The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Primitive neural stem cells from the mammalian epiblast differentiate to definitive neural stem cells under the control of Notch signaling
Open accessAbstract
Basic fibroblast growth factor (FGF2)-responsive definitive neural stem cells first appear in embryonic day 8.5 (E8.5) mouse embryos, but not in earlier embryos, although neural tissue exists at E7.5. Here, we demonstrate that leukemia inhibitory factor-dependent (but not FGF2-dependent) sphere-forming cells are present in the earlier (E5.5–E7.5) mouse embryo. The resultant clonal sphere cells possess self-renewal capacity and neural multipotentiality, cardinal features of the neural stem cell. However, they also retain some nonneural properties, suggesting that they are the in vivo cells' equivalent of the primitive neural stem cells that form in vitro from embryonic stem cells. The generation of the in vivo primitive neural stem cell was independent of Notch signaling, but the activation of the Notch pathway was important for the transition from the primitive to full definitive neural stem cell properties and for the maintenance of the definitive neural stem cell state.
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Cites
Subventricular zone astrocytes are neural stem cells in the adult mammalian brain
Doetsch, F., Caillé, I., Lim, D. A., García-Verdugo, J. M., & Alvarez-Buylla, A. (1999) · Cell · doi:10.1016/s0092-8674(00)80783-7 · Cited by 3,898
Conversion of embryonic stem cells into neuroectodermal precursors in adherent monoculture
Ying, Q.-L., Stavridis, M., Griffiths, D., Li, M., & Smith, A. (2003) · Nature Biotechnology · doi:10.1038/nbt780 · Cited by 1,504
Wood, H. B., & Episkopou, V. (1999) · Mechanisms of Development · doi:10.1016/s0925-4773(99)00116-1 · Cited by 550
The bHLH Gene Hes1 as a Repressor of the Neuronal Commitment of CNS Stem Cells
Nakamura, Y., Sakakibara, S.-I., Miyata, T., Ogawa, M., Shimazaki, T., Weiss, S., Kageyama, R., & Okano, H. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-01-00283.2000 · Cited by 316
Cited by
Adult neurogenesis and functional plasticity in neuronal circuits
Lledo, P.-M., Alonso, M., & Grubb, M. S. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1867 · Cited by 1,366
Notch Promotes Radioresistance of Glioma Stem Cells
Wang, J., Wakeman, T. P., Lathia, J. D., Hjelmeland, A. B., Wang, X.-F., White, R. R., Rich, J. N., & Sullenger, B. A. (2010) · Stem Cells · doi:10.1002/stem.261 · Cited by 656
Direct reprogramming of mouse fibroblasts to neural progenitors
Kim, J., Efe, J. A., Zhu, S., Talantova, M., Yuan, X., Wang, S., Lipton, S. A., Zhang, K., & Ding, S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1103113108 · Cited by 572
Reinhardt, P., Schmid, B., Burbulla, L. F., Schöndorf, D. C., Wagner, L., Glatza, M., Höing, S., Hargus, G., Heck, S. A., Dhingra, A., et al. (2013) · Cell Stem Cell · doi:10.1016/j.stem.2013.01.008 · Cited by 502
Roles of bHLH genes in neural stem cell differentiation
Kageyama, R., Ohtsuka, T., Hatakeyama, J., & Ohsawa, R. (2005) · Experimental Cell Research · doi:10.1016/j.yexcr.2005.03.015 · Cited by 481
Metadata
- Authors
- Hitoshi, S., Seaberg, R. M., Koscik, C., Alexson, T., Kusunoki, S., Kanazawa, I., Tsuji, S., & van der Kooy, D.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2004-08-01
- Volume
- 18
- Issue
- 15
- Pages
- 1806-1811
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2137835411
- Cited by
- 190
- References
- 4
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Hitoshi, S., Seaberg, R. M., Koscik, C., Alexson, T., Kusunoki, S., Kanazawa, I., Tsuji, S., & van der Kooy, D. (2004). Primitive neural stem cells from the mammalian epiblast differentiate to definitive neural stem cells under the control of Notch signaling. Genes & Development. https://doi.org/10.1101/gad.1208404
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
