The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
The sigma(E) and the Cpx signal transduction systems control the synthesis of periplasmic protein-folding enzymes in Escherichia coli.
Open accessAbstract
In Escherichia coli, the heat shock-inducible sigma-factor sigma(E) and the Cpx two-component signal transduction system are both attuned to extracytoplasmic stimuli. For example, sigma(E) activity rises in response to the overproduction of various outer-membrane proteins. Similarly, the activity of the Cpx signal transduction pathway, which consists of an inner-membrane sensor (CpxA) and a cognate response regulator (CpxR), is stimulated by overproduction of the outer-membrane lipoprotein, NlpE. In response to these extracytoplasmic stimuli, sigma(E) and CpxA/CpxR stimulate the transcription of degP, which encodes a periplasmic protease. This suggests that CpxA/CpxR and sigma(E) both mediate protein turnover within the bacterial envelope. Here, we show that CpxA/CpxR and sigma(E) also control the synthesis of periplasmic enzymes that can facilitate protein-folding reactions. Specifically, sigma(E) controls transcription of fkpA, which specifies a periplasmic peptidyl-prolyl cis/trans isomerase. Similarly, the Cpx system controls transcription of the dsbA locus, which encodes a periplasmic enzyme required for efficient disulfide bond formation in several extracytoplasmic proteins. Taken together, these results indicate that sigma(E) and CpxA/CpxR are involved in regulating both protein-turnover and protein-folding activities within the bacterial envelope.
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Los, D. A., & Murata, N. (2004) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2004.08.002 · Cited by 1,020
Defining the roles of the periplasmic chaperones SurA, Skp, and DegP in Escherichia coli
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Self-citationTranscriptome analysis of all two‐component regulatory system mutants of Escherichia coli K‐12
Oshima, T., Aiba, H., Masuda, Y., Kanaya, S., Sugiura, M., Wanner, B. L., Mori, H., & Mizuno, T. (2002) · Molecular Microbiology · doi:10.1046/j.1365-2958.2002.03170.x · Cited by 375
β-Barrel Membrane Protein Assembly by the Bam Complex
Hagan, C. L., Silhavy, T. J., & Kahne, D. (2011) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-061408-144611 · Cited by 317
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Metadata
- Authors
- Danese, P. N., & Silhavy, T. J.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1997-05-01
- Volume
- 11
- Issue
- 9
- Pages
- 1183-1193
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2009376936
- Cited by
- 273
- References
- 30
- Type
- posted content
- Language
- en
- Open access
- diamond
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