The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Homeodomain factor Nkx2-5 controls left/right asymmetric expression of bHLH gene eHand during murine heart development.
Open accessAbstract
One of the first morphological manifestations of left/right (L/R) asymmetry in mammalian embryos is a pronounced rightward looping of the linear heart tube. The direction of looping is thought to be controlled by signals from an embryonic L/R axial system. We report here that morphological L/R asymmetry in the murine heart first became apparent at the linear tube stage as a leftward displacement of its caudal aspect. Beginning at the same stage, the basic helix-loop-helix (bHLH) factor gene eHand was expressed in a strikingly left-dominant pattern in myocardium, reflecting an intrinsic molecular asymmetry. In hearts of embryos lacking the homeobox gene Nkx2-5, which do not loop, left-sided eHand expression was abolished. However, expression was unaffected in Sc1-/- hearts that loop poorly because of hematopoietic insufficiency, and was right-sided in hearts of inv/inv embryos that display situs inversus. The data predict that eHand expression is enhanced in descendants of the left heart progenitor pool as one response to inductive signaling from the L/R axial system, and that eHand controls intrinsic morphogenetic pathways essential for looping. One aspect of the intrinsic response to L/R information falls under Nkx2-5 homeobox control.
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Cites
Absence of yolk sac hematopoiesis from mice with a targeted disruption of the scl gene.
Robb, L., Lyons, I., Li, R., Hartley, L., Köntgen, F., Harvey, R. P., Metcalf, D., & Begley, C. G. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.15.7075 · Cited by 577
Self-citationGATA-4/5/6, a subfamily of three transcription factors transcribed in developing heart and gut.
Laverriere, A. C., MacNeill, C., Mueller, C., Poelmann, R. E., Burch, J. B., & Evans, T. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31636-8 · Cited by 558
Cited by
Mutations in the cardiac transcription factor NKX2.5 affect diverse cardiac developmental pathways
Benson, D. W., Silberbach, G. M., Kavanaugh-McHugh, A., Cottrill, C., Zhang, Y., Riggs, S., Smalls, O., Johnson, M. C., Watson, M. S., Seidman, J. G., et al. (1999) · Journal of Clinical Investigation · doi:10.1172/jci8154 · Cited by 690
Cardioids reveal self-organizing principles of human cardiogenesis
Hofbauer, P., Jahnel, S. M., Papai, N., Giesshammer, M., Deyett, A., Schmidt, C., Penc, M., Tavernini, K., Grdseloff, N., Meledeth, C., et al. (2021) · Cell · doi:10.1016/j.cell.2021.04.034 · Cited by 588
Embryonic retinoic acid synthesis is essential for heart morphogenesis in the mouse
Niederreither, K., Vermot, J., Messaddeq, N., Schuhbaur, B., Chambon, P., & Dollé, P. (2001) · Development · doi:10.1242/dev.128.7.1019 · Cited by 420
Firulli, A. B., McFadden, D. G., Lin, Q., Srivastava, D., & Olson, E. N. (1998) · Nature Genetics · doi:10.1038/ng0398-266 · Cited by 386
Neuronal MicroRNA Deregulation in Response to Alzheimer's Disease Amyloid-β
Schonrock, N., Ke, Y. D., Humphreys, D., Staufenbiel, M., Ittner, L. M., Preiss, T., & Götz, J. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011070 · Cited by 211
Metadata
- Authors
- Biben, C., & Harvey, R. P.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1997-06-01
- Volume
- 11
- Issue
- 11
- Pages
- 1357-1369
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2102609766
- Cited by
- 323
- References
- 2
- Type
- posted content
- Language
- en
- Open access
- diamond
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- CoChat. (2026). Citation check: Homeodomain factor Nkx2-5 controls left/right asymmetric expression of bHLH gene eHand during murine heart development. https://app.cochat.ai/papers/10.1101/gad.11.11.1357
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- Biben, C., & Harvey, R. P. (1997). Homeodomain factor Nkx2-5 controls left/right asymmetric expression of bHLH gene eHand during murine heart development. Genes & Development. https://doi.org/10.1101/gad.11.11.1357
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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