [29,30,95].”
BackgroundTranscription Factor AP4 Mediates Cell Fate Decisions: To Divide, Age, or Die
Wong, M. M.-K., Joyson, S. M., Hermeking, H., & Chiu, S. K. (2021) · Cancers · doi:10.3390/cancers13040676 · Cited by 36
Molecular mechanisms underlying nuchal hump formation in dolphin cichlid, Cyrtocara moorii
Lecaudey, L. A., Sturmbauer, C., Singh, P., & Ahi, E. P. (2019) · Scientific Reports · doi:10.1038/s41598-019-56771-7 · Cited by 30
Metadata
- Authors
- Huang, M., & Weiss, W. A.
- Venue
- Cold Spring Harbor Perspectives in Medicine
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2013-10-01
- Volume
- 3
- Issue
- 10
- Pages
- a014415-a014415
- ISSN
- 2157-1422 (ISSN-L)
- OpenAlex
- W2098282574
- Cited by
- 647
- References
- 173
- Type
- posted content
- Language
- en
- Open access
- bronze
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