The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Sonic hedgehog-dependent activation of Gli2 is essential for embryonic hair follicle development
Open accessAbstract
Sonic hedgehog (Shh) signaling plays a critical role in hair follicle development and skin cancer, but how it controls these processes remains unclear. Of the three Gli transcription factors involved in transducing Shh signals in vertebrates, we demonstrate here that Gli2 is the key mediator of Shh responses in skin. Similar to Shh −/− mice, Gli2 −/− mutants exhibit an arrest in hair follicle development with reduced cell proliferation and Shh-responsive gene expression, but grossly normal epidermal differentiation. By transgenic rescue experiments, we show that epidermal Gli2 function alone is sufficient to restore hair follicle development in Gli2 −/− skin. Furthermore, only a constitutively active form of Gli2, but not wild-type Gli2, can activate Shh-responsive gene expression and promote cell proliferation in Shh −/− skin. These observations indicate that Shh-dependent Gli2 activator function in the epidermis is essential for hair follicle development. Our data also reveal that Gli2 mediates the mitogenic effects of Shh by transcriptional activation of cyclin D1 and cyclin D2 in the developing hair follicles. Together, our results suggest that Shh-dependent Gli2 activation plays a critical role in epithelial homeostasis by promoting proliferation through the transcriptional control of cell cycle regulators.
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Cites
Bitgood, M. J., & McMahon, A. P. (1995) · Developmental Biology · doi:10.1006/dbio.1995.0010 · Cited by 1,370
Wang, B., Fallon, J. F., & Beachy, P. A. (2000) · Cell · doi:10.1016/s0092-8674(00)80678-9 · Cited by 1,014
Molecular Mechanisms Regulating Hair Follicle Development
Millar, S. E. (2002) · Journal of Investigative Dermatology · doi:10.1046/j.0022-202x.2001.01670.x · Cited by 967
Sasaki, H., Nishizaki, Y., Hui, C.-C., Nakafuku, M., & Kondoh, H. (1999) · Development · doi:10.1242/dev.126.17.3915 · Cited by 715
Self-citationSato, N., Leopold, P. L., & Crystal, R. G. (1999) · Journal of Clinical Investigation · doi:10.1172/jci7691 · Cited by 253
Cited by
Chromatin Potential Identified by Shared Single-Cell Profiling of RNA and Chromatin
Ma, S., Zhang, B., LaFave, L. M., Earl, A. S., Chiang, Z., Hu, Y., Ding, J., Brack, A., Kartha, V. K., Tay, T., et al. (2020) · Cell · doi:10.1016/j.cell.2020.09.056 · Cited by 1,146
Epidermal Stem Cells of the Skin
Blanpain, C., & Fuchs, E. (2006) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.22.010305.104357 · Cited by 849
Hedgehog signalling in cancer formation and maintenance
di Magliano, M. P., & Hebrok, M. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1229 · Cited by 829
Mechanisms of ectodermal organogenesis.
Pispa, J., & Thesleff, I. (2003) · Developmental Biology · doi:10.1016/s0012-1606(03)00325-7 · Cited by 499
Wylie, R. G., Ahsan, S., Aizawa, Y., Maxwell, K. L., Morshead, C. M., & Shoichet, M. S. (2011) · Nature Materials · doi:10.1038/nmat3101 · Cited by 480
Metadata
- Authors
- Mill, P., Mo, R., Fu, H., Grachtchouk, M., Kim, P. C. W., Dlugosz, A. A., & Hui, C.-C.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2003-01-15
- Volume
- 17
- Issue
- 2
- Pages
- 282-294
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2110333944
- Cited by
- 325
- References
- 5
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Mill, P., Mo, R., Fu, H., Grachtchouk, M., Kim, P. C. W., Dlugosz, A. A., & Hui, C.-C. (2003). Sonic hedgehog-dependent activation of Gli2 is essential for embryonic hair follicle development. Genes & Development. https://doi.org/10.1101/gad.1038103
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