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The serine/threonine kinase Pim-2 is a transcriptionally regulated apoptotic inhibitor
Open accessAbstract
Growth factor withdrawal results in the termination of factor-dependent transcription. One transcript that declines rapidly following growth factor deprivation of hematopoietic cells is the serine/threonine kinase pim-2 . When constitutively expressed, Pim-2 conferred long-term resistance to a variety of apoptotic stimuli including growth factor withdrawal and endogenous levels of Pim-2 contributed to growth factor-mediated apoptotic resistance. Pim-2 expression maintained cell size and mitochondrial potential independently of the PI3K/Akt/TOR pathway. Pim-2-dependent maintenance of cell size and survival correlated with its ability to maintain rapamycin-resistant phosphorylation of the translational repressor 4E-BP1 and phosphorylation of the BH3 protein BAD. These results establish Pim-2 as a direct link between growth factor-induced transcription and a novel, kinase-dependent pathway that promotes cell-autonomous survival.
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“Extracts were evaporated to dryness under nitrowith the U6 promoter, as previously described (Fox et al., 2003).”
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Metadata
- Authors
- Fox, C. J., Hammerman, P. S., Cinalli, R. M., Master, S. R., Chodosh, L. A., & Thompson, C. B.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2003-07-17
- Volume
- 17
- Issue
- 15
- Pages
- 1841-1854
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2137723669
- Cited by
- 336
- References
- 2
- Type
- posted content
- Language
- en
- Open access
- diamond
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