The Autophagy Lysosomal Pathway and Neurodegeneration

Cited by (196)

Items 101–196 of 196

1. Age-Associated Molecular Changes in Human Hippocampus Subfields as Determined by Quantitative Proteomics
   Praseeda Mol, Oishi Chatterjee, Lathika Gopalakrishnan, Kiran Kumar Mangalaparthi, Firdous Ahmad Bhat, Manish Kumar, Bipin Gopalakrishnan Nair, Susarla Krishna Shankar, Anita Mahadevan, Thottethodi Subrahmanya Keshava Prasad · 2022 · OMICS A Journal of Integrative Biology
2. Amyloid-like aggregates cause lysosomal defects in neurons via gain-of-function toxicity
   Irene Riera-Tur, Tillman Schäfer, Daniel Hornburg, Archana Mishra, Lorena Fernández-Mosquera, Dennis Feigenbutz, Patrick Auer, Matthias Mann, Wolfgang P. Baumeister, Rüdiger Klein et al. · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
3. Interconnected cell death pathways: central mechanisms and therapeutic targets in impaired follicular development of polycystic ovary syndrome
   Shuang Ma, Chang Sun, Yasong Wang, Xuanning Zhang, Hongying Kuang · 2026 · Journal of Ovarian Research
4. Untangling the complex mechanisms associated with Alzheimer's disease in elderly patients using high-throughput RNA sequencing data and next-generation knowledge discovery methods: Focus on potential gene signatures and drugs for dementia
   Hind Ali Alkhatabi, Peter Natesan Pushparaj · 2024 · Heliyon
5. KBTBD8/RRP15 as a potential novel therapeutic target associates with lenvatinib-inhibited progression in hepatocellular carcinoma both in vitro and in vivo
   Saili Zhao, Xuran Wang, Rui Ting Wu, Fenglan Wang, Xiaoxuan Tang, Junhui Chen, Runqiu Jiang, Wei Kang, Guifang Xu, Lei Wang et al. · 2024 · Journal of Advanced Research
6. A novel allosteric GCase modulator prevents Tau accumulation in GBA1WT and GBA1L444P/L444P cellular models
   Matteo Ciccaldo, N. Pérez-Carmona, Ester Piovesana, S. Cano-Crespo, Ana Ruano, A. Delgado, Ilaria Fregno, Beatriz Calvo-Flores Guzmán, M. Bellotto, Maurizio Molinari et al. · 2025 · Scientific Reports
7. Axenic Culture of Caenorhabditis elegans Alters Lysosomal/Proteasomal Balance and Increases Neuropeptide Expression
   Huaihan Cai, Ping Wu, Lieselot Vandemeulebroucke, Ineke Dhondt, Madina Rasulova, Andy R. Vierstraete, Bart P. Braeckman · 2022 · International Journal of Molecular Sciences
8. Transactivation Response DNA-Binding Protein of 43 (TDP-43) and Glial Cell Roles in Neurological Disorders
   Hussain Hussain, Tamara Djurin, Jacqueline Rodriguez, Lia Daneelian, Sardar Sundi, Aya Fadel, Zahraa F. Saadoon · 2022 · Cureus
9. The abscopal effect: Implications for drug discovery in autoimmunity
   Sylviane Muller · 2023 · Autoimmunity Reviews
10. Regulating autophagy: a novel role for SETX (Senataxin)
    Patricia Richard, Emanuel Rosonina · 2021 · Neural Regeneration Research
11. Proteostasis imbalance: Unraveling protein aggregation in neurodegenerative diseases and emerging therapeutic strategies
    Chandrabose Selvaraj, Periyasamy Vijayalakshmi, Dipali Desai, Jayakumar Manoharan · 2025 · Advances in protein chemistry and structural biology
12. Leveraging Proteomics to Explore the Molecular Mechanisms of Primary Tauopathies
    Laura R. Nementzik, Tomas Kavanagh, Sian Genoud, Eleanor Drummond · 2025 · Journal of Neurochemistry
13. Restoration of autophagy-lysosomal function via transcranial focused ultrasound stimulation ameliorates β-amyloid pathology and cognitive deficits in an Alzheimer’s disease model
    Mengke Wang, Baochen Zhang, Renhao Guo, Haiqin Wang, Di Wu, Xiaoqian Peng, Hongsong Guo, Jiawei Duan, Weina Yang, Pengyu Ren et al. · 2026 · Ultrasonics
14. A genetically-encoded fluorescence-based reporter to spatiotemporally investigate mannose-6-phosphate pathway
    Mallika Bhat, Akshaya Nambiar, Lakshmi Edakkandiyil, Irine Maria Abraham, Ritoprova Sen, Mamta Negi, Ravi R. Manjithaya · 2024 · Molecular Biology of the Cell
15. Combination of Epigallocatechin-3-Gallate and Tramiprosate Prevent Accumulation of Intracellular Aβ and Dysfunctional Autophagy–Lysosomal Pathway at Earliest Stage of Transdifferentiation of Mesenchymal Stromal Cells into PSEN1 E280A Cholinergic-like Neurons
    Viviana Soto‐Mercado, Miguel Mendivil‐Perez, Marlene Jiménez-Del-Río, Carlos Velez‐Pardo · 2025 · International Journal of Molecular Sciences
16. The AKT-USP15 axis modulates autophagy in MPP+-induced Parkinson's disease model of SN4741 cells
    Xian Guo Wu, Yue Wen, YuYu Yuan, Tianyao Bai, Nanfei Yang, Lingling Xu, Yujie Ma, Peng Su, Wenjing Luo, Wenjun Li · 2025 · Cellular Signalling
17. Protein Quality Control in Neurodegeneration and Neuroprotection
    Yasmeena Akhter, Jahangir Nabi, Hinna Hamid, Nahida Tabassum, Faheem Hyder Pottoo, Aashish Sharma · 2020 · Advances in medical diagnosis, treatment, and care (AMDTC) book series
18. Inhibiting SNX14 Alleviates Epileptic Seizures by Regulating GluA2 Degradation via the Lysosomal Pathway
    Jing Wang, Cao Qingqing, Yan Xia, Ningxiang Qin, Xu Demei, Wang Xuefeng, Ming Ai, Xi Peng, Liang Wang · 2025 · Molecular Neurobiology
19. Rapamycin and Autophagy: Potential Therapeutic Approach for Parkinson's Disease Treatment
    Ahsas Goyal, Anuradha Kumari, Aanchal Verma, Neetu Agrawal · 2025 · CNS & Neurological Disorders - Drug Targets
20. Human clearance systems have a layered architecture across tissues and cell types that supports varied proteome compositions
    Ekaterina Vinogradov-Talyah, Bar Edri, Lior Ravkaie, Or Lazarescu, Fadi Gharra, Juman Jubran, Anat Ben-Zvi, Esti Yeger-Lotem · 2025 · Autophagy
21. DDOX expands the repertoire of tetracyclines for Parkinson’s disease by preventing the cellular uptake and intracellular impact of α-synuclein preformed fibrils
    María del Milagro Terán, Rodrigo Hernán Tomas‐Grau, Silvana Estefanía Soliz-Santander, María Laura Guayán, Valentina Budeguer Isa, Alvaro Luna Mercado, César L. Ávila, Bernardo Sosa‐Padilla, Hernán Cruz, Ismaïla Ciss et al. · 2025 · Scientific Reports
22. Lifestyle strategies and mechanistic implications for slowing neurodegeneration
    Jordan Gunning, Mario I. Hernandez, Behzad Gudarzi, Hana M. Roushdy, Yonas E. Geda, Susan B. Racette · 2026 · npj Metabolic Health and Disease
23. Research note: Effect of a biotechnologically produced Pleurotus sapidus mycelium on expression of genes involved in protein synthesis and degradation in breast muscle of broilers
    Lea Schäfer, Javier Herrero-Encinas, Martin Rühl, Holger Zorn, Erika Most, Klaus Eder, Robert Ringseis · 2024 · Poultry Science
24. Actinomyces viscosus promotes neuroprotection in C. elegans models of Parkinson’s disease
    Germain Sophie Ngana, Mercedes A. Di Bernardo, Michael Gordon Surette, Lesley T. MacNeil · 2025 · Mechanisms of Ageing and Development
25. Autophagy Induced by Trehalose Alleviates Apoptosis of Human Aortic Endothelial Cells After Cryopreservation
    Siyang Huang, Sheng Xue, Qian Zhang, Junyu Chen, Wenjie Zhu, Qing Chang · 2021 · Biopreservation and Biobanking
26. RAB31 in glioma‐derived endothelial cells promotes glioma cell invasion via extracellular vesicle‐mediated enrichment of MYO1C
    Jinghao Suo, Yuxin Wang, Lin Wang, Bojun Qiu, Zhixing Wang, Yan An, Boqin Qiang, Wei Han, Xiaozhong Peng · 2023 · FEBS Open Bio
27. RIT2 reduces LRRK2 kinase activity and protects against alpha-synuclein neuropathology
    Julia Obergasteiger, Anne-Marie Castonguay, Giulia Frapporti, Evy Lobbestael, Veerle Baekelandt, Andrew A. Hicks, Peter Paul Pramstaller, Claude Gravel, Corrado Corti, Martin Lévesque et al. · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
28. Age-related Dysregulation of Autophagy Contributes to Microglial Dysfunction and Chronic Neurobehavioral Deficits After Traumatic Brain Injury
    Rodney M. Ritzel, Yun Li, Zhuofan Lei, Jordan Carter, Junyun He, Harry Choi, Niaz Khan, Hui Li, Samantha Allen, Marta M. Lipinski et al. · 2021 · Research Square
29. The Kinesin-3 KIF1A Functions as a Diligent Worker during Axonal Transport
    Jesse Cisneros Solis, Teresa Lynne Blasius, Kristen J. Verhey · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
30. Adult-Onset Neuronal Ceroid Lipofuscinosis: CLN5 Variant Presenting as Focal Dystonia
    Madhavi Karri, Rukmini Mridula Kandadai, Sruthi Kola, Rupam Borgohain, Rajesh Alugolu, V.V.S.R.K. Prasad, Bevinahalli N. Nandeesh, Periyasamy Govindaraj · 2024 · Tremor and Other Hyperkinetic Movements
31. Overview of Lysosomal Storage Diseases (LSDs)
    Parastoo Rostami, Maryam Razavi · 2025 · Springer eBooks
32. Immunomodulatory Effects of Intermittent Fasting and Its Implication on Cancer: Ramadan Fasting Perspective
    Mohamed Labib Salem, Saleh Hamad Alwasel, MoezAlIslam E. Faris, Waleed Aldahmash, Noura E. Sanoh, Hager A. Elkomy, Esraa M. Khallaf, Amr Abdelsalam Shaheraldin, Toqa Solaiman, Nada Mostafa et al. · 2025 · Springer eBooks
33. Exploring the role of HIF-1α in pathogenesis of parkinson’s disease and its potential as a therapeutic target
    Navpreet Kaur, Khadga Raj Aran · 2025 · Molecular Biology Reports
34. Presenilin 1 E280A mutation induces dysfunctional astrocytic phenotype in menstrual stromal-derived astrocyte-like cells
    Natalia Quiroz Correa, Miguel Mendivil‐Perez, Carlos Velez‐Pardo, Marlene Jiménez-Del-Río, Q. Quiroz-Correa · 2025 · Cellular and Molecular Life Sciences
35. Comparative Genomics Reveals Autophagy‐Lysosome Pathway Expansion and Adaptive Gene Selection in Anguillid Eels
    Hyeongwoo Choi, H.-W. Choi, Junil Ko, Yeongjin Gwon, Jeong Kyu Kim, Young-Jin Seo, Seong‐il Eyun · 2025 · Journal of Zoological Systematics & Evolutionary Research
36. α‐ O ‐Glycosylation at Tyrosine 10 Promotes the Astrocyte Clearance of Amyloid‐β Peptide 1–42
    Lu Huang, Dangliang Liu, Qijia Wei, Changdong He, Jun Zhang, Suwei Dong · 2025 · ChemBioChem
37. Targeted degradation of intracellular organelles: Strategies and implications
    Yifei Lu, Yunting Zhang, Keran Wang, Renhe Liu, Yao Fu · 2026 · Journal of Controlled Release
38. Survey of the human proteostasis network: the autophagy-lysosome pathway
    Evan T. Powers, Suzanne Elsasser, Ee Phie Tan, Christian M. Cole, Qiang Xiao, Thomas Stoeger, Xiaojing Sui, Roy D. Kurtzbard, Patricia Martínez-Botía, Reese A. K. Richardson et al. · 2026 · Autophagy
39. The Biology of Death
    Gary C. Howard · 2021
40. Proteostasis function and dysfunction in Huntington's disease
    Juliana Abramovich, Korbin M. Kleczko, Vincent B. Masto, Judith Frydman · 2024 · Elsevier eBooks
41. MicroRNAs Regulating Autophagy in Neurodegeneration
    Qingxuan Lai, Nikolai Kovzel, Ruslan Konovalov, Ilya A. Vinnikov · 2021 · Advances in experimental medicine and biology
42. Aging and Senescence
    Gary C. Howard · 2021 · Oxford University Press eBooks
43. Measuring Autophagic Flux in Neurons by Optical Pulse Labeling
    Nicholas A. Castello, Steven M. Finkbeiner · 2021 · Neuromethods
44. Death in Life
    Gary C. Howard · 2021 · Oxford University Press eBooks
45. Genetics of Life and Death
    Gary C. Howard · 2021 · Oxford University Press eBooks
46. Death Is More than Dying
    Gary C. Howard · 2021 · Oxford University Press eBooks
47. Bioethics
    Gary C. Howard · 2021 · Oxford University Press eBooks
48. Dying
    Gary C. Howard · 2021 · Oxford University Press eBooks
49. A Brief Overview of Pathological Tau and Inhibitors and Modifiers of Tau Aggregation for Treatment of Tauopathies
    Siri Sahithi Manthapuri, Emily Davis · 2021 · Journal of Student Research
50. Exploring the role of protein quality control in aging and age-associated neurodegenerative diseases
    Neha Gogia, Víctor Olmos, Fatema Haidery, Kimberly P. Luttik, Leon Tejwani, Janghoo Lim · 2022 · Elsevier eBooks
51. Death of Cells
    Gary C. Howard · 2021 · Oxford University Press eBooks
52. Defining Life and Death
    Gary C. Howard · 2021 · Oxford University Press eBooks
53. Ashes to Ashes and Dust to Dust
    Gary C. Howard · 2021 · Oxford University Press eBooks
54. Death in Plants
    Gary C. Howard · 2021 · Oxford University Press eBooks
55. What Kills Humans
    Gary C. Howard · 2021 · Oxford University Press eBooks
56. Death in Bacteria, Fungi, and Protista
    Gary C. Howard · 2021 · Oxford University Press eBooks
57. Future of Death
    Gary C. Howard · 2021 · Oxford University Press eBooks
58. Death on a Grand Scale
    Gary C. Howard · 2021 · Oxford University Press eBooks
59. Programmed Cell Death in Humans
    Gary C. Howard · 2021 · Oxford University Press eBooks
60. Last Hominid Standing
    Gary C. Howard · 2021 · Oxford University Press eBooks
61. Dedication
    Gary C. Howard · 2021 · Oxford University Press eBooks
62. Copyright Page
    Gary C. Howard · 2021 · Oxford University Press eBooks
63. Glossary
    Gary C. Howard · 2021 · Oxford University Press eBooks
64. Preface
    Gary C. Howard · 2021 · Oxford University Press eBooks
65. About the Dead Man and Fungi
    Marvin Bell · 2021 · Oxford University Press eBooks
66. Gallic acid relieved bortezomib-induced peripheral neurotoxicity by restoring Schwann cell lysosomal activity
    Xiaoliang Liu, Ke Wang, Xingxian Zhang, Jiayu Qi, Danyan Zhu, Zechao Wang, Zhi He, Jianbiao Yao, Xiangnan Zhang, Jiaying Wu · 2025 · Toxicological Sciences
67. Proteostasis and pathogenesis: Unraveling the complexity of protein misfolding disorders
    Tripti Nair, Ditsa Sarkar, Sumit Murmu, Rahul Singh Rawat, Biplab Singha · 2025 · Advances in protein chemistry and structural biology
68. Cocktail gene therapy (CGT) for neurodegenerative diseases: Targeting protein clearance systems
    Haoyun Zhang, David B. Teplow · 2025 · Medical Hypotheses
69. Protein Aggregation, Oxidative Stress, and Autophagic Dysfunction in Neurodegenerative Diseases
    Prarambh S. R. Dwivedi, Pavithra Pradeep Prabhu, Abhishek Ankur Balmik · 2025 · Springer eBooks
70. Protein degradation pathways in Parkinsons disease
    Riddhi Upadhyay, Gowshika Velmurugan, Murugan Sevanan, Subashchandrabose Chinnathambi · 2025 · Advances in protein chemistry and structural biology
71. Proteasome and Ribosome Ubiquitination in Retinal Pigment Epithelial (RPE) Cells in Response to Oxidized Low-Density Lipoprotein (OxLDL)
    Francesco Giorgianni, Šárka Beranová-Giorgianni · 2025 · Biomedicines
72. Additional file 2 of Sex differences in response to obesity and caloric restriction on cognition and hippocampal measures of autophagic-lysosomal transcripts and signaling pathways
    Sadie B. Baer, Adrianah D. Dorn, Danielle Maria Osborne · 2024 · Figshare
73. Additional file 3 of Sex differences in response to obesity and caloric restriction on cognition and hippocampal measures of autophagic-lysosomal transcripts and signaling pathways
    Sadie B. Baer, Adrianah D. Dorn, Danielle Maria Osborne · 2024 · Figshare
74. Additional file 1 of Sex differences in response to obesity and caloric restriction on cognition and hippocampal measures of autophagic-lysosomal transcripts and signaling pathways
    Sadie B. Baer, Adrianah D. Dorn, Danielle Maria Osborne · 2024 · Figshare
75. Mitochondrial and lysosomal dysfunctions might be involved in the pathogenesis of the CACNA1A-related neurodevelopmental disorders according to in vitro studies
    Miriam Kessi, Langui Pan, Baiyu Chen, Li Yang, Lifen Yang, Olumuyiwa A. Bamgbade, Guoli Wang, Jing Peng, Fei Yin, Fang Ping He · 2025 · Biological Research
76. Proteostasis in type 2 diabetes
    Atul K. Tiwari, Sadhna Soni, Arun Upadhyay · 2026 · Elsevier eBooks
77. Activation of α7nAChR reduces inflammation and apoptosis, promoting muscle regeneration through the AKT-FOXO1 pathway
    Xiaolu Jin, Zhou Ya, Li Sun, Li Li, Chaozhu Zheng, Zhongliang Shan, Chao Ding, Daqian Huang, QiPeng ZHANG, Rongrong Fan et al. · 2026 · Cell Death and Differentiation
78. Impact de la déficience de la protéine de réponse au stress TP53INP1 sur la dégénérescence des neurones dopaminergiques nigraux au cours du vieillissement normal et en condition parkinsonienne
    Emilie Hoang Dinh · 2020
79. Investigation of IAPP fibrillation inhibition by co-chaperonin prefoldin
    Ricarda Törner · 2021 · theses.fr (ABES)
80. Immunoproteasome Inhibition Modulates Microglial Polarization to Facilitate Anti-Inflammatory Responses and Hematoma Resolution After Intracerebral Hemorrhage
    Wei-Fen Hu, Chien-Hui Lee, Hsin-Yi Huang, Cheng‐Yoong Pang, Yi‐Feng Wu, Tsung‐Jen Lin, Peter Bor‐Chian Lin, Sheng‐Tzung Tsai, Chia-Ho Lin, Hock‐Kean Liew · 2026 · Cells
81. Progranulin deficiency in the brain activates an insulin signaling pathway that may promote neurodegeneration
    Mini P. Sajan, Geetika Aggarwal, Joel Jihwan Hwang, Denise M. Smith, Denise R. Cooper, Mildred Acevedo Duncan, BARBARA CALEEN HANSEN, Andrew D. Nguyen, Robert V. Farese · 2026 · iScience
82. Molecular mechanisms of autophagy-lysosomal pathway dysfunction in neurodegenerative diseases and therapeutic strategies for lysosomal repair: a review
    Weilin Wang, Xianguo Meng · 2026 · Frontiers in Neuroscience
83. Withaferin A in breast cancer therapy: multi-targeted modulation of redox homeostasis, autophagy, and apoptosis
    Neeraj Patel, Aditi Gupta, Riya Mishra, Surya Nath Pandey, Kavita Goyal, Haider Ali, Chandana Maji, A. Rekha, Md Sadique Hussain, Sachin Kumar Singh et al. · 2026 · Journal of Asian Natural Products Research
84. Small molecular chaperones regulate protein quality control in neurodegenerative diseases
    Nagaraj Rangappa, Amit Mishra, Subashchandrabose Chinnathambi · 2026 · Advances in protein chemistry and structural biology
85. Kinesin-3 KIF1A functions as a diligent worker and its functionality is regulated by the ubiquitin-proteasome system
    Jesse Cisneros Solis, Lynne Blasius, Kristen J. Verhey · 2026 · Molecular Biology of the Cell
86. 2-Amino-5-hydroxyhexanoic acid mitigates diabetes-induced skeletal muscle atrophy by preserving protein homeostasis
    Pawan Kumar, S Kumar, Nikita Chhikara, Rahul Baghel, Mohit Chourasiya, Ishbal Ahmad, T. Narender, Akhilesh Kumar Tamrakar · 2026 · Fitoterapia
87. IL17A disrupts autophagy-lysosomal function and lysosome reformation through the GSK3B-TFE3 signaling pathway in Huntington disease
    Kai-Po Chen, Tz‐Chuen Ju · 2026 · Autophagy
88. New insights on microglial lysosomal acidification: A therapeutic target of neurodegenerative diseases
    Ravindran Jaganathan, Srilakshmi Vijayakumar, Yinchi Chen, Jiaxi Ye, Pugazhandhi Bakthavatchalam, Dapkupar Wankhar, Chuanbin Yang, Ashok Iyaswamy, Min Li · 2026 · Neurobiology of Disease
89. Gastrodia elata Blume–Acorus tatarinowii Schott herb pair alleviates seizures and hippocampal injury in TLE rats with alterations in mitophagy and NLRP3 inflammasome pathways
    Jiaqing Hu, Xufei Chen, Ruoshi Tian, Qiulian Zeng, Yan Yang, Xirui He · 2026 · Journal of Ethnopharmacology
90. Autophagy-lysosomal pathway in neurodegeneration
    Samantha R. McDonough, Aditya K. Rao, Jacqueline M. McAleer, Bergan M. Babrowicz, Manu Sharma · 2026 · Molecular Neurodegeneration Advances
91. Daily regulation of glucocerebrosidase activity and impact of fixed-time rotarod training in a mouse model of Gba1-associated Parkinson's disease
    Chiara Bertasini, Shima Tavakolian Haghighi, Maria Giusy Bruno, Fabio Paio, Carlo Alberto Artusi, Matteo Brunelli, Federico F. Schena, Massimo Venturelli, Ugo Moretti, Maria Grazia Romanelli et al. · 2026 · Frontiers in Cellular Neuroscience
92. Stress granules at the crossroads of the proteostasis network
    Rachel Kim, Erika N. Calle Urgiles, Stephanie L. Moon · 2026 · RNA Biology
93. HAP40 functions as a proteostasis regulator by controlling huntingtin interactions and its release into the extracellular space
    Eduardo Silva Ramos, Annett Boeddrich, Christian Haenig, Philipp Trepte, Orchid Ammar, Christopher Secker, Oliver Popp, Andranik Ivanov, Stephanie Beetz, Leonard Roth et al. · 2026 · Proceedings of the National Academy of Sciences
94. The Glymphatic–Meningeal Lymphatic System and Autophagy in ME/CFS and Long COVID: A Mechanistic Perspective
    Mohsen Nemat‐Gorgani, Michael A. Jensen, Ronald Wayne Davis · 2026 · International Journal of Molecular Sciences
95. Repurposing existing drugs for Parkinson's disease management
    Moaz Elsayed Abouelmagd, Mark Messak, Ahmed Farid Gadelmawla, Mrinmoy Kundu · 2026 · Elsevier eBooks
96. Single‐Cell Dissection of Microglial Dysfunction in Diabetes‐Associated Neurodegenerative Vulnerability
    Jizhou Zhang, Tsz Kwan Yau, Joyce Ka Yu Tse, Tsz Ho Li, Dongjie Hu, Yong Juan Zhao, Ting‐Fung Chan · 2026 · Advanced Science