The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
trachealess encodes a bHLH-PAS protein that is an inducer of tracheal cell fates in Drosophila.
Open accessAbstract
The embryonic tracheal system in Drosophila develops from placodes of precursor cells on the ectoderm. A transcription factor of the basic helix-loop-helix (bHLH)-PAS family, which is expressed in the nuclei of the tracheal cells throughout development, was identified. The protein shows the highest degree of homology to the Single-minded (Sim) protein. The transcript represents the previously identified trachealess (trh) locus, essential for tracheal development. Ectopic expression of trh leads to generation of extra tracheal pits and branches and to the expression of tracheal markers by patches of ectodermal cells. The expression of trh is consistent with a biphasic mode of transcriptional regulation. Expression is first induced by exogenous cues and is subsequently autoregulated. trh is also expressed and required in the posterior spiracles and the salivary gland ducts. The role of Trachealess in the formation of several tubular tissues in the embryo suggests that it may induce a general fate of branched tubular structures of epithelial origin.
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Cites
Matsushita, N., Sogawa, K., Ema, M., Yoshida, A., & Fujii-Kuriyama, Y. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)36885-1 · Cited by 149
Cited by
Risau, W. (1997) · Nature · doi:10.1038/386671a0 · Cited by 5,727
Hypoxia-inducible factors in physiology and medicine
Semenza, G. L. (2012) · Cell · doi:10.1016/j.cell.2012.01.021 · Cited by 3,645
Positional Cloning of the Mouse Circadian Gene
King, D. P., Zhao, Y., Sangoram, A. M., Wilsbacher, L. D., Tanaka, M., Antoch, M. P., Steeves, T. D. L., Vitaterna, M. H., Kornhauser, J. M., Lowrey, P. L., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80245-7 · Cited by 1,382
Tian, H., McKnight, S. L., & Russell, D. W. (1997) · Genes & Development · doi:10.1101/gad.11.1.72 · Cited by 1,351
Ema, M., Taya, S., Yokotani, N., Sogawa, K., Matsuda, Y., & Fujii-Kuriyama, Y. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.9.4273 · Cited by 1,016
Metadata
- Authors
- Wilk, R., Weizman, I., & Shilo, B. Z.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1996-01-01
- Volume
- 10
- Issue
- 1
- Pages
- 93-102
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2160806267
- Cited by
- 264
- References
- 1
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Wilk, R., Weizman, I., & Shilo, B. Z. (1996). trachealess encodes a bHLH-PAS protein that is an inducer of tracheal cell fates in Drosophila. Genes & Development. https://doi.org/10.1101/gad.10.1.93
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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