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Fgf-10 is required for both limb and lung development and exhibits striking functional similarity to Drosophila branchless
Open accessAbstract
Fgf-10-deficient mice (Fgf-10−/−) were generated to determine the role(s) of Fgf-10 in vertebrate development. Limb bud initiation was abolished in Fgf-10−/− mice. Strikingly,Fgf-10−/− fetuses continued to develop until birth, despite the complete absence of both fore- and hindlimbs. Fgf-10 is necessary for apical ectodermal ridge (AER) formation and acts epistatically upstream of Fgf-8, the earliest known AER marker in mice.Fgf-10−/− mice exhibited perinatal lethality associated with complete absence of lungs. Although tracheal development was normal, main-stem bronchial formation, as well as all subsequent pulmonary branching morphogenesis, was completely disrupted. The pulmonary phenotype of Fgf-10−/− mice is strikingly similar to that of the Drosophila mutant branchless, an Fgf homolog.
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Metadata
- Authors
- Min, H., Danilenko, D. M., Scully, S. A., Bolon, B., Ring, B. D., Tarpley, J. E., DeRose, M., & Simonet, W. S.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1998-10-15
- Volume
- 12
- Issue
- 20
- Pages
- 3156-3161
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W1978596841
- Cited by
- 879
- References
- 0
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Min, H., Danilenko, D. M., Scully, S. A., Bolon, B., Ring, B. D., Tarpley, J. E., DeRose, M., & Simonet, W. S. (1998). Fgf-10 is required for both limb and lung development and exhibits striking functional similarity to Drosophila branchless. Genes & Development. https://doi.org/10.1101/gad.12.20.3156
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