The DOI matches its Crossref record; 158 of the 158 references it cites were found in a registry or an index.
Building the mammalian testis: origins, differentiation, and assembly of the component cell populations
Open accessAbstract
Development of testes in the mammalian embryo requires the formation and assembly of several cell types that allow these organs to achieve their roles in male reproduction and endocrine regulation. Testis development is unusual in that several cell types such as Sertoli, Leydig, and spermatogonial cells arise from bipotential precursors present in the precursor tissue, the genital ridge. These cell types do not differentiate independently but depend on signals from Sertoli cells that differentiate under the influence of transcription factors SRY and SOX9. While these steps are becoming better understood, the origins and roles of many testicular cell types and structures—including peritubular myoid cells, the tunica albuginea, the arterial and venous blood vasculature, lymphatic vessels, macrophages, and nerve cells—have remained unclear. This review synthesizes current knowledge of how the architecture of the testis unfolds and highlights the questions that remain to be explored, thus providing a roadmap for future studies that may help illuminate the causes of XY disorders of sex development, infertility, and testicular cancers.
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Cited by
Vermeulen, M., Del Vento, F., De Michele, F., Poels, J., & Wyns, C. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19010227 · Cited by 72
The conserved sex regulator DMRT1 recruits SOX9 in sexual cell fate reprogramming
Lindeman, R. E., Murphy, M. W., Agrimson, K. S., Gewiss, R. L., Bardwell, V. J., Gearhart, M. D., & Zarkower, D. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkab448 · Cited by 66
Metadata
- Authors
- Svingen, T., & Koopman, P.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2013-11-15
- Volume
- 27
- Issue
- 22
- Pages
- 2409-2426
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W1982171656
- Cited by
- 386
- References
- 158
- Type
- posted content
- Language
- en
- Open access
- diamond
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