The DOI matches its Crossref record; 31 of the 32 references it cites were found in a registry or an index.
Multidrug-Resistant Tuberculosis and Extensively Drug-Resistant Tuberculosis
Open accessAbstract
The continuing spread of drug-resistant tuberculosis (TB) is one of the most urgent and difficult challenges facing global TB control. Patients who are infected with strains resistant to isoniazid and rifampicin, called multidrug-resistant (MDR) TB, are practically incurable by standard first-line treatment. In 2012, there were approximately 450,000 new cases and 170,000 deaths because of MDR-TB. Extensively drug-resistant (XDR) TB refers to MDR-TB strains that are resistant to fluoroquinolones and second-line injectable drugs. The main causes of the spread of resistant TB are weak medical systems, amplification of resistance patterns through incorrect treatment, and transmission in communities and facilities. Although patients harboring MDR and XDR strains present a formidable challenge for treatment, cure is often possible with early identification of resistance and use of a properly designed regimen. Community-based programs can improve treatment outcomes by allowing patients to be treated in their homes and addressing socioeconomic barriers to adherence.
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“Treatment typically involves standard antitubercular therapy, which is effective in most cases, although multidrug-resistant TB can complicate treatment [32,33,34].”
From Head and Neck Tuberculosis: A Rare Diagnosis and the Role of Surgical Biopsy and Histopathological Evaluation in Extrapulmonary Disease (2025) · cites this paper as [32]
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Citations
Cites
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Self-citationThe Emergence of Drug-Resistant Tuberculosis in New York City
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Self-citationCommunity-Based Therapy for Multidrug-Resistant Tuberculosis in Lima, Peru
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Research works printed but not linked: 1
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Antibiotic resistance in Staphylococcus aureus. Current status and future prospects
Foster, T. J. (2017) · FEMS Microbiology Reviews · doi:10.1093/femsre/fux007 · Cited by 930
Yeh, Y.-C., Huang, T., Yang, S.-C., Chen, C.-C., & Fang, J. (2020) · Frontiers in Chemistry · doi:10.3389/fchem.2020.00286 · Cited by 436
Recent updates on drug resistance in Mycobacterium tuberculosis
Singh, R. K. B., Dwivedi, S. P., Gaharwar, U. S., Meena, R., Rajamani, P., & Prasad, T. (2019) · Journal of Applied Microbiology · doi:10.1111/jam.14478 · Cited by 340
Lange, C. G., Abubakar, I., Alffenaar, J. C., Bothamley, G. H., Caminero, J. A., Carvalho, A. C. C., Chang, K. C., Codecasa, L. R., Correia, A., Crudu, V., et al. (2014) · European Respiratory Journal · doi:10.1183/09031936.00188313 · Cited by 308
Spinal tuberculosis: a comprehensive review for the modern spine surgeon
Khanna, K., & Sabharwal, S. (2019) · The Spine Journal · doi:10.1016/j.spinee.2019.05.002 · Cited by 274
Metadata
- Authors
- Seung, K. J., Keshavjee, S., & Rich, M. L.
- Affiliations
- Brigham and Women's Hospital (US)
- Venue
- Cold Spring Harbor Perspectives in Medicine
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2015-04-27
- Volume
- 5
- Issue
- 9
- Pages
- a017863
- ISSN
- 2157-1422 (ISSN-L)
- PMC
- PMC4561400
- OpenAlex
- W2107340859
- Cited by
- 805
- References
- 32
- Citations by year
- 2026: 70 · 2025: 147 · 2024: 136 · 2023: 165 · 2022: 105 · 2021: 72 · 2020: 52 · 2019: 20 · 2018: 11 · 2017: 7 · 2016: 8 · 2015: 4
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cold Spring Harbor Perspectives in Medicine (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
- Health Sciences › Medicine › Infectious Diseases › Infectious Diseases and Tuberculosis
- Health Sciences › Medicine › Infectious Diseases › Diagnosis and treatment of tuberculosis
- Keywords
- multidrug-resistant tuberculosis, extensively drug-resistant tuberculosis, isoniazid resistance, rifampicin resistance, fluoroquinolone resistance, second-line injectable drugs, transmission of drug-resistant strains, medication adherence, community-based treatment, global tuberculosis control, resistance monitoring
- MeSH terms
- Antitubercular Agents, Child, Community Health Services, Drug Administration Schedule, Drug Therapy, Combination, Female, Humans, Isoniazid, Pregnancy, Pregnancy Complications, Infectious, Rifampin, Global Health, Drug Design, HIV Infections, Tuberculosis, Multidrug-Resistant, Fluoroquinolones, Extensively Drug-Resistant Tuberculosis, Coinfection
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