The DOI matches its Crossref record; 31 of the 32 references it cites were found in a registry or an index.
Multidrug-Resistant Tuberculosis and Extensively Drug-Resistant Tuberculosis
Open accessAbstract
The continuing spread of drug-resistant tuberculosis (TB) is one of the most urgent and difficult challenges facing global TB control. Patients who are infected with strains resistant to isoniazid and rifampicin, called multidrug-resistant (MDR) TB, are practically incurable by standard first-line treatment. In 2012, there were approximately 450,000 new cases and 170,000 deaths because of MDR-TB. Extensively drug-resistant (XDR) TB refers to MDR-TB strains that are resistant to fluoroquinolones and second-line injectable drugs. The main causes of the spread of resistant TB are weak medical systems, amplification of resistance patterns through incorrect treatment, and transmission in communities and facilities. Although patients harboring MDR and XDR strains present a formidable challenge for treatment, cure is often possible with early identification of resistance and use of a properly designed regimen. Community-based programs can improve treatment outcomes by allowing patients to be treated in their homes and addressing socioeconomic barriers to adherence.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Treatment typically involves standard antitubercular therapy, which is effective in most cases, although multidrug-resistant TB can complicate treatment [32,33,34].”
From Head and Neck Tuberculosis: A Rare Diagnosis and the Role of Surgical Biopsy and Histopathological Evaluation in Extrapulmonary Disease (2025) · cites this paper as [32]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Global tuberculosis report (2014)
Gabbasova, L. A., & Who, E. R. E. (2014) · Cited by 12,702
Gandhi, N. R., Moll, A. P., Sturm, A. W., Pawinski, R., Govender, T., Lalloo, U., Zeller, K., Andrews, J. R., & Friedland, G. H. (2006) · The Lancet · doi:10.1016/s0140-6736(06)69573-1 · Cited by 1,732
WHO guidelines for the programmatic management of drug-resistant tuberculosis: 2011 update
Falzon, D., Jaramillo, E., Schünemann, H. J., Arentz, M., Bauer, M., Bayona, J. N., Blanc, L., Caminero, J. A., Daley, C. L., Duncombe, C. J., et al. (2011) · European Respiratory Journal · doi:10.1183/09031936.00073611 · Cited by 1,098
Self-citationThe Emergence of Drug-Resistant Tuberculosis in New York City
Frieden, T. R., Sterling, T. R., Pablos-Méndez, A., Kilburn, J. O., Cauthen, G. M., & Dooley, S. W. (1993) · New England Journal of Medicine · doi:10.1056/nejm199302253280801 · Cited by 937
Short, Highly Effective, and Inexpensive Standardized Treatment of Multidrug-resistant Tuberculosis
Deun, A. V., Maug, A. K. J., Salim, M. A. H., Das, P. K., Sarker, M. R., Daru, P., & Rieder, H. L. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201001-0077oc · Cited by 646
Tuberculosis in New York City — Turning the Tide
Frieden, T. R., Fujiwara, P. I., Washko, R. M., & Hamburg, M. A. (1995) · New England Journal of Medicine · doi:10.1056/nejm199507273330406 · Cited by 644
National survey of drug-resistant tuberculosis in China.
Zhao, Y.-L., Xu, S., Wang, L.-X., Chin, D., Wang, S.-F., Jiang, G., Xia, H., Zhou, Y., Li, Q., Ou, X.-C., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1108789 · Cited by 637
Ahuja, S. D., Ashkin, D., Avendano, M., Banerjee, R., Bauer, M., Bayona, J. N., Becerra, M. C., Benedetti, A., Burgos, M. V., Centis, R., et al. (2012) · PLoS Medicine · doi:10.1371/journal.pmed.1001300 · Cited by 532
Self-citationCommunity-Based Therapy for Multidrug-Resistant Tuberculosis in Lima, Peru
Mitnick, C., Bayona, J., Palacios, E., Shin, S., Furin, J., Alcántara, F., Sánchez, E., Sarria, M., Becerra, M., Fawzi, M. C. S., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa022928 · Cited by 489
HIV Infection and Multidrug‐Resistant Tuberculosis—The Perfect Storm
Wells, C. D., Cegielski, J. P., Nelson, L. J., Laserson, K. F., Holtz, T. H., Finlay, A. M., Castro, K. G., & Weyer, K. (2007) · The Journal of Infectious Diseases · doi:10.1086/518665 · Cited by 483
Programmes and principles in treatment of multidrug-resistant tuberculosis
Mukherjee, J. S., Rich, M., Socci, A. R., Joseph, J. K., Virú, F. A. A., Shin, S. S., Furin, J. J., Becerra, M. C., Barry, D. J., Kim, J. Y., et al. (2004) · The Lancet · doi:10.1016/s0140-6736(04)15496-2 · Cited by 333
Self-citationTuberculosis, Drug Resistance, and the History of Modern Medicine
Keshavjee, S. A., & Farmer, P. E. (2012) · New England Journal of Medicine · doi:10.1056/nejmra1205429 · Cited by 315
Self-citationErasing the World's Slow Stain: Strategies to Beat Multidrug-Resistant Tuberculosis
Dye, C., Williams, B. G., Espinal, M., & Raviglione, M. C. (2002) · Science · doi:10.1126/science.1063814 · Cited by 314
Johnson, J. L., Hadad, D. J., Boom, W. H., Daley, C. L., Peloquin, C. A., Eisenach, K. D., Jankus, D. D., Debanne, S. M., Charlebois, E. D., Maciel, E. L. N., et al. (2006) · PubMed · Cited by 200
Peloquin, C. A., Hadad, D. J., Molino, L. P., Palaci, M., Boom, W. H., Dietze, R., & Johnson, J. L. (2007) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01036-07 · Cited by 185
Gelmanova, I. Y. (2007) · Bulletin of the World Health Organization · doi:10.2471/blt.06.038331 · Cited by 167
Pulmonary resection for multi–drug resistant tuberculosis
Pomerantz, B. J., Cleveland, J. C., Olson, H. K., & Pomerantz, M. (2001) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1067/mtc.2001.112339 · Cited by 163
Alarming levels of drug-resistant tuberculosis in Belarus: results of a survey in Minsk
Skrahina, A. M., Hurevich, H., Zalutskaya, A., Sahalchyk, E., Astrauko, A., Gemert, W. V., Hoffner, S., Rusovich, V., & Matteo Zignol, E. (2011) · European Respiratory Journal · doi:10.1183/09031936.00145411 · Cited by 158
Mase, S., Chorba, T. L., LoBue, P. A., & Castro, K. G. (2013) · Cited by 134
Early Outcomes of MDR-TB Treatment in a High HIV-Prevalence Setting in Southern Africa
Seung, K. J., Omatayo, D. B., Keshavjee, S. A., Furin, J. J., Farmer, P. E., & Satti, H. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007186 · Cited by 122
Self-citationTreatment outcomes in an integrated civilian and prison MDR-TB treatment program in Russia.
Shin, S., Pasechnikov, A., Gelmanova, I. Y., Gg, P., Strelis, A. K., Mishustin, S. P., Barnashov, A., Karpeichik, Y., Andreev, Y. G., Vt, G., et al. (2006) · PubMed · Cited by 91
Self-citationSomocurcio, J. G., Sotomayor, A. R., Shin, S. S., Portilla, S., Valcarcel, M., Guerra, D., & Furin, J. J. (2006) · Thorax · doi:10.1136/thx.2005.051961 · Cited by 89
Seung, K. J., Gel'manova, I. E., Gg, P., Vt, G., Pavlova, V. E., Sirotkina, O. B., Yanova, G. V., & Strelis, A. K. (2004) · Clinical Infectious Diseases · doi:10.1086/425005 · Cited by 86
Self-citationExtensively Drug‐Resistant Tuberculosis: “There must be some kind of way out of here”
Cegielski, J. P. (2010) · Clinical Infectious Diseases · doi:10.1086/651491 · Cited by 85
Pyle, M. M. (1947) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(25)10603-4 · Cited by 83
Pachas, A. M. C., Blank, R., Fawzi, M. C. S., Bayona, J. N., Becerra, M. C., & Mitnick, C. D. (2004) · PubMed · Cited by 48
Lin, H.-H., Shin, S. S., Blaya, J. A., Zhang, Z., Cegielski, P., Contreras, C. C., Asencios, L., Bonilla-Asalde, C. A., Bayona, J. N., Paciorek, C. J., et al. (2010) · Epidemiology and Infection · doi:10.1017/s0950268810002797 · Cited by 34
Diagnosis and Treatment of Drug-Resistant Tuberculosis
Caminero, J. A., Caylà, J. A., García-García, J.-M., García-Pérez, F. J., Palacios, J. J., & Manzano, J. R. (2017) · Archivos de Bronconeumología · doi:10.1016/j.arbr.2017.07.005 · Cited by 34
Tuberculosis in Children Exposed at Home to Multidrug-resistant Tuberculosis
Becerra, M. C., Franke, M. F., Appleton, S. C., Joseph, J. K., Bayona, J. N., Atwood, S. S., & Mitnick, C. D. (2012) · The Pediatric Infectious Disease Journal · doi:10.1097/inf.0b013e31826f6063 · Cited by 32
Satti, H., McLaughlin, M., Seung, K. J., Becerra, M. C., & Keshavjee, S. A. (2012) · The International Journal of Tuberculosis and Lung Disease · doi:10.5588/ijtld.12.0344 · Cited by 16
Self-citation
Flagged first, then by citations
1 of the 32 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Garcia-Prats AJ, Donald PR, Hesseling AC, Schaaf HS. 2013. Second-Line antituberculosis drugs in children: A commis- sioned review for the World Health Organization 19th Ex- pert Committee on the Selection and Use of Essential Med- icines. World Health Organization, Geneva.
Cited by
Sorted by citations
Antibiotic resistance in Staphylococcus aureus. Current status and future prospects
Foster, T. J. (2017) · FEMS Microbiology Reviews · doi:10.1093/femsre/fux007 · Cited by 930
Yeh, Y.-C., Huang, T., Yang, S.-C., Chen, C.-C., & Fang, J. (2020) · Frontiers in Chemistry · doi:10.3389/fchem.2020.00286 · Cited by 436
Recent updates on drug resistance in Mycobacterium tuberculosis
Singh, R. K. B., Dwivedi, S. P., Gaharwar, U. S., Meena, R., Rajamani, P., & Prasad, T. (2019) · Journal of Applied Microbiology · doi:10.1111/jam.14478 · Cited by 340
Lange, C. G., Abubakar, I., Alffenaar, J. C., Bothamley, G. H., Caminero, J. A., Carvalho, A. C. C., Chang, K. C., Codecasa, L. R., Correia, A., Crudu, V., et al. (2014) · European Respiratory Journal · doi:10.1183/09031936.00188313 · Cited by 308
Spinal tuberculosis: a comprehensive review for the modern spine surgeon
Khanna, K., & Sabharwal, S. (2019) · The Spine Journal · doi:10.1016/j.spinee.2019.05.002 · Cited by 274
Metadata
- Authors
- Seung, K. J., Keshavjee, S., & Rich, M. L.
- Affiliations
- Brigham and Women's Hospital (US)
- Venue
- Cold Spring Harbor Perspectives in Medicine
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2015-04-27
- Volume
- 5
- Issue
- 9
- Pages
- a017863
- ISSN
- 2157-1422 (ISSN-L)
- PMC
- PMC4561400
- OpenAlex
- W2107340859
- Cited by
- 805
- References
- 32
- Citations by year
- 2026: 70 · 2025: 147 · 2024: 136 · 2023: 165 · 2022: 105 · 2021: 72 · 2020: 52 · 2019: 20 · 2018: 11 · 2017: 7 · 2016: 8 · 2015: 4
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cold Spring Harbor Perspectives in Medicine (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
- Health Sciences › Medicine › Infectious Diseases › Infectious Diseases and Tuberculosis
- Health Sciences › Medicine › Infectious Diseases › Diagnosis and treatment of tuberculosis
- Keywords
- multidrug-resistant tuberculosis, extensively drug-resistant tuberculosis, isoniazid resistance, rifampicin resistance, fluoroquinolone resistance, second-line injectable drugs, transmission of drug-resistant strains, medication adherence, community-based treatment, global tuberculosis control, resistance monitoring
- MeSH terms
- Antitubercular Agents, Child, Community Health Services, Drug Administration Schedule, Drug Therapy, Combination, Female, Humans, Isoniazid, Pregnancy, Pregnancy Complications, Infectious, Rifampin, Global Health, Drug Design, HIV Infections, Tuberculosis, Multidrug-Resistant, Fluoroquinolones, Extensively Drug-Resistant Tuberculosis, Coinfection
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
