The Epigenomics of Cancer
Open accessAbstract
Aberrant gene function and altered patterns of gene expression are key features of cancer. Growing evidence shows that acquired epigenetic abnormalities participate with genetic alterations to cause this dysregulation. Here, we review recent advances in understanding how epigenetic alterations participate in the earliest stages of neoplasia, including stem/precursor cell contributions, and discuss the growing implications of these advances for strategies to control cancer.
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Abnormal DNA methylation has been linked to many human diseases, among them several cancers.
“Many studies have shown that aberrant DNA methylation is associated with various human diseases, including some types of cancer19–21.”
From Transcription factors as readers and effectors of DNA methylation (2016) · cites this paper as [20]
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BackgroundEZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer.
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Aberrant methylation of gene associated CpG sites occurs in borderline personality disorder
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- Authors
- Jones, P. A., & Baylin, S. B.
- Affiliations
- University of Southern California (US)
- Johns Hopkins University (US)
- Corresponding author
- Jones, Peter A.
- Baylin, Stephen B.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2007-02
- Volume
- 128
- Issue
- 4
- Pages
- 683-692
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC3894624
- OpenAlex
- W2141410747
- Semantic Scholar
- ff48858ce717b18a950ea6c4749c4382e661c21f
- Cited by
- 4,515
- References
- 9
- Citations by year
- 2026: 96 · 2025: 120 · 2024: 145 · 2023: 157 · 2022: 169 · 2021: 201 · 2020: 176 · 2019: 180 · 2018: 199 · 2017: 220 · 2016: 272 · 2015: 288 · 2014: 313 · 2013: 339 · 2012: 372
- FWCI
- 22.83
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (R01CA116160, R01 CA04318, R01CA043318, R01CA082422, R01CA083867)
- National Institute of Environmental Health Sciences (R01ES011858)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- epigenetics, cancer epigenomics, epigenetic modifications, gene expression dysregulation, cancer, cancer stem cells, precursor cells, cancer prevention strategies
- MeSH terms
- Animals, Cell Differentiation, Cell Transformation, Neoplastic, Humans, Mutation, Neoplasms, Stem Cells, Genetic Therapy, Gene Expression Regulation, Neoplastic, Gene Silencing, Epigenesis, Genetic
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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