The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
The Med proteins of yeast and their function through the RNA polymerase II carboxy-terminal domain
Open accessAbstract
Mediator was resolved from yeast as a multiprotein complex on the basis of its requirement for transcriptional activation in a fully defined system. Three groups of mediator polypeptides could be distinguished: the products of five SRB genes, identified as suppressors of carboxy-terminal domain (CTD)-truncation mutants; products of four genes identified as global repressors; and six members of a new protein family, termed Med, thought to be primarily responsible for transcriptional activation. Notably absent from the purified mediator were Srbs 8, 9, 10, and 11, as well as members of the SWI/SNF complex. The CTD was required for function of mediator in vitro, in keeping with previous indications of involvement of the CTD in transcriptional activation in vivo. Evidence for human homologs of several mediator proteins, including Med7, points to similar mechanisms in higher cells.
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Citations
Cites
A novel mediator between activator proteins and the RNA polymerase II transcription apparatus
Kelleher, R. J., Flanagan, P. M., & Kornberg, R. D. (1990) · Cell · doi:10.1016/0092-8674(90)90685-8 · Cited by 450
Self-citationA mediator required for activation of RNA polymerase II transcription in vitro
Flanagan, P. M., Kelleher, R. J., Sayre, M. H., Tschochner, H., & Kornberg, R. D. (1991) · Nature · doi:10.1038/350436a0 · Cited by 386
Self-citation
Cited by
Dissecting the regulatory circuitry of a eukaryotic genome
Holstege, F. C. P., Jennings, E. G., Wyrick, J. J., Lee, T. I., Hengartner, C. J., Green, M. R., Golub, T. R., Lander, E. S., & Young, R. A. (1998) · Cell · doi:10.1016/s0092-8674(00)81641-4 · Cited by 1,670
The Mediator complex: a central integrator of transcription
Allen, B. L., & Taatjes, D. J. (2015) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3951 · Cited by 922
How the ubiquitin–proteasome system controls transcription
Muratani, M., & Tansey, W. P. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1049 · Cited by 693
Transcriptional coactivator complexes.
Näär, A. M., Lemon, B. D., & Tjian, R. (2001) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.70.1.475 · Cited by 571
The code and beyond: transcription regulation by the RNA polymerase II carboxy-terminal domain
Harlen, K. M., & Churchman, L. S. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.10 · Cited by 499
Metadata
- Authors
- Myers, L. C., Gustafsson, C. M., Bushnell, D. A., Lui, M., Erdjument-Bromage, H., Tempst, P., & Kornberg, R. D.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1998-01-01
- Volume
- 12
- Issue
- 1
- Pages
- 45-54
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2135992596
- Cited by
- 306
- References
- 2
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Myers, L. C., Gustafsson, C. M., Bushnell, D. A., Lui, M., Erdjument-Bromage, H., Tempst, P., & Kornberg, R. D. (1998). The Med proteins of yeast and their function through the RNA polymerase II carboxy-terminal domain. Genes & Development. https://doi.org/10.1101/gad.12.1.45
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