An Overview of MYC and Its Interactome

The landscape of somatic copy-number alteration across human cancers

Beroukhim, R., Mermel, C. H., Porter, D., Wei, G., Raychaudhuri, S., Donovan, J., Barretina, J., Boehm, J. S., Dobson, J., Urashima, M., et al. (2010) · Nature · doi:10.1038/nature08822 · Cited by 4,017 · see citing works

Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers

Lovén, J., Hoke, H. A., Lin, C. Y., Lau, A., Orlando, D. A., Vakoc, C. R., Bradner, J. E., Lee, T. I., & Young, R. A. (2013) · Cell · doi:10.1016/j.cell.2013.03.036 · Cited by 2,961 · see citing works

BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc

Delmore, J. E., Issa, G. C., Lemieux, M. E., Rahl, P. B., Shi, J., Jacobs, H. M., Kastritis, E., Gilpatrick, T., Paranal, R. M., Qi, J., et al. (2011) · Cell · doi:10.1016/j.cell.2011.08.017 · Cited by 2,820 · see citing works

A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins

Murre, C., Page-McCaw, P., & Baltimore, D. (1989) · Cell · doi:10.1016/0092-8674(89)90682-x · Cited by 2,713 · see citing works

Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor

Kelly, K., Cochran, B., Stiles, C. D., & Leder, P. (1983) · Cell · doi:10.1016/0092-8674(83)90092-2 · Cited by 2,296 · see citing works

Amplification of N- myc in Untreated Human Neuroblastomas Correlates with Advanced Disease Stage

Brodeur, G. M., Seeger, R. C., Schwab, M., VARMUS, H. E., & Bishop, J. M. (1984) · Science · doi:10.1126/science.6719137 · Cited by 2,261 · see citing works

The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation

Wang, R., Dillon, C. P., Shi, L. Z., Milasta, S., Carter, R., Finkelstein, D., McCormick, L. L., Fitzgerald, P., Chi, H., Munger, J., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.09.021 · Cited by 2,140 · cited 2× · see citing works

RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

Zuber, J., Shi, J., Wang, E., Rappaport, A. R., Herrmann, H., Sison, E. A., Magoon, D., Qi, J., Blatt, K., Wunderlich, M., et al. (2011) · Nature · doi:10.1038/nature10334 · Cited by 1,870 · see citing works

The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice

Adams, J. M., Harris, A. W., Pinkert, C. A., Corcoran, L. M., Alexander, W. S., Cory, S., Palmiter, R. D., & Brinster, R. L. (1985) · Nature · doi:10.1038/318533a0 · Cited by 1,778 · see citing works

Human c-myc onc gene is located on the region of chromosome 8 that is translocated in Burkitt lymphoma cells.

Dalla‐Favera, R., Bregni, M., Erikson, J., Patterson, D., Gallo, R. C., & Croce, C. M. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.24.7824 · Cited by 1,764 · see citing works

Max: A Helix-Loop-Helix Zipper Protein That Forms a Sequence-Specific DNA-Binding Complex with Myc

Blackwood, E. M., & Eisenman, R. N. (1991) · Science · doi:10.1126/science.2006410 · Cited by 1,681 · see citing works

Activation of a cellular onc gene by promoter insertion in ALV-induced lymphoid leukosis

Hayward, W. S., Neel, B. G., & Astrin, S. M. (1981) · Nature · doi:10.1038/290475a0 · Cited by 1,569 · see citing works

Two Rounds of Whole Genome Duplication in the Ancestral Vertebrate

Dehal, P., & Boore, J. L. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030314 · Cited by 1,526 · see citing works

Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

Dawson, M. A., Prinjha, R. K., Dittmann, A., Giotopoulos, G., Bantscheff, M., Chan, W.-I., Robson, S. C., Chung, C., Hopf, C., Savitski, M. M., et al. (2011) · Nature · doi:10.1038/nature10509 · Cited by 1,512 · see citing works

Transcriptional Amplification in Tumor Cells with Elevated c-Myc

Lin, C. Y., Lovén, J., Rahl, P. B., Paranal, R. M., Burge, C. B., Bradner, J. E., Lee, T. I., & Young, R. A. (2012) · Cell · doi:10.1016/j.cell.2012.08.026 · Cited by 1,498 · see citing works

Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cells.

Taub, R. A., Kirsch, I. R., Morton, C. C., Lenoir, G., Swan, D., Tronick, S. R., Aaronson, S. A., & Leder, P. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.24.7837 · Cited by 1,421 · see citing works

Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour

Schwab, M., Alitalo, K. K., Klempnauer, K.-H., VARMUS, H. E., Bishop, J. M., Gilbert, F., Brodeur, G. M., Goldstein, M. N., & Trent, J. M. (1983) · Nature · doi:10.1038/305245a0 · Cited by 1,405 · see citing works

Multiple Ras-dependent phosphorylation pathways regulate Myc protein stabilityPreprint

Sears, R. C., Nuckolls, F., Haura, E. B., Taya, Y., Tamai, K., & Nevins, J. R. (2000) · Genes & Development · doi:10.1101/gad.836800 · Cited by 1,379 · see citing works

c-Myc Regulates Transcriptional Pause Release

Rahl, P. B., Lin, C. Y., Seila, A. C., Flynn, R. A., McCuine, S., Burge, C. B., Sharp, P. A., & Young, R. A. (2010) · Cell · doi:10.1016/j.cell.2010.03.030 · Cited by 1,279 · see citing works

A complex containing N-CoR, mSln3 and histone deacetylase mediates transcriptional repression

Heinzel, T., Lavinsky, R. M., Mullen, T.-M., Söderström, M., Laherty, C. D., Torchia, J., Yang, W., Brard, G., Ngo, S. D., Davie, J., et al. (1997) · Nature · doi:10.1038/387043a0 · Cited by 1,210 · see citing works

MYC oncogenes and human neoplastic disease

Nesbit, C. E., Tersak, J. M., & Prochownik, E. V. (1999) · Oncogene · doi:10.1038/sj.onc.1202746 · Cited by 1,163 · see citing works

Targeting MYC dependence in cancer by inhibiting BET bromodomains

Mertz, J. A., Conery, A. R., Bryant, B. M., Sandy, P., Balasubramanian, S., Mele, D. A., Bergeron, L., & Sims, R. J. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1108190108 · Cited by 1,118 · see citing works

FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation

Welcker, M., & Clurman, B. E. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2290 · Cited by 1,084 · see citing works

c-Myc Is a Universal Amplifier of Expressed Genes in Lymphocytes and Embryonic Stem Cells

Nie, Z., Hu, G., Wei, G., Cui, K., Yamane, A., Resch, W., Wang, R., Green, D. R., Tessarollo, L., Casellas, R. C., et al. (2012) · Cell · doi:10.1016/j.cell.2012.08.033 · Cited by 1,075 · see citing works

Genomic targets of the human c-Myc proteinPreprint

Fernandez, P. C., Frank, S. R., Wang, L., Schroeder, M., Liu, S., Greene, J. R., Cocito, A., & Amati, B. B. (2003) · Genes & Development · doi:10.1101/gad.1067003 · Cited by 963 · see citing works

The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation

Welcker, M., Orian, A., Jin, J., Grim, J. A., Harper, J. W., Eisenman, R. N., & Clurman, B. E. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402770101 · Cited by 942 · see citing works

Histone Deacetylases Associated with the mSin3 Corepressor Mediate Mad Transcriptional Repression

Laherty, C. D., Yang, W., Sun, J.-M., Davie, J., Seto, E., & Eisenman, R. N. (1997) · Cell · doi:10.1016/s0092-8674(00)80215-9 · Cited by 933 · see citing works

Myc’s broad reach

Eilers, M., & Eisenman, R. N. (2008) · Genes & Development · doi:10.1101/gad.1712408 · Cited by 927 · see citing works

c-Myc Can Induce DNA Damage, Increase Reactive Oxygen Species, and Mitigate p53 Function

Vafa, O., Wade, M., Kern, S., Beeche, M., Pandita, T. K., Hampton, G. M., & Wahl, G. M. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00520-8 · Cited by 876 · see citing works

Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression

Alland, L., Muhle, R., Hou, H., Potes, J., Chin, L., Schreiber‐Agus, N., & DePinho, R. A. (1997) · Nature · doi:10.1038/387049a0 · Cited by 841 · see citing works

RNA tumor viruses

Weiss, R. A., & Bernstein, A. (1982) · Cold Spring Harbor Laboratory eBooks · Cited by 817 · see citing works

MyoD is a sequence-specific DNA binding protein requiring a region of myc homology to bind to the muscle creatine kinase enhancer

Lassar, A. B., Buskin, J. N., Lockshon, D., Davis, R. L., Apone, S., Hauschka, S. D., & Weintraub, H. M. (1989) · Cell · doi:10.1016/0092-8674(89)90935-5 · Cited by 817 · see citing works

Phosphorylation‐dependent degradation of c‐Myc is mediated by the F‐box protein Fbw7

Yada, M., Hatakeyama, S., Kamura, T., Nishiyama, M., Tsunematsu, R., Imaki, H., Ishida, N., Okumura, F., Nakayama, K., & Nakayama, K. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600217 · Cited by 810 · see citing works

MYC Activation Is a Hallmark of Cancer Initiation and MaintenancePreprint

Gabay, M., Li, Y., & Felsher, D. W. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a014241 · Cited by 808 · see citing works

A Complex with Chromatin Modifiers That Occupies E2F- and Myc-Responsive Genes in G 0 Cells

Ogawa, H., Ishiguro, K., Gaubatz, S., Livingston, D. M., & Nakatani, Y. (2002) · Science · doi:10.1126/science.1069861 · Cited by 769 · see citing works

Mxi1, a protein that specifically interacts with Max to bind Myc-Max recognition sites

Zervos, A. S., Gyuris, J., & Brent, R. (1993) · Cell · doi:10.1016/0092-8674(93)90662-a · Cited by 769 · see citing works

Homogeneously staining chromosomal regions contain amplified copies of an abundantly expressed cellular oncogene (c-myc) in malignant neuroendocrine cells from a human colon carcinoma.

Alitalo, K., Schwab, M., Lin, C. C., Varmus, H. E., & Bishop, J. M. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.6.1707 · Cited by 761 · see citing works

LIF/STAT3 controls ES cell self-renewal and pluripotency by a Myc-dependent mechanism

Cartwright, P., McLean, C. A., Sheppard, A. M., Rivett, D., Jones, K., & Dalton, S. (2005) · Development · doi:10.1242/dev.01670 · Cited by 758 · see citing works

Histone Deacetylase Activity Is Required for Full Transcriptional Repression by mSin3A

Hassig, C. A., Fleischer, T. C., Billin, A. N., Schreiber, S. L., & Ayer, D. E. (1997) · Cell · doi:10.1016/s0092-8674(00)80214-7 · Cited by 740 · see citing works

Transposition and amplification of oncogene-related sequences in human neuroblastomas

Kohl, N. E., Kanda, N., Schreck, R. R., Bruns, G. A. P., Latt, S. A., Gilbert, F., & Alt, F. W. (1983) · Cell · doi:10.1016/0092-8674(83)90169-1 · Cited by 729 · see citing works

Recognition by Max of its cognate DNA through a dimeric b/HLH/Z domain

Ferré-D’Amaré, A. R., Prendergast, G. C., Ziff, E. B., & Burley, S. K. (1993) · Nature · doi:10.1038/363038a0 · Cited by 719 · see citing works

Mad: A heterodimeric partner for Max that antagonizes Myc transcriptional activity

Ayer, D. E., Kretzner, L., & Eisenman, R. N. (1993) · Cell · doi:10.1016/0092-8674(93)90661-9 · Cited by 697 · see citing works

The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins

McMahon, S. B., Van Buskirk, H. A., Dugan, K. A., Copeland, T. D., & Cole, M. D. (1998) · Cell · doi:10.1016/s0092-8674(00)81479-8 · Cited by 693 · see citing works

A Myc rather than core pluripotency module accounts for the shared signatures of embryonic stem and cancer cells

Kim, J., Woo, A., Chu, J., Snow, J. W., Fujiwara, Y., Kim, C., Cantor, A., & Orkin, S. (2010) · Cell · doi:10.1016/j.cell.2010.09.010 · Cited by 670 · see citing works

Non-transcriptional control of DNA replication by c-Myc

Dominguez-Sola, D., Ying, C. Y., Grandori, C., Ruggiero, L., Chen, B., Li, M., Galloway, D. A., Gu, W. J., Gautier, J., & Dalla‐Favera, R. (2007) · Nature · doi:10.1038/nature05953 · Cited by 652 · see citing works

Neuroblastoma and MYCNPreprint

Huang, M., & Weiss, W. A. (2013) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a014415 · Cited by 652 · see citing works

L-myc, a new myc-related gene amplified and expressed in human small cell lung cancer

Nau, M. M., Brooks, B. J., Battey, J. F., Sausville, E. A., Gazdar, A. F., Kirsch, I. R., McBride, O. W., Bertness, V. L., Hollis, G. F., & Minna, J. D. (1985) · Nature · doi:10.1038/318069a0 · Cited by 649 · see citing works

Drosophila myc Regulates Cellular Growth during Development

Johnston, L. A., Prober, D. A., Edgar, B. A., Eisenman, R. N., & Gallant, P. (1999) · Cell · doi:10.1016/s0092-8674(00)81512-3 · Cited by 648 · see citing works

onc gene amplification in promyelocytic leukaemia cell line HL-60 and primary leukaemic cells of the same patient

Favera, R. D., Wong‐Staal, F., & Gallo, R. C. (1982) · Nature · doi:10.1038/299061a0 · Cited by 637 · see citing works

Targeting MYCN in Neuroblastoma by BET Bromodomain Inhibition

Puissant, A., Frumm, S. M., Alexe, G., Bassil, C. F., Qi, J., Chanthery, Y. H., Nekritz, E. A., Zeid, R., Gustafson, W. C., Greninger, P., et al. (2013) · Cancer Discovery · doi:10.1158/2159-8290.cd-12-0418 · Cited by 637 · see citing works

Multiple arrangements of viral DNA and an activated host oncogene in bursal lymphomas

Payne, G. S., Bishop, J. M., & VARMUS, H. E. (1982) · Nature · doi:10.1038/295209a0 · Cited by 625 · see citing works

Revisiting Global Gene Expression Analysis

Lovén, J., Orlando, D. A., Sigova, A. A., Lin, C. Y., Rahl, P. B., Burge, C. B., Levens, D. L., Lee, T. I., & Young, R. A. (2012) · Cell · doi:10.1016/j.cell.2012.10.012 · Cited by 616 · see citing works

Amplification of endogenous myc-related DNA sequences in a human myeloid leukaemia cell line

Collins, S. J., & Groudine, M. T. (1982) · Nature · doi:10.1038/298679a0 · Cited by 613 · see citing works

Mad-max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3

Ayer, D. E., Lawrence, Q., & Eisenman, R. N. (1995) · Cell · doi:10.1016/0092-8674(95)90355-0 · Cited by 587 · see citing works

Histone Deacetylases and SAP18, a Novel Polypeptide, Are Components of a Human Sin3 Complex

Zhang, Y., Iratni, R., Erdjument-Bromage, H., Tempst, P., & Reinberg, D. (1997) · Cell · doi:10.1016/s0092-8674(00)80216-0 · Cited by 578 · see citing works

Oncogenic activity of the c-Myc protein requires dimerization with Max

Amati, B. B., Brooks, M. W., Levy-Strumpf, N., Littlewood, T. D., Evan, G. I., & Land, H. (1993) · Cell · doi:10.1016/0092-8674(93)90663-b · Cited by 559 · see citing works

The Myc oncoprotein as a therapeutic target for human cancer

Vita, M. F., & Arsenian‐Henriksson, M. (2006) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2006.07.015 · Cited by 554 · see citing works

X-Ray Structures of Myc-Max and Mad-Max Recognizing DNA

Nair, S. K., & Burley, S. K. (2003) · Cell · doi:10.1016/s0092-8674(02)01284-9 · Cited by 551 · see citing works

Exome sequencing identifies MAX mutations as a cause of hereditary pheochromocytoma

Comino‐Méndez, I., Gracia-Aznárez, F. J., Schiavi, F., Landa, I., Leandro-Garcia, L. J., Letón, R., Honrado, E., Ramos‐Medina, R., Caronia, D., Pita, G., et al. (2011) · Nature Genetics · doi:10.1038/ng.861 · Cited by 528 · see citing works

Global mapping of c-Myc binding sites and target gene networks in human B cells

Zeller, K. I., Zhao, X., Lee, C. W. H., Chiu, K. P., Yao, F., Yustein, J. T., Ooi, H., Orlov, Y. L., Shahab, A., Yong, H. C., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604129103 · Cited by 518 · see citing works

Skp2 Regulates Myc Protein Stability and Activity

Kim, S. Y., Herbst, A., Tworkowski, K. A., Salghetti, S. E., & Tansey, W. P. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00173-4 · Cited by 508 · see citing works

Proteins encoded by the human c-myc oncogene: differential expression in neoplastic cells.

Hann, S., & Eisenman, R. N. (1984) · Molecular and Cellular Biology · doi:10.1128/mcb.4.11.2486 · Cited by 503 · see citing works

The F-Box Protein Skp2 Participates in c-Myc Proteosomal Degradation and Acts as a Cofactor for c-Myc-Regulated Transcription

von der Lehr, N., Johansson, S. M., Wu, S., Bahram, F., Castell, A., Cetinkaya, C., Hydbring, P., Weidung, I., Nakayama, K., Nakayama, K., et al. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00193-x · Cited by 475 · see citing works

c-Myc Proteolysis by the Ubiquitin-Proteasome Pathway: Stabilization of c-Myc in Burkitt's Lymphoma Cells

Gregory, M. A., & Hann, S. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.7.2423-2435.2000 · Cited by 469 · see citing works

MYC degradation

Farrell, A. S., & Sears, R. C. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a014365 · Cited by 468 · see citing works

Novel myc oncogene RNA from abortive immunoglobulin-gene recombination in mouse plasmacytomas

Shen-Ong, G. L. C., Keath, E. J., Piccoli, S. P., & Cole, M. D. (1982) · Cell · doi:10.1016/0092-8674(82)90137-4 · Cited by 454 · see citing works

Evasion of the p53 tumour surveillance network by tumour-derived MYC mutants

Hemann, M. T., Bric, A., Teruya‐Feldstein, J., Herbst, A., Nilsson, J. A., Cordon‐Cardo, C., Cleveland, J. L., Tansey, W. P., & Lowe, S. W. (2005) · Nature · doi:10.1038/nature03845 · Cited by 452 · see citing works

Definition of regions in human c-myc that are involved in transformation and nuclear localization.

Stone, J. C., de Lange, T., Ramsay, G. M., Jakobovits, E. B., Bishop, J. M., VARMUS, H. E., & Lee, W. (1987) · Molecular and Cellular Biology · doi:10.1128/mcb.7.5.1697 · Cited by 446 · see citing works

Destruction of Myc by ubiquitin‐mediated proteolysis: cancer‐associated and transforming mutations stabilize Myc

Salghetti, S. E., Kim, S. Y., & Tansey, W. P. (1999) · The EMBO Journal · doi:10.1093/emboj/18.3.717 · Cited by 445 · see citing works

Myc and Max proteins possess distinct transcriptional activities

Kretzner, L., Blackwood, E. M., & Eisenman, R. N. (1992) · Nature · doi:10.1038/359426a0 · Cited by 445 · see citing works

Direct activation of RNA polymerase III transcription by c-Myc

Gomez-Roman, N., Grandori, C., Eisenman, R. N., & White, R. J. (2003) · Nature · doi:10.1038/nature01327 · Cited by 434 · see citing works

The histone H3K4 demethylase SMCX links REST target genes to X-linked mental retardation

Tahiliani, M., Mei, P., Fang, R., Leonor, T., Rutenberg, M. S., Shimizu, F., Li, J., Rao, A., & Shi, Y. G. (2007) · Nature · doi:10.1038/nature05823 · Cited by 429 · see citing works

Three new types of viral oncogene of cellular origin specific for haematopoietic cell transformation

Roussel, M. F., Saule, S., Lagrou, C., Rommens, C., Beug, H., Graf, T., & Stéhelin, D. (1979) · Nature · doi:10.1038/281452a0 · Cited by 423 · see citing works

Avian leukemia viruses interaction with their target cells in vivo and in vitro

Graf, T., & Beug, H. (1978) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/0304-419x(78)90011-2 · Cited by 418 · see citing works

Myc and Max associate in vivo.Preprint

Blackwood, E. M., Lüscher, B., & Eisenman, R. N. (1992) · Genes & Development · doi:10.1101/gad.6.1.71 · Cited by 415 · see citing works

c-MYC interacts with INI1/hSNF5 and requires the SWI/SNF complex for transactivation function

Cheng, S., Davies, K. P., Yung, E., Beltran, R. J., Yu, J. C., & Kalpana, G. V. (1999) · Nature Genetics · doi:10.1038/8811 · Cited by 396 · see citing works

Structure and function of the b/HLH/Z domain of USF.

Ferré-D’Amaré, A. R., Pognonec, P., Roeder, R. G., & Burley, S. K. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06247.x · Cited by 394 · see citing works

Genomic binding by the Drosophila Myc, Max, Mad/Mnt transcription factor networkPreprint

Orian, A., van Steensel, B., Delrow, J. J., Bussemaker, H. J., Li, L., Sawado, T., Williams, E., Loo, L. W. M., Cowley, S. M., Yost, C., et al. (2003) · Genes & Development · doi:10.1101/gad.1066903 · Cited by 385 · see citing works

c-myc oncogene protein synthesis is independent of the cell cycle in human and avian cells

Hann, S., Thompson, C. B., & Eisenman, R. N. (1985) · Nature · doi:10.1038/314366a0 · Cited by 369 · see citing works

Myc-binding-site recognition in the human genome is determined by chromatin context

Guccione, E., Martinato, F., Finocchiaro, G., Luzi, L., Tizzoni, L., Olio, V. D., Zardo, G., Nervi, C., Bernard, L., & Amati, B. B. (2006) · Nature Cell Biology · doi:10.1038/ncb1434 · Cited by 365 · see citing works

An amino-terminal domain of Mxi1 mediates anti-myc oncogenic activity and interacts with a homolog of the Yeast Transcriptional Repressor SIN3

Schreiber‐Agus, N., Chin, L., Chen, K., Torres, R., Rao, G., Guida, P. M., Skoultchi, A. I., & DePinho, R. A. (1995) · Cell · doi:10.1016/0092-8674(95)90356-9 · Cited by 361 · see citing works

An alternative pathway for gene regulation by Myc

Peukert, K., Staller, P., Schneider, A., Carmichael, G., Hänel, F., & Eilers, M. (1997) · The EMBO Journal · doi:10.1093/emboj/16.18.5672 · Cited by 359 · see citing works

Phospho Switch Triggers Brd4 Chromatin Binding and Activator Recruitment for Gene-Specific Targeting

Wu, S.-Y., Lee, A.-Y., Lai, H., Zhang, H., & Chiang, C. (2013) · Molecular Cell · doi:10.1016/j.molcel.2012.12.006 · Cited by 350 · see citing works

The Ubiquitin Ligase FBXW7 Modulates Leukemia-Initiating Cell Activity by Regulating MYC Stability

King, B., Trimarchi, T., Reavie, L. B., Xu, L., Mullenders, J., Ntziachristos, P., Aranda-Orgillés, B., Pérez-García, A., Shi, J., Vakoc, C. R., et al. (2013) · Cell · doi:10.1016/j.cell.2013.05.041 · Cited by 347 · see citing works

High mutation rate and predominance of insertions in the Caenorhabditis elegans nuclear genome

Denver, D. R., Morris, K., Lynch, M., & Thomas, W. K. (2004) · Nature · doi:10.1038/nature02697 · Cited by 340 · see citing works

Mad3 and Mad4: novel Max‐interacting transcriptional repressors that suppress c‐myc dependent transformation and are expressed during neural and epidermal differentiation.

Hurlin, P. J., Quéva, C., Koskinen, P. J., Steingrı́msson, E., Ayer, D. E., Copeland, N. G., Jenkins, N. A., & Eisenman, R. N. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb00252.x · Cited by 337 · see citing works

Regulation of cyclin D2 gene expression by the Myc/Max/Mad network: Myc-dependent TRRAP recruitment and histone acetylation at the cyclin D2 promoterPreprint

Bouchard, C., Dittrich, O., Kiermaier, A. C., Dohmann, K., Menkel, A. R., Eilers, M., & Lüscher, B. (2001) · Genes & Development · doi:10.1101/gad.907901 · Cited by 335 · see citing works

Switch from Myc/Max to Mad1/Max binding and decrease in histone acetylation at the telomerase reverse transcriptase promoter during differentiation of HL60 cells

Xu, D., Popov, N., Hou, M., Wang, Q., Björkholm, M., Gruber, A., Menkel, A. R., & Arsenian‐Henriksson, M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.071043198 · Cited by 324 · see citing works

A Nucleolar Isoform of the Fbw7 Ubiquitin Ligase Regulates c-Myc and Cell Size

Welcker, M., Orian, A., Grim, J. A., Eisenman, R. N., & Clurman, B. E. (2004) · Current Biology · doi:10.1016/j.cub.2004.09.083 · Cited by 311 · see citing works

Nuclear localization and DNA binding of the transforming gene product of avian myelocytomatosis virus

Donner, P., Greiser‐Wilke, I., & Moelling, K. (1982) · Nature · doi:10.1038/296262a0 · Cited by 297 · see citing works

A switch from Myc:Max to Mad:Max heterocomplexes accompanies monocyte/macrophage differentiation.Preprint

Ayer, D. E., & Eisenman, R. N. (1993) · Genes & Development · doi:10.1101/gad.7.11.2110 · Cited by 293 · see citing works

Proteins encoded by v-myc and c-myc oncogenes: Identification and localization in acute leukemia virus transformants and bursal lymphoma cell lines

Hann, S., Abrams, H. D., Rohrschneider, L. R., & Eisenman, R. N. (1983) · Cell · doi:10.1016/0092-8674(83)90535-4 · Cited by 290 · see citing works

MicroRNA miR-210 modulates cellular response to hypoxia through the MYC antagonist MNT

Zhang, Z., Sun, H., Dai, H. A., Walsh, R., Imakura, M., Schelter, J. M., Burchard, J., Dai, X., Chang, A. N., Diaz, R. L., et al. (2009) · Cell Cycle · doi:10.4161/cc.8.17.9387 · Cited by 284 · see citing works

c-Myc hot spot mutations in lymphomas result in inefficient ubiquitination and decreased proteasome-mediated turnover

Bahram, F., von der Lehr, N., Cetinkaya, C., & Larsson, L. (2000) · Blood · doi:10.1182/blood.v95.6.2104 · Cited by 283 · see citing works

Glucose sensing by MondoA:Mlx complexes: a role for hexokinases and direct regulation of thioredoxin-interacting protein expression

Stoltzman, C. A., Peterson, C. W., Breen, K. T., Muoio, D. M., Billin, A. N., & Ayer, D. E. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0712199105 · Cited by 283 · see citing works

Ski is a component of the histone deacetylase complex required for transcriptional repression by Mad and thyroid hormone receptorPreprint

Nomura, T., Khan, M. M., Kaul, S. C., Dong, H., Wadhwa, R., Colmenares, C., Kohno, I., & Ishii, S. (1999) · Genes & Development · doi:10.1101/gad.13.4.412 · Cited by 275 · see citing works

DNA and RNA from Uninfected Vertebrate Cells Contain Nucleotide Sequences Related to the Putative Transforming Gene of Avian Myelocytomatosis Virus

Sheiness, D. K., & Bishop, J. M. (1979) · Journal of Virology · doi:10.1128/jvi.31.2.514-521.1979 · Cited by 274 · see citing works

Defectiveness of avian myelocytomatosis virus MC29: Isolation of long-term nonproducer cultures and analysis of virus-specific polypeptide synthesis

Bister, K., Hayman, M. J., & Vogt, P. K. (1977) · Virology · doi:10.1016/0042-6822(77)90017-4 · Cited by 259 · see citing works

Myc Recruits P-TEFb to Mediate the Final Step in the Transcriptional Activation of the cad Promoter

Eberhardy, S. R., & Farnham, P. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m207441200 · Cited by 259 · see citing works

Upregulation of c- MYC in cis through a Large Chromatin Loop Linked to a Cancer Risk-Associated Single-Nucleotide Polymorphism in Colorectal Cancer Cells

Wright, J. B., Brown, S. J., & Cole, M. D. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.01384-09 · Cited by 255 · see citing works

Nuclear location of the putative transforming protein of avian myelocytomatosis virus

Abrams, H. D., Rohrschneider, L. R., & Eisenman, R. N. (1982) · Cell · doi:10.1016/0092-8674(82)90159-3 · Cited by 247 · see citing works

Activation of PI3K/Akt and MAPK pathways regulates Myc-mediated transcription by phosphorylating and promoting the degradation of Mad1

Zhu, J., Blenis, J., & Yuan, J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0802785105 · Cited by 246 · see citing works

Oncogenic Mechanisms in Burkitt LymphomaPreprint

Schmitz, R., Ceribelli, M., Pittaluga, S., Wright, G. W., & Staudt, L. M. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a014282 · Cited by 245 · see citing works

Negative autoregulation of c‐myc transcription.

Penn, L. Z., Brooks, M. W., Laufer, E., & Land, H. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb08217.x · Cited by 244 · see citing works

Mnt, a novel Max-interacting protein is coexpressed with Myc in proliferating cells and mediates repression at Myc binding sites.Preprint

Hurlin, P. J., Quéva, C., & Eisenman, R. N. (1997) · Genes & Development · doi:10.1101/gad.11.1.44 · Cited by 244 · see citing works

Therapeutic Strategies to Inhibit MYCPreprint

McKeown, M. R., & Bradner, J. E. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a014266 · Cited by 226 · see citing works

Myc-Nick: A Cytoplasmic Cleavage Product of Myc that Promotes α-Tubulin Acetylation and Cell Differentiation

Conacci‐Sorrell, M., Ngouenet, C., & Eisenman, R. N. (2010) · Cell · doi:10.1016/j.cell.2010.06.037 · Cited by 219 · see citing works

Casein kinase II inhibits the DNA-binding activity of Max homodimers but not Myc/Max heterodimers.Preprint

Berberich, S. J., & Cole, M. D. (1992) · Genes & Development · doi:10.1101/gad.6.2.166 · Cited by 218 · see citing works

Mice Lacking a Myc Enhancer That Includes Human SNP rs6983267 Are Resistant to Intestinal Tumors

Sur, I., Hallikas, O. K., Vähärautio, A., Yan, J., Turunen, M. M., Enge, M., Taipale, M., Karhu, A., Aaltonen, L. A., & Taipale, J. (2012) · Science · doi:10.1126/science.1228606 · Cited by 213 · see citing works

The c‐myc Promoter: Still MysterY and Challenge

(2008) · Advances in Cancer Research · doi:10.1016/s0065-230x(07)99004-1 · Cited by 211 · see citing works

Mutation of the MXI1 gene in prostate cancer

Grove, L. E., Yin, X., Brothman, A. R., Williams, B. J., Atkin, N. B., & Prochownik, E. V. (1995) · Nature Genetics · doi:10.1038/ng0395-249 · Cited by 199 · see citing works

Myc proteins as therapeutic targets

Gustafson, W. C., & Weiss, W. A. (2010) · Oncogene · doi:10.1038/onc.2009.512 · Cited by 199 · see citing works

An 8q24 gene desert variant associated with prostate cancer risk confers differential in vivo activity to a MYC enhancerPreprint

Wasserman, N. F., Aneas, I., & Nóbrega, M. A. (2010) · Genome Research · doi:10.1101/gr.105361.110 · Cited by 198 · see citing works

High-resolution genomic profiling of chronic lymphocytic leukemia reveals new recurrent genomic alterations

Edelmann, J., Holzmann, K., Miller, F., Winkler, D. F. H., Bühler, A., Zenz, T., Bullinger, L., Kühn, M. W. M., Gerhardinger, A., Bloehdorn, J., et al. (2012) · Blood · doi:10.1182/blood-2012-04-423517 · Cited by 196 · see citing works

Role of Mxi1 in ageing organ systems and the regulation of normal and neoplastic growth

Schreiber‐Agus, N., Meng, Y., Hoang, T., Hou, H., Chen, K., Greenberg, R. A., Cordon‐Cardo, C., Lee, H.-W., & DePinho, R. A. (1998) · Nature · doi:10.1038/31008 · Cited by 191 · see citing works

Mga, a dual‐specificity transcription factor that interacts with Max and contains a T‐domain DNA‐binding motif

Hurlin, P. J., Steingrı́msson, E., Copeland, N. G., Jenkins, N. A., & Eisenman, R. N. (1999) · The EMBO Journal · doi:10.1093/emboj/18.24.7019 · Cited by 185 · see citing works

c-Myc recruits P-TEFb for transcription, cellular proliferation and apoptosis

Kanazawa, S., Soucek, L., Evan, G. I., Okamoto, T., & Peterlin, B. M. (2003) · Oncogene · doi:10.1038/sj.onc.1206800 · Cited by 181 · see citing works

Role of MYC in medulloblastoma

Roussel, M. F., & Robinson, G. W. (2013) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a014308 · Cited by 180 · see citing works

Combinatorial Analysis of Transcription Factor Partners Reveals Recruitment of c-MYC to Estrogen Receptor-α Responsive Promoters

Cheng, A. S. L., Jin, V. X., Fan, M., Smith, L. T., Liyanarachchi, S., Yan, P. S., Leu, Y., Chan, M. W. Y., Plass, C., Nephew, K. P., et al. (2006) · Molecular Cell · doi:10.1016/j.molcel.2005.12.016 · Cited by 177 · see citing works

Myc and Max Homologs in Drosophila

Gallant, P., Shiio, Y., Cheng, P. F., Parkhurst, S. M., & Eisenman, R. N. (1996) · Science · doi:10.1126/science.274.5292.1523 · Cited by 176 · see citing works

Role of post-translational modifications in regulating c-Myc proteolysis, transcriptional activity and biological function

Hann, S. (2006) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2006.08.004 · Cited by 173 · see citing works

Visualization of Myc/Max/Mad Family Dimers and the Competition for Dimerization in Living Cells

Grinberg, A. V., Hu, C., & Kerppola, T. K. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.10.4294-4308.2004 · Cited by 169 · see citing works

EGFR Mutation-Induced Alternative Splicing of Max Contributes to Growth of Glycolytic Tumors in Brain Cancer

Babić, I., Anderson, E. S., Tanaka, K., Guo, D., Masui, K., Li, B., Zhu, S., Gu, Y., Villa, G. R., Akhavan, D., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.04.013 · Cited by 165 · see citing works

Phosphorylation Regulates c-Myc's Oncogenic Activity in the Mammary Gland

Wang, X., Cunningham, M., Zhang, X., Tokarz, S. A., Laraway, B. J., Troxell, M. L., & Sears, R. C. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-1032 · Cited by 165 · see citing works

Cell-Type Independent MYC Target Genes Reveal a Primordial Signature Involved in Biomass Accumulation

Ji, H., Wu, G. Y., Zhan, X., Nolan, A., Koh, C. M., Marzo, A. D., Doan, H. M., Fan, J., Cheadle, C., Fallahi, M., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026057 · Cited by 162 · see citing works

Expression of mad, mxi1, max and c-myc during induced differentiation of hematopoietic cells: opposite regulation of mad and c-myc.

Larsson, L., Pettersson, M., Oberg, F. G., Nilsson, K., & Lüscher, B. (1994) · PubMed · Cited by 158 · see citing works

Identification of nucleotide sequences which may encode the oncogenic capacity of avian retrovirus MC29

Sheiness, D. K., Fanshier, L., & Bishop, J. M. (1978) · Journal of Virology · doi:10.1128/jvi.28.2.600-610.1978 · Cited by 155 · see citing works

Molecular Timing of Primate Divergences as Estimated by Two Nonprimate Calibration Points

Árnason, Ú., Gullberg, A., & Janke, A. (1998) · Journal of Molecular Evolution · doi:10.1007/pl00006431 · Cited by 150 · see citing works

Landmark article (JAMA 1911;56:198). Transmission of a malignant new growth by means of a cell-free filtrate. By Peyton Rous

Rous, P. (1983) · JAMA · doi:10.1001/jama.250.11.1445 · Cited by 150 · see citing works

Role of Fat Body Lipogenesis in Protection against the Effects of Caloric Overload in Drosophila

Musselman, L. P., Fink, J. L., Ramachandran, P. V., Patterson, B. W., Okunade, A. L., Maier, E. J., Brent, M. R., TURK, J. W., & Baranski, T. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.371047 · Cited by 144 · see citing works

Regulation of Myc and Mad during epidermal differentiation and HPV-associated tumorigenesis.

Hurlin, P. J., Foley, K., Ayer, D. E., Eisenman, R. N., Hanahan, D., & Arbeit, J. M. (1995) · PubMed · Cited by 143 · see citing works

Specific RNA sequences and gene products of MC29 avian acute leukemia virus

Mellon, P. L., Pawson, A. J., Bister, K., Martin, G. S., & DUESBERG, P. H. (1978) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.75.12.5874 · Cited by 132 · see citing works

The Drosophila F Box Protein Archipelago Regulates dMyc Protein Levels In Vivo

Moberg, K. H., Mukherjee, A., Veraksa, A. N., Artavanis‐Tsakonas, S., & Hariharan, I. K. (2004) · Current Biology · doi:10.1016/j.cub.2004.04.040 · Cited by 132 · see citing works

Analysis of Myc-Induced Histone Modifications on Target Chromatin

Martinato, F., Cesaroni, M., Amati, B. B., & Guccione, E. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003650 · Cited by 131 · see citing works

MondoA, a Novel Basic Helix-Loop-Helix–Leucine Zipper Transcriptional Activator That Constitutes a Positive Branch of a Max-Like Network

Billin, A. N., Eilers, A. L., Coulter, K. L., Logan, J. S., & Ayer, D. E. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.23.8845-8854.2000 · Cited by 130 · see citing works

Targeted disruption of the MYC antagonist MAD1 inhibits cell cycle exit during granulocyte differentiation

Foley, K. P., McArthur, G. A., Quéva, C., Hurlin, P. J., Soriano, P. M., & Eisenman, R. N. (1998) · The EMBO Journal · doi:10.1093/emboj/17.3.774 · Cited by 129 · see citing works

Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non‐canonical E box and acts as a transcriptional repressor

Meroni, G., Reymond, A., Alcalay, M., Borsani, G., Tanigami, A., Tonlorenzi, R., Nigro, C. L., Messali, S., Zollo, M., Ledbetter, D. H., et al. (1997) · The EMBO Journal · doi:10.1093/emboj/16.10.2892 · Cited by 125 · see citing works

c-MYC-Induced Genomic InstabilityPreprint

Kuzyk, A. C., & Mai, S. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a014373 · Cited by 124 · see citing works

Alternative Forms of Max as Enhancers or Suppressors of Myc-Ras Cotransformation

Mäkelä, T. P., Koskinen, P. J., Västrik, I., & Alitalo, K. K. (1992) · Science · doi:10.1126/science.256.5055.373 · Cited by 123 · see citing works

Sequential expression of the MAD family of transcriptional repressors during differentiation and development

Quéva, C., Hurlin, P. J., Foley, K. P., & Eisenman, R. N. (1998) · Oncogene · doi:10.1038/sj.onc.1201611 · Cited by 123 · see citing works

Inhibition of Cell Proliferation by the Mad1 Transcriptional Repressor

Roussel, M. F., Ashmun, R. A., Sherr, C. J., Eisenman, R. N., & Ayer, D. E. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.6.2796 · Cited by 121 · see citing works

c-Myc mediates pre-TCR-induced proliferation but not developmental progression

Dose, M., Khan, I., Guo, Z., Kovalovsky, D., Krueger, A., von Boehmer, H., Khazaie, K., & Gounari, F. (2006) · Blood · doi:10.1182/blood-2006-02-005900 · Cited by 120 · see citing works

Suppression of Myc, but not E1a, transformation activity by Max-associated proteins, Mad and Mxi1.

Lahoz, E. G., Xu, L., Schreiber‐Agus, N., & DePinho, R. A. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.12.5503 · Cited by 119 · see citing works

MYC and Transcription ElongationPreprint

Rahl, P. B., & Young, R. A. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a020990 · Cited by 112 · see citing works

The Role of MIZ-1 in MYC-Dependent TumorigenesisPreprint

Wiese, K. E., Walz, S., von Eyß, B., Wolf, E., Athineos, D., Sansom, O. J., & Eilers, M. (2013) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a014290 · Cited by 111 · see citing works

N‐myc transgene promotes B lymphoid proliferation, elicits lymphomas and reveals cross‐regulation with c‐myc.

Rosenbaum, H., Webb, E., Adams, J. M., Cory, S., & Harris, A. W. (1989) · The EMBO Journal · doi:10.1002/j.1460-2075.1989.tb03435.x · Cited by 110 · see citing works

Avian acute leukemia viruses MC29 and MH2 share specific RNA sequences: Evidence for a second class of transforming genes

DUESBERG, P. H., & Vogt, P. K. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.4.1633 · Cited by 110 · see citing works

Genome Recognition by MYCPreprint

Sabò, A., & Amati, B. B. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a014191 · Cited by 109 · see citing works

Negative autoregulation of c‐myc gene expression is inactivated in transformed cells.

Grignani, F., Lombardi, L. T., Inghirami, G., Sternas, L. A., Cechova, K., & Dalla‐Favera, R. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb07612.x · Cited by 107 · see citing works

Mondo/ChREBP-Mlx-Regulated Transcriptional Network Is Essential for Dietary Sugar Tolerance in Drosophila

Havula, E., Teesalu, M., Hyötyläinen, T., Seppälä, H., Hasygar, K., Auvinen, P., Orešič, M., Sandmann, T., & Hietakangas, V. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003438 · Cited by 105 · see citing works

Stem cell-specific activation of an ancestral myc protooncogene with conserved basic functions in the early metazoan Hydra

Hartl, M., Mitterstiller, A., Valovka, T., Breuker, K., Hobmayer, B., & Bister, K. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911060107 · Cited by 105 · see citing works

Effects of the MYC oncogene antagonist, MAD, on proliferation, cell cycling and the malignant phenotype of human brain tumour cells

Chen, J., Willingham, T., Margraf, L. R., Schreiber‐Agus, N., DePinho, R. A., & Nisen, P. D. (1995) · Nature Medicine · doi:10.1038/nm0795-638 · Cited by 105 · see citing works

Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature

Skinner, M. K., Rawls, A., Wilson‐Rawls, J., & Roalson, E. H. (2010) · Differentiation · doi:10.1016/j.diff.2010.02.003 · Cited by 104 · see citing works

Mechanism for the transcriptional repression by c-Myc on PDGF β-receptor

Izumi, H., Molander, C., Penn, L. Z., Ishisaki, A., Kohno, K., & Funa, K. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.8.1533 · Cited by 102 · see citing works

Solution Structure of the Interacting Domains of the Mad–Sin3 Complex

Brubaker, K., Cowley, S. M., Huang, K., Loo, L. W. M., Yochum, G. S., Ayer, D. E., Eisenman, R. N., & Radhakrishnan, I. (2000) · Cell · doi:10.1016/s0092-8674(00)00168-9 · Cited by 100 · see citing works

Drosophila Myc is oncogenic in mammalian cells and plays a role in the diminutive phenotype

Schreiber‐Agus, N., Stein, D., Chen, K., Goltz, J. S., Stevens, L. M., & DePinho, R. A. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.4.1235 · Cited by 99 · see citing works

Mlx, a Novel Max-like BHLHZip Protein That Interacts with the Max Network of Transcription Factors

Billin, A. N., Eilers, A. L., Quéva, C., & Ayer, D. E. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.51.36344 · Cited by 99 · see citing works

Modulation of T‐lymphocyte development, growth and cell size by the Myc antagonist and transcriptional repressor Mad1

Iritani, B. M., Delrow, J. J., Grandori, C., Gomez, I. G., Klacking, M., Carlos, L. S., & Eisenman, R. N. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf492 · Cited by 97 · see citing works

Glucose Controls Nuclear Accumulation, Promoter Binding, and Transcriptional Activity of the MondoA-Mlx Heterodimer

Peterson, C. W., Stoltzman, C. A., Sighinolfi, M. P., Han, K., & Ayer, D. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.01613-09 · Cited by 97 · see citing works

MYC Regulation of Cell Growth through Control of Transcription by RNA Polymerases I and IIIPreprint

Campbell, K. J., & White, R. J. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a018408 · Cited by 95 · see citing works

A conserved element in Myc that negatively regulates its proapoptotic activity

Herbst, A., Hemann, M. T., Tworkowski, K. A., Salghetti, S. E., Lowe, S. W., & Tansey, W. P. (2005) · EMBO Reports · doi:10.1038/sj.embor.7400333 · Cited by 94 · see citing works

A Conserved Myc Protein Domain, MBIV, Regulates DNA Binding, Apoptosis, Transformation, and G 2 Arrest

Cowling, V. H., Chandriani, S. J., Whitfield, M. L., & Cole, M. D. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.01959-05 · Cited by 93 · see citing works

Mnt Loss Triggers Myc Transcription Targets, Proliferation, Apoptosis, and Transformation

Nilsson, J. A., Maclean, K. H., Keller, U. B., Pendeville, H., Baudino, T. A., & Cleveland, J. L. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.4.1560-1569.2004 · Cited by 91 · see citing works

Max-independent functions of Myc in Drosophila melanogaster

Steiger, D., Furrer, M., Schwinkendorf, D., & Gallant, P. (2008) · Nature Genetics · doi:10.1038/ng.178 · Cited by 90 · see citing works

The Nerve Growth Factor-Responsive PC12 Cell Line Does Not Express the Myc Dimerization Partner Max

Hopewell, R., & Ziff, E. B. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.7.3470 · Cited by 87 · see citing works

P-TEFb is a Crucial Co-Factor for Myc Transactivation

Gargano, B., Amente, S., Majello, B., & Lania, L. (2007) · Cell Cycle · doi:10.4161/cc.6.16.4554 · Cited by 86 · see citing works

Deletion of Mnt leads to disrupted cell cycle control and tumorigenesis

Hurlin, P. J., Zhou, Z., Toyo‐oka, K., Ota, S., Walker, W. L., Hirotsune, S., & Wynshaw-Boris, A. J. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg442 · Cited by 86 · see citing works

MYC and the Control of DNA ReplicationPreprint

Dominguez-Sola, D., & Gautier, J. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a014423 · Cited by 86 · see citing works

MYC Acts via the PTEN Tumor Suppressor to Elicit Autoregulation and Genome-Wide Gene Repression by Activation of the Ezh2 Methyltransferase

Kaur, M., & Cole, M. D. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-2522 · Cited by 84 · see citing works

Commonly occurring loss and mutation of the MXI1 gene in prostate cancer

Prochownik, E. V., Grove, L. E., Deubler, D. A., Zhu, X. L., Stephenson, R. A., Rohr, L. R., Yin, X., & Brothman, A. R. (1998) · Genes Chromosomes and Cancer · doi:10.1002/(sici)1098-2264(199808)22:4 · Cited by 84 · see citing works

Mlx, a new Max-like bHLHZip family member: the center stage of a novel transcription factors regulatory pathway?

Meroni, G., Cairo, S., Merla, G., Messali, S., Brent, R., Ballabio, A., & Reymond, A. (2000) · Oncogene · doi:10.1038/sj.onc.1203634 · Cited by 83 · see citing works

c-Myc/Max Heterodimers Bind Cooperatively to the E-Box Sequences Located in the First Intron of the Rat Ornithine Decarboxylase (ODC) Gene

Walhout, A. J. M., Gubbels, M., Bernards, R., van der Vliet, P. C., & Timmers, H. T. M. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.8.1493 · Cited by 83 · see citing works

MGA, a suppressor ofMYC, is recurrently inactivated in high risk chronic lymphocytic leukemia

Paoli, L. D., Cerri, M., Monti, S. M., Rasi, S., Spina, V., Bruscaggin, A., Greco, M., Ciardullo, C., Famà, R., Cresta, S., et al. (2012) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.3109/10428194.2012.723706 · Cited by 82 · see citing works

Socializing with MYC: Cell Competition in Development and as a Model for Premalignant CancerPreprint

Johnston, L. A. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a014274 · Cited by 82 · see citing works

Of Myc and Mnt

Hooker, C. W., & Hurlin, P. J. (2006) · Journal of Cell Science · doi:10.1242/jcs.02815 · Cited by 81 · see citing works

Gene Regulation and Epigenetic Remodeling in Murine Embryonic Stem Cells by c-Myc

Lin, C.-H., Lin, C. W., Tanaka, H., Fero, M. L., & Eisenman, R. N. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007839 · Cited by 79 · see citing works

Nematode genome evolution

Coghlan, A. (2005) · WormBook · doi:10.1895/wormbook.1.15.1 · Cited by 76 · see citing works

Strain MC29 Avian Leukosis Virus. Myelocytoma, Endothelioma, and Renal Growths: Pathomorphological and Ultrastructural Aspects 2

Mladenov, Z., Heine, U., Beard, D., & Beard, J. W. (1967) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/38.3.251 · Cited by 75 · see citing works

Mnt–Max to Myc–Max complex switching regulates cell cycle entry

Walker, W., Zhou, Z.-Q., Ota, S., Wynshaw-Boris, A. J., & Hurlin, P. J. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200411013 · Cited by 74 · see citing works

c-Myc Accelerates S-Phase and Requires WRN to Avoid Replication Stress

Robinson, K. L., Asawachaicharn, N., Galloway, D. A., & Grandori, C. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005951 · Cited by 74 · see citing works

Myc Function in DrosophilaPreprint

Gallant, P. (2013) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a014324 · Cited by 74 · see citing works

Mutants of avian myelocytomatosis virus with smaller gag gene-related proteins have an altered transforming ability

Ramsay, G. M., Graf, T., & Hayman, M. J. (1980) · Nature · doi:10.1038/288170a0 · Cited by 72 · see citing works

Evolution of the holozoan ribosome biogenesis regulon

Brown, S. J., Cole, M. D., & Erives, A. J. (2008) · BMC Genomics · doi:10.1186/1471-2164-9-442 · Cited by 70 · see citing works

Synthetic Lethal Screens as a Means to Understand and Treat MYC-Driven CancersPreprint

Cermelli, S., Jang, I. S., Bernard, B. M., & Grandori, C. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a014209 · Cited by 68 · see citing works

The Mlx Network: Evidence for a Parallel Max-Like Transcriptional Network That Regulates Energy Metabolism

Billin, A. N., & Ayer, D. E. (2006) · Springer eBooks · doi:10.1007/3-540-32952-8_10 · Cited by 67 · see citing works

Two MAD tails: what the recent knockouts of Mad1 and Mxi1 tell us about the MYC/MAX/MAD network

Foley, K. P., & Eisenman, R. N. (1999) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/s0304-419x(99)00012-8 · Cited by 67 · see citing works

Premetazoan Ancestry of the Myc–Max Network

Young, S. L., Diolaiti, D., Conacci‐Sorrell, M., Ruiz‐Trillo, I., Eisenman, R. N., & King, N. (2011) · Molecular Biology and Evolution · doi:10.1093/molbev/msr132 · Cited by 65 · see citing works

Mad4 is regulated by a transcriptional repressor complex that contains Miz-1 and c-Myc

Kime, L., & Wright, S. C. (2003) · Biochemical Journal · doi:10.1042/bj20021679 · Cited by 64 · see citing works

Isolation and characterization of s-myc, a member of the rat myc gene family.

Sugiyama, A., Kume, A., Nemoto, K., Lee, S. Y., Asami, Y., Nemoto, F., Nishimura, S., & Kuchino, Y. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.23.9144 · Cited by 62 · see citing works

Repression of Myc-Ras cotransformation by Mad is mediated by multiple protein-protein interactions.

Koskinen, P. J., Ayer, D. E., & Eisenman, R. N. (1995) · PubMed · Cited by 62 · see citing works

Structure and expression of B-myc, a new member of the myc gene family.

Ingvarsson, S., Asker, C., Axelson, H., Klein, G., & Sümegi, J. (1988) · Molecular and Cellular Biology · doi:10.1128/mcb.8.8.3168 · Cited by 62 · see citing works

Genetic Structure of Avian Acute Leukemia VirusesPreprint

Bister, K., & Duesberg, P. H. (1980) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1980.044.01.086 · Cited by 60 · see citing works

MYC Cofactors: Molecular Switches Controlling Diverse Biological OutcomesPreprint

Hann, S. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a014399 · Cited by 60 · see citing works

Loss of the Max-interacting protein Mnt in mice results in decreased viability, defective embryonic growth and craniofacial defects: relevance to Miller-Dieker syndrome

Toyo‐oka, K. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh116 · Cited by 60 · see citing works

Cellular MYCro Economics: Balancing MYC Function with MYC ExpressionPreprint

Levens, D. (2013) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a014233 · Cited by 60 · see citing works

New members of the Drosophila Myc transcription factor subfamily revealed by a genome-wide examination for basic helix-loop-helix genes

Peyrefitte, S., Kahn, D., & Haenlin, M. (2001) · Mechanisms of Development · doi:10.1016/s0925-4773(01)00360-4 · Cited by 59 · see citing works

Max and inhibitory c-Myc mutants induce erythroid differentiation and resistance to apoptosis in human myeloid leukemia cells

Cañelles, M., Delgado, M. D., Hyland, K. M., Lerga, A., Richard, C., Dang, C. V., & León, J. (1997) · Oncogene · doi:10.1038/sj.onc.1200948 · Cited by 58 · see citing works

Identification and Characterization of SAP25, a Novel Component of the mSin3 Corepressor Complex

Shiio, Y., Rose, D. W., Aur, R., Donohoe, S., Aebersold, R. H., & Eisenman, R. N. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.4.1386-1397.2006 · Cited by 57 · see citing works

Myc/Max/Mad in Invertebrates: The Evolution of the Max Network

Gallant, P. (2006) · Springer eBooks · doi:10.1007/3-540-32952-8_9 · Cited by 56 · see citing works

MYC and the Art of MicroRNA MaintenancePreprint

Psathas, J. N., & Thomas‐Tikhonenko, A. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a014175 · Cited by 55 · see citing works

MYC, Metabolism, and Cancer

Stine, Z. E., Walton, Z. E., Altman, B. J., Hsieh, A. L., & Dang, C. V. (2015) · Cancer Discovery · doi:10.1158/2159-8290.cd-15-0507 · Cited by 1,375 · see citing works

The MYC oncogene — the grand orchestrator of cancer growth and immune evasion

Dhanasekaran, R., Deutzmann, A., Mahauad‐Fernandez, W. D., Hansen, A. S., Gouw, A. M., & Felsher, D. W. (2021) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-021-00549-2 · Cited by 1,010 · see citing works

MYC Activation Is a Hallmark of Cancer Initiation and MaintenancePreprint

Gabay, M., Li, Y., & Felsher, D. W. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a014241 · Cited by 808 · see citing works

MYC, Metabolism, Cell Growth, and TumorigenesisPreprint

Dang, C. V. (2013) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a014217 · Cited by 600 · see citing works

MYC as a target for cancer treatment

Duffy, M. J., O’Grady, S., Tang, M., & Crown, J. P. (2021) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2021.102154 · Cited by 524 · see citing works

Germinal centres and B cell lymphomagenesis

Basso, K., & Dalla-Favera, R. (2015) · Nature Reviews Immunology · doi:10.1038/nri3814 · Cited by 510 · see citing works

Therapeutic targeting of “undruggable” MYC

Llombart, V., & Mansour, M. R. (2021) · EBioMedicine · doi:10.1016/j.ebiom.2021.103756 · Cited by 483 · see citing works

Cancer-cell-secreted exosomal miR-105 promotes tumour growth through the MYC-dependent metabolic reprogramming of stromal cells

Yan, W., Wu, X., Zhou, W., Fong, M., Cao, M., Liu, J., Liu, X., Chen, C.-H., Fadare, O., Pizzo, D. P., et al. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0083-6 · Cited by 466 · see citing works

Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas

Schaub, F. X., Dhankani, V., Berger, A. C., Trivedi, M., Richardson, A. B., Shaw, R., Zhao, W., Zhang, X., Ventura, A., Liu, Y., et al. (2018) · Cell Systems · doi:10.1016/j.cels.2018.03.003 · Cited by 431 · see citing works

Recent advances in targeting the “undruggable” proteins: from drug discovery to clinical trials

Xie, X., Yu, T., Li, X., Zhang, N., Foster, L. J., Peng, C., Huang, W., & He, G. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01589-z · Cited by 396 · see citing works

Pharmacological properties and derivatives of shikonin—A review in recent years

Guo, C., He, J., Song, X., Tan, L., Wang, M., Jiang, P., Li, Y., Cao, Z., & Peng, C. Y. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104463 · Cited by 379 · see citing works

Target gene-independent functions of MYC oncoproteins

Baluapuri, A., Wolf, E., & Eilers, M. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0215-2 · Cited by 310 · see citing works

The MYC transcription factor network: balancing metabolism, proliferation and oncogenesis

Carroll, P. A., Freie, B. W., Mathsyaraja, H., & Eisenman, R. N. (2018) · Frontiers of Medicine · doi:10.1007/s11684-018-0650-z · Cited by 289 · see citing works

Strategies to Inhibit Myc and Their Clinical Applicability

Whitfield, J. R., Beaulieu, M.-È., & Soucek, L. (2017) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2017.00010 · Cited by 295 · see citing works

Directly visualized glioblastoma-derived extracellular vesicles transfer RNA to microglia/macrophages in the brain

van der Vos, K. E., Abels, E. R., Zhang, X., Lai, C., Carrizosa, E., Oakley, D., Prabhakar, S., Mardini, O., Crommentuijn, M. H. W., Skog, J., et al. (2016) · Neuro-Oncology · doi:10.1093/neuonc/nov244 · Cited by 315 · see citing works

Genetics of diffuse large B-cell lymphoma

Pasqualucci, L., & Dalla‐Favera, R. (2018) · Blood · doi:10.1182/blood-2017-11-764332 · Cited by 284 · see citing works

MYC Oncogene Contributions to Release of Cell Cycle Brakes

García-Gutiérrez, L., Delgado, M. D., & León, J. (2019) · Genes · doi:10.3390/genes10030244 · Cited by 249 · see citing works

Metabolic reprogramming in triple-negative breast cancer

Sun, X., Wang, M., Wang, M., Yu, X., Guo, J., Sun, T., Li, X., Yao, L., Dong, H., & Xu, Y. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00428 · Cited by 243 · see citing works

Therapeutic Strategies to Inhibit MYCPreprint

McKeown, M. R., & Bradner, J. E. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a014266 · Cited by 226 · see citing works

The OncoPPi network of cancer-focused protein–protein interactions to inform biological insights and therapeutic strategies

Li, Z., Ivanov, A. A., Su, R., González-Pecchi, V., Qi, Q., Liu, S., Webber, P. J., McMillan, E. A., Rusnak, L. E., Pham, C., et al. (2017) · Nature Communications · doi:10.1038/ncomms14356 · Cited by 227 · see citing works

Intrinsic cell-penetrating activity propels Omomyc from proof of concept to viable anti-MYC therapy

Beaulieu, M.-È., Jauset, T., Massó-Vallés, D., Martínez-Martín, S., Rahl, P. B., Maltais, L., Fluck, M. F. Z., Casacuberta‐Serra, S., del Pozo, E. S., Fiore, C., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aar5012 · Cited by 211 · see citing works

Deregulated Myc Requires MondoA/Mlx for Metabolic Reprogramming and Tumorigenesis

Carroll, P. A., Diolaiti, D., McFerrin, L. G., Gu, H., Djukovic, D., Du, J., Cheng, P. F., Anderson, S., Ulrich, M. L., Hurley, J. B., et al. (2015) · Cancer Cell · doi:10.1016/j.ccell.2014.11.024 · Cited by 202 · see citing works

HAUSP deubiquitinates and stabilizes N-Myc in neuroblastoma

Tavana, O., Li, D., Dai, C., López, G., Banerjee, D., Kon, N., Chen, C., Califano, A., Yamashiro, D. J., Sun, H., et al. (2016) · Nature Medicine · doi:10.1038/nm.4180 · Cited by 202 · see citing works

CDK9-mediated transcription elongation is required for MYC addiction in hepatocellular carcinomaPreprint

Huang, C., Lujambio, A., Zuber, J. A., Tschaharganeh, D. F., Doran, M. G., Evans, M. J., Kitzing, T. M., Zhu, N., de Stanchina, E., Sawyers, C. L., et al. (2014) · Genes & Development · doi:10.1101/gad.244368.114 · Cited by 201 · see citing works

The Role for Myc in Coordinating Glycolysis, Oxidative Phosphorylation, Glutaminolysis, and Fatty Acid Metabolism in Normal and Neoplastic Tissues

Goetzman, E. S., & Prochownik, E. V. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00129 · Cited by 199 · see citing works

Role of MYC in medulloblastoma

Roussel, M. F., & Robinson, G. W. (2013) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a014308 · Cited by 180 · see citing works

The MYCN Protein in Health and Disease

Ruiz-Pérez, M. V., Henley, A. B., & Arsenian‐Henriksson, M. (2017) · Genes · doi:10.3390/genes8040113 · Cited by 181 · see citing works

Therapeutic Inhibition of Myc in Cancer. Structural Bases and Computer-Aided Drug Discovery Approaches

Carabet, L. A., Rennie, P. S., & Cherkasov, A. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms20010120 · Cited by 172 · see citing works

MYC: a complex problem

Das, S., Lewis, B. A., & Levens, D. (2022) · Trends in Cell Biology · doi:10.1016/j.tcb.2022.07.006 · Cited by 166 · see citing works

Occupancy maps of 208 chromatin-associated proteins in one human cell type

Partridge, E. C., Chhetri, S. B., Prokop, J. W., Ramaker, R. C., Jansen, C. S., Goh, S.-T., Mackiewicz, M., Newberry, K. M., Brandsmeier, L. A., Meadows, S. K., et al. (2020) · Nature · doi:10.1038/s41586-020-2023-4 · Cited by 154 · see citing works

A Myc-dependent division timer complements a cell-death timer to regulate T cell and B cell responses

Heinzel, S., Giang, T. B., Kan, A., Marchingo, J. M., Lye, B., Corcoran, L. M., & Hodgkin, P. D. (2016) · Nature Immunology · doi:10.1038/ni.3598 · Cited by 167 · see citing works

Different promoter affinities account for specificity in MYC-dependent gene regulation

Lorenzin, F., Benary, U., Baluapuri, A., Walz, S., Jung, L. A., von Eyß, B., Kisker, C., Wolf, J., Eilers, M., & Wolf, E. (2016) · eLife · doi:10.7554/elife.15161 · Cited by 162 · see citing works

MYC protein stability is negatively regulated by BRD4

Devaiah, B. N., Mu, J., Akman, B., Uppal, S., Weissman, J. D., Cheng, D., Baranello, L., Nie, Z., Levens, D., & Singer, D. S. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1919507117 · Cited by 159 · see citing works

MYC in pancreatic cancer: novel mechanistic insights and their translation into therapeutic strategies

Heßmann, E., Schneider, G., Ellenrieder, V., & Siveke, J. T. (2015) · Oncogene · doi:10.1038/onc.2015.216 · Cited by 172 · see citing works

Mission Possible: Advances in MYC Therapeutic Targeting in Cancer

Allen-Petersen, B. L., & Sears, R. C. (2019) · BioDrugs · doi:10.1007/s40259-019-00370-5 · Cited by 143 · see citing works

MYC Is a Major Determinant of Mitotic Cell Fate

Topham, C. H., Tighe, A., Ly, P., Bennett, A., Sloss, O., Nelson, L., Ridgway, R. A., Huels, D. J., Littler, S., Schandl, C., et al. (2015) · Cancer Cell · doi:10.1016/j.ccell.2015.06.001 · Cited by 142 · see citing works

Blocking Myc to Treat Cancer: Reflecting on Two Decades of Omomyc

Massó-Vallés, D., & Soucek, L. (2020) · Cells · doi:10.3390/cells9040883 · Cited by 141 · see citing works

Stabilization of the Max Homodimer with a Small Molecule Attenuates Myc-Driven Transcription

Struntz, N. B., Chen, A., Deutzmann, A., Wilson, R. M., Stefan, E., Evans, H. L., Ramirez, M. A., Liang, T., Caballero, F., Wildschut, M. H. E., et al. (2019) · Cell Chemical Biology · doi:10.1016/j.chembiol.2019.02.009 · Cited by 130 · see citing works

FoxO transcription factors in cancer metabolism

Yadav, R. K., Chauhan, A. S., Zhuang, L., & Gan, B. (2018) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2018.01.004 · Cited by 131 · see citing works

Inhibition of CDK4/6 Promotes CD8 T-cell Memory Formation

Heckler, M., Ali, L. R., Clancy-Thompson, E., Li, Q., Ventre, K. S., Lenehan, P., Roehle, K., Luoma, A., Boelaars, K., Peters, V., et al. (2021) · Cancer Discovery · doi:10.1158/2159-8290.cd-20-1540 · Cited by 130 · see citing works

c-MYC-Induced Genomic InstabilityPreprint

Kuzyk, A. C., & Mai, S. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a014373 · Cited by 124 · see citing works

Transcription Factor Inhibition: Lessons Learned and Emerging Targets

Chen, A. W., & Koehler, A. N. (2020) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2020.01.004 · Cited by 118 · see citing works

The Role of MIZ-1 in MYC-Dependent TumorigenesisPreprint

Wiese, K. E., Walz, S., von Eyß, B., Wolf, E., Athineos, D., Sansom, O. J., & Eilers, M. (2013) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a014290 · Cited by 111 · see citing works

Targeting Translation Initiation Bypasses Signaling Crosstalk Mechanisms That Maintain High MYC Levels in Colorectal Cancer

Wiegering, A., Uthe, F. W., Jamieson, T. J., Ruoss, Y., Hüttenrauch, M., Küspert, M., Pfann, C., Nixon, C., Herold, S., Walz, S., et al. (2015) · Cancer Discovery · doi:10.1158/2159-8290.cd-14-1040 · Cited by 113 · see citing works

Structural and Biophysical Insights into the Function of the Intrinsically Disordered Myc Oncoprotein

Beaulieu, M.-È., Castillo, F., & Soucek, L. (2020) · Cells · doi:10.3390/cells9041038 · Cited by 110 · see citing works

MYC Targeted Long Noncoding RNA DANCR Promotes Cancer in Part by Reducing p21 Levels

Lu, Y., Hu, Z., Mangala, L. S., Stine, Z. E., Hu, Z., Jiang, D., Xiang, Y., Zhang, Y., Pradeep, S., Rodriguez‐Aguayo, C., et al. (2017) · Cancer Research · doi:10.1158/0008-5472.can-17-0815 · Cited by 111 · see citing works

MYC and Transcription ElongationPreprint

Rahl, P. B., & Young, R. A. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a020990 · Cited by 112 · see citing works

Genome Recognition by MYCPreprint

Sabò, A., & Amati, B. B. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a014191 · Cited by 109 · see citing works

PRMT5-dependent transcriptional repression of c-Myc target genes promotes gastric cancer progression

Liu, M., Yao, B., Gui, T., Guo, C., Wu, X., Li, J., Ma, L., Deng, Y., Xu, P., Wang, Y., et al. (2020) · Theranostics · doi:10.7150/thno.42047 · Cited by 108 · see citing works

MYC in Regulating Immunity: Metabolism and Beyond

Gnanaprakasam, J. R., & Wang, R. (2017) · Genes · doi:10.3390/genes8030088 · Cited by 106 · see citing works

MYC in cancer: from undruggable target to clinical trials

Whitfield, J. R., & Soucek, L. (2025) · Nature Reviews Drug Discovery · doi:10.1038/s41573-025-01143-2 · Cited by 106 · see citing works

Stress-Induced Epstein-Barr Virus Reactivation

Sausen, D. G., Bhutta, M., Gallo, E. S., Dahari, H., & Borenstein, R. (2021) · Biomolecules · doi:10.3390/biom11091380 · Cited by 104 · see citing works

C-myc Contributes to Malignancy of Lung Cancer: A Potential Anticancer Drug Target

Pithi Chanvorachote, B., Sriratanasak, N., & Nonpanya, N. (2020) · Anticancer Research · doi:10.21873/anticanres.13990 · Cited by 103 · see citing works

MYC function and regulation in physiological perspective

Jha, R., Kouzine, F., & Levens, D. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1268275 · Cited by 106 · see citing works

Cancer cell metabolism and the modulating effects of nitric oxide

Chang, C.-F., Diers, A. R., & Hogg, N. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.11.012 · Cited by 101 · see citing works

The long journey to bring a Myc inhibitor to the clinic

Whitfield, J. R., & Soucek, L. (2021) · The Journal of Cell Biology · doi:10.1083/jcb.202103090 · Cited by 97 · see citing works

Integrated genomic analysis identifies deregulated JAK/STAT-MYC-biosynthesis axis in aggressive NK-cell leukemia

Huang, L., Liu, D., Wang, N., Ling, S., Tang, Y., Wu, J., Hao, L., Luo, H., Hu, X., Sheng, L., et al. (2017) · Cell Research · doi:10.1038/cr.2017.146 · Cited by 94 · see citing works

Inhibition of MUC1-C Suppresses MYC Expression and Attenuates Malignant Growth in KRAS Mutant Lung Adenocarcinomas

Bouillez, A., Rajabi, H. N., Pitroda, S. P., Jin, C., Alam, M., Kharbanda, A., Tagde, A., Wong, K., & Kufe, D. W. (2016) · Cancer Research · doi:10.1158/0008-5472.can-15-1804 · Cited by 91 · see citing works

Molecular Crosstalk Between MYC and HIF in Cancer

Li, Y., Sun, X., Qian, D. Z., & Dai, M. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.590576 · Cited by 90 · see citing works

Drugging “undruggable” genes for cancer treatment: Are we making progress?

Duffy, M. J., & Crown, J. P. (2020) · International Journal of Cancer · doi:10.1002/ijc.33197 · Cited by 85 · see citing works

The Interaction of Myc with Miz1 Defines Medulloblastoma Subgroup Identity

Vo, B. T., Wolf, E., Kawauchi, D., Gebhardt, A., Rehg, J. E., Finkelstein, D., Walz, S., Murphy, B. L., Youn, Y. H., Han, Y.-G., et al. (2016) · Cancer Cell · doi:10.1016/j.ccell.2015.12.003 · Cited by 82 · see citing works

Imp/IGF2BP levels modulate individual neural stem cell growth and division through myc mRNA stability

Samuels, T. J., Järvelin, A. I., Ish‐Horowicz, D., & Davis, I. (2020) · eLife · doi:10.7554/elife.51529 · Cited by 83 · see citing works

MYC regulates the non-coding transcriptome

Hart, J. R., Roberts, T. C., Weinberg, M. S., Morris, K. V., & Vogt, P. K. (2014) · Oncotarget · doi:10.18632/oncotarget.3033 · Cited by 83 · see citing works

MYC and the unfolded protein response in cancer: synthetic lethal partners in crime?

Zhang, T., Li, N., Sun, C., Jin, Y., & Sheng, X. (2020) · EMBO Molecular Medicine · doi:10.15252/emmm.201911845 · Cited by 82 · see citing works

Blood feeding activates the vitellogenic stage of oogenesis in the mosquito Aedes aegypti through inhibition of glycogen synthase kinase 3 by the insulin and TOR pathways

Valzania, L., Mattee, M. T., Strand, M. R., & Brown, M. R. (2019) · Developmental Biology · doi:10.1016/j.ydbio.2019.05.011 · Cited by 80 · see citing works

Growth suppression by MYC inhibition in small cell lung cancer cells with TP53 and RB1 inactivation

Fiorentino, F. P., Tokgün, P. E., Solé‐Sánchez, S., Giampaolo, S., Tokgün, O., Jauset, T., Kohno, T., Perucho, M., Soucek, L., & Yokota, J. (2016) · Oncotarget · doi:10.18632/oncotarget.8826 · Cited by 80 · see citing works

Myc stimulates cell cycle progression through the activation of Cdk1 and phosphorylation of p27

García-Gutiérrez, L., Bretones, G., Molina, E., Aréchaga, I., Symonds, C. E., Acosta, J. C., Blanco, R. E., Fernández, A., Alonso, L., Siciński, P., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-54917-1 · Cited by 77 · see citing works

BRD4 and MYC : power couple in transcription and disease

Kotekar, A., Singh, A. K., & Devaiah, B. N. (2022) · FEBS Journal · doi:10.1111/febs.16580 · Cited by 76 · see citing works

MYC and KRAS cooperation: from historical challenges to therapeutic opportunities in cancer

Casacuberta‐Serra, S., González-Larreategui, Í., Capitán-Leo, D., & Soucek, L. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01907-z · Cited by 80 · see citing works

Polymer effects modulate binding affinities in disordered proteins

Vancraenenbroeck, R., Harel, Y. S., Zheng, W., & Hofmann, H. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1904997116 · Cited by 75 · see citing works

Prototypical oncogene family Myc defines unappreciated distinct lineage states of small cell lung cancer

Patel, A. S., Yoo, S., Kong, R., Sato, T., Sinha, A., Karam, S., Bao, L., Fridrikh, M., Emoto, K., Nudelman, G., et al. (2021) · Science Advances · doi:10.1126/sciadv.abc2578 · Cited by 73 · see citing works

c-Myc promotes renal fibrosis by inducing integrin αv-mediated transforming growth factor-β signaling

Shen, Y., Miao, N., Wang, B., Xu, J., Gan, X., Xu, D., Zhou, L., Xue, H., Zhang, W., Yang, L., et al. (2017) · Kidney International · doi:10.1016/j.kint.2017.03.006 · Cited by 74 · see citing works

Polyploid Giant Cancer Cells, a Hallmark of Oncoviruses and a New Therapeutic Challenge

Herbein, G., & Nehme, Z. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.567116 · Cited by 71 · see citing works

The MYC–WDR5 Nexus and Cancer

Thomas, L. R., Foshage, A. M., Weissmiller, A. M., & Tansey, W. P. (2015) · Cancer Research · doi:10.1158/0008-5472.can-15-1216 · Cited by 69 · see citing works

Taking on Challenging Targets: Making MYC Druggable

Horiuchi, D., Anderton, B. N., & Goga, A. (2014) · American Society of Clinical Oncology Educational Book · doi:10.14694/edbook_am.2014.34.e497 · Cited by 67 · see citing works

Dissecting transcriptional amplification by MYC

Nie, Z., Guo, C., Das, S., Chow, C. C., Batchelor, E., Simons, S. S., & Levens, D. (2020) · eLife · doi:10.7554/elife.52483 · Cited by 68 · see citing works

Synthetic Lethal Screens as a Means to Understand and Treat MYC-Driven CancersPreprint

Cermelli, S., Jang, I. S., Bernard, B. M., & Grandori, C. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a014209 · Cited by 68 · see citing works

Control of cell metabolism by the epidermal growth factor receptor

Orofiamma, L. A., Vural, D., & Antonescu, C. N. (2022) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2022.119359 · Cited by 69 · see citing works

Menin enhances c-Myc-mediated transcription to promote cancer progression

Wu, G., Yuan, M., Shen, S., Ma, X., Fang, J., Zhu, L., Sun, L., Liu, Z., He, X., Huang, D., et al. (2017) · Nature Communications · doi:10.1038/ncomms15278 · Cited by 67 · see citing works

Recent advances in searching c-Myc transcriptional cofactors during tumorigenesis

Caforio, M., Sorino, C., Iacovelli, S., Fanciulli, M., Locatelli, F., & Folgiero, V. (2018) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-018-0912-2 · Cited by 64 · see citing works

Multi-transcriptome analysis following an acute skeletal muscle growth stimulus yields tools for discerning global and MYC regulatory networks

Murach, K. A., Liu, Z., Jude, B., Figueiredo, V. C., Wen, Y., Khadgi, S., Lim, S., da Silva, F. M., Greene, N. P., Lanner, J. T., et al. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102515 · Cited by 60 · see citing works

MYC dephosphorylation by the PP1/PNUTS phosphatase complex regulates chromatin binding and protein stability

Dingar, D. D., Tu, W. B., Resetca, D., Lourenco, C., Tamachi, A., Melo, J. D., Houlahan, K. E., Kalkat, M., Chan, P.-K., Boutros, P. C., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-05660-0 · Cited by 63 · see citing works

MYC Cofactors: Molecular Switches Controlling Diverse Biological OutcomesPreprint

Hann, S. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a014399 · Cited by 60 · see citing works

A MYC inhibitor selectively alters the MYC and MAX cistromes and modulates the epigenomic landscape to regulate target gene expression

Holmes, A. G., Parker, J. B., Sagar, V., Truica, M. I., Soni, P. N., Han, H., Schiltz, G. E., Abdulkadir, S. A., & Chakravarti, D. (2022) · Science Advances · doi:10.1126/sciadv.abh3635 · Cited by 61 · see citing works

Targeting WD Repeat-Containing Protein 5 (WDR5): A Medicinal Chemistry Perspective

Chen, X., Xu, J., Wang, X., Long, G., You, Q., & Guo, X. (2021) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.1c00037 · Cited by 63 · see citing works

MYC and EGR1 synergize to trigger tumor cell death by controlling NOXA and BIM transcription upon treatment with the proteasome inhibitor bortezomib

Wirth, M., Stojanovic, N., Christian, J. G., Paul, M. C., Stauber, R. H., Schmid, R. M., Häcker, G. A., Krämer, O. H., Saur, D., & Schneider, G. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku763 · Cited by 60 · see citing works

Resetting cancer stem cell regulatory nodes upon MYC inhibition

Galardi, S., Savino, M., Scagnoli, F., Pellegatta, S., Pisati, F., Zambelli, F., Illi, B., Annibali, D., Beji, S., Orecchini, E., et al. (2016) · EMBO Reports · doi:10.15252/embr.201541489 · Cited by 57 · see citing works

Crystal Structures and Nuclear Magnetic Resonance Studies of the Apo Form of the c-MYC:MAX bHLHZip Complex Reveal a Helical Basic Region in the Absence of DNA

Sammak, S., Hamdani, N., Gorrec, F., Allen, M. D., Freund, S. M. V., Bycroft, M., & Zinzalla, G. (2019) · Biochemistry · doi:10.1021/acs.biochem.9b00296 · Cited by 59 · see citing works

Two diphosphorylated degrons control c-Myc degradation by the Fbw7 tumor suppressor

Welcker, M., Wang, B., Rusnac, D.-V., Hussaini, Y., Swanger, J., Zheng, N., & Clurman, B. E. (2022) · Science Advances · doi:10.1126/sciadv.abl7872 · Cited by 57 · see citing works

Diffuse large B cell lymphoma (DLBCL): epidemiology, pathophysiology, risk stratification, advancement in diagnostic approaches and prospects: narrative review

Berhan, A., Almaw, A., Damtie, S., & Solomon, Y. (2025) · Discover Oncology · doi:10.1007/s12672-025-01958-w · Cited by 62 · see citing works

Proteins Recognizing DNA: Structural Uniqueness and Versatility of DNA-Binding Domains in Stem Cell Transcription Factors

Yesudhas, D., Batool, M., Anwar, M. A., Panneerselvam, S., & Choi, S. (2017) · Genes · doi:10.3390/genes8080192 · Cited by 57 · see citing works

microRNA-193a stimulates pancreatic cancer cell repopulation and metastasis through modulating TGF-β2/TGF-βRIII signalings

Fang, C., Dai, C.-Y., Mei, Z., Jiang, M., Gu, D.-N., Huang, Q., & Tian, L. (2018) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-018-0697-3 · Cited by 57 · see citing works

MYC-activated RNA N6-methyladenosine reader IGF2BP3 promotes cell proliferation and metastasis in nasopharyngeal carcinoma

Du, M., Peng, Y., Yang, L., Sun, W., Zhu, H., Wu, J., Zong, D., Wu, L., & He, X. (2022) · Cell Death Discovery · doi:10.1038/s41420-022-00844-6 · Cited by 56 · see citing works

MYC regulates a pan-cancer network of co-expressed oncogenic splicing factors

Urbanski, L. M., Brugiolo, M., Park, S., Angarola, B. L., Leclair, N. K., Yurieva, M., Palmer, P., Sahu, S. K., & Anczuków, O. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111704 · Cited by 56 · see citing works

Neuroblastoma: A Tough Nut to Crack

Speleman, F., Park, J. R., & Henderson, T. O. (2016) · American Society of Clinical Oncology Educational Book · doi:10.1200/edbk_159169 · Cited by 56 · see citing works

MYC and the Art of MicroRNA MaintenancePreprint

Psathas, J. N., & Thomas‐Tikhonenko, A. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a014175 · Cited by 55 · see citing works

<i>Max</i> deletion destabilizes MYC protein and abrogates Eµ- <i>Myc</i> lymphomagenesis

Mathsyaraja, H., Freie, B., Cheng, P.-F., Babaeva, E., Catchpole, J. T., Janssens, D., Henikoff, S., & Eisenman, R. N. (2019) · Genes &amp; Development · doi:10.1101/gad.325878.119 · Cited by 54 · see citing works

Computer-aided drug discovery of Myc-Max inhibitors as potential therapeutics for prostate cancer

Carabet, L. A., Lallous, N., Leblanc, E., Ban, F., Morin, H., Lawn, S. O., Ghaidi, F., Lee, J., Mills, I. G., Gleave, M. E., et al. (2018) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2018.09.023 · Cited by 54 · see citing works

miR-342-3p regulates MYC transcriptional activity via direct repression of E2F1 in human lung cancer

Tai, M.-C., Kajino, T., Nakatochi, M., Arima, C., Shimada, Y., Suzuki, M., Miyoshi, H., Yatabe, Y., Yanagisawa, K., & Takahashi, T. (2015) · Carcinogenesis · doi:10.1093/carcin/bgv152 · Cited by 53 · see citing works

Essential Role for Polycomb Group Protein Pcgf6 in Embryonic Stem Cell Maintenance and a Noncanonical Polycomb Repressive Complex 1 (PRC1) Integrity

Zhao, W., Tong, H., Huang, Y., Yan, Y., Teng, H., Xia, Y. Y., Jiang, Q. Y., & Qin, J. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.763961 · Cited by 51 · see citing works

Abstract IA01: Myc functions within a transcriptional regulatory network

Eisenman, R. N. (2015) · Molecular Cancer Research · doi:10.1158/1557-3125.myc15-ia01

The MYC transcription factor network: balancing metabolism, proliferation and oncogenesis

Carroll, P. A., Freie, B. W., Mathsyaraja, H., & Eisenman, R. N. (2018) · Frontiers of Medicine · doi:10.1007/s11684-018-0650-z · Cited by 289 · see citing works

The Myc/Max/Mad Network and the Transcriptional Control of Cell Behavior

Grandori, C., Cowley, S. M., James, L. P., & Eisenman, R. N. (2000) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.16.1.653 · Cited by 1,333 · see citing works

Functional interactions among members of the MAX and MLX transcriptional network during oncogenesis

Diolaiti, D., McFerrin, L. G., Carroll, P. A., & Eisenman, R. N. (2014) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2014.05.016 · Cited by 113 · see citing works

The MYC network: Hub of malignancy and blueprint for intervention

Yin, H., Liu, T., & Pan, J. (2026) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2026.189651 · Cited by 1 · see citing works