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p63 is the molecular switch for initiation of an epithelial stratification program
Open accessAbstract
Development of stratified epithelia, such as the epidermis, requires p63 expression. The p63 gene encodes isoforms that contain (TA) or lack (ΔN) a transactivation domain. We demonstrate that TAp63 isoforms are the first to be expressed during embryogenesis and are required for initiation of epithelial stratification. In addition, TAp63 isoforms inhibit terminal differentiation, suggesting that TAp63 isoforms must be counterbalanced by ΔNp63 isoforms to allow cells to respond to signals required for maturation of embryonic epidermis. Our data demonstrate that p63 plays a dual role: initiating epithelial stratification during development and maintaining proliferative potential of basal keratinocytes in mature epidermis.
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Citations
Cited by
Epidermal homeostasis: a balancing act of stem cells in the skin
Blanpain, C., & Fuchs, E. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2636 · Cited by 1,270
p63 Is Essential for the Proliferative Potential of Stem Cells in Stratified Epithelia
Senoo, M., Pinto, F., Crum, C. P., & McKeon, F. (2007) · Cell · doi:10.1016/j.cell.2007.02.045 · Cited by 881
p63 and p73: Roles in Development and Tumor Formation
Moll, U. M., & Slade, N. (2004) · Molecular Cancer Research · doi:10.1158/1541-7786.371.2.7 · Cited by 486
p63 regulates an adhesion programme and cell survival in epithelial cells
Carroll, D. K., Carroll, J. S., Leong, C.-O., Cheng, F., Brown, M., Mills, A. A., Brugge, J. S., & Ellisen, L. W. (2006) · Nature Cell Biology · doi:10.1038/ncb1420 · Cited by 403
Self-citationThe p53 family in differentiation and tumorigenesis
Stiewe, T. (2007) · Nature Reviews Cancer · doi:10.1038/nrc2072 · Cited by 306
Metadata
- Authors
- Koster, M. I., Kim, S., Mills, A. A., DeMayo, F. J., & Roop, D. R.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2004-01-15
- Volume
- 18
- Issue
- 2
- Pages
- 126-131
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2149214251
- Cited by
- 622
- References
- 0
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Koster, M. I., Kim, S., Mills, A. A., DeMayo, F. J., & Roop, D. R. (2004). p63 is the molecular switch for initiation of an epithelial stratification program. Genes & Development. https://doi.org/10.1101/gad.1165104
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