The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Essential and separable roles for Syndecan-3 and Syndecan-4 in skeletal muscle development and regeneration
Open accessAbstract
Syndecan-3 and syndecan-4 function as coreceptors for tyrosine kinases and in cell adhesion. Syndecan-3-/- mice exhibit a novel form of muscular dystrophy characterized by impaired locomotion, fibrosis, and hyperplasia of myonuclei and satellite cells. Explanted syndecan-3-/- satellite cells mislocalize MyoD, differentiate aberrantly, and exhibit a general increase in overall tyrosine phosphorylation. Following induced regeneration, the hyperplastic phenotype is recapitulated. While there are fewer apparent defects in syndecan-4-/- muscle, explanted satellite cells are deficient in activation, proliferation, MyoD expression, myotube fusion, and differentiation. Further, syndecan-4-/- satellite cells fail to reconstitute damaged muscle, suggesting a unique requirement for syndecan-4 in satellite cell function.
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“skeletal muscle harbors considerable regenerative capacity due to the presence of adult muscle stem cells (MuSC), also known as satellite cells, which play a major role in postnatal muscle growth and repair (Collins et al., 2005; Cornelison et al., 2004; Kuang et al., 2007; Montarras et al., 2005; Sacco et al., 2008).”
From Short Telomeres and Stem Cell Exhaustion Model Duchenne Muscular Dystrophy in mdx/mTR Mice (2010) · cites this paper as Cornelison et al., 2004
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“Syndecan-4 (Sdc4) is expressed in SCs and is required for SC activation21,22, but a role for Sdc4 in myofibers remains elusive.”
From In vivo partial reprogramming of myofibers promotes muscle regeneration by remodeling the stem cell niche (2021) · cites this paper as [22]
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Citations
Cites
Myogenic satellite cells: physiology to molecular biology
Hawke, T. J., & Garry, D. J. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.91.2.534 · Cited by 1,646
Cornelison, D., & Wold, B. J. (1997) · Developmental Biology · doi:10.1006/dbio.1997.8721 · Cited by 934
Self-citationSyndecans: multifunctional cell-surface co-receptors
Carey, D. J. (1997) · Biochemical Journal · doi:10.1042/bj3270001 · Cited by 687
HGF/SF Is Present in Normal Adult Skeletal Muscle and Is Capable of Activating Satellite Cells
Tatsumi, R., Anderson, J. E., Nevoret, C. J., Halevy, O., & Allen, R. E. (1998) · Developmental Biology · doi:10.1006/dbio.1997.8803 · Cited by 685
A New Look at the Origin, Function, and “Stem-Cell” Status of Muscle Satellite Cells
Seale, P., & Rudnicki, M. A. (2000) · Developmental Biology · doi:10.1006/dbio.1999.9565 · Cited by 590
Skeletal muscle satellite cells
Schultz, E., & McCormick, K. M. (1994) · Reviews of physiology, biochemistry and pharmacology · doi:10.1007/bfb0030904 · Cited by 526
Delayed wound repair and impaired angiogenesis in mice lacking syndecan-4
Echtermeyer, F. G., Streit, M., Wilcox‐Adelman, S. A., Saoncella, S., Denhez, F., Detmar, M. J., & Goetinck, P. F. (2001) · Journal of Clinical Investigation · doi:10.1172/jci10559 · Cited by 427
Self-citationHepatocyte growth factor activates quiescent skeletal muscle satellite cells in vitro
Allen, R. E., Sheehan, S. M., Taylor, R. G., Kendall, T. L., & Rice, G. M. (1995) · Journal of Cellular Physiology · doi:10.1002/jcp.1041650211 · Cited by 422
Cornelison, D., Filla, M. S., Stanley, H. M., Rapraeger, A. C., & Olwin, B. B. (2001) · Developmental Biology · doi:10.1006/dbio.2001.0416 · Cited by 399
Self-citationMyoD−/− Satellite Cells in Single-Fiber Culture Are Differentiation Defective and MRF4 Deficient
Cornelison, D., Olwin, B. B., Rudnicki, M. A., & Wold, B. J. (2000) · Developmental Biology · doi:10.1006/dbio.2000.9682 · Cited by 314
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Yamashita, Y., & Arikawa‐Hirasawa, E. (2026) · Trends in Glycoscience and Glycotechnology · doi:10.4052/tigg.2416.1e
Yamashita, Y., & Arikawa‐Hirasawa, E. (2026) · Trends in Glycoscience and Glycotechnology · doi:10.4052/tigg.2416.1j
Activating FGFR1 restores Integrin-β1–mediated fibronectin sensing in satellite cells of aged micePreprint
Chang, T.-L., Vallery, T. K., Zlatkov, T. S., Cutler, A. A., Kurland, J. V., Butcher, C. H., Anseth, K. S., & Olwin, B. B. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.02.18.706475
Self-citationGénération et optimisation de microtissus musculaires 3D in vitro
Kalman, B. (2016) · theses.fr (ABES) · doi:10.70675/826fb1c6zbf1az47f5z90fdz22cb39f3a644
The extracellular matrix as a biomaterial to optimize skeletal muscle regeneration
Trignol, A. (2019) · theses.fr (ABES) · doi:10.70675/0610b575z71faz4ea8zb917z1c4ad5f29d23
Fibrose musculaire : acteurs cellulaires et stratégies thérapeutiques
Bensalah, M. (2019) · theses.fr (ABES) · doi:10.70675/26f11f97zd40az491cz93fcz9608314a2b03
Étude du rôle de RhoA dans la plasticité du muscle squelettique
Noviello, C. (2020) · theses.fr (ABES) · doi:10.70675/c46c1ebdzfce4z41acza3c0z0443139c7e5a
Investigation of the molecular diversity defining muscle stem cell heterogeneity
Benavente-Diaz, M. (2020) · theses.fr (ABES) · doi:10.70675/a5426795z7433z497fz9698z63a9efd33839
Liu, X., Carbajal, E. E. P., Hwang, Y.-C., Mapkar, S. A., Gilman, B. W., Bliss, S. A., Tran, L. B., Mehta, K. T., Banyasz, J. O., Yu, M., et al. (2026) · Advanced Science · doi:10.1002/advs.202507444
Fu, S., Meng, Y., Liang, K., & Feng, M. (2026) · Biomolecules · doi:10.3390/biom16091238
Engelbrecht, L. (2013) · SUNScholar (Stellenbosch University)
Metadata
- Authors
- Cornelison, D. D. W., Wilcox-Adelman, S. A., Goetinck, P. F., Rauvala, H., Rapraeger, A. C., & Olwin, B. B.
- Affiliations
- University of Helsinki (FI)
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2004-09-15
- Volume
- 18
- Issue
- 18
- Pages
- 2231-2236
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- PMC
- PMC517515
- OpenAlex
- W2094191351
- Cited by
- 317
- References
- 20
- Citations by year
- 2026: 7 · 2025: 8 · 2024: 14 · 2023: 12 · 2022: 14 · 2021: 11 · 2020: 21 · 2019: 12 · 2018: 7 · 2017: 12 · 2016: 14 · 2015: 17 · 2014: 18 · 2013: 26 · 2012: 21
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genes & Development (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Heart Association
- National Institutes of Health (AR39467)
- National Institute of General Medical Sciences (GM 48850, R01GM048850)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR39467, R01AR039467)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD37490, HD21881, R01HD037490)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- syndecan-3, syndecan-4, skeletal muscle development, muscle regeneration, satellite cells, muscular dystrophy, MyoD, myotube fusion, satellite cell differentiation, tyrosine phosphorylation, muscle fibrosis
- MeSH terms
- Animals, Cell Division, Cells, Cultured, Female, Membrane Glycoproteins, Mice, Mutant Strains, Muscular Dystrophies, Proteoglycans, Regeneration, MyoD Protein, Muscle, Skeletal, Muscle Fibers, Skeletal, Gene Expression Regulation, Developmental, Muscle Development, Satellite Cells, Skeletal Muscle, Mice, Syndecan-3, Syndecan-4
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