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Meiotic maturation of mouse oocytes triggers the translation and polyadenylation of dormant tissue-type plasminogen activator mRNA.
Open accessAbstract
The serine protease tissue-type plasminogen activator (t-PA) is synthesized by murine oocytes undergoing meiotic maturation, but not by arrested primary oocytes. Dormant, stable t-PA mRNA accumulates during oocyte growth, so that fully grown, arrested primary oocytes contain in their cytoplasm approximately 10,000 copies of this molecule. Translation of t-PA mRNA is triggered upon resumption of meiosis and is accompanied by a progressive and concerted increase in its size. This structural change can be accounted for by increased polyadenylation at the 3' end of the molecule. Following its translation, t-PA mRNA is degraded; it is no longer detectable in fertilized eggs. The identification of a dormant mRNA in murine oocytes and the demonstration that its translational activation is accompanied by elongation of its poly(A) tail may provide insights into the control of gene expression during meiotic maturation and early mammalian development.
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Cited by
A POU-domain transcription factor in early stem cells and germ cells of the mammalian embryo
Rosner, M. H., Vigano, M. A., Ozato, K., Timmons, P. M., Poirie, F., Rigby, P. W. J., & Staudt, L. M. (1990) · Nature · doi:10.1038/345686a0 · Cited by 906
Do the poly(A) tail and 3’ untranslated region control mRNA translation?
Jackson, R. J., & Standart, N. (1990) · Cell · doi:10.1016/0092-8674(90)90235-7 · Cited by 590
Lyons, K. M., Pelton, R. W., & Hogan, B. L. (1989) · Genes & Development · doi:10.1101/gad.3.11.1657 · Cited by 438
McGrew, L. L., Dworkin-Rastl, E., Dworkin, M. B., & Richter, J. D. (1989) · Genes & Development · doi:10.1101/gad.3.6.803 · Cited by 403
The plasminogen activator system: biology and regulation
Irigoyen, J. P., Muñoz-Cánoves, P., Montero, L., Koziczak, M., & Nagamine, Y. (1999) · Cellular and Molecular Life Sciences · doi:10.1007/pl00000615 · Cited by 368
Metadata
- Authors
- Huarte, J., Belin, D., Vassalli, A., Strickland, S., & Vassalli, J. D.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1987-12
- Volume
- 1
- Issue
- 10
- Pages
- 1201-1211
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W1988326966
- Cited by
- 204
- References
- 0
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Huarte, J., Belin, D., Vassalli, A., Strickland, S., & Vassalli, J. D. (1987). Meiotic maturation of mouse oocytes triggers the translation and polyadenylation of dormant tissue-type plasminogen activator mRNA. Genes & Development. https://doi.org/10.1101/gad.1.10.1201
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