The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis.
Open accessAbstract
The zinc finger transcription factor GATA4 has been implicated in heart development based on its early expression in precardiogenic splanchnic mesoderm and its ability to activate the expression of a number of cardiac-specific genes. To determine the role of GATA4 in embryogenesis, we generated mice homozygous for a GATA4 null allele. Homozygous GATA4 null mice arrested in development between E7.0 and E9.5 because of severe developmental abnormalities. Mutant embryos most notably lacked a primitive heart tube and foregut and developed partially outside the yolk sac. In the mutants, the two bilaterally symmetric promyocardial primordia failed to migrate ventrally but instead remained lateral and generated two independent heart tubes that contained differentiated cardiomyocytes. We show that these deformities resulted from a general loss in lateral to ventral folding throughout the embryo. GATA4 is most highly expressed within the precardiogenic splanchnic mesoderm at the posterior lip of the anterior intestinal portal, corresponding to the region of the embryo that undergoes ventral fusion. We propose that GATA4 is required for the migration or folding morphogenesis of the precardiogenic splanchnic mesodermal cells at the level of the AIP.
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Cites
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GATA-4/5/6, a subfamily of three transcription factors transcribed in developing heart and gut.
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Depletion of definitive gut endoderm in Sox17 -null mutant mice
Kanai-Azuma, M., Kanai, Y., Gad, J. M., Tajima, Y., Taya, C., Kurohmaru, M., Sanai, Y., Yonekawa, H., Yazaki, K., Tam, P. P. L., et al. (2002) · Development · doi:10.1242/dev.129.10.2367 · Cited by 704
MicroRNA therapy stimulates uncontrolled cardiac repair after myocardial infarction in pigs
Gabisonia, K., Prosdocimo, G., Aquaro, G. D., Carlucci, L., Zentilin, L., Secco, I., Ali, H., Braga, L., Gorgodze, N., Bernini, F., et al. (2019) · Nature · doi:10.1038/s41586-019-1191-6 · Cited by 478
Circuitry and Dynamics of Human Transcription Factor Regulatory Networks
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Metadata
- Authors
- Molkentin, J. D., Lin, Q., Duncan, S. A., & Olson, E. N.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1997-04-15
- Volume
- 11
- Issue
- 8
- Pages
- 1061-1072
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2064586774
- Cited by
- 1,150
- References
- 4
- Type
- posted content
- Language
- en
- Open access
- diamond
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