The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Induction of DNA synthesis and apoptosis are separable functions of E2F-1.
Open accessAbstract
The family of E2F transcription factors have an essential role in mediating cell cycle progression, and recently, one of the E2F protein family, E2F-1, has been shown to participate in the induction of apoptosis. Cooperation between E2F and the p53 tumor suppressor protein in this apoptotic response had led to the suggestion that cell cycle progression induced by E2F-1 expression provides an apoptotic signal when placed in conflict with an arrest to cell cycle progression, such as provided by p53. We show here that although apoptosis is clearly enhanced by p53, E2F-1 can induce significant apoptosis in the absence of p53. Furthermore, this apoptotic function of E2F-1 is separable from the ability to accelerate entry into DNA synthesis. Analysis of E2F-1 mutants indicates that although DNA-binding is required, transcriptional transactivation is not necessary for the induction of apoptosis by E2F-1, suggesting that it may be mediated through alleviation of E2F-dependent transcriptional repression. These results indicate that E2F-1 can show independent cell cycle progression and apoptotic functions, consistent with its putative role as a tumor suppressor.
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Cites
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Cited by
The regulation of E2F by pRB-family proteins.
Dyson, N. (1998) · Genes & Development · doi:10.1101/gad.12.15.2245 · Cited by 2,317
A Matter of Life and Cell Death
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The Rb/E2F pathway: expanding roles and emerging paradigms
Harbour, J. W., & Dean, D. C. (2000) · Genes & Development · doi:10.1101/gad.813200 · Cited by 1,153
Sibling rivalry in the E2F family
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Role for the p53 homologue p73 in E2F-1-induced apoptosis
Irwin, M., Marin, M. C., Phillips, A. C., Seelan, R. S., Smith, D. I., Liu, W., Flores, E. R., Tsai, K. Y., Jacks, T., Vousden, K. H., et al. (2000) · Nature · doi:10.1038/35036614 · Cited by 710
Self-citation
Metadata
- Authors
- Phillips, A. C., Bates, S., Ryan, K. M., Helin, K., & Vousden, K. H.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1997-07-15
- Volume
- 11
- Issue
- 14
- Pages
- 1853-1863
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W1996759876
- Cited by
- 259
- References
- 47
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Phillips, A. C., Bates, S., Ryan, K. M., Helin, K., & Vousden, K. H. (1997). Induction of DNA synthesis and apoptosis are separable functions of E2F-1. Genes & Development. https://doi.org/10.1101/gad.11.14.1853
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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