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Pdgfr-α mediates testis cord organization and fetal Leydig cell development in the XY gonad
Open accessAbstract
During testis development, the rapid morphological changes initiated by Sry require the coordinate integration of many signaling pathways. Based on the established role of the platelet-derived growth factor (PDGF) family of ligands and receptors in migration, proliferation, and differentiation of cells in various organ systems, we have investigated the role of PDGF in testis organogenesis. Analysis of expression patterns and characterization of the gonad phenotype in Pdgfr-α−/−embryos identified PDGFR-α as a critical mediator of signaling in the early testis at multiple steps of testis development.Pdgfr-α−/−XY gonads displayed disruptions in the organization of the vasculature and in the partitioning of interstitial and testis cord compartments. Closer examination revealed severe reductions in characteristic XY proliferation, mesonephric cell migration, and fetal Leydig cell differentiation. This work identifies PDGF signaling through the α receptor as an important event downstream of Sry in testis organogenesis and Leydig cell differentiation.
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Cites
PDGF-A signaling is a critical event in lung alveolar myofibroblast development and alveogenesis
Boström, H., Willetts, K., Pekny, M., Levéen, P., Lindahl, P., Hedstrand, H., Pekna, M., Hellström, M., Gebre-Medhin, S., Schalling, M., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81270-2 · Cited by 864
Cited by
Somatic Sex Reprogramming of Adult Ovaries to Testes by FOXL2 Ablation
Uhlenhaut, N. H., Jakob, S., Anlag, K., Eisenberger, T., Sekido, R., Kress, J., Treier, A.-C., Klugmann, C., Klasen, C., Holter, N. I., et al. (2009) · Cell · doi:10.1016/j.cell.2009.11.021 · Cited by 962
Sex Determination and Gonadal Development in Mammals
Wilhelm, D., Palmer, S., & Koopman, P. (2007) · Physiological Reviews · doi:10.1152/physrev.00009.2006 · Cited by 686
One tissue, two fates: molecular genetic events that underlie testis versus ovary development
Brennan, J., & Capel, B. (2004) · Nature Reviews Genetics · doi:10.1038/nrg1381 · Cited by 549
Self-citationInsight into the physiological functions of PDGF through genetic studies in mice
Betsholtz, C. (2004) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2004.03.005 · Cited by 437
Svingen, T., & Koopman, P. (2013) · Genes & Development · doi:10.1101/gad.228080.113 · Cited by 386
Metadata
- Authors
- Brennan, J., Tilmann, C., & Capel, B.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2003-03-15
- Volume
- 17
- Issue
- 6
- Pages
- 800-810
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2118705276
- Cited by
- 409
- References
- 1
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Brennan, J., Tilmann, C., & Capel, B. (2003). Pdgfr-α mediates testis cord organization and fetal Leydig cell development in the XY gonad. Genes & Development. https://doi.org/10.1101/gad.1052503
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