Molecular Mechanisms Regulating Hair Follicle Development

Label-retaining cells reside in the bulge area of pilosebaceous unit: Implications for follicular stem cells, hair cycle, and skin carcinogenesis

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Mutations of the Human Homolog of Drosophila patched in the Nevoid Basal Cell Carcinoma Syndrome

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MECHANISMS OF WNT SIGNALING IN DEVELOPMENT

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Human Homolog of patched , a Candidate Gene for the Basal Cell Nevus Syndrome

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Controls of Hair Follicle Cycling

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HedgehogandBmpGenes Are Coexpressed at Many Diverse Sites of Cell–Cell Interaction in the Mouse Embryo

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β-Catenin Controls Hair Follicle Morphogenesis and Stem Cell Differentiation in the Skin

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De Novo Hair Follicle Morphogenesis and Hair Tumors in Mice Expressing a Truncated β-Catenin in Skin

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Involvement of Follicular Stem Cells in Forming Not Only the Follicle but Also the Epidermis

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Morphogenesis and Renewal of Hair Follicles from Adult Multipotent Stem Cells

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Development of several organs that require inductive epithelial-mesenchymal interactions is impaired in LEF-1-deficient mice.Preprint

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Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation

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The secret life of the hair follicle

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Sonic hedgehog signaling is essential for hair development

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The role of the human homologue of Drosophila patched in sporadic basal cell carcinomas

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X-linked anhidrotic (hypohidrotic) ectodermal dysplasia is caused by mutation in a novel transmembrane protein

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Msx2 deficiency in mice causes pleiotropic defects in bone growth and ectodermal organ formation

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TGFα deficiency results in hair follicle and eye abnormalities in targeted and waved-1 mice

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Activation of the transcription factor Gli1 and the Sonic hedgehog signalling pathway in skin tumours

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New member of the winged-helix protein family disrupted in mouse and rat nude mutations

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A common human skin tumour is caused by activating mutations in β-catenin

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FGF5 as a regulator of the hair growth cycle: Evidence from targeted and spontaneous mutations

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Multiple defects and perinatal death in mice deficient in follistatin

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Mice with a null mutation of the TGFα gene have abnormal skin architecture, wavy hair, and curly whiskers and often develop corneal inflammation

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Functional analysis of activins during mammalian development

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Tcf3 and Lef1 regulate lineage differentiation of multipotent stem cells in skinPreprint

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The C8/144B monoclonal antibody recognizes cytokeratin 15 and defines the location of human hair follicle stem cells

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Wnt signaling maintains the hair-inducing activity of the dermal papillaPreprint

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Essential Role forSonic hedgehogduring Hair Follicle Morphogenesis

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Characterization of Wnt gene expression in developing and postnatal hair follicles and identification of Wnt5a as a target of Sonic hedgehog in hair follicle morphogenesis

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Lymphoid enhancer factor 1 directs hair follicle patterning and epithelial cell fate.Preprint

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Male hormone stimulation is prerequisite and an incitant in common baldness

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The coat of the mouse (Mus musculus)

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The mouse waved-2 phenotype results from a point mutation in the EGF receptor tyrosine kinase.Preprint

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Hyperproliferation and Defects in Epithelial Polarity upon Conditional Ablation of α-Catenin in Skin

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Lef1 expression is activated by BMP-4 and regulates inductive tissue interactions in tooth and hair development.Preprint

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Ultraviolet and ionizing radiation enhance the growth of BCCs and trichoblastomas in patched heterozygous knockout mice

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Noggin is a mesenchymally derived stimulator of hair-follicle induction

Botchkarev, V. A., Botchkareva, N. V., Roth, W., Nakamura, M., Chen, L.-H., Herzog, W., Lindner, G., McMahon, J. A., Peters, C., Lauster, R., et al. (1999) · Nature Cell Biology · doi:10.1038/11078 · Cited by 414 · see citing works

Alopecia Universalis Associated with a Mutation in the Human hairless Gene

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Mutations in the human homologue of mouse dl cause autosomal recessive and dominant hypohidrotic ectodermal dysplasia

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Conditional Ablation of β1 Integrin in Skin

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Involvement of a novel Tnf receptor homologue in hair follicle induction.

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Local Inhibitory Action of BMPs and Their Relationships with Activators in Feather Formation: Implications for Periodic Patterning

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Skin and hair follicle integrity is crucially dependent on β1 integrin expression on keratinocytes

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The BMP antagonist Gremlin regulates outgrowth, chondrogenesis and programmed cell death in the developing limb

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Two Members of the Tcf Family Implicated in Wnt/β-Catenin Signaling during Embryogenesis in the Mouse

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Two-Amino Acid Molecular Switch in an Epithelial Morphogen That Regulates Binding to Two Distinct Receptors

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Inhibition of Bmp signaling affects growth and differentiation in the anagen hair follicle

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The Tabby phenotype is caused by mutation in a mouse homologue of the EDA gene that reveals novel mouse and human exons and encodes a protein (ectodysplasin-A) with collagenous domains

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Towards a molecular understanding of hair loss and its treatment

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WNT Signaling in the Control of Hair Growth and Structure

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Defective trophoblast function in mice with a targeted mutation of Ets2Preprint

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From Egg to Embryo

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Exposing the human nude phenotype

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Fibroblast Growth Factor Receptor 2-IIIb Acts Upstream of Shh and Fgf4 and Is Required for Limb Bud Maintenance but Not for the Induction of Fgf8, Fgf10, Msx1, or Bmp4

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Induction of the hair growth phase in postnatal mice by localized transient expression of Sonic hedgehog

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Hoxc13 mutant mice lack external hairPreprint

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Expression of activin subunits, activin receptors and follistatin in postimplantation mouse embryos suggests specific developmental functions for different activins

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Trans-gender induction of hair follicles

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Self-organization of periodic patterns by dissociated feather mesenchymal cells and the regulation of size, number and spacing of primordia

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Mutations in Sox18 underlie cardiovascular and hair follicle defects in ragged mice

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Roles for PDGF-A and sonic hedgehog in development of mesenchymal components of the hair follicle

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ovo/svb integrates Wingless and DER pathways to control epidermis differentiation

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Conditional Disruption of Hedgehog Signaling Pathway Defines its Critical Role in Hair Development and Regeneration

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BMPs mediate lateral inhibition at successive stages in feather tract development

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Mutations in the human homologue of Drosophila patched (PTCH) in basal cell carcinomas and the Gorlin syndrome: different in vivo mechanisms of PTCH inactivation.

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The feasibility of targeted selective gene therapy of the hair follicle

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β-catenin signaling can initiate feather bud development

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Immunization via hair follicles by topical application of naked DNA to normal skin

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Structure and expression of the hairless gene of mice.

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Mesodermal development in mouse embryos mutant for fibronectin

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The TGF-β2 Isoform Is Both a Required and Sufficient Inducer of Murine Hair Follicle Morphogenesis

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Transgenic mice as a model to study the role of TGF-beta-related molecules in hair follicles.Preprint

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Cloning of Tabby, the murine homolog of the human EDA gene: evidence for a membrane-associated protein with a short collagenous domain

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β-catenin in Epithelial Morphogenesis: Conversion of Part of Avian Foot Scales into Feather Buds with a Mutated β-Catenin

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Activation of Expression of Hedgehog Target Genes in Basal Cell Carcinomas

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Wnt signals are targets and mediators of Gli function

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Hair anatomy for the clinician

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Mouse notch: expression in hair follicles correlates with cell fate determination.

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The ovo gene required for cuticle formation and oogenesis in flies is involved in hair formation and spermatogenesis in micePreprint

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Expression of the mouse Gli and Ptc genes is adjacent to embryonic sources of hedgehog signals suggesting a conservation of pathways between flies and mice

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Splitting Hairs

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Restricted High Level Expression of Tcf-4 Protein in Intestinal and Mammary Gland Epithelium

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Expression of messenger ribonucleic acids encoding the inhibin/activin system during mid- and late-gestation rat embryogenesis.

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The product of the mouse nude locus, Whn, regulates the balance between epithelial cell growth and differentiation.Preprint

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Involvement of hepatocyte growth factor/scatter factor and Met receptor signaling in hair follicle morphogenesis and cycling

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Localized in vivo genotypic and phenotypic correction of the albino mutation in skin by RNA-DNA oligonucleotide

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Cells within the bulge region of mouse hair follicle transiently proliferate during early anagen: heterogeneity and functional differences of various hair cycles

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TROY, a Newly Identified Member of the Tumor Necrosis Factor Receptor Superfamily, Exhibits a Homology with Edar and Is Expressed in Embryonic Skin and Hair Follicles

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COMMENTARY See related article on pg 1497 Many Paths to Alopecia via Compromised Regeneration of Hair

Cells, F. S., Li, J., Jiang, T. X., & Chuong, C. M. (2013)

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