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KAP-1, a novel corepressor for the highly conserved KRAB repression domain.
Open accessAbstract
The KRAB repression domain is one of the most widely distributed transcriptional effector domains yet identified, but its mechanism of repression is unknown. We have cloned a corepressor, KAP-1, which associates with the KRAB domain but not with KRAB mutants that have lost repression activity. KAP-1 can enhance KRAB-mediated repression and is a repressor when directly tethered to DNA. KAP-1 contains a RING finger, B boxes, and a PHD finger; the RING-B1-B2 structure is required for KRAB binding and corepression. We propose that KAP-1 may be a universal corepressor for the large family of KRAB domain-containing transcription factors.
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Schultz, D. C., Ayyanathan, K., Negorev, D., Maul, G. G., & Rauscher, F. J. (2002) · Genes & Development · doi:10.1101/gad.973302 · Cited by 1,313
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Ozato, K., Shin, D.-M., Chang, T.-H., & Morse, H. C. (2008) · Nature Reviews Immunology · doi:10.1038/nri2413 · Cited by 1,120
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Metadata
- Authors
- Friedman, J. R., Fredericks, W. J., Jensen, D. E., Speicher, D. W., Huang, X. P., Neilson, E. G., & Rauscher, F. J.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1996-08-15
- Volume
- 10
- Issue
- 16
- Pages
- 2067-2078
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2106109160
- Cited by
- 681
- References
- 3
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Friedman, J. R., Fredericks, W. J., Jensen, D. E., Speicher, D. W., Huang, X. P., Neilson, E. G., & Rauscher, F. J. (1996). KAP-1, a novel corepressor for the highly conserved KRAB repression domain. Genes & Development. https://doi.org/10.1101/gad.10.16.2067
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